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Tag Content
iUUCD ID IUUC-Ncr-068824
Ensembl Protein ID EAA31901
UniProt Accession Q9C245; URM1_NEUCR
Genbank Protein ID CAC28714.2; EAA31901.2
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID AL513445; CM002240
Gene Name urm1; B7A16.010; NCU04177
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
NCU04177 EAA31901 EAA31901
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 42.72 2.00e-20 91.70 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Neurospora crassa
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog nit-1/uba4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as ahp1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog nit-1/uba4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as ahp1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MSDQKDQMID ITVDFSGGLE ILFSNQKHHA LSVPAQDAQG KPANVGFLIN YLCQTLMTDP 60
RADLFVLGGE LRPGILCLIN DCDWELEEED AYVLQPGDNI LFISTLHGG 109
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Protein Fasta Sequence


>IUUC-Ncr-068824|ULD,UBQ_Other|Neurospora crassa
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Nucleotide Sequence
(Fasta)
CACAATTTAA CCTGAATTTC GTCAACTTCA TCCGTACAAT ACCATAGACG TTTGTTTTGT 60
ATCACACTTC GATTTTGGAC ACATATCACT ATGTCGGACC AAAAGGATCA AATGATCGAC 120
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Nucleotide Fasta Sequence


>IUUC-Ncr-068824|ULD,UBQ_Other|Neurospora crassa
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0034227--P:tRNA thio-modification
KEGG ncr:NCU04177
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 43.56 6.00e-20 87.00
IUUC-Atr-003089 Amborella trichopoda 43.43 6.00e-19 83.60
IUUC-Apl-003382 Anas platyrhynchos 47.37 1.00e-19 85.90
IUUC-Aca-004981 Anolis carolinensis 44.55 4.00e-20 87.40
IUUC-Aly-005517 Arabidopsis lyrata 38.30 1.00e-13 65.90
IUUC-Ath-006718 Arabidopsis thaliana 48.21 6.00e-12 60.50
IUUC-Ago-007917 Ashbya gossypii 43.69 2.00e-21 91.70
IUUC-Acl-008054 Aspergillus clavatus 62.26 7.00e-17 76.30
IUUC-Afl-008704 Aspergillus flavus 52.81 5.00e-27 110.00
IUUC-Aor-009890 Aspergillus oryzae 53.47 6.00e-32 127.00
IUUC-Bta-012448 Bos taurus 43.56 3.00e-20 87.80
IUUC-Bci-013865 Botrytis cinerea 61.39 2.00e-35 138.00
IUUC-Bdi-014980 Brachypodium distachyon 39.08 2.00e-12 62.00
IUUC-Bol-016055 Brassica oleracea 46.43 6.00e-12 60.50
IUUC-Bra-016845 Brassica rapa 46.43 6.00e-12 60.50
IUUC-Cel-018485 Caenorhabditis elegans 34.62 6.00e-10 53.90
IUUC-Cja-019587 Callithrix jacchus 44.55 3.00e-20 87.80
IUUC-Cfa-020653 Canis familiaris 44.55 2.00e-20 88.60
IUUC-Cpo-021622 Cavia porcellus 44.55 3.00e-20 87.80
IUUC-Cre-023015 Chlamydomonas reinhardtii 48.04 1.00e-23 99.40
IUUC-Csa-023756 Chlorocebus sabaeus 39.74 3.00e-13 65.90
IUUC-Cgl-026518 Colletotrichum gloeosporioides 61.90 3.00e-38 148.00
IUUC-Cne-026953 Cryptococcus neoformans 40.37 7.00e-20 87.40
IUUC-Cme-027314 Cyanidioschyzon merolae 45.19 3.00e-17 77.80
IUUC-Dre-027884 Danio rerio 42.57 3.00e-18 81.30
IUUC-Dno-029262 Dasypus novemcinctus 36.67 5.00e-12 62.00
IUUC-Dor-030601 Dipodomys ordii 46.77 6.00e-07 43.50
IUUC-Dme-031893 Drosophila melanogaster 44.55 2.00e-19 85.10
IUUC-Ete-032773 Echinops telfairi 46.46 6.00e-20 87.00
IUUC-Eca-034187 Equus caballus 45.54 2.00e-20 88.20
IUUC-Eeu-034808 Erinaceus europaeus 42.57 6.00e-19 83.60
IUUC-Fca-036107 Felis catus 45.54 1.00e-20 89.40
IUUC-Fal-036607 Ficedula albicollis 47.37 2.00e-19 85.10
IUUC-Fox-037698 Fusarium oxysporum 64.36 2.00e-37 145.00
IUUC-Gmo-039492 Gadus morhua 46.53 2.00e-20 88.60
IUUC-Ggr-039965 Gaeumannomyces graminis 63.21 4.00e-36 141.00
IUUC-Gga-041268 Gallus gallus 46.53 2.00e-21 92.00
IUUC-Gac-042111 Gasterosteus aculeatus 47.52 2.00e-20 88.60
IUUC-Gma-043240 Glycine max 36.47 3.00e-12 61.60
IUUC-Ggo-045176 Gorilla gorilla 39.74 8.00e-11 57.80
IUUC-Hsa-046077 Homo sapiens 44.55 1.00e-17 79.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 46.24 1.00e-15 72.40
IUUC-Kpa-049157 Komagataella pastoris 44.66 3.00e-19 84.30
IUUC-Lch-049889 Latimeria chalumnae 43.56 9.00e-20 86.30
IUUC-Lpe-050783 Leersia perrieri 41.46 2.00e-11 58.50
IUUC-Loc-052400 Lepisosteus oculatus 45.54 4.00e-20 87.40
IUUC-Lma-053259 Leptosphaeria maculans 61.47 1.00e-38 149.00
IUUC-Laf-053596 Loxodonta africana 43.69 2.00e-19 85.50
IUUC-Mcc-054845 Macaca mulatta 46.32 6.00e-18 80.10
IUUC-Meu-055968 Macropus eugenii 46.53 8.00e-22 93.20
IUUC-Mor-057126 Magnaporthe oryzae 58.49 1.00e-33 133.00
IUUC-Mpo-057311 Magnaporthe poae 65.09 1.00e-38 149.00
IUUC-Mtr-058266 Medicago truncatula 37.93 8.00e-13 63.20
IUUC-Mla-058847 Melampsora laricipopulina 38.89 1.00e-13 66.60
IUUC-Mga-059468 Meleagris gallopavo 48.42 2.00e-20 88.20
IUUC-Mvi-060235 Microbotryum violaceum 32.43 4.00e-17 78.60
IUUC-Mdo-061948 Monodelphis domestica 47.52 7.00e-22 93.20
IUUC-Mmu-063946 Mus musculus 46.46 4.00e-20 87.40
IUUC-Mac-064812 Musa acuminata 37.65 3.00e-12 61.20
IUUC-Mpu-066763 Mustela putorius furo 45.54 7.00e-20 86.70
IUUC-Mlu-066970 Myotis lucifugus 39.74 1.00e-13 65.50
IUUC-Nle-069849 Nomascus leucogenys 39.74 3.00e-13 65.90
IUUC-Opr-070227 Ochotona princeps 44.55 3.00e-20 87.80
IUUC-Ont-072530 Oreochromis niloticus 46.53 2.00e-20 88.60
IUUC-Oan-073191 Ornithorhynchus anatinus 45.74 2.00e-18 81.60
IUUC-Ocu-074460 Oryctolagus cuniculus 45.54 9.00e-21 89.70
IUUC-Oba-075499 Oryza barthii 39.53 2.00e-11 59.70
IUUC-Obr-076896 Oryza brachyantha 39.53 8.00e-12 61.60
IUUC-Ogl-077834 Oryza glaberrima 38.37 6.00e-12 60.50
IUUC-Ogu-078622 Oryza glumaepatula 38.37 6.00e-12 60.50
IUUC-Oin-079358 Oryza indica 39.53 3.00e-11 59.70
IUUC-Olo-081035 Oryza longistaminata 39.80 2.00e-13 66.60
IUUC-Oni-082425 Oryza nivara 38.37 6.00e-12 60.50
IUUC-Opu-083461 Oryza punctata 38.82 2.00e-11 59.70
IUUC-Oru-084875 Oryza rufipogon 60.53 2.00e-08 48.10
IUUC-Oga-089128 Otolemur garnettii 45.54 3.00e-20 88.20
IUUC-Oar-089896 Ovis aries 43.56 3.00e-20 87.80
IUUC-Ptr-091618 Pan troglodytes 39.74 9.00e-11 57.40
IUUC-Pan-092238 Papio anubis 39.74 2.00e-13 65.90
IUUC-Psi-093879 Pelodiscus sinensis 45.54 1.00e-20 89.00
IUUC-Pma-094484 Petromyzon marinus 44.58 4.00e-14 67.80
IUUC-Pno-094827 Phaeosphaeria nodorum 39.39 1.70e-01 28.50
IUUC-Ppa-095801 Physcomitrella patens 40.00 5.00e-13 63.90
IUUC-Pfo-097192 Poecilia formosa 44.55 5.00e-19 84.00
IUUC-Pab-098203 Pongo abelii 44.55 2.00e-17 78.60
IUUC-Pop-099614 Populus trichocarpa 48.98 1.00e-10 55.80
IUUC-Pca-100507 Procavia capensis 38.46 1.00e-13 65.10
IUUC-Ppe-101174 Prunus persica 39.60 6.00e-17 76.60
IUUC-Pva-102735 Pteropus vampyrus 44.55 1.00e-17 79.30
IUUC-Pgr-103510 Puccinia graminis 42.06 5.00e-17 77.80
IUUC-Ptt-103918 Puccinia triticina 44.86 7.00e-16 73.90
IUUC-Pte-104173 Pyrenophora teres 59.63 2.00e-35 138.00
IUUC-Pyt-104806 Pyrenophora triticirepentis 60.55 8.00e-36 139.00
IUUC-Rno-105820 Rattus norvegicus 46.46 9.00e-20 86.30
IUUC-Sce-106366 Saccharomyces cerevisiae 42.72 2.00e-21 91.70
IUUC-Sja-107727 Schizosaccharomyces japonicus 44.44 2.00e-20 89.00
IUUC-Spo-108074 Schizosaccharomyces pombe 44.44 2.00e-15 72.00
IUUC-Smo-108944 Selaginella moellendorffii 37.63 4.00e-13 63.50
IUUC-Sit-110277 Setaria italica 44.19 9.00e-15 69.70
IUUC-Sly-111505 Solanum lycopersicum 40.96 3.00e-14 68.20
IUUC-Stu-112076 Solanum tuberosum 39.76 8.00e-14 66.60
IUUC-Sbi-114274 Sorghum bicolor 35.79 5.00e-12 60.80
IUUC-Sre-114953 Sporisorium reilianum 52.38 2.00e-27 112.00
IUUC-Ssc-115418 Sus scrofa 47.52 6.00e-21 90.10
IUUC-Tgu-117311 Taeniopygia guttata 47.37 2.00e-19 85.10
IUUC-Tru-118598 Takifugu rubripes 48.94 4.00e-20 87.40
IUUC-Tni-120109 Tetraodon nigroviridis 44.12 5.00e-18 80.90
IUUC-Tca-120942 Theobroma cacao 45.31 3.00e-12 61.60
IUUC-Tre-122099 Trichoderma reesei 61.70 1.00e-28 115.00
IUUC-Tvi-122285 Trichoderma virens 59.41 3.00e-30 121.00
IUUC-Tae-125193 Triticum aestivum 38.37 8.00e-12 60.10
IUUC-Tur-126677 Triticum urartu 33.67 3.00e-09 52.00
IUUC-Tme-127120 Tuber melanosporum 57.43 5.00e-34 134.00
IUUC-Tbe-128050 Tupaia belangeri 37.62 8.00e-13 63.20
IUUC-Ttr-129019 Tursiops truncatus 43.56 7.00e-19 83.60
IUUC-Uma-129483 Ustilago maydis 51.46 6.00e-26 107.00
IUUC-Vda-129690 Verticillium dahliae 45.54 6.00e-25 103.00
IUUC-Vvi-131174 Vitis vinifera 39.76 1.00e-12 62.80
IUUC-Xma-133862 Xiphophorus maculatus 44.55 5.00e-19 84.00
IUUC-Yli-134398 Yarrowia lipolytica 47.62 3.00e-23 97.80
IUUC-Zma-134964 Zea mays 39.53 3.00e-13 64.70
Created Date 25-Jun-2017

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