iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-105366

Ensembl Protein ID

ENSRNOP00000021904.3

UniProt Accession

Q5U303; TAB2_RAT

Genbank Protein ID

AAH85788.1; ENSRNOP00000021904

Protein Name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TGF-beta-activated kinase 1-binding protein 2

Genbank Nucleotide ID

BC085788; CK364963

Gene Name

Tab2; Map3k7ip2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000016054.7	ENSRNOT00000061999.5	ENSRNOP00000058709.2
ENSRNOG00000016054.7	ENSRNOT00000021905.6	ENSRNOP00000021904.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	15029239; 18299187

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	1.10e-14	54.0	665	692
UBD/Alpha-Helix/CUE	1.00e-07	32.2	11	50

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           +aqW+C+aCTflN+P++++Ce+C++pR+
   Q: 665  GAQWNCTACTFLNHPALIRCEQCEMPRH 692
           79*************************8 PP

UBD/Alpha-Helix/CUE

   S: 4    taleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           + l+ L++ FP++++ v+ +++++n+++l+a++  L ++s
   Q: 11   QVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQES 50
           689**********************************998 PP

Organism

Rattus norvegicus

Functional Description
(View)

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (By similarity).

Protein Sequence
(Fasta)

MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES TRYLYGEGDL 60
NFSDESGISG LRNHMTSLNL DLQSQNVYHH GREGSRVNGS RTLTHSVSDG QLQGGQSNNE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGCTGGC GGGCGGGCGG CCGAGGTGAC GGAGGCGGCA GCAGCGGCGG CGACGACGGG 60
GGAGACGGCT GCCCAAGTGG GAGAGGCGGC GGCGGCGGAC GAGGAGGAGG GGGAAGCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003892--CUE
IPR001876--Znf_RanBP2

PROSITE

PS51140--CUE
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF02845--CUE

SMART

SM00546--CUE
SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0070530--F:K63-linked polyubiquitin binding
GO:0008270--F:zinc ion binding
GO:0007507--P:heart development
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045860--P:positive regulation of protein kinase activity

KEGG

rno:308267

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001681	Ailuropoda melanoleuca	94.37	0.00e+00	1268.00
IUUC-Apl-004125	Anas platyrhynchos	73.40	0.00e+00	981.00
IUUC-Aca-005332	Anolis carolinensis	83.29	0.00e+00	1106.00
IUUC-Ame-010937	Astyanax mexicanus	56.06	9.00e-179	620.00
IUUC-Bta-012567	Bos taurus	93.65	0.00e+00	1246.00
IUUC-Cja-020008	Callithrix jacchus	93.22	0.00e+00	1206.00
IUUC-Cfa-020602	Canis familiaris	93.94	0.00e+00	1262.00
IUUC-Cpo-022483	Cavia porcellus	89.99	0.00e+00	1162.00
IUUC-Csa-024196	Chlorocebus sabaeus	93.94	0.00e+00	1234.00
IUUC-Cho-025022	Choloepus hoffmanni	88.57	2.00e-52	199.00
IUUC-Cin-025456	Ciona intestinalis	34.31	8.00e-26	110.00
IUUC-Csv-025843	Ciona savignyi	39.09	8.00e-14	70.10
IUUC-Dre-027773	Danio rerio	53.18	3.00e-150	525.00
IUUC-Dno-029801	Dasypus novemcinctus	91.92	0.00e+00	1231.00
IUUC-Dor-030605	Dipodomys ordii	95.09	0.00e+00	1296.00
IUUC-Ete-032438	Echinops telfairi	90.33	0.00e+00	1223.00
IUUC-Eca-033410	Equus caballus	94.37	0.00e+00	1272.00
IUUC-Eeu-034509	Erinaceus europaeus	91.49	0.00e+00	1229.00
IUUC-Fca-035548	Felis catus	93.94	0.00e+00	1216.00
IUUC-Fal-037250	Ficedula albicollis	85.82	0.00e+00	1149.00
IUUC-Gmo-039053	Gadus morhua	58.38	3.00e-47	180.00
IUUC-Gga-040871	Gallus gallus	85.67	0.00e+00	1124.00
IUUC-Gac-041832	Gasterosteus aculeatus	62.91	0.00e+00	718.00
IUUC-Ggo-044976	Gorilla gorilla	93.94	0.00e+00	1235.00
IUUC-Hsa-045963	Homo sapiens	93.94	0.00e+00	1235.00
IUUC-Itr-048861	Ictidomys tridecemlineatus	93.63	0.00e+00	932.00
IUUC-Lch-050144	Latimeria chalumnae	74.96	0.00e+00	971.00
IUUC-Loc-052931	Lepisosteus oculatus	63.36	0.00e+00	816.00
IUUC-Laf-053883	Loxodonta africana	94.52	0.00e+00	1256.00
IUUC-Mcc-054597	Macaca mulatta	93.80	0.00e+00	1231.00
IUUC-Meu-056202	Macropus eugenii	89.82	0.00e+00	835.00
IUUC-Mor-057018	Magnaporthe oryzae	64.00	1.00e-05	44.30
IUUC-Mla-059157	Melampsora laricipopulina	46.15	1.00e-03	37.00
IUUC-Mga-059601	Meleagris gallopavo	72.26	0.00e+00	908.00
IUUC-Mmr-061047	Microcebus murinus	94.95	0.00e+00	1260.00
IUUC-Mdo-061944	Monodelphis domestica	90.98	0.00e+00	1186.00
IUUC-Mmu-063095	Mus musculus	97.69	0.00e+00	1346.00
IUUC-Mpu-066232	Mustela putorius furo	94.23	0.00e+00	1267.00
IUUC-Mlu-067513	Myotis lucifugus	93.51	0.00e+00	1251.00
IUUC-Nle-069405	Nomascus leucogenys	94.08	0.00e+00	1242.00
IUUC-Opr-071184	Ochotona princeps	92.67	9.00e-120	424.00
IUUC-Ont-071678	Oreochromis niloticus	61.54	0.00e+00	682.00
IUUC-Oan-072975	Ornithorhynchus anatinus	79.02	2.00e-160	559.00
IUUC-Ocu-073763	Oryctolagus cuniculus	94.37	0.00e+00	1238.00
IUUC-Olo-080805	Oryza longistaminata	40.00	2.00e-03	35.40
IUUC-Ola-087478	Oryzias latipes	55.94	0.00e+00	636.00
IUUC-Oga-088892	Otolemur garnettii	85.77	0.00e+00	1167.00
IUUC-Oar-089573	Ovis aries	94.37	0.00e+00	1253.00
IUUC-Ptr-091270	Pan troglodytes	93.94	0.00e+00	1235.00
IUUC-Pan-092250	Papio anubis	93.80	0.00e+00	1234.00
IUUC-Psi-093732	Pelodiscus sinensis	84.38	0.00e+00	1123.00
IUUC-Pma-094397	Petromyzon marinus	35.12	5.00e-35	141.00
IUUC-Pfo-097098	Poecilia formosa	60.42	0.00e+00	664.00
IUUC-Pab-098776	Pongo abelii	94.08	0.00e+00	1236.00
IUUC-Pca-100202	Procavia capensis	89.47	0.00e+00	1158.00
IUUC-Pva-103025	Pteropus vampyrus	93.94	0.00e+00	1233.00
IUUC-Sha-107249	Sarcophilus harrisii	90.35	0.00e+00	1200.00
IUUC-Ssl-108582	Sclerotinia sclerotiorum	31.71	2.00e-03	38.10
IUUC-Stu-112401	Solanum tuberosum	35.21	6.00e-04	37.00
IUUC-Sar-113207	Sorex araneus	93.63	0.00e+00	935.00
IUUC-Ssc-116409	Sus scrofa	92.64	0.00e+00	1229.00
IUUC-Tgu-116911	Taeniopygia guttata	86.10	0.00e+00	1151.00
IUUC-Tru-118667	Takifugu rubripes	58.12	0.00e+00	652.00
IUUC-Tsy-119562	Tarsius syrichta	93.19	0.00e+00	711.00
IUUC-Tni-120195	Tetraodon nigroviridis	55.71	6.00e-179	620.00
IUUC-Tbe-127934	Tupaia belangeri	92.35	0.00e+00	1240.00
IUUC-Ttr-128519	Tursiops truncatus	94.50	0.00e+00	713.00
IUUC-Vpa-130279	Vicugna pacos	90.66	0.00e+00	1197.00
IUUC-Xtr-131844	Xenopus tropicalis	76.82	0.00e+00	1003.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence