iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000003616.10	ENSDART00000019581.10	ENSDARP00000006476.9
ENSDARG00000003616.10	ENSDART00000160402.1	ENSDARP00000141969.1

Status

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	1.40e-54	185.6	156	345

Active Site

Position(s)	Description	Evidence
327	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelk.ikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalk 89
           C++C+l+++++ +t  leC h+fC++C+ +yl++k i+eg+ ++iscpa++c   ++++++++l+++++++ +y++l ++++ve+++ lk
   Q: 156  CQICYLNYPNSYFTG-LECGHKFCMQCWGDYLTTKiIEEGMGQTISCPAHSCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLK 244
           **********99985.5**************66652799999************************************************ PP
   S: 90   wcpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnh 179
           wcpapdC++vv ++   +++ v+c kcg++fC++C e+wH++++Ck+l+++ +k++   +++e++++++an+k+CpkC+v+iek++gCnh
   Q: 245  WCPAPDCHHVVKVQYP-DAKPVRC-KCGRQFCFNCGENWHDPVKCKWLRKWIKKCD---DDSETSNWIAANTKECPKCHVTIEKDGGCNH 329
           ***************7.9999999.9******************************...99***************************** PP
   S: 180  mtC..akCkaefCwlC 193
           m C  ++CkaefCw+C
   Q: 330  MVCrnQNCKAEFCWVC 345
           ***9999********* PP

Organism

Danio rerio

Functional Description
(View)

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes.

Protein Sequence
(Fasta)

MDSDEGYNYE FDDEEEECSE DSGEEETADD TLELGEVELV DPVVAGGERD DCGETGGSGL 60
GPGQDEEDYR FEVLTAEQIL QHMVECIREV NEVIQNPATI TRILLSHFNW DKEKLMERYF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTCTTTGTT GGCCCAGCAG CAGCGTCGCT CCTCTGTTGT TGTTTTCTCT GCTGCTGGAA 60
AAACTGGAAT GCTAGCGAGC TAAAGAAGTA TTCTCGTTTG CTTCTGCTCT CCCCGCCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR

Gene Ontology

GO:0005737--C:cytoplasm
GO:0097413--C:Lewy body
GO:0016604--C:nuclear body
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

dre:327005

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000970	Aegilops tauschii	29.78	2.00e-54	207.00
IUUC-Aml-001385	Ailuropoda melanoleuca	97.39	0.00e+00	911.00
IUUC-Atr-002480	Amborella trichopoda	30.82	4.00e-64	239.00
IUUC-Apl-004184	Anas platyrhynchos	95.93	0.00e+00	861.00
IUUC-Aca-004976	Anolis carolinensis	97.01	0.00e+00	862.00
IUUC-Aly-005807	Arabidopsis lyrata	32.08	5.00e-65	242.00
IUUC-Ath-007166	Arabidopsis thaliana	33.04	5.00e-65	242.00
IUUC-Ago-007926	Ashbya gossypii	29.14	1.00e-53	204.00
IUUC-Acl-008252	Aspergillus clavatus	41.53	6.00e-104	371.00
IUUC-Afl-008468	Aspergillus flavus	42.52	1.00e-104	374.00
IUUC-Afu-009062	Aspergillus fumigatus	43.45	2.00e-105	376.00
IUUC-Ani-009219	Aspergillus nidulans	42.73	2.00e-106	379.00
IUUC-Ang-009538	Aspergillus niger	43.60	2.00e-99	356.00
IUUC-Aor-010009	Aspergillus oryzae	42.52	4.00e-104	372.00
IUUC-Ate-010497	Aspergillus terreus	44.25	7.00e-98	351.00
IUUC-Ame-011264	Astyanax mexicanus	98.79	0.00e+00	1030.00
IUUC-Bgr-012016	Blumeria graminis	40.69	4.00e-100	358.00
IUUC-Bta-013518	Bos taurus	96.98	0.00e+00	917.00
IUUC-Bci-013819	Botrytis cinerea	41.81	9.00e-105	374.00
IUUC-Bdi-014685	Brachypodium distachyon	31.91	4.00e-67	249.00
IUUC-Bol-016507	Brassica oleracea	29.71	4.00e-53	202.00
IUUC-Bra-018038	Brassica rapa	31.72	2.00e-53	204.00
IUUC-Cel-018521	Caenorhabditis elegans	52.30	1.00e-139	489.00
IUUC-Cja-019869	Callithrix jacchus	89.51	0.00e+00	822.00
IUUC-Cfa-020812	Canis familiaris	96.77	0.00e+00	910.00
IUUC-Cpo-021627	Cavia porcellus	96.98	0.00e+00	917.00
IUUC-Csa-023034	Chlorocebus sabaeus	97.45	0.00e+00	857.00
IUUC-Cho-024444	Choloepus hoffmanni	94.40	0.00e+00	887.00
IUUC-Cin-025135	Ciona intestinalis	68.17	0.00e+00	681.00
IUUC-Csv-026243	Ciona savignyi	66.33	0.00e+00	664.00
IUUC-Cgl-026434	Colletotrichum gloeosporioides	41.97	2.00e-105	376.00
IUUC-Cne-026861	Cryptococcus neoformans	41.46	3.00e-102	365.00
IUUC-Dno-029205	Dasypus novemcinctus	96.98	0.00e+00	917.00
IUUC-Dor-030769	Dipodomys ordii	79.86	0.00e+00	708.00
IUUC-Dse-031171	Dothistroma septosporum	41.67	6.00e-105	374.00
IUUC-Dme-031903	Drosophila melanogaster	69.08	0.00e+00	696.00
IUUC-Ete-032929	Echinops telfairi	80.48	6.00e-130	457.00
IUUC-Eca-033431	Equus caballus	97.30	0.00e+00	880.00
IUUC-Eeu-034838	Erinaceus europaeus	83.80	0.00e+00	737.00
IUUC-Fca-035882	Felis catus	93.22	0.00e+00	771.00
IUUC-Fal-037068	Ficedula albicollis	97.08	0.00e+00	880.00
IUUC-Fox-037790	Fusarium oxysporum	50.36	3.00e-77	281.00
IUUC-Fso-038125	Fusarium solani	41.61	3.00e-103	369.00
IUUC-Gmo-038703	Gadus morhua	96.99	0.00e+00	993.00
IUUC-Ggr-039722	Gaeumannomyces graminis	41.16	9.00e-105	374.00
IUUC-Gga-040319	Gallus gallus	97.71	0.00e+00	686.00
IUUC-Gac-041708	Gasterosteus aculeatus	97.39	0.00e+00	971.00
IUUC-Gma-043188	Glycine max	32.37	4.00e-59	222.00
IUUC-Ggo-045178	Gorilla gorilla	96.98	0.00e+00	917.00
IUUC-Hsa-045718	Homo sapiens	96.98	0.00e+00	917.00
IUUC-Hvu-047322	Hordeum vulgare	32.21	1.00e-58	220.00
IUUC-Itr-048934	Ictidomys tridecemlineatus	98.71	6.00e-177	613.00
IUUC-Kpa-049350	Komagataella pastoris	32.16	9.00e-65	241.00
IUUC-Lpe-051110	Leersia perrieri	33.41	2.00e-68	253.00
IUUC-Loc-052442	Lepisosteus oculatus	97.99	0.00e+00	1027.00
IUUC-Lma-053253	Leptosphaeria maculans	43.10	1.00e-109	390.00
IUUC-Laf-054351	Loxodonta africana	97.45	0.00e+00	858.00
IUUC-Mcc-054670	Macaca mulatta	93.53	0.00e+00	904.00
IUUC-Meu-056335	Macropus eugenii	91.04	8.00e-142	496.00
IUUC-Mor-057179	Magnaporthe oryzae	42.00	1.00e-104	374.00
IUUC-Mpo-057553	Magnaporthe poae	41.16	2.00e-103	369.00
IUUC-Mtr-058263	Medicago truncatula	31.62	2.00e-59	223.00
IUUC-Mla-058889	Melampsora laricipopulina	36.42	6.00e-77	281.00
IUUC-Mga-059385	Meleagris gallopavo	95.74	0.00e+00	867.00
IUUC-Mvi-060517	Microbotryum violaceum	40.42	2.00e-105	376.00
IUUC-Mmr-061439	Microcebus murinus	90.36	0.00e+00	832.00
IUUC-Mdo-062890	Monodelphis domestica	96.77	0.00e+00	915.00
IUUC-Mmu-063433	Mus musculus	96.98	0.00e+00	917.00
IUUC-Mac-065341	Musa acuminata	33.05	2.00e-64	239.00
IUUC-Mpu-066288	Mustela putorius furo	96.98	0.00e+00	916.00
IUUC-Mlu-067187	Myotis lucifugus	96.98	0.00e+00	911.00
IUUC-Nfi-068339	Neosartorya fischeri	43.23	5.00e-105	375.00
IUUC-Ncr-068947	Neurospora crassa	43.10	2.00e-101	363.00
IUUC-Nle-069263	Nomascus leucogenys	96.98	0.00e+00	917.00
IUUC-Opr-071000	Ochotona princeps	98.25	1.00e-96	347.00
IUUC-Ont-072309	Oreochromis niloticus	97.39	0.00e+00	967.00
IUUC-Oan-073731	Ornithorhynchus anatinus	97.33	0.00e+00	816.00
IUUC-Ocu-074000	Oryctolagus cuniculus	95.70	0.00e+00	860.00
IUUC-Oba-075628	Oryza barthii	32.06	2.00e-62	233.00
IUUC-Obr-076492	Oryza brachyantha	32.96	1.00e-68	254.00
IUUC-Ogl-077447	Oryza glaberrima	33.41	4.00e-69	256.00
IUUC-Ogu-078881	Oryza glumaepatula	33.41	3.00e-69	256.00
IUUC-Oin-079573	Oryza indica	33.41	4.00e-67	249.00
IUUC-Olo-080774	Oryza longistaminata	33.41	6.00e-70	258.00
IUUC-Ome-081275	Oryza meridionalis	32.05	1.00e-61	231.00
IUUC-Oni-082267	Oryza nivara	32.05	1.00e-61	231.00
IUUC-Opu-084135	Oryza punctata	33.41	4.00e-69	255.00
IUUC-Oru-084849	Oryza rufipogon	33.41	6.00e-69	255.00
IUUC-Osa-085435	Oryza sativa	33.41	8.00e-69	254.00
IUUC-Ola-086792	Oryzias latipes	98.48	0.00e+00	952.00
IUUC-Olu-087826	Ostreococcus lucimarinus	32.13	5.00e-49	188.00
IUUC-Oga-088706	Otolemur garnettii	96.98	0.00e+00	917.00
IUUC-Oar-089354	Ovis aries	96.77	0.00e+00	916.00
IUUC-Ptr-091287	Pan troglodytes	96.98	0.00e+00	917.00
IUUC-Pan-091701	Papio anubis	97.45	0.00e+00	857.00
IUUC-Psi-093814	Pelodiscus sinensis	97.45	0.00e+00	858.00
IUUC-Pno-095124	Phaeosphaeria nodorum	34.00	2.00e-77	283.00
IUUC-Ppa-095545	Physcomitrella patens	32.44	3.00e-61	229.00
IUUC-Pfo-096449	Poecilia formosa	96.61	0.00e+00	970.00
IUUC-Pab-098132	Pongo abelii	96.98	0.00e+00	917.00
IUUC-Pop-099139	Populus trichocarpa	32.88	8.00e-63	234.00
IUUC-Pca-100303	Procavia capensis	98.18	0.00e+00	645.00
IUUC-Ppe-101740	Prunus persica	32.29	4.00e-59	222.00
IUUC-Pva-102457	Pteropus vampyrus	96.98	0.00e+00	917.00
IUUC-Pgr-103443	Puccinia graminis	41.43	9.00e-103	367.00
IUUC-Ptt-103795	Puccinia triticina	40.29	9.00e-93	334.00
IUUC-Pte-104022	Pyrenophora teres	40.04	1.00e-101	363.00
IUUC-Pyt-104643	Pyrenophora triticirepentis	41.63	3.00e-109	389.00
IUUC-Rno-106083	Rattus norvegicus	96.98	0.00e+00	917.00
IUUC-Sce-106154	Saccharomyces cerevisiae	30.63	1.00e-63	237.00
IUUC-Sha-106765	Sarcophilus harrisii	95.27	0.00e+00	867.00
IUUC-Sja-107977	Schizosaccharomyces japonicus	42.44	2.00e-98	352.00
IUUC-Spo-108222	Schizosaccharomyces pombe	44.30	1.00e-109	390.00
IUUC-Smo-108845	Selaginella moellendorffii	32.57	8.00e-60	224.00
IUUC-Sit-110348	Setaria italica	32.37	6.00e-65	241.00
IUUC-Sly-111454	Solanum lycopersicum	32.08	2.00e-61	230.00
IUUC-Stu-112599	Solanum tuberosum	32.71	2.00e-57	216.00
IUUC-Sar-113023	Sorex araneus	97.22	0.00e+00	852.00
IUUC-Sbi-114262	Sorghum bicolor	32.81	1.00e-65	244.00
IUUC-Sre-115120	Sporisorium reilianum	42.74	8.00e-109	387.00
IUUC-Ssc-115667	Sus scrofa	87.81	4.00e-179	620.00
IUUC-Tgu-117273	Taeniopygia guttata	97.00	0.00e+00	858.00
IUUC-Tru-118338	Takifugu rubripes	93.23	0.00e+00	973.00
IUUC-Tsy-119096	Tarsius syrichta	89.12	0.00e+00	763.00
IUUC-Tni-120238	Tetraodon nigroviridis	94.13	0.00e+00	972.00
IUUC-Tca-121037	Theobroma cacao	31.69	6.00e-65	241.00
IUUC-Tre-121902	Trichoderma reesei	41.89	4.00e-102	365.00
IUUC-Tvi-122474	Trichoderma virens	41.54	1.00e-102	367.00
IUUC-Tae-124132	Triticum aestivum	32.16	2.00e-67	250.00
IUUC-Tur-126320	Triticum urartu	30.51	1.00e-54	207.00
IUUC-Tme-127089	Tuber melanosporum	42.47	7.00e-103	367.00
IUUC-Tbe-127409	Tupaia belangeri	89.40	1.00e-117	416.00
IUUC-Ttr-128909	Tursiops truncatus	88.24	0.00e+00	799.00
IUUC-Uma-129487	Ustilago maydis	42.98	8.00e-109	387.00
IUUC-Vda-129939	Verticillium dahliae	41.16	1.00e-104	373.00
IUUC-Vpa-130259	Vicugna pacos	93.75	0.00e+00	874.00
IUUC-Vvi-131463	Vitis vinifera	31.87	3.00e-57	216.00
IUUC-Xtr-132219	Xenopus tropicalis	97.83	0.00e+00	913.00
IUUC-Xma-133423	Xiphophorus maculatus	96.61	0.00e+00	970.00
IUUC-Yli-134622	Yarrowia lipolytica	35.00	1.00e-71	264.00
IUUC-Zma-135131	Zea mays	32.66	3.00e-66	246.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence