iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069685

Ensembl Protein ID

ENSNLEP00000009760.2

UniProt Accession

G1R971; G1R971_NOMLE

Genbank Protein ID

ENSNLEP00000009760

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01054186

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000007989.2	ENSNLET00000010231.1	ENSNLEP00000009760.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.50e-15	56.9	10	64

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 10   VVRAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--TLNGRTGWFPSNYVREVK 64
           78999*********************7..999*******..8**************996 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MTDNSNNQLV VRAKFNFQQT NEDELSFSKG DVIHVTRVEE GGWWEGTLNG RTGWFPSNYV 60
REVKASEKPV SPKSGTLKSP PKGFDTTAIN KSYYNVVLQN ILETENEYSK ELQTVLSTYL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGAGCAGG TTGGCATCTG GGGCAGCGGG CTCGCTCCAG GCCGTCGGGG GCCGCTCGCC 60
AGCGTCGCCC GCTGTGTTGG GAGCGCGGGC CGTGGGCGTC GCTCGGCCTT GTCCGCGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005925--C:focal adhesion
GO:0005622--C:intracellular
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0043234--C:protein complex
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0035556--P:intracellular signal transduction
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	89.01	0.00e+00	959.00
IUUC-Aca-004591	Anolis carolinensis	84.40	0.00e+00	871.00
IUUC-Ame-010759	Astyanax mexicanus	74.51	0.00e+00	800.00
IUUC-Bta-013328	Bos taurus	88.65	0.00e+00	951.00
IUUC-Bci-013864	Botrytis cinerea	41.54	6.00e-12	66.60
IUUC-Cja-018742	Callithrix jacchus	93.09	0.00e+00	996.00
IUUC-Cfa-020756	Canis familiaris	92.26	0.00e+00	1138.00
IUUC-Cpo-021284	Cavia porcellus	88.12	0.00e+00	924.00
IUUC-Csa-023162	Chlorocebus sabaeus	93.79	0.00e+00	1008.00
IUUC-Cho-024736	Choloepus hoffmanni	68.70	3.00e-130	459.00
IUUC-Cin-025535	Ciona intestinalis	40.99	5.00e-92	331.00
IUUC-Cne-026866	Cryptococcus neoformans	50.79	9.00e-14	73.20
IUUC-Dre-028646	Danio rerio	64.87	0.00e+00	849.00
IUUC-Dno-029461	Dasypus novemcinctus	89.01	0.00e+00	966.00
IUUC-Dor-030623	Dipodomys ordii	76.24	0.00e+00	783.00
IUUC-Dme-032219	Drosophila melanogaster	45.34	1.00e-102	368.00
IUUC-Ete-032236	Echinops telfairi	77.27	0.00e+00	660.00
IUUC-Eca-034137	Equus caballus	92.61	0.00e+00	967.00
IUUC-Fca-035742	Felis catus	91.45	0.00e+00	1121.00
IUUC-Fal-037205	Ficedula albicollis	89.73	0.00e+00	944.00
IUUC-Gmo-039475	Gadus morhua	72.43	0.00e+00	904.00
IUUC-Gga-040539	Gallus gallus	91.18	0.00e+00	1119.00
IUUC-Gac-042615	Gasterosteus aculeatus	70.75	0.00e+00	849.00
IUUC-Ggo-044470	Gorilla gorilla	93.44	0.00e+00	1004.00
IUUC-Hsa-046398	Homo sapiens	93.62	0.00e+00	1001.00
IUUC-Loc-052146	Lepisosteus oculatus	81.98	0.00e+00	910.00
IUUC-Laf-053891	Loxodonta africana	91.35	0.00e+00	996.00
IUUC-Mcc-055483	Macaca mulatta	93.44	0.00e+00	1001.00
IUUC-Mga-059410	Meleagris gallopavo	86.70	0.00e+00	935.00
IUUC-Mmr-060758	Microcebus murinus	90.60	0.00e+00	929.00
IUUC-Mdo-061900	Monodelphis domestica	88.85	0.00e+00	1122.00
IUUC-Mmu-063849	Mus musculus	87.94	0.00e+00	915.00
IUUC-Mpu-065876	Mustela putorius furo	89.77	0.00e+00	1130.00
IUUC-Mlu-067970	Myotis lucifugus	91.71	0.00e+00	962.00
IUUC-Opr-071132	Ochotona princeps	59.21	2.00e-167	582.00
IUUC-Ont-071815	Oreochromis niloticus	63.67	0.00e+00	863.00
IUUC-Oan-073057	Ornithorhynchus anatinus	88.29	0.00e+00	932.00
IUUC-Ola-086663	Oryzias latipes	62.97	0.00e+00	824.00
IUUC-Oga-088103	Otolemur garnettii	89.18	0.00e+00	922.00
IUUC-Ptr-091162	Pan troglodytes	93.44	0.00e+00	998.00
IUUC-Pan-092093	Papio anubis	83.25	0.00e+00	884.00
IUUC-Pma-094261	Petromyzon marinus	66.14	3.00e-125	441.00
IUUC-Pfo-096736	Poecilia formosa	71.52	0.00e+00	918.00
IUUC-Pab-097641	Pongo abelii	94.81	0.00e+00	1186.00
IUUC-Pva-102819	Pteropus vampyrus	84.93	0.00e+00	894.00
IUUC-Pte-104123	Pyrenophora teres	42.86	1.00e-10	62.40
IUUC-Pyt-104567	Pyrenophora triticirepentis	42.86	1.00e-10	62.40
IUUC-Rno-106099	Rattus norvegicus	90.27	0.00e+00	918.00
IUUC-Sha-106845	Sarcophilus harrisii	88.70	0.00e+00	1121.00
IUUC-Sly-111123	Solanum lycopersicum	46.15	6.00e-10	58.20
IUUC-Stu-112434	Solanum tuberosum	46.15	7.00e-10	57.80
IUUC-Ssc-116036	Sus scrofa	89.47	0.00e+00	1114.00
IUUC-Tgu-117498	Taeniopygia guttata	87.41	0.00e+00	943.00
IUUC-Tru-118278	Takifugu rubripes	72.29	0.00e+00	788.00
IUUC-Tsy-118990	Tarsius syrichta	94.98	0.00e+00	836.00
IUUC-Tni-120852	Tetraodon nigroviridis	71.71	0.00e+00	917.00
IUUC-Ttr-128922	Tursiops truncatus	83.87	0.00e+00	872.00
IUUC-Xtr-132012	Xenopus tropicalis	77.70	0.00e+00	810.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence