iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.60e-08	35.0	1187	1228

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCl+ f  +++++ lpC H+fh+dC+ +w        ++ +CP+Cr
   Q: 1187 CAICLNLFeiENEVRRLPCMHLFHTDCVDQW------LVTNKHCPICR 1228
           ******9988888******************......**********8 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MDSLENDQEE LHHQPRVTLA YGSVATSSGG QENHSQYAMY YNQQRDSEGY MLMTPFLSSS 60
QSHSHTRSPP TYTAMVEPRR EESSGFEGLA RRCDKCSSLD GLCRCESMVA SSSRYADSTQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTTCGGTG TTGTTACTGC TATAAAATCC AGTAACACAT ACAAAATGAT TAAATCGTGA 60
GAACATATAT ATCGCAAATT TGCATGTGCA TAATGTAAAT TTGTTCCGGA CAGCAGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000667	Aegilops tauschii	48.28	9.00e-14	71.20
IUUC-Aml-001378	Ailuropoda melanoleuca	50.50	2.00e-25	110.00
IUUC-Apl-003783	Anas platyrhynchos	57.89	3.00e-27	114.00
IUUC-Aca-005299	Anolis carolinensis	58.33	2.00e-27	115.00
IUUC-Aly-006490	Arabidopsis lyrata	48.21	1.00e-12	66.60
IUUC-Ath-006799	Arabidopsis thaliana	56.00	4.00e-13	68.20
IUUC-Acl-008067	Aspergillus clavatus	44.26	3.00e-13	69.70
IUUC-Afl-008676	Aspergillus flavus	47.92	2.00e-11	63.50
IUUC-Ani-009491	Aspergillus nidulans	50.00	3.00e-12	66.60
IUUC-Ang-009544	Aspergillus niger	52.08	4.00e-12	66.20
IUUC-Aor-010095	Aspergillus oryzae	47.92	3.00e-11	60.80
IUUC-Ate-010250	Aspergillus terreus	50.00	4.00e-12	65.90
IUUC-Ame-011948	Astyanax mexicanus	61.70	4.00e-28	117.00
IUUC-Bta-012823	Bos taurus	50.50	2.00e-25	110.00
IUUC-Bdi-014235	Brachypodium distachyon	37.50	1.00e-14	73.20
IUUC-Bol-016276	Brassica oleracea	32.81	1.00e-13	69.70
IUUC-Cja-019798	Callithrix jacchus	56.25	5.00e-26	110.00
IUUC-Cfa-021062	Canis familiaris	53.76	7.00e-26	112.00
IUUC-Cpo-021467	Cavia porcellus	52.48	3.00e-26	113.00
IUUC-Csa-024048	Chlorocebus sabaeus	53.76	6.00e-26	112.00
IUUC-Cho-024278	Choloepus hoffmanni	50.00	4.00e-23	102.00
IUUC-Cne-026985	Cryptococcus neoformans	35.29	6.00e-12	65.90
IUUC-Cme-027122	Cyanidioschyzon merolae	49.09	3.00e-12	66.20
IUUC-Dre-028365	Danio rerio	61.70	2.00e-28	118.00
IUUC-Dno-029962	Dasypus novemcinctus	52.63	8.00e-24	103.00
IUUC-Dor-030727	Dipodomys ordii	56.67	2.00e-21	95.50
IUUC-Ete-032985	Echinops telfairi	50.50	2.00e-25	110.00
IUUC-Eca-033659	Equus caballus	50.50	2.00e-25	110.00
IUUC-Eeu-034773	Erinaceus europaeus	50.50	2.00e-25	110.00
IUUC-Fca-035560	Felis catus	53.76	7.00e-26	112.00
IUUC-Fal-037200	Ficedula albicollis	57.29	5.00e-27	114.00
IUUC-Gmo-039613	Gadus morhua	56.84	1.00e-25	109.00
IUUC-Gga-040277	Gallus gallus	57.89	4.00e-27	114.00
IUUC-Gac-041830	Gasterosteus aculeatus	52.53	6.00e-25	108.00
IUUC-Gma-043223	Glycine max	53.85	2.00e-13	69.30
IUUC-Ggo-044921	Gorilla gorilla	50.50	2.00e-25	110.00
IUUC-Hsa-046529	Homo sapiens	50.50	2.00e-25	110.00
IUUC-Itr-048765	Ictidomys tridecemlineatus	50.50	2.00e-25	110.00
IUUC-Lch-049512	Latimeria chalumnae	52.69	6.00e-25	108.00
IUUC-Loc-052174	Lepisosteus oculatus	55.06	2.00e-24	107.00
IUUC-Laf-053804	Loxodonta africana	50.50	2.00e-25	110.00
IUUC-Mcc-055297	Macaca mulatta	53.76	6.00e-26	112.00
IUUC-Meu-055988	Macropus eugenii	53.68	1.00e-23	103.00
IUUC-Mtr-057782	Medicago truncatula	50.00	3.00e-12	63.50
IUUC-Mla-059171	Melampsora laricipopulina	36.36	2.00e-10	59.70
IUUC-Mga-059350	Meleagris gallopavo	51.49	7.00e-26	112.00
IUUC-Mvi-060247	Microbotryum violaceum	48.94	2.00e-09	57.00
IUUC-Mmr-061666	Microcebus murinus	53.76	6.00e-26	112.00
IUUC-Mdo-061958	Monodelphis domestica	53.76	9.00e-26	111.00
IUUC-Mmu-063900	Mus musculus	50.50	1.00e-25	110.00
IUUC-Mac-064897	Musa acuminata	36.28	1.00e-14	72.80
IUUC-Mpu-066492	Mustela putorius furo	53.76	7.00e-26	112.00
IUUC-Mlu-067464	Myotis lucifugus	49.51	5.00e-24	105.00
IUUC-Nfi-068528	Neosartorya fischeri	50.00	6.00e-12	65.50
IUUC-Nle-069235	Nomascus leucogenys	56.25	6.00e-26	110.00
IUUC-Opr-070646	Ochotona princeps	52.63	1.00e-23	103.00
IUUC-Ont-072005	Oreochromis niloticus	57.45	3.00e-26	111.00
IUUC-Oan-072924	Ornithorhynchus anatinus	54.74	7.00e-24	103.00
IUUC-Ocu-074718	Oryctolagus cuniculus	56.25	5.00e-26	110.00
IUUC-Ogu-078123	Oryza glumaepatula	35.43	1.00e-14	73.20
IUUC-Oin-079313	Oryza indica	35.43	1.00e-14	73.20
IUUC-Ola-087046	Oryzias latipes	56.84	3.00e-26	111.00
IUUC-Olu-087692	Ostreococcus lucimarinus	48.94	4.00e-10	57.00
IUUC-Oga-087993	Otolemur garnettii	56.25	4.00e-26	110.00
IUUC-Oar-090286	Ovis aries	53.76	7.00e-26	112.00
IUUC-Ptr-091341	Pan troglodytes	56.25	4.00e-26	110.00
IUUC-Pan-091775	Papio anubis	56.25	4.00e-26	110.00
IUUC-Psi-092966	Pelodiscus sinensis	57.89	5.00e-27	114.00
IUUC-Pma-094624	Petromyzon marinus	52.94	4.00e-25	109.00
IUUC-Pfo-096103	Poecilia formosa	55.79	1.00e-25	109.00
IUUC-Pab-097885	Pongo abelii	53.76	5.00e-26	112.00
IUUC-Pop-099421	Populus trichocarpa	51.02	6.00e-13	67.40
IUUC-Pca-100561	Procavia capensis	50.50	3.00e-25	110.00
IUUC-Ppe-101804	Prunus persica	35.29	1.00e-13	70.10
IUUC-Pva-102891	Pteropus vampyrus	50.50	1.00e-25	111.00
IUUC-Pgr-103420	Puccinia graminis	48.89	7.00e-10	58.90
IUUC-Rno-105327	Rattus norvegicus	50.50	1.00e-25	111.00
IUUC-Sha-107401	Sarcophilus harrisii	53.76	1.00e-25	111.00
IUUC-Sja-107932	Schizosaccharomyces japonicus	48.94	6.00e-11	61.60
IUUC-Sly-111768	Solanum lycopersicum	50.00	2.00e-11	62.80
IUUC-Stu-112684	Solanum tuberosum	48.08	2.00e-11	62.40
IUUC-Sar-113238	Sorex araneus	50.50	2.00e-25	110.00
IUUC-Sbi-114628	Sorghum bicolor	37.50	3.00e-14	70.10
IUUC-Ssc-116436	Sus scrofa	50.50	2.00e-25	110.00
IUUC-Tgu-117345	Taeniopygia guttata	57.29	5.00e-27	114.00
IUUC-Tru-118054	Takifugu rubripes	49.04	6.00e-24	105.00
IUUC-Tni-120063	Tetraodon nigroviridis	57.30	3.00e-25	109.00
IUUC-Tca-120953	Theobroma cacao	34.09	1.00e-13	69.30
IUUC-Tae-124899	Triticum aestivum	48.28	1.00e-13	69.70
IUUC-Tur-126765	Triticum urartu	38.00	6.00e-12	64.30
IUUC-Ttr-128623	Tursiops truncatus	66.67	7.00e-21	95.50
IUUC-Vpa-130662	Vicugna pacos	50.50	1.00e-25	111.00
IUUC-Vvi-130970	Vitis vinifera	39.81	4.00e-14	71.20
IUUC-Xtr-132963	Xenopus tropicalis	52.48	2.00e-26	113.00
IUUC-Xma-133967	Xiphophorus maculatus	55.79	1.00e-25	109.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence