iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/VHS	VHS	12230472

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/VHS	3.70e-51	173.0	77	205

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/VHS

   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           ats+l+ ++dwe+il+icdli++ +++ak+a+++++k++n+knphval+aL++++s+v+nCg+++h+eva+k+++eel+ellk+++e++
   Q: 77   ATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVN 165
           799************************************************************************************** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v++K+++li++Wa++++nep++++++++++ +k eG++fp
   Q: 166  VRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP 205
           ***************************************8 PP

Organism

Rattus norvegicus

Functional Description
(View)

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex.

Protein Sequence
(Fasta)

MSGPMDAQSP CASARLVSEQ DSGRRGDIAR ARAEKERRKR KLGGASAPKE GAPAASVRSG 60
VAMGRGSGTF ERLLDKATSQ LLLETDWESI LQICDLIRQG DTQAKYAVNS IKKKVNDKNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTCCTGCC CACTCGGCGC GGAAGGATAT TCTGAAGGCG TTTCACCAGC AGGGTCTTTC 60
CGACTCCCGC AGCTCCTAGC AGGAGACACA TCCCTTGCCT GGTCAAGGCG CTAGTACCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF12210--Hrs_helical
PF00790--VHS

SMART

SM00064--FYVE
SM00288--VHS

Gene Ontology

GO:0005829--C:cytosol
GO:0031901--C:early endosome membrane
GO:0016020--C:membrane
GO:0032585--C:multivesicular body membrane
GO:0030141--C:secretory granule
GO:0046872--F:metal ion binding
GO:0019904--F:protein domain specific binding
GO:0008333--P:endosome to lysosome transport
GO:0006886--P:intracellular protein transport

KEGG

rno:56084

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001518	Ailuropoda melanoleuca	87.94	0.00e+00	998.00
IUUC-Apl-003662	Anas platyrhynchos	81.07	0.00e+00	986.00
IUUC-Aca-004940	Anolis carolinensis	83.58	0.00e+00	1145.00
IUUC-Ago-007931	Ashbya gossypii	30.33	1.00e-26	114.00
IUUC-Acl-008274	Aspergillus clavatus	31.41	1.00e-39	157.00
IUUC-Afl-008521	Aspergillus flavus	33.60	1.00e-40	161.00
IUUC-Afu-008774	Aspergillus fumigatus	32.48	2.00e-40	160.00
IUUC-Ani-009445	Aspergillus nidulans	33.09	3.00e-41	163.00
IUUC-Ang-009863	Aspergillus niger	33.21	2.00e-42	167.00
IUUC-Ate-010444	Aspergillus terreus	34.81	2.00e-42	166.00
IUUC-Ame-011111	Astyanax mexicanus	78.05	0.00e+00	947.00
IUUC-Bgr-012087	Blumeria graminis	31.07	2.00e-43	170.00
IUUC-Bta-012506	Bos taurus	91.35	0.00e+00	1171.00
IUUC-Bci-013782	Botrytis cinerea	31.16	4.00e-42	166.00
IUUC-Cel-018493	Caenorhabditis elegans	52.51	5.00e-68	252.00
IUUC-Cja-019998	Callithrix jacchus	90.81	0.00e+00	1100.00
IUUC-Cfa-020615	Canis familiaris	88.71	0.00e+00	1077.00
IUUC-Cpo-022019	Cavia porcellus	93.22	0.00e+00	1250.00
IUUC-Csa-023596	Chlorocebus sabaeus	92.69	0.00e+00	1109.00
IUUC-Cin-025488	Ciona intestinalis	47.59	1.00e-127	450.00
IUUC-Csv-025802	Ciona savignyi	50.00	3.00e-114	405.00
IUUC-Cgl-026560	Colletotrichum gloeosporioides	35.42	1.00e-40	161.00
IUUC-Cne-026847	Cryptococcus neoformans	32.11	4.00e-38	153.00
IUUC-Dre-028353	Danio rerio	77.19	0.00e+00	920.00
IUUC-Dno-029005	Dasypus novemcinctus	87.80	0.00e+00	1148.00
IUUC-Dor-030280	Dipodomys ordii	92.42	0.00e+00	1186.00
IUUC-Dse-031238	Dothistroma septosporum	38.71	6.00e-43	169.00
IUUC-Dme-031952	Drosophila melanogaster	47.65	2.00e-78	286.00
IUUC-Ete-032235	Echinops telfairi	97.27	5.00e-133	468.00
IUUC-Eca-033873	Equus caballus	92.74	0.00e+00	1161.00
IUUC-Eeu-034652	Erinaceus europaeus	96.65	3.00e-105	376.00
IUUC-Fca-036563	Felis catus	90.57	0.00e+00	1130.00
IUUC-Fal-036649	Ficedula albicollis	83.17	0.00e+00	1028.00
IUUC-Fox-037962	Fusarium oxysporum	32.97	2.00e-39	157.00
IUUC-Fso-038396	Fusarium solani	33.70	9.00e-40	158.00
IUUC-Gmo-039510	Gadus morhua	75.57	0.00e+00	933.00
IUUC-Ggr-039938	Gaeumannomyces graminis	33.15	5.00e-39	156.00
IUUC-Gga-040201	Gallus gallus	83.15	0.00e+00	1113.00
IUUC-Gac-041459	Gasterosteus aculeatus	75.48	0.00e+00	949.00
IUUC-Ggo-044573	Gorilla gorilla	93.64	0.00e+00	1198.00
IUUC-Hsa-046009	Homo sapiens	93.91	0.00e+00	1243.00
IUUC-Itr-049065	Ictidomys tridecemlineatus	94.86	0.00e+00	1264.00
IUUC-Kpa-049327	Komagataella pastoris	31.42	3.00e-33	136.00
IUUC-Lch-049944	Latimeria chalumnae	75.78	1.00e-156	545.00
IUUC-Loc-051850	Lepisosteus oculatus	79.22	0.00e+00	1028.00
IUUC-Lma-053252	Leptosphaeria maculans	34.40	3.00e-41	163.00
IUUC-Laf-053346	Loxodonta africana	83.67	0.00e+00	1036.00
IUUC-Mcc-055789	Macaca mulatta	92.69	0.00e+00	1177.00
IUUC-Meu-056329	Macropus eugenii	71.15	3.00e-157	548.00
IUUC-Mor-057205	Magnaporthe oryzae	33.56	7.00e-39	155.00
IUUC-Mpo-057295	Magnaporthe poae	33.33	7.00e-41	162.00
IUUC-Mla-058849	Melampsora laricipopulina	33.19	3.00e-32	133.00
IUUC-Mga-059361	Meleagris gallopavo	82.76	0.00e+00	1046.00
IUUC-Mvi-060561	Microbotryum violaceum	32.72	2.00e-40	160.00
IUUC-Mmr-061122	Microcebus murinus	94.57	0.00e+00	1039.00
IUUC-Mdo-062171	Monodelphis domestica	89.17	0.00e+00	1189.00
IUUC-Mmu-063952	Mus musculus	97.70	0.00e+00	1343.00
IUUC-Mpu-065852	Mustela putorius furo	89.76	0.00e+00	1087.00
IUUC-Mlu-066996	Myotis lucifugus	83.45	3.00e-144	505.00
IUUC-Nfi-068539	Neosartorya fischeri	32.48	1.00e-40	161.00
IUUC-Ncr-068726	Neurospora crassa	39.19	6.00e-40	159.00
IUUC-Nle-070148	Nomascus leucogenys	87.96	0.00e+00	1072.00
IUUC-Opr-070833	Ochotona princeps	73.42	0.00e+00	807.00
IUUC-Ont-071261	Oreochromis niloticus	77.33	0.00e+00	962.00
IUUC-Oan-073684	Ornithorhynchus anatinus	71.66	1.00e-160	559.00
IUUC-Ola-087570	Oryzias latipes	75.17	0.00e+00	972.00
IUUC-Oga-089087	Otolemur garnettii	88.55	0.00e+00	1089.00
IUUC-Oar-089534	Ovis aries	90.91	0.00e+00	1175.00
IUUC-Ptr-091654	Pan troglodytes	87.96	0.00e+00	1088.00
IUUC-Pan-092652	Papio anubis	92.69	0.00e+00	1178.00
IUUC-Pno-095125	Phaeosphaeria nodorum	38.53	2.00e-42	167.00
IUUC-Pfo-096757	Poecilia formosa	74.93	0.00e+00	936.00
IUUC-Pab-097788	Pongo abelii	94.22	0.00e+00	833.00
IUUC-Pca-100145	Procavia capensis	78.33	0.00e+00	897.00
IUUC-Pva-102965	Pteropus vampyrus	88.54	0.00e+00	1107.00
IUUC-Pgr-103609	Puccinia graminis	34.69	1.00e-33	137.00
IUUC-Ptt-103865	Puccinia triticina	35.71	2.00e-34	140.00
IUUC-Pte-104095	Pyrenophora teres	35.24	5.00e-42	166.00
IUUC-Pyt-104668	Pyrenophora triticirepentis	35.87	2.00e-41	164.00
IUUC-Sce-106192	Saccharomyces cerevisiae	28.00	2.00e-26	114.00
IUUC-Sha-107066	Sarcophilus harrisii	89.48	0.00e+00	1145.00
IUUC-Sja-107931	Schizosaccharomyces japonicus	32.57	4.00e-42	166.00
IUUC-Spo-108220	Schizosaccharomyces pombe	32.85	1.00e-36	147.00
IUUC-Stu-112464	Solanum tuberosum	45.90	4.00e-13	70.90
IUUC-Sar-113393	Sorex araneus	92.11	2.00e-106	379.00
IUUC-Sre-114986	Sporisorium reilianum	38.12	1.00e-42	168.00
IUUC-Tgu-117505	Taeniopygia guttata	81.68	0.00e+00	1041.00
IUUC-Tru-118494	Takifugu rubripes	76.53	0.00e+00	994.00
IUUC-Tsy-119626	Tarsius syrichta	98.97	9.00e-54	204.00
IUUC-Tni-120174	Tetraodon nigroviridis	74.80	0.00e+00	980.00
IUUC-Tre-122191	Trichoderma reesei	33.82	1.00e-40	161.00
IUUC-Tvi-122318	Trichoderma virens	32.76	6.00e-42	165.00
IUUC-Tme-126914	Tuber melanosporum	35.36	1.00e-44	174.00
IUUC-Ttr-129095	Tursiops truncatus	92.04	0.00e+00	1208.00
IUUC-Uma-129475	Ustilago maydis	30.93	1.00e-39	158.00
IUUC-Vda-129908	Verticillium dahliae	32.84	8.00e-36	145.00
IUUC-Xtr-131900	Xenopus tropicalis	77.60	0.00e+00	1037.00
IUUC-Xma-133124	Xiphophorus maculatus	75.10	0.00e+00	972.00
IUUC-Yli-134682	Yarrowia lipolytica	35.71	9.00e-33	134.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence