iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-068228

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02047017

Gene Name

UBE3C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000010737.2	ENSMLUT00000010749.2	ENSMLUP00000009799.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.40e-105	351.3	747	1084

Active Site

Position(s)	Description	Evidence
1052	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ + +    ++++flGr+lgkal++
   Q: 747  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGD-SFARHYYFLGRMLGKALYE 832
           689**********99**9************************************9999999999965.999**************** PP
   S: 85   grlldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           + l++lp++ +f+++llg+  ++++++l+++dpe+y++l ++k++ e d+eelgl++t+   ++ lge++++eLk gG++ipVt +N
   Q: 833  NMLVELPFAGFFLSKLLGTsaDVDIHHLASLDPEVYRNLLFLKSY-EGDVEELGLNFTVV--NNDLGEAQVVELKCGGKDIPVTSAN 916
           ******************9666889******************99.78999987777765..888********************** PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevlee 255
           + +Y++lv++yrl+++i++++ afr+G+ +v++le+l++F+++e+++li+G    i++edlk++t+y ggy++d+p+i+ Fw+v+e+
   Q: 917  RIAYIHLVADYRLNRQIRQHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAqVPISLEDLKSFTNYSGGYSADHPVIRAFWRVVEG 1003
           ****************************************************899******************************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           f++ee++++L+FvT++sr Pl Gf+el p  f+i++ +sd +rlP+++TC+n+LkLPe++ +  l++kLlyAie ++gFels
   Q: 1004 FTDEEKRKLLKFVTSCSRPPLLGFKELYPA-FCIHNGGSDlERLPTASTCMNLLKLPEFQDEALLRSKLLYAIECAAGFELS 1084
           ****************************88.*****99999**************************************985 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

KCSFIYDEKT LKFINLITIK KLEEKASLLH RTQEERRKRE VQCDRIYKKV ILTSFLLVKY 60
KHAKPQYAIQ RTAFDRCANS SQAGGTLSIA NGPNLTLLVR QLLFFYKQNE DSKRLIWMYQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATGCAGTT TTATTTATGA TGAAAAAACA TTAAAATTTA TTAATTTGAT AACCATAAAG 60
AAATTGATTT TTCCATTGAA ATTTGTTTTA AGATAATTGT AGACTTCTGT GCAGCTGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	89.22	0.00e+00	1884.00
IUUC-Apl-003731	Anas platyrhynchos	85.98	0.00e+00	1844.00
IUUC-Aca-005248	Anolis carolinensis	84.76	0.00e+00	1841.00
IUUC-Aly-005768	Arabidopsis lyrata	35.90	2.00e-110	394.00
IUUC-Ath-006576	Arabidopsis thaliana	33.47	3.00e-110	392.00
IUUC-Ago-007748	Ashbya gossypii	41.90	5.00e-78	286.00
IUUC-Acl-008158	Aspergillus clavatus	38.17	8.00e-77	282.00
IUUC-Afl-008398	Aspergillus flavus	37.87	8.00e-77	282.00
IUUC-Afu-008937	Aspergillus fumigatus	38.64	3.00e-79	290.00
IUUC-Ani-009252	Aspergillus nidulans	37.95	5.00e-81	296.00
IUUC-Ang-009773	Aspergillus niger	33.85	2.00e-78	287.00
IUUC-Aor-009940	Aspergillus oryzae	37.87	8.00e-77	282.00
IUUC-Ate-010395	Aspergillus terreus	39.02	7.00e-77	282.00
IUUC-Ame-010769	Astyanax mexicanus	63.12	0.00e+00	1045.00
IUUC-Bgr-012269	Blumeria graminis	37.77	2.00e-75	276.00
IUUC-Bta-012841	Bos taurus	88.38	0.00e+00	1860.00
IUUC-Bci-013743	Botrytis cinerea	30.09	5.00e-88	319.00
IUUC-Bdi-014123	Brachypodium distachyon	46.81	1.00e-102	367.00
IUUC-Bol-015390	Brassica oleracea	35.23	2.00e-102	367.00
IUUC-Bra-016853	Brassica rapa	35.32	2.00e-109	390.00
IUUC-Cel-018638	Caenorhabditis elegans	39.37	1.00e-89	324.00
IUUC-Cja-019743	Callithrix jacchus	87.48	0.00e+00	1856.00
IUUC-Cfa-021031	Canis familiaris	89.14	0.00e+00	1902.00
IUUC-Cpo-022401	Cavia porcellus	87.17	0.00e+00	1850.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	44.50	2.00e-85	309.00
IUUC-Csa-024107	Chlorocebus sabaeus	89.38	0.00e+00	1892.00
IUUC-Cho-024750	Choloepus hoffmanni	82.29	0.00e+00	798.00
IUUC-Cin-025432	Ciona intestinalis	44.90	2.00e-97	349.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	34.72	7.00e-88	319.00
IUUC-Cne-026841	Cryptococcus neoformans	36.45	4.00e-94	340.00
IUUC-Cme-027265	Cyanidioschyzon merolae	47.10	4.00e-103	369.00
IUUC-Dre-028196	Danio rerio	74.88	0.00e+00	1543.00
IUUC-Dno-029024	Dasypus novemcinctus	88.73	0.00e+00	1900.00
IUUC-Dor-030483	Dipodomys ordii	91.38	0.00e+00	688.00
IUUC-Dse-031416	Dothistroma septosporum	33.90	3.00e-78	287.00
IUUC-Dme-031946	Drosophila melanogaster	36.32	0.00e+00	653.00
IUUC-Ete-032240	Echinops telfairi	79.33	4.00e-173	602.00
IUUC-Eca-033828	Equus caballus	90.69	0.00e+00	1914.00
IUUC-Eeu-034604	Erinaceus europaeus	86.15	3.00e-128	452.00
IUUC-Fca-035907	Felis catus	88.27	0.00e+00	1898.00
IUUC-Fal-037389	Ficedula albicollis	85.96	0.00e+00	1864.00
IUUC-Fox-037788	Fusarium oxysporum	37.61	1.00e-92	334.00
IUUC-Fso-038088	Fusarium solani	36.01	9.00e-90	325.00
IUUC-Gmo-039254	Gadus morhua	63.99	0.00e+00	1173.00
IUUC-Ggr-039941	Gaeumannomyces graminis	34.32	7.00e-84	305.00
IUUC-Gga-040310	Gallus gallus	86.06	0.00e+00	1863.00
IUUC-Gac-042054	Gasterosteus aculeatus	66.40	0.00e+00	1235.00
IUUC-Gma-042836	Glycine max	34.33	3.00e-103	370.00
IUUC-Ggo-045031	Gorilla gorilla	89.66	0.00e+00	1897.00
IUUC-Hsa-045880	Homo sapiens	89.57	0.00e+00	1896.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	77.59	0.00e+00	634.00
IUUC-Kpa-049307	Komagataella pastoris	36.75	3.00e-65	243.00
IUUC-Lch-050403	Latimeria chalumnae	78.84	0.00e+00	1607.00
IUUC-Loc-052218	Lepisosteus oculatus	78.53	0.00e+00	1637.00
IUUC-Lma-053096	Leptosphaeria maculans	38.58	9.00e-81	295.00
IUUC-Laf-054162	Loxodonta africana	85.33	0.00e+00	1625.00
IUUC-Mcc-055127	Macaca mulatta	89.47	0.00e+00	1893.00
IUUC-Meu-056187	Macropus eugenii	82.61	8.00e-106	378.00
IUUC-Mor-057021	Magnaporthe oryzae	34.08	5.00e-79	289.00
IUUC-Mpo-057570	Magnaporthe poae	36.68	1.00e-76	281.00
IUUC-Mtr-058154	Medicago truncatula	35.42	3.00e-106	380.00
IUUC-Mla-059124	Melampsora laricipopulina	48.28	5.00e-102	364.00
IUUC-Mga-059581	Meleagris gallopavo	86.10	0.00e+00	1858.00
IUUC-Mvi-060445	Microbotryum violaceum	38.36	3.00e-106	379.00
IUUC-Mmr-061360	Microcebus murinus	87.16	0.00e+00	1795.00
IUUC-Mdo-062194	Monodelphis domestica	87.49	0.00e+00	1862.00
IUUC-Mmu-064189	Mus musculus	87.72	0.00e+00	1881.00
IUUC-Mac-065275	Musa acuminata	50.12	1.00e-110	394.00
IUUC-Mpu-066439	Mustela putorius furo	89.65	0.00e+00	1871.00
IUUC-Nfi-068280	Neosartorya fischeri	38.64	2.00e-79	290.00
IUUC-Ncr-068869	Neurospora crassa	35.96	2.00e-82	301.00
IUUC-Nle-069687	Nomascus leucogenys	90.22	0.00e+00	1880.00
IUUC-Opr-070592	Ochotona princeps	96.00	4.00e-113	402.00
IUUC-Ont-071836	Oreochromis niloticus	75.35	0.00e+00	1593.00
IUUC-Oan-072800	Ornithorhynchus anatinus	86.06	0.00e+00	1853.00
IUUC-Ocu-074587	Oryctolagus cuniculus	89.75	0.00e+00	1904.00
IUUC-Ola-087209	Oryzias latipes	75.25	0.00e+00	1559.00
IUUC-Olu-087699	Ostreococcus lucimarinus	43.67	1.00e-88	320.00
IUUC-Oga-088776	Otolemur garnettii	85.12	0.00e+00	1724.00
IUUC-Oar-089441	Ovis aries	87.56	0.00e+00	1840.00
IUUC-Ptr-091273	Pan troglodytes	89.57	0.00e+00	1896.00
IUUC-Pan-091981	Papio anubis	89.57	0.00e+00	1894.00
IUUC-Psi-093203	Pelodiscus sinensis	84.62	0.00e+00	1601.00
IUUC-Pma-094738	Petromyzon marinus	63.84	0.00e+00	1300.00
IUUC-Pno-095132	Phaeosphaeria nodorum	34.67	3.00e-57	216.00
IUUC-Ppa-095682	Physcomitrella patens	35.62	5.00e-113	402.00
IUUC-Pfo-097511	Poecilia formosa	75.67	0.00e+00	1600.00
IUUC-Pab-098634	Pongo abelii	86.44	0.00e+00	1811.00
IUUC-Pop-099574	Populus trichocarpa	42.06	2.00e-95	344.00
IUUC-Pca-100987	Procavia capensis	98.17	0.00e+00	789.00
IUUC-Ppe-102040	Prunus persica	37.61	6.00e-97	348.00
IUUC-Pva-103034	Pteropus vampyrus	86.17	0.00e+00	1794.00
IUUC-Pgr-103513	Puccinia graminis	40.03	1.00e-108	388.00
IUUC-Ptt-103967	Puccinia triticina	41.92	6.00e-96	345.00
IUUC-Pte-104105	Pyrenophora teres	34.61	1.00e-81	298.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	37.72	1.00e-78	288.00
IUUC-Rno-105380	Rattus norvegicus	85.76	0.00e+00	1622.00
IUUC-Sce-106446	Saccharomyces cerevisiae	40.53	5.00e-68	253.00
IUUC-Sha-107108	Sarcophilus harrisii	81.31	0.00e+00	1711.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	43.19	5.00e-96	345.00
IUUC-Spo-108097	Schizosaccharomyces pombe	44.36	2.00e-94	340.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	31.02	1.00e-84	308.00
IUUC-Sit-110457	Setaria italica	48.77	1.00e-99	358.00
IUUC-Sly-111362	Solanum lycopersicum	36.08	5.00e-102	365.00
IUUC-Sar-113687	Sorex araneus	82.44	0.00e+00	917.00
IUUC-Sre-115038	Sporisorium reilianum	44.72	4.00e-99	356.00
IUUC-Ssc-115378	Sus scrofa	96.29	0.00e+00	757.00
IUUC-Tgu-116729	Taeniopygia guttata	85.79	0.00e+00	1851.00
IUUC-Tru-118068	Takifugu rubripes	74.52	0.00e+00	1555.00
IUUC-Tsy-118942	Tarsius syrichta	91.30	0.00e+00	701.00
IUUC-Tni-120732	Tetraodon nigroviridis	73.39	0.00e+00	1504.00
IUUC-Tca-121737	Theobroma cacao	35.58	2.00e-107	384.00
IUUC-Tre-121892	Trichoderma reesei	36.22	3.00e-88	320.00
IUUC-Tvi-122354	Trichoderma virens	36.04	4.00e-90	326.00
IUUC-Tme-127102	Tuber melanosporum	36.00	1.00e-92	335.00
IUUC-Tbe-127351	Tupaia belangeri	78.32	0.00e+00	1477.00
IUUC-Ttr-129061	Tursiops truncatus	86.16	0.00e+00	1808.00
IUUC-Uma-129343	Ustilago maydis	44.72	8.00e-100	358.00
IUUC-Vda-129748	Verticillium dahliae	38.82	8.00e-81	295.00
IUUC-Vvi-131234	Vitis vinifera	35.19	5.00e-104	372.00
IUUC-Xtr-132094	Xenopus tropicalis	82.40	0.00e+00	1716.00
IUUC-Xma-133923	Xiphophorus maculatus	75.94	0.00e+00	1605.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence