iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-027095

Ensembl Protein ID

AAW45380

UniProt Accession

Q5KBV2; Q5KBV2_CRYNJ

Genbank Protein ID

AAW45380.2

Protein Name

Ubiquitin-protein ligase, putative

Genbank Nucleotide ID

AE017349

Gene Name

CNI01260

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CNI01260	AAW45380	AAW45380

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.70e-104	346.5	2924	3250
UBD/Alpha-Helix/UBA	1.20e-06	26.9	1147	1184

Active Site

Position(s)	Description	Evidence
3310	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkk.rlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklll 101
           +lk+ +l v+f+ E+g+d gGvtre+++ l++++++p+  lf+  + d++t+qpn++s + n  hl++F+f+Gr++g     grlld+ ++++fyk++l
   Q: 2924 ELKYgKLSVKFRHEDGVDVGGVTREWYSVLAQQIFDPNFALFEPCAADQQTYQPNKTSWI-NDVHLSYFKFVGRVIG-----GRLLDAYFNRAFYKQIL 3016
           56755899**************************************************99.56************99.....89*************** PP
   S: 102  gkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnev 200
           g+ +++ dle++dpe++ksl+++++n   di+   +d +f+++++++ge k++eLk++G+nipVt+ NkeeYv+lvv+yrl ++i+ q+++f eGf+++
   Q: 3017 GRTVDMRDLESIDPEYHKSLQWMLDN---DITGV-IDQEFTIEDDQFGEKKTVELKENGANIPVTEGNKEEYVRLVVSYRLDNSIRDQIKSFLEGFYDI 3111
           ************************99...99998.**************************************************************** PP
   S: 201  iplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirk.das 294
           ip+el+++F++ +lelli+G +++dv++lk+ t+  +g+++++p++ wFw++l++fs+eer++fL FvT+ssr+PlgGf +l+     +  +++k  ++
   Q: 3112 IPQELIQIFEPDQLELLISGITTVDVDELKNATQL-NGWKATDPEVAWFWRALRSFSQEERSRFLMFVTSSSRVPLGGFSQLQgssgTQPLQLQKlHGK 3209
           ***********************************.55*********************************************9888777788889999 PP
   S: 295  ddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +  lP+++TCfn+L LP+Y s+e+l+e+L++Ai+et gF++
   Q: 3210 EGGLPQASTCFNLLLLPTYASYEQLRERLQFAITETGGFGK 3250
           9**************************************86 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLld 40
           d   ++qlv+MGF+r  a +aL ++ nn+  A+++Ll+
   Q: 1147 DPTSVDQLVDMGFPRRGAERALIRSRNNITTATDLLLT 1184
           67789*******************************97 PP

Organism

Cryptococcus neoformans

Protein Sequence
(Fasta)

MLKTYHSNEG QEICKEAERS TSGDDLTIVL KQFQVWRYPR GDLHAWIPVL DRFDNLLAEI 60
IKSYDLTKLQ INDFTPKTKD MLLEILRLQR ILMENCTNRK LFNSYDRLAD LLLTNDLDVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTCAAGA CCTACCATAG CAATGAAGGT CAAGAAATCT GCAAAGAAGC AGAGCGCTCC 60
AGTGAGTATC ACCTCACCTG CTCCCCTCAC TCACTACTCA TCACTCAATA TCTTGTTTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS50237--HECT
PS50030--UBA

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

cne:CNI01260

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	30.02	1.00e-92	335.00
IUUC-Aml-001684	Ailuropoda melanoleuca	40.80	1.00e-105	378.00
IUUC-Atr-002582	Amborella trichopoda	45.65	9.00e-107	381.00
IUUC-Apl-003729	Anas platyrhynchos	45.15	1.00e-79	287.00
IUUC-Aca-005263	Anolis carolinensis	40.75	3.00e-107	383.00
IUUC-Aly-006083	Arabidopsis lyrata	30.62	6.00e-113	402.00
IUUC-Ath-007160	Arabidopsis thaliana	30.43	4.00e-112	399.00
IUUC-Ago-008005	Ashbya gossypii	34.53	1.00e-153	537.00
IUUC-Acl-008254	Aspergillus clavatus	46.38	2.00e-162	566.00
IUUC-Afl-008712	Aspergillus flavus	38.42	0.00e+00	694.00
IUUC-Afu-009022	Aspergillus fumigatus	47.60	1.00e-164	573.00
IUUC-Ani-009412	Aspergillus nidulans	41.00	0.00e+00	654.00
IUUC-Ang-009771	Aspergillus niger	40.34	0.00e+00	639.00
IUUC-Aor-010186	Aspergillus oryzae	44.38	6.00e-159	553.00
IUUC-Ate-010253	Aspergillus terreus	45.83	2.00e-161	563.00
IUUC-Ame-011067	Astyanax mexicanus	40.42	1.00e-102	367.00
IUUC-Bgr-012043	Blumeria graminis	38.76	0.00e+00	631.00
IUUC-Bta-012813	Bos taurus	40.80	2.00e-105	377.00
IUUC-Bci-013995	Botrytis cinerea	42.10	7.00e-156	545.00
IUUC-Bdi-014884	Brachypodium distachyon	47.06	3.00e-108	386.00
IUUC-Bra-016637	Brassica rapa	40.36	9.00e-111	394.00
IUUC-Cel-018179	Caenorhabditis elegans	44.13	2.00e-97	351.00
IUUC-Cja-018741	Callithrix jacchus	40.23	3.00e-105	376.00
IUUC-Cfa-020083	Canis familiaris	40.80	1.00e-105	377.00
IUUC-Cpo-021923	Cavia porcellus	35.78	5.00e-78	286.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	47.99	1.00e-111	394.00
IUUC-Csa-023853	Chlorocebus sabaeus	40.80	2.00e-105	377.00
IUUC-Cin-025627	Ciona intestinalis	46.92	3.00e-109	389.00
IUUC-Csv-025872	Ciona savignyi	46.68	2.00e-107	380.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	35.61	1.00e-180	627.00
IUUC-Cme-027267	Cyanidioschyzon merolae	43.44	2.00e-96	346.00
IUUC-Dre-028525	Danio rerio	38.81	1.00e-93	338.00
IUUC-Dno-029680	Dasypus novemcinctus	40.80	1.00e-105	377.00
IUUC-Dor-030902	Dipodomys ordii	38.78	1.00e-84	308.00
IUUC-Dse-031197	Dothistroma septosporum	38.33	1.00e-179	623.00
IUUC-Dme-032122	Drosophila melanogaster	45.02	9.00e-98	352.00
IUUC-Ete-032966	Echinops telfairi	38.90	1.00e-85	309.00
IUUC-Eca-033915	Equus caballus	41.07	6.00e-105	375.00
IUUC-Eeu-034963	Erinaceus europaeus	43.57	2.00e-102	367.00
IUUC-Fca-035824	Felis catus	40.80	1.00e-105	377.00
IUUC-Fox-037756	Fusarium oxysporum	37.03	0.00e+00	669.00
IUUC-Fso-038464	Fusarium solani	37.13	0.00e+00	644.00
IUUC-Gmo-039073	Gadus morhua	40.42	7.00e-104	372.00
IUUC-Ggr-039946	Gaeumannomyces graminis	40.28	6.00e-180	624.00
IUUC-Gac-042430	Gasterosteus aculeatus	40.12	7.00e-104	372.00
IUUC-Gma-042956	Glycine max	31.00	3.00e-109	389.00
IUUC-Ggo-044465	Gorilla gorilla	38.90	2.00e-85	308.00
IUUC-Hsa-046879	Homo sapiens	40.80	1.00e-105	378.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	41.00	5.00e-106	377.00
IUUC-Kpa-049228	Komagataella pastoris	42.97	8.00e-146	511.00
IUUC-Lch-050252	Latimeria chalumnae	40.92	8.00e-105	375.00
IUUC-Lpe-050915	Leersia perrieri	30.42	3.00e-112	399.00
IUUC-Loc-052472	Lepisosteus oculatus	40.61	1.00e-104	375.00
IUUC-Lma-053159	Leptosphaeria maculans	38.06	0.00e+00	658.00
IUUC-Laf-054154	Loxodonta africana	40.80	2.00e-105	377.00
IUUC-Mcc-055085	Macaca mulatta	40.80	2.00e-105	377.00
IUUC-Mor-057201	Magnaporthe oryzae	37.79	0.00e+00	638.00
IUUC-Mpo-057597	Magnaporthe poae	46.01	3.00e-159	556.00
IUUC-Mtr-058128	Medicago truncatula	35.21	9.00e-111	394.00
IUUC-Mla-058888	Melampsora laricipopulina	53.45	1.00e-121	427.00
IUUC-Mvi-060320	Microbotryum violaceum	47.97	0.00e+00	746.00
IUUC-Mmr-060820	Microcebus murinus	40.80	1.00e-105	378.00
IUUC-Mdo-062930	Monodelphis domestica	40.26	3.00e-107	383.00
IUUC-Mmu-063601	Mus musculus	40.80	1.00e-105	377.00
IUUC-Mac-065229	Musa acuminata	32.35	2.00e-114	406.00
IUUC-Mpu-066653	Mustela putorius furo	40.80	2.00e-105	377.00
IUUC-Mlu-067418	Myotis lucifugus	40.38	2.00e-106	380.00
IUUC-Nfi-068278	Neosartorya fischeri	47.28	2.00e-163	570.00
IUUC-Ncr-068813	Neurospora crassa	44.97	4.00e-160	559.00
IUUC-Nle-069418	Nomascus leucogenys	40.80	2.00e-105	377.00
IUUC-Ont-071300	Oreochromis niloticus	40.23	3.00e-103	370.00
IUUC-Oan-073046	Ornithorhynchus anatinus	40.60	3.00e-106	380.00
IUUC-Ocu-074178	Oryctolagus cuniculus	40.80	1.00e-105	378.00
IUUC-Oba-075757	Oryza barthii	32.40	1.00e-116	414.00
IUUC-Obr-076553	Oryza brachyantha	32.40	2.00e-115	410.00
IUUC-Ogl-077520	Oryza glaberrima	32.40	1.00e-116	414.00
IUUC-Ogu-078278	Oryza glumaepatula	37.22	2.00e-111	397.00
IUUC-Oin-079767	Oryza indica	32.50	7.00e-117	415.00
IUUC-Olo-080326	Oryza longistaminata	31.12	6.00e-109	389.00
IUUC-Ome-081925	Oryza meridionalis	32.05	3.00e-115	409.00
IUUC-Oni-082619	Oryza nivara	32.40	9.00e-117	414.00
IUUC-Opu-083428	Oryza punctata	31.46	6.00e-110	392.00
IUUC-Oru-084501	Oryza rufipogon	32.50	5.00e-117	415.00
IUUC-Osa-086251	Oryza sativa	37.22	4.00e-111	393.00
IUUC-Ola-086777	Oryzias latipes	39.13	3.00e-84	304.00
IUUC-Olu-087813	Ostreococcus lucimarinus	42.16	1.00e-92	331.00
IUUC-Oga-088903	Otolemur garnettii	40.80	1.00e-105	377.00
IUUC-Oar-090210	Ovis aries	40.80	1.00e-105	377.00
IUUC-Pan-092368	Papio anubis	39.75	9.00e-96	345.00
IUUC-Psi-093969	Pelodiscus sinensis	39.36	4.00e-85	307.00
IUUC-Pno-094871	Phaeosphaeria nodorum	36.27	0.00e+00	655.00
IUUC-Ppa-095834	Physcomitrella patens	46.59	2.00e-105	377.00
IUUC-Pfo-096232	Poecilia formosa	40.42	5.00e-104	372.00
IUUC-Pab-098583	Pongo abelii	40.80	1.00e-105	377.00
IUUC-Pop-099468	Populus trichocarpa	31.53	2.00e-118	420.00
IUUC-Ppe-101641	Prunus persica	32.43	1.00e-114	407.00
IUUC-Pva-102116	Pteropus vampyrus	38.89	1.00e-94	341.00
IUUC-Pgr-103465	Puccinia graminis	39.57	0.00e+00	671.00
IUUC-Ptt-103813	Puccinia triticina	39.64	0.00e+00	670.00
IUUC-Pte-104018	Pyrenophora teres	36.27	0.00e+00	663.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	35.30	0.00e+00	649.00
IUUC-Rno-105153	Rattus norvegicus	39.13	1.00e-85	309.00
IUUC-Sce-106449	Saccharomyces cerevisiae	34.08	1.00e-161	563.00
IUUC-Sha-106961	Sarcophilus harrisii	40.57	5.00e-107	382.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	37.23	0.00e+00	628.00
IUUC-Spo-108024	Schizosaccharomyces pombe	35.84	0.00e+00	631.00
IUUC-Smo-109640	Selaginella moellendorffii	45.65	1.00e-105	378.00
IUUC-Sit-110598	Setaria italica	32.90	5.00e-115	409.00
IUUC-Sly-111706	Solanum lycopersicum	37.81	1.00e-111	397.00
IUUC-Sar-113291	Sorex araneus	44.82	2.00e-99	357.00
IUUC-Sbi-114042	Sorghum bicolor	32.75	2.00e-116	413.00
IUUC-Sre-114958	Sporisorium reilianum	51.46	1.00e-146	511.00
IUUC-Ssc-115754	Sus scrofa	40.80	2.00e-105	377.00
IUUC-Tru-118570	Takifugu rubripes	40.31	2.00e-104	374.00
IUUC-Tca-121646	Theobroma cacao	39.11	5.00e-112	399.00
IUUC-Tre-121909	Trichoderma reesei	36.21	0.00e+00	644.00
IUUC-Tvi-122370	Trichoderma virens	36.28	0.00e+00	634.00
IUUC-Tae-125214	Triticum aestivum	31.06	6.00e-108	384.00
IUUC-Tur-126774	Triticum urartu	29.76	1.00e-47	182.00
IUUC-Tme-127172	Tuber melanosporum	38.52	0.00e+00	737.00
IUUC-Ttr-129253	Tursiops truncatus	40.80	3.00e-105	377.00
IUUC-Uma-129355	Ustilago maydis	51.56	4.00e-146	509.00
IUUC-Vda-129886	Verticillium dahliae	42.94	2.00e-158	553.00
IUUC-Vpa-130708	Vicugna pacos	40.80	2.00e-105	377.00
IUUC-Vvi-131170	Vitis vinifera	39.03	9.00e-111	393.00
IUUC-Xtr-132123	Xenopus tropicalis	38.00	2.00e-94	340.00
IUUC-Xma-133869	Xiphophorus maculatus	40.42	4.00e-104	373.00
IUUC-Yli-134657	Yarrowia lipolytica	36.27	8.00e-180	624.00
IUUC-Zma-135570	Zea mays	40.93	6.00e-110	392.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence