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Tag Content
UUCD2 ID IUUC-Oga-088460
UUCD1 version UUC-OtG-00558
Ensembl Protein ID ENSOGAP00000013993.2
UniProt Accession H0XDN9; H0XDN9_OTOGA
Genbank Protein ID ENSOGAP00000013993
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAQR03056953
Gene Name NEDD4L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOGAG00000015613.2 ENSOGAT00000015625.2 ENSOGAP00000013993.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.70e-135 451.1 543 874
Active Site
Position(s) Description Evidence
844 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 543  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 631
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 632  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 715
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 716  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 804
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 805  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 874
           *********************************************************************8 PP
   
Organism Otolemur garnettii
Protein Sequence
(Fasta)
TRDDFLGQVD VPLSHLPTED PTMERPYTFK DFLLRPRSHK SRVKGFLRLK MAYMPKNGGQ 60
DEESGEQRDD VEHGWEVVDS NDSASQHQEE LPPPPLPPGW EEKVDNLGRT YYVNHNNRTT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Oga-088460|E3,HECT|Otolemur garnettii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCCGAGACG ACTTCCTGGG CCAGGTGGAC GTGCCCCTTA GTCATCTTCC GGTAAGGGCA 60
TCACATGTGT TCTGCTACAT GCTGTGGGAG GTGGTTTATT TTCAGAGTAA TTTCTTGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Oga-088460|E3,HECT|Otolemur garnettii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001314 Ailuropoda melanoleuca 91.56 0.00e+00 1514.00
IUUC-Apl-003893 Anas platyrhynchos 90.19 0.00e+00 1534.00
IUUC-Aca-004744 Anolis carolinensis 86.45 0.00e+00 1470.00
IUUC-Ago-007742 Ashbya gossypii 48.91 1.00e-161 563.00
IUUC-Acl-008273 Aspergillus clavatus 49.26 9.00e-164 570.00
IUUC-Afl-008713 Aspergillus flavus 49.01 2.00e-161 562.00
IUUC-Afu-009103 Aspergillus fumigatus 49.02 8.00e-164 570.00
IUUC-Ani-009259 Aspergillus nidulans 49.16 1.00e-161 563.00
IUUC-Ang-009738 Aspergillus niger 49.33 5.00e-162 565.00
IUUC-Aor-010053 Aspergillus oryzae 58.05 2.00e-101 361.00
IUUC-Ate-010529 Aspergillus terreus 49.42 2.00e-164 573.00
IUUC-Ame-010810 Astyanax mexicanus 70.14 0.00e+00 1135.00
IUUC-Bgr-012148 Blumeria graminis 47.91 4.00e-154 538.00
IUUC-Bta-012679 Bos taurus 93.06 0.00e+00 1531.00
IUUC-Bci-013785 Botrytis cinerea 47.99 3.00e-156 545.00
IUUC-Cel-018564 Caenorhabditis elegans 52.53 0.00e+00 632.00
IUUC-Cja-018732 Callithrix jacchus 93.63 0.00e+00 1575.00
IUUC-Cfa-021226 Canis familiaris 93.16 0.00e+00 1567.00
IUUC-Cpo-021671 Cavia porcellus 91.45 0.00e+00 1523.00
IUUC-Csa-023344 Chlorocebus sabaeus 91.40 0.00e+00 1564.00
IUUC-Cho-024832 Choloepus hoffmanni 100.00 0.00e+00 741.00
IUUC-Cin-025157 Ciona intestinalis 63.95 0.00e+00 788.00
IUUC-Csv-026098 Ciona savignyi 59.04 0.00e+00 654.00
IUUC-Cgl-026642 Colletotrichum gloeosporioides 48.34 2.00e-155 542.00
IUUC-Cne-026849 Cryptococcus neoformans 47.53 1.00e-158 553.00
IUUC-Dre-027770 Danio rerio 77.67 0.00e+00 1246.00
IUUC-Dno-029466 Dasypus novemcinctus 93.61 0.00e+00 1579.00
IUUC-Dor-030138 Dipodomys ordii 89.88 0.00e+00 1466.00
IUUC-Dse-031241 Dothistroma septosporum 47.70 6.00e-160 558.00
IUUC-Dme-032166 Drosophila melanogaster 67.09 0.00e+00 710.00
IUUC-Ete-033145 Echinops telfairi 83.71 0.00e+00 1215.00
IUUC-Eca-033445 Equus caballus 93.61 0.00e+00 1534.00
IUUC-Eeu-035247 Erinaceus europaeus 85.63 0.00e+00 1356.00
IUUC-Fca-035489 Felis catus 90.51 0.00e+00 1469.00
IUUC-Fal-037604 Ficedula albicollis 87.50 0.00e+00 1505.00
IUUC-Fox-037774 Fusarium oxysporum 48.76 8.00e-159 554.00
IUUC-Fso-038393 Fusarium solani 47.41 8.00e-154 537.00
IUUC-Gmo-039674 Gadus morhua 75.06 0.00e+00 1216.00
IUUC-Ggr-040107 Gaeumannomyces graminis 47.75 6.00e-156 544.00
IUUC-Gga-040703 Gallus gallus 89.51 0.00e+00 1526.00
IUUC-Gac-042020 Gasterosteus aculeatus 78.65 0.00e+00 1255.00
IUUC-Ggo-045332 Gorilla gorilla 91.45 0.00e+00 1553.00
IUUC-Hsa-045968 Homo sapiens 93.39 0.00e+00 1574.00
IUUC-Kpa-049273 Komagataella pastoris 49.16 5.00e-162 564.00
IUUC-Lch-050443 Latimeria chalumnae 84.07 0.00e+00 1397.00
IUUC-Loc-052662 Lepisosteus oculatus 80.14 0.00e+00 1264.00
IUUC-Laf-053850 Loxodonta africana 91.79 0.00e+00 1560.00
IUUC-Mcc-055821 Macaca mulatta 93.27 0.00e+00 1573.00
IUUC-Meu-056712 Macropus eugenii 75.83 0.00e+00 645.00
IUUC-Mor-057097 Magnaporthe oryzae 47.75 2.00e-156 546.00
IUUC-Mpo-057442 Magnaporthe poae 52.16 2.00e-145 510.00
IUUC-Mla-058996 Melampsora laricipopulina 47.48 1.00e-155 543.00
IUUC-Mga-059264 Meleagris gallopavo 69.82 0.00e+00 1018.00
IUUC-Mvi-060395 Microbotryum violaceum 53.70 7.00e-150 524.00
IUUC-Mmr-060798 Microcebus murinus 90.00 0.00e+00 1456.00
IUUC-Mdo-062173 Monodelphis domestica 90.62 0.00e+00 1574.00
IUUC-Mmu-064136 Mus musculus 92.47 0.00e+00 1542.00
IUUC-Mpu-066765 Mustela putorius furo 93.39 0.00e+00 1541.00
IUUC-Mlu-067565 Myotis lucifugus 92.26 0.00e+00 1520.00
IUUC-Nfi-068427 Neosartorya fischeri 49.02 5.00e-164 571.00
IUUC-Ncr-068918 Neurospora crassa 47.40 2.00e-157 550.00
IUUC-Nle-069070 Nomascus leucogenys 89.41 0.00e+00 1482.00
IUUC-Opr-071044 Ochotona princeps 96.43 0.00e+00 1198.00
IUUC-Ont-072044 Oreochromis niloticus 76.44 0.00e+00 1283.00
IUUC-Oan-073032 Ornithorhynchus anatinus 88.37 0.00e+00 1387.00
IUUC-Ocu-074160 Oryctolagus cuniculus 89.86 0.00e+00 1493.00
IUUC-Ola-087467 Oryzias latipes 77.78 0.00e+00 1269.00
IUUC-Oar-090198 Ovis aries 92.70 0.00e+00 1528.00
IUUC-Ptr-090939 Pan troglodytes 93.39 0.00e+00 1574.00
IUUC-Pan-092284 Papio anubis 93.39 0.00e+00 1576.00
IUUC-Psi-093645 Pelodiscus sinensis 90.42 0.00e+00 1533.00
IUUC-Pma-094364 Petromyzon marinus 82.63 0.00e+00 859.00
IUUC-Pno-095118 Phaeosphaeria nodorum 48.17 4.00e-164 571.00
IUUC-Pab-098088 Pongo abelii 93.39 0.00e+00 1575.00
IUUC-Pca-100714 Procavia capensis 78.34 0.00e+00 1257.00
IUUC-Pva-102354 Pteropus vampyrus 91.22 0.00e+00 1519.00
IUUC-Pgr-103620 Puccinia graminis 53.53 8.00e-148 517.00
IUUC-Ptt-103806 Puccinia triticina 53.38 1.00e-122 433.00
IUUC-Pte-104016 Pyrenophora teres 49.00 4.00e-162 565.00
IUUC-Pyt-104550 Pyrenophora triticirepentis 49.00 4.00e-162 565.00
IUUC-Rno-105318 Rattus norvegicus 92.70 0.00e+00 1543.00
IUUC-Sce-106289 Saccharomyces cerevisiae 49.25 7.00e-164 571.00
IUUC-Sha-107482 Sarcophilus harrisii 92.18 0.00e+00 1563.00
IUUC-Sja-107786 Schizosaccharomyces japonicus 48.74 5.00e-152 531.00
IUUC-Spo-108171 Schizosaccharomyces pombe 48.91 1.00e-160 560.00
IUUC-Ssl-108514 Sclerotinia sclerotiorum 48.49 8.00e-158 550.00
IUUC-Ssc-115950 Sus scrofa 71.12 0.00e+00 1175.00
IUUC-Tgu-117130 Taeniopygia guttata 89.74 0.00e+00 1531.00
IUUC-Tru-118610 Takifugu rubripes 78.11 0.00e+00 1286.00
IUUC-Tsy-119492 Tarsius syrichta 91.22 0.00e+00 1536.00
IUUC-Tni-120113 Tetraodon nigroviridis 72.57 0.00e+00 1220.00
IUUC-Tre-122203 Trichoderma reesei 47.45 3.00e-152 532.00
IUUC-Tvi-122595 Trichoderma virens 47.27 2.00e-154 539.00
IUUC-Ttr-128235 Tursiops truncatus 98.92 0.00e+00 1084.00
IUUC-Vda-129753 Verticillium dahliae 47.85 6.00e-157 548.00
IUUC-Xtr-132859 Xenopus tropicalis 87.36 0.00e+00 1471.00
IUUC-Xma-133797 Xiphophorus maculatus 78.93 0.00e+00 1278.00
IUUC-Yli-134668 Yarrowia lipolytica 46.42 2.00e-162 566.00
Created Date 25-Jun-2017

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