iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071300

Ensembl Protein ID

ENSONIP00000015130.1

UniProt Accession

I3K1Y5; I3K1Y5_ORENI

Genbank Protein ID

ENSONIP00000015130

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01019402

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000012021.1	ENSONIT00000015143.1	ENSONIP00000015130.1
ENSONIG00000012021.1	ENSONIT00000015144.1	ENSONIP00000015131.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-120	402.9	4035	4369
UBD/Alpha-Helix/UBA	3.20e-06	27.5	1322	1359

Active Site

Position(s)	Description	Evidence
4337	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++d+k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 4035 PEDMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRVVAKAVYDNRLL 4120
           689********************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d  +++ l +++en   d+++lg +ltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 4121 ECYFTRSFYKHILGKSVRYTDMESEDYPFFQGLVYLLEN---DVSTLGYELTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 4204
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv++++++  i++q++af eGf+e+ip++l+s+Fte+elelli+G + id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 4205 LVCQMKMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPAIDIDDLKANTEYHK-YQSSSIQIQWFWRALRSFDQADRA 4290
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s+e+l+++Ll+Ai+e+ +gF+l
   Q: 4291 KFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESYEKLRHMLLLAIQECsEGFGL 4369
           *********************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++ +l ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1322 NQAQLTQLMDMGFSREHAMEALLN-TSTMEQATEYLLTH 1359
           67899*******************.7***********98 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MKVDRSKLKK TPTEAPADCR ILIEKLKACN DEQLLVELQH IKTWNIGKCE LYHWVDLLDR 60
FDGILCDAGQ TVENMSWLLV CDRPENGQLK ALLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGGTCG ACAGAAGCAA GTTAAAGAAA ACACCTACGG AAGCTGTGAG TATATTTGAT 60
GCTGGCTGTG TTTTCTTTCA TAGCTCCTAA CCTCGCTGCT GCCTAAATTG CATATAGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA
SM00678--WWE

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	46.95	2.00e-106	383.00
IUUC-Aml-001684	Ailuropoda melanoleuca	84.06	0.00e+00	3723.00
IUUC-Atr-003044	Amborella trichopoda	52.69	7.00e-126	447.00
IUUC-Apl-003729	Anas platyrhynchos	91.29	0.00e+00	681.00
IUUC-Aca-005263	Anolis carolinensis	82.32	0.00e+00	3706.00
IUUC-Aly-006083	Arabidopsis lyrata	51.77	2.00e-126	449.00
IUUC-Ath-007472	Arabidopsis thaliana	51.77	2.00e-126	449.00
IUUC-Ago-008005	Ashbya gossypii	47.79	1.00e-131	466.00
IUUC-Acl-008254	Aspergillus clavatus	53.43	8.00e-134	473.00
IUUC-Afl-008712	Aspergillus flavus	45.42	3.00e-135	476.00
IUUC-Afu-009022	Aspergillus fumigatus	46.37	2.00e-133	472.00
IUUC-Ani-009412	Aspergillus nidulans	47.33	3.00e-135	478.00
IUUC-Ang-009771	Aspergillus niger	46.37	2.00e-134	476.00
IUUC-Aor-010186	Aspergillus oryzae	44.68	2.00e-125	444.00
IUUC-Ate-010253	Aspergillus terreus	46.65	3.00e-134	475.00
IUUC-Ame-011067	Astyanax mexicanus	86.01	0.00e+00	5141.00
IUUC-Bgr-012043	Blumeria graminis	47.61	5.00e-139	491.00
IUUC-Bta-012813	Bos taurus	83.89	0.00e+00	3752.00
IUUC-Bci-013995	Botrytis cinerea	46.65	5.00e-137	484.00
IUUC-Bdi-014884	Brachypodium distachyon	51.99	4.00e-127	451.00
IUUC-Bol-016533	Brassica oleracea	57.97	1.00e-88	319.00
IUUC-Bra-016637	Brassica rapa	43.85	4.00e-122	434.00
IUUC-Cel-018179	Caenorhabditis elegans	61.52	0.00e+00	647.00
IUUC-Cja-018741	Callithrix jacchus	84.00	0.00e+00	3739.00
IUUC-Cfa-020083	Canis familiaris	82.84	0.00e+00	3711.00
IUUC-Cpo-021923	Cavia porcellus	83.53	0.00e+00	3707.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	48.36	2.00e-118	419.00
IUUC-Csa-023853	Chlorocebus sabaeus	84.05	0.00e+00	3737.00
IUUC-Cho-024718	Choloepus hoffmanni	97.33	0.00e+00	797.00
IUUC-Cin-025627	Ciona intestinalis	45.28	0.00e+00	1611.00
IUUC-Csv-025824	Ciona savignyi	47.37	0.00e+00	1411.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	52.00	7.00e-136	480.00
IUUC-Cne-027095	Cryptococcus neoformans	41.49	9.00e-103	370.00
IUUC-Cme-027267	Cyanidioschyzon merolae	50.00	4.00e-115	410.00
IUUC-Dre-028525	Danio rerio	87.92	0.00e+00	4804.00
IUUC-Dno-029680	Dasypus novemcinctus	82.82	0.00e+00	3674.00
IUUC-Dor-030902	Dipodomys ordii	84.93	0.00e+00	1067.00
IUUC-Dse-031197	Dothistroma septosporum	47.07	2.00e-136	482.00
IUUC-Dme-032122	Drosophila melanogaster	69.29	0.00e+00	788.00
IUUC-Ete-032690	Echinops telfairi	79.74	0.00e+00	1139.00
IUUC-Eca-033915	Equus caballus	83.34	0.00e+00	3692.00
IUUC-Eeu-034963	Erinaceus europaeus	82.34	0.00e+00	2610.00
IUUC-Fca-035824	Felis catus	84.18	0.00e+00	3736.00
IUUC-Fox-037756	Fusarium oxysporum	46.86	1.00e-136	483.00
IUUC-Fso-038464	Fusarium solani	47.71	9.00e-137	483.00
IUUC-Gmo-039073	Gadus morhua	93.45	0.00e+00	4038.00
IUUC-Ggr-039946	Gaeumannomyces graminis	45.99	5.00e-134	474.00
IUUC-Gga-040309	Gallus gallus	96.75	0.00e+00	642.00
IUUC-Gac-042430	Gasterosteus aculeatus	95.09	0.00e+00	4242.00
IUUC-Gma-044247	Glycine max	52.22	7.00e-126	447.00
IUUC-Ggo-044785	Gorilla gorilla	83.96	0.00e+00	3709.00
IUUC-Hsa-046879	Homo sapiens	84.00	0.00e+00	3712.00
IUUC-Hvu-047697	Hordeum vulgare	51.99	1.00e-127	452.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	89.54	0.00e+00	1369.00
IUUC-Kpa-049228	Komagataella pastoris	48.66	4.00e-139	491.00
IUUC-Lch-050252	Latimeria chalumnae	82.64	0.00e+00	3099.00
IUUC-Lpe-051550	Leersia perrieri	51.15	3.00e-127	451.00
IUUC-Loc-052472	Lepisosteus oculatus	86.59	0.00e+00	3798.00
IUUC-Lma-053159	Leptosphaeria maculans	46.37	4.00e-135	478.00
IUUC-Laf-054154	Loxodonta africana	83.26	0.00e+00	3685.00
IUUC-Mcc-055085	Macaca mulatta	83.05	0.00e+00	3692.00
IUUC-Meu-056727	Macropus eugenii	88.43	0.00e+00	1793.00
IUUC-Mor-057201	Magnaporthe oryzae	47.15	3.00e-135	478.00
IUUC-Mpo-057597	Magnaporthe poae	46.11	8.00e-133	470.00
IUUC-Mtr-058273	Medicago truncatula	52.93	1.00e-127	453.00
IUUC-Mla-058888	Melampsora laricipopulina	49.62	2.00e-116	412.00
IUUC-Mvi-060320	Microbotryum violaceum	49.29	1.00e-121	433.00
IUUC-Mmr-060820	Microcebus murinus	81.94	0.00e+00	3691.00
IUUC-Mdo-062930	Monodelphis domestica	82.74	0.00e+00	3689.00
IUUC-Mmu-063601	Mus musculus	83.73	0.00e+00	3668.00
IUUC-Mac-065557	Musa acuminata	52.09	5.00e-119	424.00
IUUC-Mpu-066653	Mustela putorius furo	82.17	0.00e+00	3603.00
IUUC-Mlu-067418	Myotis lucifugus	83.67	0.00e+00	3788.00
IUUC-Nfi-068278	Neosartorya fischeri	46.56	6.00e-134	474.00
IUUC-Ncr-068813	Neurospora crassa	46.95	2.00e-136	482.00
IUUC-Nle-069418	Nomascus leucogenys	83.95	0.00e+00	3694.00
IUUC-Opr-070187	Ochotona princeps	79.90	0.00e+00	841.00
IUUC-Oan-073046	Ornithorhynchus anatinus	79.12	0.00e+00	3820.00
IUUC-Ocu-074178	Oryctolagus cuniculus	83.85	0.00e+00	3770.00
IUUC-Oba-075757	Oryza barthii	51.15	1.00e-127	452.00
IUUC-Obr-076553	Oryza brachyantha	51.61	2.00e-127	452.00
IUUC-Ogl-077520	Oryza glaberrima	51.15	1.00e-127	452.00
IUUC-Ogu-078278	Oryza glumaepatula	51.15	1.00e-127	453.00
IUUC-Oin-079767	Oryza indica	51.15	1.00e-127	453.00
IUUC-Olo-080380	Oryza longistaminata	50.68	9.00e-126	446.00
IUUC-Ome-081925	Oryza meridionalis	50.68	7.00e-126	447.00
IUUC-Oni-082619	Oryza nivara	51.15	1.00e-127	452.00
IUUC-Opu-083684	Oryza punctata	50.68	8.00e-126	447.00
IUUC-Oru-084501	Oryza rufipogon	51.15	1.00e-127	453.00
IUUC-Osa-086251	Oryza sativa	51.15	4.00e-126	446.00
IUUC-Ola-087437	Oryzias latipes	94.99	0.00e+00	2328.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.25	1.00e-113	402.00
IUUC-Oga-088903	Otolemur garnettii	83.82	0.00e+00	3718.00
IUUC-Oar-090210	Ovis aries	82.88	0.00e+00	3709.00
IUUC-Ptr-090502	Pan troglodytes	82.47	0.00e+00	2783.00
IUUC-Pan-092368	Papio anubis	82.67	0.00e+00	2815.00
IUUC-Pma-094246	Petromyzon marinus	73.77	0.00e+00	1258.00
IUUC-Pno-094871	Phaeosphaeria nodorum	51.12	3.00e-133	471.00
IUUC-Ppa-095657	Physcomitrella patens	51.58	2.00e-125	446.00
IUUC-Pfo-096232	Poecilia formosa	90.35	0.00e+00	7050.00
IUUC-Pab-098583	Pongo abelii	84.05	0.00e+00	3716.00
IUUC-Pop-099613	Populus trichocarpa	53.40	1.00e-128	456.00
IUUC-Pca-100310	Procavia capensis	74.90	0.00e+00	1462.00
IUUC-Ppe-102109	Prunus persica	52.69	3.00e-127	451.00
IUUC-Pva-102116	Pteropus vampyrus	83.65	0.00e+00	3773.00
IUUC-Pgr-103465	Puccinia graminis	44.34	1.00e-127	453.00
IUUC-Ptt-103813	Puccinia triticina	42.23	2.00e-115	412.00
IUUC-Pte-104018	Pyrenophora teres	51.23	7.00e-132	467.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	51.24	1.00e-131	466.00
IUUC-Rno-105889	Rattus norvegicus	77.61	0.00e+00	3310.00
IUUC-Sce-106449	Saccharomyces cerevisiae	44.57	7.00e-127	450.00
IUUC-Sha-106961	Sarcophilus harrisii	82.13	0.00e+00	3676.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	45.79	9.00e-128	453.00
IUUC-Spo-108024	Schizosaccharomyces pombe	42.79	6.00e-130	460.00
IUUC-Smo-109428	Selaginella moellendorffii	50.88	5.00e-130	461.00
IUUC-Sit-110598	Setaria italica	52.46	1.00e-127	453.00
IUUC-Sly-111285	Solanum lycopersicum	51.89	2.00e-128	455.00
IUUC-Stu-112582	Solanum tuberosum	32.68	3.00e-56	213.00
IUUC-Sar-113291	Sorex araneus	77.45	0.00e+00	2258.00
IUUC-Sbi-114042	Sorghum bicolor	51.99	4.00e-127	451.00
IUUC-Sre-114958	Sporisorium reilianum	56.03	6.00e-138	484.00
IUUC-Ssc-115754	Sus scrofa	84.00	0.00e+00	3724.00
IUUC-Tru-118570	Takifugu rubripes	92.82	0.00e+00	7027.00
IUUC-Tsy-119159	Tarsius syrichta	89.94	0.00e+00	1749.00
IUUC-Tni-120836	Tetraodon nigroviridis	88.45	0.00e+00	2758.00
IUUC-Tca-121479	Theobroma cacao	51.76	2.00e-125	446.00
IUUC-Tre-121909	Trichoderma reesei	53.65	1.00e-133	473.00
IUUC-Tvi-122370	Trichoderma virens	53.41	1.00e-133	473.00
IUUC-Tae-125214	Triticum aestivum	51.04	1.00e-125	445.00
IUUC-Tme-127172	Tuber melanosporum	47.23	2.00e-137	485.00
IUUC-Tbe-127506	Tupaia belangeri	74.29	0.00e+00	1137.00
IUUC-Ttr-129253	Tursiops truncatus	73.20	0.00e+00	1726.00
IUUC-Uma-129355	Ustilago maydis	49.24	1.00e-138	486.00
IUUC-Vda-129886	Verticillium dahliae	47.25	3.00e-138	488.00
IUUC-Vpa-130708	Vicugna pacos	82.84	0.00e+00	3259.00
IUUC-Vvi-131170	Vitis vinifera	51.22	2.00e-127	451.00
IUUC-Xtr-132123	Xenopus tropicalis	81.66	0.00e+00	3617.00
IUUC-Xma-133869	Xiphophorus maculatus	90.20	0.00e+00	7096.00
IUUC-Yli-134657	Yarrowia lipolytica	46.07	1.00e-129	459.00
IUUC-Zma-135570	Zea mays	51.99	2.00e-127	452.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence