iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063095

Ensembl Protein ID

ENSMUSP00000121266.1

UniProt Accession

Q99K90; Q3UGP1; Q8BTP4; Q8CHD3; Q99KP4; TAB2_MOUSE

Genbank Protein ID

AAM10487.1; AAH04072.1; AAH04813.1; BAC40772.1; BAE28166.1; BAC41446.1

Protein Name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TGF-beta-activated kinase 1-binding protein 2

Genbank Nucleotide ID

AY093701; BC004072; BC004813; AK089164; AK147830; AB093262

Gene Name

Tab2; Kiaa0733; Map3k7ip2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000015755.16	ENSMUST00000146444.7	ENSMUSP00000121266.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	15029239; 16603398; 19927120

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	1.90e-14	54.0	665	692
UBD/Alpha-Helix/CUE	1.80e-07	32.2	11	50

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           +aqW+C+aCTflN+P++++Ce+C++pR+
   Q: 665  GAQWNCTACTFLNHPALIRCEQCEMPRH 692
           79*************************8 PP

UBD/Alpha-Helix/CUE

   S: 4    taleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           + l+ L++ FP++++ v+ +++++n+++l+a++  L ++s
   Q: 11   QVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQES 50
           689**********************************998 PP

Organism

Mus musculus

Functional Description
(View)

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187' (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development (By similarity).

Protein Sequence
(Fasta)

MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES TRYLYGEGDL 60
NFSDESGISG LRNHMTSLNL DLQSQNVYHH GREGSRVNGS RTLTHSVSDG QLHGGQSNNE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCTGGCGG AGCCGCGGCG CGAGCGGGCG AGCGAGCGAG AGCTGGGGGG GTGGGGGGAG 60
GGCAGGCGAG CGGCAGGGGG GTGGGGGCGG AGGGAGGCAG GGCGGCCGTG CGAGCCGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003892--CUE
IPR001876--Znf_RanBP2

PROSITE

PS51140--CUE
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF02845--CUE

SMART

SM00546--CUE
SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0070530--F:K63-linked polyubiquitin binding
GO:0008270--F:zinc ion binding
GO:0007507--P:heart development
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045860--P:positive regulation of protein kinase activity

KEGG

mmu:68652

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001681	Ailuropoda melanoleuca	95.53	0.00e+00	1274.00
IUUC-Apl-004125	Anas platyrhynchos	74.08	0.00e+00	983.00
IUUC-Aca-005332	Anolis carolinensis	83.29	0.00e+00	1103.00
IUUC-Ame-010937	Astyanax mexicanus	56.06	6.00e-178	617.00
IUUC-Bta-012567	Bos taurus	94.95	0.00e+00	1255.00
IUUC-Cja-020008	Callithrix jacchus	94.08	0.00e+00	1207.00
IUUC-Cfa-020602	Canis familiaris	94.66	0.00e+00	1263.00
IUUC-Cpo-022483	Cavia porcellus	90.84	0.00e+00	1164.00
IUUC-Csa-024196	Chlorocebus sabaeus	94.81	0.00e+00	1237.00
IUUC-Cho-025022	Choloepus hoffmanni	87.62	1.00e-51	197.00
IUUC-Cin-025456	Ciona intestinalis	33.82	2.00e-25	109.00
IUUC-Dre-027773	Danio rerio	53.36	3.00e-151	528.00
IUUC-Dno-029801	Dasypus novemcinctus	92.64	0.00e+00	1236.00
IUUC-Dor-030605	Dipodomys ordii	95.24	0.00e+00	1294.00
IUUC-Ete-032438	Echinops telfairi	91.49	0.00e+00	1232.00
IUUC-Eca-033410	Equus caballus	95.82	0.00e+00	1282.00
IUUC-Eeu-034509	Erinaceus europaeus	92.64	0.00e+00	1240.00
IUUC-Fca-035548	Felis catus	94.95	0.00e+00	1221.00
IUUC-Fal-037250	Ficedula albicollis	86.68	0.00e+00	1154.00
IUUC-Gmo-039053	Gadus morhua	65.62	3.00e-47	180.00
IUUC-Gga-040871	Gallus gallus	86.82	0.00e+00	1132.00
IUUC-Gac-041832	Gasterosteus aculeatus	63.18	0.00e+00	720.00
IUUC-Ggo-044976	Gorilla gorilla	94.66	0.00e+00	1235.00
IUUC-Hsa-045963	Homo sapiens	94.66	0.00e+00	1235.00
IUUC-Itr-048861	Ictidomys tridecemlineatus	94.57	0.00e+00	934.00
IUUC-Lch-050144	Latimeria chalumnae	75.25	0.00e+00	969.00
IUUC-Loc-052931	Lepisosteus oculatus	63.80	0.00e+00	820.00
IUUC-Laf-053883	Loxodonta africana	95.38	0.00e+00	1259.00
IUUC-Mcc-054597	Macaca mulatta	94.66	0.00e+00	1233.00
IUUC-Meu-056202	Macropus eugenii	90.22	0.00e+00	831.00
IUUC-Mor-057018	Magnaporthe oryzae	64.00	2.00e-05	44.30
IUUC-Mla-059157	Melampsora laricipopulina	46.15	2.00e-03	36.60
IUUC-Mga-059601	Meleagris gallopavo	73.23	0.00e+00	914.00
IUUC-Mmr-061047	Microcebus murinus	95.53	0.00e+00	1263.00
IUUC-Mdo-061944	Monodelphis domestica	91.85	0.00e+00	1189.00
IUUC-Mpu-066232	Mustela putorius furo	95.24	0.00e+00	1273.00
IUUC-Mlu-067513	Myotis lucifugus	94.37	0.00e+00	1255.00
IUUC-Nle-069405	Nomascus leucogenys	94.95	0.00e+00	1244.00
IUUC-Opr-071184	Ochotona princeps	93.77	3.00e-120	426.00
IUUC-Ont-071678	Oreochromis niloticus	61.76	0.00e+00	682.00
IUUC-Oan-072975	Ornithorhynchus anatinus	79.27	1.00e-160	560.00
IUUC-Ocu-073763	Oryctolagus cuniculus	95.24	0.00e+00	1242.00
IUUC-Olo-080805	Oryza longistaminata	40.00	2.00e-03	35.40
IUUC-Ola-087478	Oryzias latipes	56.08	0.00e+00	639.00
IUUC-Oga-088892	Otolemur garnettii	86.59	0.00e+00	1174.00
IUUC-Oar-089573	Ovis aries	95.67	0.00e+00	1261.00
IUUC-Ptr-091270	Pan troglodytes	94.66	0.00e+00	1235.00
IUUC-Pan-092250	Papio anubis	94.66	0.00e+00	1236.00
IUUC-Psi-093732	Pelodiscus sinensis	85.24	0.00e+00	1129.00
IUUC-Pma-094397	Petromyzon marinus	36.02	7.00e-35	141.00
IUUC-Pfo-097098	Poecilia formosa	60.69	0.00e+00	665.00
IUUC-Pab-098776	Pongo abelii	94.95	0.00e+00	1238.00
IUUC-Pca-100202	Procavia capensis	90.48	0.00e+00	1164.00
IUUC-Pva-103025	Pteropus vampyrus	94.81	0.00e+00	1236.00
IUUC-Rno-105366	Rattus norvegicus	97.69	0.00e+00	1346.00
IUUC-Sha-107249	Sarcophilus harrisii	90.92	0.00e+00	1200.00
IUUC-Stu-112401	Solanum tuberosum	37.29	9.00e-04	36.60
IUUC-Sar-113207	Sorex araneus	94.57	0.00e+00	941.00
IUUC-Ssc-116409	Sus scrofa	93.36	0.00e+00	1230.00
IUUC-Tgu-116911	Taeniopygia guttata	86.82	0.00e+00	1156.00
IUUC-Tru-118667	Takifugu rubripes	58.44	0.00e+00	653.00
IUUC-Tsy-119562	Tarsius syrichta	93.90	0.00e+00	710.00
IUUC-Tni-120195	Tetraodon nigroviridis	55.31	7.00e-177	613.00
IUUC-Tbe-127934	Tupaia belangeri	93.22	0.00e+00	1244.00
IUUC-Ttr-128519	Tursiops truncatus	95.81	0.00e+00	720.00
IUUC-Vpa-130279	Vicugna pacos	91.38	0.00e+00	1203.00
IUUC-Xtr-131844	Xenopus tropicalis	77.40	0.00e+00	1008.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence