iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028689

Ensembl Protein ID

ENSDARP00000136264.1

UniProt Accession

Q9W6T7; PSN1_DANRE

Genbank Protein ID

CAB40386.1; AAH54639.1

Protein Name

Presenilin-1

Genbank Nucleotide ID

AJ132931; BC054639

Gene Name

psen1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000004870.10	ENSDART00000149864.2	ENSDARP00000124467.1
ENSDARG00000004870.10	ENSDART00000166687.1	ENSDARP00000136264.1

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/CUE	CUE	25796185

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/CUE	8.90e-11	42.4	261	299

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e+++ iFP+l+ys+++v+L+++++s e+  n+ +
   Q: 261  VETAQERNEAIFPALIYSSTMVWLFNMADSAETRNNSSH 299
           89********************************99976 PP

Organism

Danio rerio

Functional Description
(View)

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) (PubMed:10521267). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity).

Protein Sequence
(Fasta)

MADLVQNAAN NVLNDGMDTS RHTSSTAAPP SRNEVELNGQ PPTAPPPQVV TDSEEDEDEE 60
LTLKYGAKHV IMLFIPVTLC MVVVVATIKS VSFYTQKDGQ QLIYTPFRED TETVGQRALH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTCCCTA TTTACAATTT TCAAAGAATA CTTTTCTGAA ATTATATTAT TAAGGAGAAA 60
GTCTGGATAT CCAAATATAA AACCAACTTT CCCTCTATTG ACTTCATCTG CATTTGTTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0030424--C:axon
GO:0030054--C:cell junction
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0031224--C:intrinsic component of membrane
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005790--C:smooth endoplasmic reticulum
GO:0045202--C:synapse
GO:0030018--C:Z disc
GO:0042500--F:aspartic endopeptidase activity, intramembrane cleaving
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0004175--F:endopeptidase activity
GO:0034205--P:beta-amyloid formation
GO:0007420--P:brain development
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0001946--P:lymphangiogenesis
GO:0030318--P:melanocyte differentiation
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0052548--P:regulation of endopeptidase activity
GO:0001666--P:response to hypoxia
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis
GO:0061053--P:somite development
GO:0036269--P:swimming behavior

KEGG

dre:30221

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	33.55	1.00e-22	102.00
IUUC-Aml-001648	Ailuropoda melanoleuca	75.20	2.00e-125	442.00
IUUC-Apl-003727	Anas platyrhynchos	77.23	4.00e-146	511.00
IUUC-Aca-004582	Anolis carolinensis	75.77	2.00e-149	522.00
IUUC-Ame-011500	Astyanax mexicanus	85.34	0.00e+00	627.00
IUUC-Bta-013026	Bos taurus	75.98	1.00e-147	516.00
IUUC-Bra-017580	Brassica rapa	33.12	1.00e-27	117.00
IUUC-Cel-018553	Caenorhabditis elegans	51.38	2.00e-94	339.00
IUUC-Cja-019994	Callithrix jacchus	78.80	9.00e-148	516.00
IUUC-Cfa-020074	Canis familiaris	78.45	8.00e-148	516.00
IUUC-Cpo-022237	Cavia porcellus	78.80	2.00e-148	518.00
IUUC-Csa-023537	Chlorocebus sabaeus	79.15	3.00e-148	518.00
IUUC-Cho-024735	Choloepus hoffmanni	68.98	3.00e-132	465.00
IUUC-Dno-029758	Dasypus novemcinctus	79.20	5.00e-150	524.00
IUUC-Eeu-035134	Erinaceus europaeus	73.87	4.00e-109	387.00
IUUC-Fca-036243	Felis catus	78.70	9.00e-149	520.00
IUUC-Fal-036600	Ficedula albicollis	76.46	2.00e-149	521.00
IUUC-Gmo-039665	Gadus morhua	77.40	4.00e-121	428.00
IUUC-Gga-040993	Gallus gallus	77.28	1.00e-148	519.00
IUUC-Gac-042342	Gasterosteus aculeatus	74.30	3.00e-151	528.00
IUUC-Hsa-046822	Homo sapiens	79.15	3.00e-148	518.00
IUUC-Hvu-047141	Hordeum vulgare	34.08	4.00e-24	106.00
IUUC-Lch-049946	Latimeria chalumnae	68.04	4.00e-129	454.00
IUUC-Lpe-051132	Leersia perrieri	32.70	2.00e-27	117.00
IUUC-Laf-053979	Loxodonta africana	77.19	9.00e-138	483.00
IUUC-Mcc-055682	Macaca mulatta	79.15	3.00e-148	518.00
IUUC-Meu-056004	Macropus eugenii	61.50	3.00e-118	418.00
IUUC-Mga-059466	Meleagris gallopavo	78.05	2.00e-148	518.00
IUUC-Mdo-062122	Monodelphis domestica	72.94	4.00e-150	524.00
IUUC-Mmu-063176	Mus musculus	78.14	1.00e-141	496.00
IUUC-Mpu-065927	Mustela putorius furo	78.45	1.00e-147	516.00
IUUC-Mlu-067079	Myotis lucifugus	78.54	4.00e-150	524.00
IUUC-Nle-070180	Nomascus leucogenys	79.15	3.00e-148	518.00
IUUC-Opr-070847	Ochotona princeps	75.44	5.00e-140	491.00
IUUC-Ont-071846	Oreochromis niloticus	83.75	6.00e-163	567.00
IUUC-Oan-072783	Ornithorhynchus anatinus	75.79	2.00e-113	401.00
IUUC-Ocu-074527	Oryctolagus cuniculus	78.70	1.00e-148	519.00
IUUC-Oba-075256	Oryza barthii	31.82	4.00e-26	112.00
IUUC-Obr-076302	Oryza brachyantha	30.65	6.00e-27	115.00
IUUC-Ogl-077097	Oryza glaberrima	31.30	4.00e-27	115.00
IUUC-Ogu-078570	Oryza glumaepatula	31.30	4.00e-27	115.00
IUUC-Oin-079244	Oryza indica	31.30	6.00e-27	115.00
IUUC-Olo-080484	Oryza longistaminata	34.28	6.00e-23	101.00
IUUC-Ome-081814	Oryza meridionalis	32.96	4.00e-27	115.00
IUUC-Oni-082057	Oryza nivara	31.30	6.00e-27	115.00
IUUC-Opu-084176	Oryza punctata	32.22	2.00e-28	120.00
IUUC-Oru-084618	Oryza rufipogon	31.30	6.00e-27	115.00
IUUC-Osa-085602	Oryza sativa	31.30	5.00e-27	115.00
IUUC-Oar-090348	Ovis aries	71.37	5.00e-148	517.00
IUUC-Ptr-091060	Pan troglodytes	79.15	3.00e-148	518.00
IUUC-Pan-091855	Papio anubis	75.38	6.00e-134	471.00
IUUC-Psi-093505	Pelodiscus sinensis	72.14	2.00e-149	522.00
IUUC-Pfo-097396	Poecilia formosa	81.41	2.00e-172	598.00
IUUC-Pab-098591	Pongo abelii	79.15	4.00e-148	517.00
IUUC-Pca-101029	Procavia capensis	75.83	1.00e-139	489.00
IUUC-Ppe-101495	Prunus persica	30.72	9.00e-31	128.00
IUUC-Pva-102244	Pteropus vampyrus	73.54	5.00e-140	491.00
IUUC-Rno-105861	Rattus norvegicus	76.30	4.00e-143	501.00
IUUC-Sha-107045	Sarcophilus harrisii	74.12	4.00e-151	528.00
IUUC-Smo-109325	Selaginella moellendorffii	35.85	2.00e-35	143.00
IUUC-Stu-112433	Solanum tuberosum	33.66	1.00e-30	127.00
IUUC-Sar-113169	Sorex araneus	70.06	7.00e-107	380.00
IUUC-Ssc-115766	Sus scrofa	77.86	5.00e-149	521.00
IUUC-Tru-117732	Takifugu rubripes	83.08	3.00e-163	568.00
IUUC-Tsy-119624	Tarsius syrichta	67.94	5.00e-133	467.00
IUUC-Tni-119852	Tetraodon nigroviridis	77.12	1.00e-153	536.00
IUUC-Tae-123984	Triticum aestivum	33.44	3.00e-24	106.00
IUUC-Tur-126237	Triticum urartu	33.44	3.00e-24	106.00
IUUC-Tbe-128148	Tupaia belangeri	68.01	2.00e-101	362.00
IUUC-Ttr-128793	Tursiops truncatus	77.19	6.00e-143	500.00
IUUC-Vpa-130625	Vicugna pacos	62.86	1.00e-114	407.00
IUUC-Vvi-131312	Vitis vinifera	33.67	3.00e-30	126.00
IUUC-Xtr-131790	Xenopus tropicalis	76.87	2.00e-138	486.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence