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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064130
Ensembl Protein ID ENSMUSP00000108294.1
UniProt Accession Q08376; ZBT14_MOUSE
Genbank Protein ID AAA02940.1; AAH52017.1
Protein Name Zinc finger and BTB domain-containing protein 14; Zinc finger protein 161; Zinc finger protein 5
Genbank Nucleotide ID L15325; BC052017
Gene Name Zbtb14; Zfp-5; Zfp161; Zfp5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000049672.14 ENSMUST00000112674.7 ENSMUSP00000108294.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsiteJASPARmiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 6.60e-15 56.3 36 101
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgklden 68
           +D+ +vv++++f+ah++vLaa+S +F++lf ++le +s  ++ +ei+ +  + f+++l+++Yt k++ +
   Q: 36   CDIAIVVEDVKFRAHRCVLAACSTYFKKLF-KKLEvDS--SSVIEIDFLRSDIFEEVLNYMYTAKISVK 101
           8*****************************.4566466..89*****9****************99865 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene (By similarity). Transcriptional repressor of MYC and thymidine kinase promoters.
 Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene (By similarity). Transcriptional repressor of MYC and thymidine kinase promoters.
Protein Sequence
(Fasta)
MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH RCVLAACSTY 60
FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV KKEDVNLMMS SGQILGIRFL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064130|E3,BTB_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGTGTGCT CGTGCAGGAG GAGGGCTGCC ACCACCAGGG ACGTGCACGA TTCCCCCCCT 60
ACCCCACCCC CTCCCCAAAC TCAGAAAAAA AAAAATTAAA AAAAAATCCA AAACACTGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064130|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0016235--C:aggresome
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0003279--P:cardiac septum development
GO:0060976--P:coronary vasculature development
GO:0003170--P:heart valve development
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:22666
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001753 Ailuropoda melanoleuca 99.33 0.00e+00 845.00
IUUC-Apl-003283 Anas platyrhynchos 93.99 0.00e+00 815.00
IUUC-Aca-004393 Anolis carolinensis 92.87 0.00e+00 808.00
IUUC-Ame-011467 Astyanax mexicanus 75.11 0.00e+00 631.00
IUUC-Bta-012973 Bos taurus 98.88 0.00e+00 841.00
IUUC-Cja-019628 Callithrix jacchus 99.33 0.00e+00 848.00
IUUC-Cfa-020023 Canis familiaris 99.55 0.00e+00 847.00
IUUC-Csa-023821 Chlorocebus sabaeus 99.33 0.00e+00 848.00
IUUC-Cho-024977 Choloepus hoffmanni 99.11 0.00e+00 844.00
IUUC-Dre-027417 Danio rerio 76.51 3.00e-180 624.00
IUUC-Dor-030435 Dipodomys ordii 99.11 0.00e+00 847.00
IUUC-Ete-032628 Echinops telfairi 97.10 0.00e+00 826.00
IUUC-Eca-033287 Equus caballus 99.11 0.00e+00 845.00
IUUC-Fca-036098 Felis catus 99.11 0.00e+00 847.00
IUUC-Fal-037053 Ficedula albicollis 94.22 0.00e+00 796.00
IUUC-Gmo-039037 Gadus morhua 63.35 8.00e-105 373.00
IUUC-Gga-040669 Gallus gallus 94.89 0.00e+00 824.00
IUUC-Gac-041324 Gasterosteus aculeatus 65.65 4.00e-153 534.00
IUUC-Ggo-045482 Gorilla gorilla 99.33 0.00e+00 848.00
IUUC-Hsa-046032 Homo sapiens 99.33 0.00e+00 848.00
IUUC-Itr-048659 Ictidomys tridecemlineatus 98.44 0.00e+00 838.00
IUUC-Lch-050626 Latimeria chalumnae 87.36 0.00e+00 758.00
IUUC-Loc-052339 Lepisosteus oculatus 81.21 0.00e+00 700.00
IUUC-Laf-054425 Loxodonta africana 87.50 0.00e+00 707.00
IUUC-Mcc-054963 Macaca mulatta 99.33 0.00e+00 848.00
IUUC-Meu-056097 Macropus eugenii 95.32 0.00e+00 835.00
IUUC-Mga-060044 Meleagris gallopavo 94.15 0.00e+00 813.00
IUUC-Mmr-060645 Microcebus murinus 99.11 0.00e+00 848.00
IUUC-Mdo-062972 Monodelphis domestica 95.32 0.00e+00 837.00
IUUC-Mpu-066481 Mustela putorius furo 99.33 0.00e+00 848.00
IUUC-Mlu-067950 Myotis lucifugus 85.27 0.00e+00 707.00
IUUC-Nle-069887 Nomascus leucogenys 99.11 0.00e+00 846.00
IUUC-Ont-071683 Oreochromis niloticus 70.44 9.00e-178 616.00
IUUC-Oan-073523 Ornithorhynchus anatinus 89.53 0.00e+00 777.00
IUUC-Ocu-074079 Oryctolagus cuniculus 99.11 0.00e+00 847.00
IUUC-Ola-087045 Oryzias latipes 52.12 4.00e-121 427.00
IUUC-Oga-088178 Otolemur garnettii 99.33 0.00e+00 845.00
IUUC-Ptr-091539 Pan troglodytes 98.89 0.00e+00 844.00
IUUC-Pan-092044 Papio anubis 99.33 0.00e+00 848.00
IUUC-Psi-093698 Pelodiscus sinensis 93.90 0.00e+00 814.00
IUUC-Pma-094150 Petromyzon marinus 41.11 3.00e-88 318.00
IUUC-Pfo-096504 Poecilia formosa 71.75 1.00e-180 625.00
IUUC-Pab-098387 Pongo abelii 99.33 0.00e+00 848.00
IUUC-Pop-098852 Populus trichocarpa 39.24 7.00e-08 52.40
IUUC-Pca-100494 Procavia capensis 99.11 0.00e+00 846.00
IUUC-Pva-102568 Pteropus vampyrus 99.33 0.00e+00 848.00
IUUC-Rno-105873 Rattus norvegicus 100.00 0.00e+00 850.00
IUUC-Sha-107503 Sarcophilus harrisii 94.48 0.00e+00 625.00
IUUC-Tru-118010 Takifugu rubripes 70.73 3.00e-171 594.00
IUUC-Tni-120503 Tetraodon nigroviridis 71.11 2.00e-176 611.00
IUUC-Tbe-127288 Tupaia belangeri 98.89 0.00e+00 845.00
IUUC-Xtr-132271 Xenopus tropicalis 88.74 0.00e+00 771.00
Created Date 25-Jun-2017

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