iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000026491.13	ENSMUST00000027768.13	ENSMUSP00000027768.7
ENSMUSG00000026491.13	ENSMUST00000140489.1	ENSMUSP00000115253.1
ENSMUSG00000026491.13	ENSMUST00000125816.1	ENSMUSP00000119738.1
ENSMUSG00000026491.13	ENSMUST00000127250.1	ENSMUSP00000120551.1
ENSMUSG00000026491.13	ENSMUST00000145968.2	ENSMUSP00000115795.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	23.40	3.00e-04	46.20	IUUC-Ath-006911
E3 activity/RING/RING	21.10	1.40e-02	40.40	IUUC-Osa-086280

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis (By similarity). Has also been proposed to function as a transcription factor which may play a specific role in hematopoietic tissues (PubMed:11952839).

Protein Sequence
(Fasta)

MQDLTAQVTS DLLHFPEVTI EALGEDEITL ESVLRGKFAA GKNGLACLAC GPQLEVVNSL 60
TGERLSAYRF SGVNEQPPVV LAVKEFSWHK RTGLLIGLEE ADGSVLCLYD LGISRVVKAV 120

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Nucleotide Sequence
(Fasta)

GGCCACGATC CTTCCCTGGG CGGAGAGGCT GTGTGTGTGG GGTTCGGGCA GTGCGCCCGG 60
GGTAATGCGC AGAGCGCGGC CCGAGCGGTG CCAGCCCAGT AAGTCGAGTC GCCAGCGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0995--Kinetochore
KW-0498--Mitosis
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0804--Transcription
KW-0811--Translocation
KW-0813--Transport

Interpro

IPR032040--ELYS-bb
IPR025151--ELYS_dom
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF13934--ELYS
PF16687--ELYS-bb

Gene Ontology

GO:0000785--C:chromatin
GO:0000777--C:condensed chromosome kinetochore
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016363--C:nuclear matrix
GO:0031965--C:nuclear membrane
GO:0031080--C:nuclear pore outer ring
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000910--P:cytokinesis
GO:0030097--P:hemopoiesis
GO:0007067--P:mitotic nuclear division
GO:0051028--P:mRNA transport
GO:0051292--P:nuclear pore complex assembly
GO:0015031--P:protein transport
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:226747

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001495	Ailuropoda melanoleuca	63.28	0.00e+00	2576.00
IUUC-Atr-003128	Amborella trichopoda	21.20	9.00e-11	62.80
IUUC-Aca-004538	Anolis carolinensis	49.31	0.00e+00	1920.00
IUUC-Ath-006911	Arabidopsis thaliana	23.57	1.00e-05	45.80
IUUC-Ago-007983	Ashbya gossypii	23.94	4.00e-01	31.20
IUUC-Bdi-014716	Brachypodium distachyon	19.60	6.00e-04	40.00
IUUC-Cja-019346	Callithrix jacchus	66.88	0.00e+00	2684.00
IUUC-Cfa-021184	Canis familiaris	63.32	0.00e+00	2543.00
IUUC-Cpo-021809	Cavia porcellus	66.22	0.00e+00	2837.00
IUUC-Csa-024229	Chlorocebus sabaeus	71.01	0.00e+00	2880.00
IUUC-Eeu-034782	Erinaceus europaeus	61.42	0.00e+00	1134.00
IUUC-Fca-036466	Felis catus	62.49	0.00e+00	2541.00
IUUC-Fal-036694	Ficedula albicollis	53.74	0.00e+00	2118.00
IUUC-Gmo-039692	Gadus morhua	58.96	0.00e+00	1434.00
IUUC-Ggo-045004	Gorilla gorilla	68.21	0.00e+00	2729.00
IUUC-Hsa-046642	Homo sapiens	69.98	0.00e+00	3000.00
IUUC-Itr-048971	Ictidomys tridecemlineatus	71.10	0.00e+00	3043.00
IUUC-Loc-052453	Lepisosteus oculatus	67.73	0.00e+00	1728.00
IUUC-Mcc-055404	Macaca mulatta	70.33	0.00e+00	3002.00
IUUC-Mmr-061515	Microcebus murinus	71.76	0.00e+00	3144.00
IUUC-Nle-070006	Nomascus leucogenys	72.40	0.00e+00	2688.00
IUUC-Ogl-077653	Oryza glaberrima	21.05	2.00e-04	41.60
IUUC-Osa-086280	Oryza sativa	23.57	1.00e-05	45.80
IUUC-Oga-089130	Otolemur garnettii	68.21	0.00e+00	2916.00
IUUC-Pan-092702	Papio anubis	67.61	0.00e+00	2570.00
IUUC-Ppa-095437	Physcomitrella patens	24.50	7.00e-10	59.70
IUUC-Pab-097569	Pongo abelii	69.94	0.00e+00	3008.00
IUUC-Pop-099913	Populus trichocarpa	22.54	1.00e-07	52.40
IUUC-Ppe-102080	Prunus persica	24.77	1.00e-12	68.90
IUUC-Sly-111501	Solanum lycopersicum	21.47	4.00e-06	47.40
IUUC-Stu-112823	Solanum tuberosum	20.30	4.00e-05	44.30
IUUC-Sre-114890	Sporisorium reilianum	22.57	5.00e-06	47.00
IUUC-Tni-119734	Tetraodon nigroviridis	60.40	0.00e+00	1462.00
IUUC-Tca-121088	Theobroma cacao	23.08	1.00e-07	52.80
IUUC-Tae-123947	Triticum aestivum	19.87	6.00e-05	43.50
IUUC-Uma-129330	Ustilago maydis	22.45	6.00e-05	43.50
IUUC-Vvi-130863	Vitis vinifera	20.53	3.00e-10	60.80
IUUC-Xtr-132698	Xenopus tropicalis	68.77	0.00e+00	1528.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence