iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/SKP1	2.30e-31	108.0	127	174

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/SKP1

   S: 1    ksLLdltcktVadmikgktpeeiRktFnienDftpeEeakvReEnqWA 48
           k+LLd+tcktVa+mikgk+peeiR+tFni+nDftpeEe+++R+En+W+
   Q: 127  KGLLDVTCKTVANMIKGKSPEEIRRTFNIKNDFTPEEEEQIRKENAWC 174
           89*********************************************8 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates cell proliferation during embryonic and larval development (PubMed:11864567, PubMed:11864566). Involved in synapse elimination in early synapse development (PubMed:17626846). May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress (PubMed:18340346). Plays a role in sex determination (PubMed:18718460).

Protein Sequence
(Fasta)

MADQKKVSEA AKEREIKISS SDNEIFLVPR NVIRLSNTIN TLLMDLGLDD EEGTNAEPIP 60
VQNVTASILK KVISWCNHHH SDPISTEDSD NREKRTDDIG SWDVEFLKVD QGTLFELILA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACACACTCAC ATTCTATTCG CTCATTTCTC AACGTTCTCA TTCTATTTTT CGTTGTTTTT 60
CTTTGTTTTG CAGGTATTTT GCGTTGGAAA ATTTAAAACT TTTAATTTTT CTCGATGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016897--SKP1
IPR001232--SKP1-like
IPR011333--SKP1/BTB/POZ
IPR016072--Skp1_comp_dimer
IPR016073--Skp1_comp_POZ

Pfam

PF01466--Skp1
PF03931--Skp1_POZ

SMART

SM00512--Skp1

Gene Ontology

GO:0046660--P:female sex differentiation
GO:0010826--P:negative regulation of centrosome duplication
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0010629--P:negative regulation of gene expression
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0007399--P:nervous system development
GO:0043065--P:positive regulation of apoptotic process
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_F46A9.5

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001036	Aegilops tauschii	51.19	2.00e-43	166.00
IUUC-Aml-002023	Ailuropoda melanoleuca	67.70	1.00e-51	194.00
IUUC-Atr-002858	Amborella trichopoda	53.42	4.00e-35	139.00
IUUC-Apl-003393	Anas platyrhynchos	67.70	1.00e-51	194.00
IUUC-Aca-004709	Anolis carolinensis	67.70	1.00e-51	194.00
IUUC-Aly-006066	Arabidopsis lyrata	51.48	8.00e-36	141.00
IUUC-Ath-007456	Arabidopsis thaliana	51.53	3.00e-39	152.00
IUUC-Ago-007847	Ashbya gossypii	58.47	2.00e-37	147.00
IUUC-Acl-008178	Aspergillus clavatus	58.39	3.00e-50	189.00
IUUC-Afl-008452	Aspergillus flavus	60.25	2.00e-52	196.00
IUUC-Afu-008785	Aspergillus fumigatus	59.01	3.00e-50	189.00
IUUC-Ani-009312	Aspergillus nidulans	56.71	1.00e-46	177.00
IUUC-Aor-010012	Aspergillus oryzae	60.25	2.00e-52	196.00
IUUC-Ate-010375	Aspergillus terreus	59.75	1.00e-50	190.00
IUUC-Ame-011025	Astyanax mexicanus	67.08	2.00e-51	193.00
IUUC-Bgr-012280	Blumeria graminis	50.68	9.00e-32	127.00
IUUC-Bta-013519	Bos taurus	67.70	1.00e-51	194.00
IUUC-Bci-013888	Botrytis cinerea	58.06	2.00e-33	133.00
IUUC-Bdi-014547	Brachypodium distachyon	49.10	7.00e-34	134.00
IUUC-Bol-015842	Brassica oleracea	54.04	2.00e-37	146.00
IUUC-Bra-017558	Brassica rapa	48.78	3.00e-37	145.00
IUUC-Cja-019823	Callithrix jacchus	64.60	3.00e-47	179.00
IUUC-Cfa-020931	Canis familiaris	67.70	1.00e-51	193.00
IUUC-Cpo-022487	Cavia porcellus	67.08	2.00e-49	186.00
IUUC-Cre-022751	Chlamydomonas reinhardtii	53.70	5.00e-39	152.00
IUUC-Csa-023459	Chlorocebus sabaeus	67.08	2.00e-51	192.00
IUUC-Cho-024854	Choloepus hoffmanni	66.22	2.00e-18	82.80
IUUC-Cin-025538	Ciona intestinalis	65.22	1.00e-47	180.00
IUUC-Csv-025865	Ciona savignyi	64.60	6.00e-52	194.00
IUUC-Cgl-026548	Colletotrichum gloeosporioides	52.98	5.00e-41	158.00
IUUC-Cne-027058	Cryptococcus neoformans	55.29	7.00e-51	191.00
IUUC-Cme-027174	Cyanidioschyzon merolae	46.30	1.00e-36	144.00
IUUC-Dre-027756	Danio rerio	67.08	2.00e-51	193.00
IUUC-Dno-028924	Dasypus novemcinctus	67.70	1.00e-51	194.00
IUUC-Dor-030847	Dipodomys ordii	63.98	3.00e-49	186.00
IUUC-Dse-031209	Dothistroma septosporum	55.56	7.00e-47	178.00
IUUC-Dme-032028	Drosophila melanogaster	63.35	8.00e-58	214.00
IUUC-Ete-033117	Echinops telfairi	65.84	3.00e-48	182.00
IUUC-Eca-033320	Equus caballus	67.70	1.00e-51	194.00
IUUC-Eeu-034817	Erinaceus europaeus	89.36	2.00e-20	88.20
IUUC-Fca-035423	Felis catus	67.70	1.00e-51	194.00
IUUC-Fal-036956	Ficedula albicollis	67.70	1.00e-51	194.00
IUUC-Fox-037761	Fusarium oxysporum	54.78	3.00e-44	169.00
IUUC-Fso-038451	Fusarium solani	53.95	6.00e-41	158.00
IUUC-Gmo-039178	Gadus morhua	67.70	9.00e-52	194.00
IUUC-Ggr-039831	Gaeumannomyces graminis	56.00	2.00e-42	163.00
IUUC-Gga-040238	Gallus gallus	67.70	1.00e-51	194.00
IUUC-Gac-041965	Gasterosteus aculeatus	67.70	9.00e-52	194.00
IUUC-Gma-042996	Glycine max	53.42	1.00e-34	137.00
IUUC-Ggo-045025	Gorilla gorilla	67.70	1.00e-51	194.00
IUUC-Hsa-046875	Homo sapiens	67.70	1.00e-51	194.00
IUUC-Hvu-047497	Hordeum vulgare	50.59	5.00e-38	148.00
IUUC-Itr-047900	Ictidomys tridecemlineatus	65.84	6.00e-50	188.00
IUUC-Kpa-049138	Komagataella pastoris	45.70	2.00e-37	147.00
IUUC-Lch-050522	Latimeria chalumnae	71.34	7.00e-57	211.00
IUUC-Lpe-051398	Leersia perrieri	49.39	6.00e-38	149.00
IUUC-Loc-052596	Lepisosteus oculatus	67.70	9.00e-52	194.00
IUUC-Lma-053020	Leptosphaeria maculans	53.95	1.00e-39	154.00
IUUC-Laf-053847	Loxodonta africana	67.70	1.00e-51	194.00
IUUC-Mor-057176	Magnaporthe oryzae	55.03	6.00e-43	165.00
IUUC-Mpo-057471	Magnaporthe poae	56.00	2.00e-42	163.00
IUUC-Mtr-058458	Medicago truncatula	51.88	3.00e-42	162.00
IUUC-Mla-059153	Melampsora laricipopulina	56.52	6.00e-44	168.00
IUUC-Mga-059864	Meleagris gallopavo	67.70	1.00e-51	194.00
IUUC-Mvi-060342	Microbotryum violaceum	57.32	1.00e-47	180.00
IUUC-Mdo-062509	Monodelphis domestica	67.70	1.00e-51	194.00
IUUC-Mmu-063694	Mus musculus	67.70	9.00e-52	194.00
IUUC-Mac-064537	Musa acuminata	53.42	4.00e-34	135.00
IUUC-Mpu-065990	Mustela putorius furo	67.70	1.00e-51	194.00
IUUC-Mlu-068168	Myotis lucifugus	67.70	1.00e-51	194.00
IUUC-Nfi-068309	Neosartorya fischeri	59.01	3.00e-50	189.00
IUUC-Ncr-068658	Neurospora crassa	53.69	2.00e-41	159.00
IUUC-Nle-070101	Nomascus leucogenys	67.70	1.00e-51	194.00
IUUC-Opr-070881	Ochotona princeps	67.70	1.00e-51	194.00
IUUC-Ont-071529	Oreochromis niloticus	67.70	9.00e-52	194.00
IUUC-Oan-073000	Ornithorhynchus anatinus	87.72	7.00e-27	110.00
IUUC-Ocu-073780	Oryctolagus cuniculus	67.70	1.00e-51	194.00
IUUC-Oba-075368	Oryza barthii	46.33	3.00e-34	135.00
IUUC-Obr-076526	Oryza brachyantha	52.66	7.00e-36	141.00
IUUC-Ogl-077679	Oryza glaberrima	46.33	4.00e-34	135.00
IUUC-Ogu-078125	Oryza glumaepatula	46.89	3.00e-34	136.00
IUUC-Oin-079779	Oryza indica	46.33	2.00e-34	136.00
IUUC-Olo-080736	Oryza longistaminata	43.11	4.00e-32	129.00
IUUC-Ome-081330	Oryza meridionalis	47.16	2.00e-34	136.00
IUUC-Oni-082143	Oryza nivara	46.33	2.00e-34	136.00
IUUC-Opu-083354	Oryza punctata	48.02	4.00e-32	129.00
IUUC-Oru-084246	Oryza rufipogon	47.46	5.00e-31	125.00
IUUC-Osa-085416	Oryza sativa	46.33	2.00e-34	136.00
IUUC-Ola-087270	Oryzias latipes	67.70	9.00e-52	194.00
IUUC-Olu-087667	Ostreococcus lucimarinus	51.55	5.00e-42	161.00
IUUC-Oga-089073	Otolemur garnettii	67.70	1.00e-51	194.00
IUUC-Oar-089762	Ovis aries	58.01	7.00e-43	165.00
IUUC-Ptr-090872	Pan troglodytes	63.98	5.00e-49	185.00
IUUC-Pan-091780	Papio anubis	67.70	1.00e-51	194.00
IUUC-Psi-093135	Pelodiscus sinensis	67.70	1.00e-51	194.00
IUUC-Pno-094810	Phaeosphaeria nodorum	52.90	3.00e-38	149.00
IUUC-Ppa-095244	Physcomitrella patens	52.47	3.00e-39	152.00
IUUC-Pfo-097529	Poecilia formosa	67.70	9.00e-52	194.00
IUUC-Pab-098533	Pongo abelii	67.70	1.00e-51	194.00
IUUC-Pop-098957	Populus trichocarpa	55.28	4.00e-39	152.00
IUUC-Pca-100783	Procavia capensis	58.39	1.00e-40	157.00
IUUC-Ppe-101463	Prunus persica	54.38	5.00e-44	168.00
IUUC-Pva-102901	Pteropus vampyrus	67.70	1.00e-51	194.00
IUUC-Pgr-103499	Puccinia graminis	54.94	4.00e-44	168.00
IUUC-Ptt-103874	Puccinia triticina	66.94	8.00e-45	172.00
IUUC-Pte-104224	Pyrenophora teres	52.35	1.00e-34	137.00
IUUC-Pyt-104750	Pyrenophora triticirepentis	52.26	2.00e-36	143.00
IUUC-Rno-105499	Rattus norvegicus	67.70	7.00e-52	194.00
IUUC-Sce-106387	Saccharomyces cerevisiae	60.17	6.00e-37	145.00
IUUC-Sja-107902	Schizosaccharomyces japonicus	55.21	8.00e-46	174.00
IUUC-Spo-108033	Schizosaccharomyces pombe	57.06	4.00e-47	179.00
IUUC-Ssl-108591	Sclerotinia sclerotiorum	55.78	7.00e-41	158.00
IUUC-Smo-109307	Selaginella moellendorffii	51.88	1.00e-37	147.00
IUUC-Sit-110435	Setaria italica	48.54	1.00e-35	140.00
IUUC-Sly-111529	Solanum lycopersicum	53.99	2.00e-37	147.00
IUUC-Stu-112023	Solanum tuberosum	55.70	9.00e-37	144.00
IUUC-Sar-112973	Sorex araneus	65.22	2.00e-44	170.00
IUUC-Sbi-114394	Sorghum bicolor	50.00	3.00e-38	149.00
IUUC-Sre-115178	Sporisorium reilianum	56.17	1.00e-49	187.00
IUUC-Tgu-116474	Taeniopygia guttata	67.70	1.00e-51	194.00
IUUC-Tru-118429	Takifugu rubripes	67.70	9.00e-52	194.00
IUUC-Tsy-118896	Tarsius syrichta	67.70	1.00e-51	194.00
IUUC-Tni-119960	Tetraodon nigroviridis	67.70	9.00e-52	194.00
IUUC-Tca-121022	Theobroma cacao	55.56	1.00e-37	147.00
IUUC-Tre-122004	Trichoderma reesei	53.29	1.00e-35	140.00
IUUC-Tvi-122449	Trichoderma virens	51.85	8.00e-36	141.00
IUUC-Tae-125854	Triticum aestivum	51.19	2.00e-43	166.00
IUUC-Tur-126793	Triticum urartu	50.90	3.00e-41	159.00
IUUC-Tme-127078	Tuber melanosporum	57.67	2.00e-42	163.00
IUUC-Tbe-127720	Tupaia belangeri	67.70	1.00e-51	194.00
IUUC-Ttr-129035	Tursiops truncatus	67.70	1.00e-51	194.00
IUUC-Uma-129517	Ustilago maydis	54.94	3.00e-48	182.00
IUUC-Vda-129691	Verticillium dahliae	57.24	2.00e-37	146.00
IUUC-Vpa-130128	Vicugna pacos	68.32	1.00e-51	194.00
IUUC-Vvi-130876	Vitis vinifera	52.76	4.00e-43	165.00
IUUC-Xtr-132393	Xenopus tropicalis	67.70	1.00e-51	194.00
IUUC-Xma-133603	Xiphophorus maculatus	67.70	9.00e-52	194.00
IUUC-Yli-134499	Yarrowia lipolytica	55.42	4.00e-44	169.00
IUUC-Zma-135354	Zea mays	50.00	7.00e-36	141.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence