iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000019902.3	ENSMMUT00000027965.3	ENSMMUP00000026162.3
ENSMMUG00000019902.3	ENSMMUT00000070009.1	ENSMMUP00000052681.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.00e-08	36.7	246	284
UBD/Alpha-Helix/CUE	4.50e-11	43.6	361	402

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 246  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 284
           ********99.******************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 361  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 402
           5889*********************.***************95 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MLVAKLIQCI VFGPLRVSER QHLKDKFWNF IFYKFIFIFG VLNVQTVEEV VMWCLWFAGL 60
VFLHLMVQLC KDRFEYLSFS PTTPMSSHGR VLSLLVAMLL SCCGLAAVCC ITGYTHGMHT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACAGCGAC GCCAGAGCCC GTGGGCGCCG TTCGCGAGAC CGCGGCAGGG GCCCGGCCGC 60
AGCGCGGGGA GGCCCGGAGA CCGGAGGTCG CCGCTGCCGC CATGCCGCTG CTCTTCCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0004872--F:receptor activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

mcc:699972

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	94.31	0.00e+00	1004.00
IUUC-Apl-003404	Anas platyrhynchos	88.32	0.00e+00	915.00
IUUC-Aca-004559	Anolis carolinensis	85.66	0.00e+00	872.00
IUUC-Ame-011640	Astyanax mexicanus	73.90	0.00e+00	748.00
IUUC-Bta-012980	Bos taurus	95.99	0.00e+00	1025.00
IUUC-Cel-018598	Caenorhabditis elegans	24.57	2.00e-28	120.00
IUUC-Cja-019577	Callithrix jacchus	98.54	0.00e+00	1045.00
IUUC-Cfa-020793	Canis familiaris	94.73	0.00e+00	994.00
IUUC-Cpo-022387	Cavia porcellus	96.53	0.00e+00	1014.00
IUUC-Csa-023168	Chlorocebus sabaeus	99.45	0.00e+00	1053.00
IUUC-Cho-024433	Choloepus hoffmanni	96.69	0.00e+00	842.00
IUUC-Cin-025215	Ciona intestinalis	48.95	1.00e-142	500.00
IUUC-Csv-026133	Ciona savignyi	49.81	1.00e-129	456.00
IUUC-Dre-027594	Danio rerio	72.44	0.00e+00	705.00
IUUC-Dno-029407	Dasypus novemcinctus	96.90	0.00e+00	1001.00
IUUC-Dor-030961	Dipodomys ordii	96.72	0.00e+00	1021.00
IUUC-Ete-032962	Echinops telfairi	87.04	0.00e+00	847.00
IUUC-Eca-033683	Equus caballus	94.35	0.00e+00	983.00
IUUC-Eeu-034515	Erinaceus europaeus	100.00	2.00e-80	293.00
IUUC-Fca-035398	Felis catus	96.20	0.00e+00	962.00
IUUC-Fal-036758	Ficedula albicollis	81.61	0.00e+00	879.00
IUUC-Gmo-039014	Gadus morhua	73.92	0.00e+00	694.00
IUUC-Gga-040575	Gallus gallus	88.87	0.00e+00	940.00
IUUC-Gac-041414	Gasterosteus aculeatus	72.69	0.00e+00	674.00
IUUC-Hsa-046272	Homo sapiens	99.27	0.00e+00	1052.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	96.17	0.00e+00	1012.00
IUUC-Lch-050491	Latimeria chalumnae	80.78	0.00e+00	799.00
IUUC-Loc-052758	Lepisosteus oculatus	80.23	0.00e+00	751.00
IUUC-Laf-053452	Loxodonta africana	97.08	0.00e+00	1013.00
IUUC-Meu-056726	Macropus eugenii	87.67	0.00e+00	751.00
IUUC-Mga-059937	Meleagris gallopavo	88.87	0.00e+00	928.00
IUUC-Mmr-060730	Microcebus murinus	96.35	0.00e+00	1014.00
IUUC-Mdo-062771	Monodelphis domestica	93.18	0.00e+00	972.00
IUUC-Mmu-064219	Mus musculus	95.83	0.00e+00	1016.00
IUUC-Mpu-066796	Mustela putorius furo	95.80	0.00e+00	1020.00
IUUC-Mlu-068189	Myotis lucifugus	93.61	0.00e+00	961.00
IUUC-Nle-069239	Nomascus leucogenys	99.45	0.00e+00	1054.00
IUUC-Opr-070702	Ochotona princeps	90.22	7.00e-141	494.00
IUUC-Ont-072033	Oreochromis niloticus	75.00	0.00e+00	734.00
IUUC-Oan-073717	Ornithorhynchus anatinus	85.43	0.00e+00	852.00
IUUC-Ocu-074145	Oryctolagus cuniculus	94.16	0.00e+00	1010.00
IUUC-Ogl-077929	Oryza glaberrima	53.49	7.00e-11	60.10
IUUC-Ola-087152	Oryzias latipes	73.03	0.00e+00	709.00
IUUC-Oga-088486	Otolemur garnettii	97.63	0.00e+00	1026.00
IUUC-Oar-089310	Ovis aries	95.99	0.00e+00	1026.00
IUUC-Ptr-090649	Pan troglodytes	99.27	0.00e+00	1051.00
IUUC-Pan-091692	Papio anubis	94.89	0.00e+00	991.00
IUUC-Psi-093064	Pelodiscus sinensis	94.97	0.00e+00	778.00
IUUC-Pma-094763	Petromyzon marinus	77.35	2.00e-91	328.00
IUUC-Ppa-095969	Physcomitrella patens	30.28	5.00e-36	145.00
IUUC-Pfo-096810	Poecilia formosa	73.44	0.00e+00	714.00
IUUC-Pab-097859	Pongo abelii	99.27	0.00e+00	1055.00
IUUC-Pop-099576	Populus trichocarpa	27.06	1.00e-28	120.00
IUUC-Pca-100344	Procavia capensis	94.91	0.00e+00	970.00
IUUC-Pva-103114	Pteropus vampyrus	67.34	4.00e-178	618.00
IUUC-Rno-105880	Rattus norvegicus	93.74	0.00e+00	989.00
IUUC-Sha-107015	Sarcophilus harrisii	93.40	0.00e+00	937.00
IUUC-Smo-109664	Selaginella moellendorffii	31.35	2.00e-33	136.00
IUUC-Sar-113397	Sorex araneus	98.92	0.00e+00	771.00
IUUC-Ssc-115988	Sus scrofa	92.71	4.00e-144	503.00
IUUC-Tgu-116717	Taeniopygia guttata	89.77	0.00e+00	896.00
IUUC-Tru-117805	Takifugu rubripes	72.05	0.00e+00	739.00
IUUC-Tsy-119442	Tarsius syrichta	90.51	0.00e+00	926.00
IUUC-Tni-119777	Tetraodon nigroviridis	71.56	2.00e-171	595.00
IUUC-Tbe-127322	Tupaia belangeri	68.01	6.00e-110	391.00
IUUC-Ttr-128181	Tursiops truncatus	95.07	0.00e+00	1023.00
IUUC-Vpa-130483	Vicugna pacos	85.37	0.00e+00	647.00
IUUC-Xtr-132614	Xenopus tropicalis	81.18	0.00e+00	748.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence