iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-026336

UUCD1 version

UUC-CiS-00380

Ensembl Protein ID

ENSCSAVP00000011840.1

UniProt Accession

H2Z2M8; H2Z2M8_CIOSA

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000006946.1	ENSCSAVT00000011977.1	ENSCSAVP00000011839.1
ENSCSAVG00000006946.1	ENSCSAVT00000011978.1	ENSCSAVP00000011840.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.00e-76	255.6	4231	4559

Active Site

Position(s)	Description	Evidence
4528	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
           +r++ v+f+gE++ d+gG  +e ++++++elqn +++l+  ++n++ +   n+d ++ n       h+++F+flG l+g+a+++g 
   Q: 4231 HRIWkVKFLGESVDDCGGGYSESITEICDELQNGSVPLLSITPNGRDESGANRDCFIFNSaassdVHIRMFKFLGLLIGIAMRTGS 4316
           56677***************************************99999******99999999999******************** PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkee 172
           +l ++l+++++k+l + k  l+d+ e+d++++   ++i++ + ++++++  ++ f+     ++ + + e+  ++ +  V+ +N++e
   Q: 4317 PLSINLAEPVWKQLASIKPCLKDITEIDKHFVPKSMYIRDCEPHELDNM--QMPFT----TYSACGK-EISLSSTHQTVNAQNRNE 4395
           ***************************************9976666665..55554....2445555.59999************* PP
   S: 173  YvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           Y++l ++yrl+e ++++v+a+reG+  v+p  llslFt++ele+ +cG+++i ++ lk+  + kg + ++++ iqwFwe+le f++
   Q: 4396 YIRLAIQYRLHE-FDQMVAAVREGMACVVPVPLLSLFTASELETTVCGSPDIPLHLLKSVSTCKG-VPPNDELIQWFWETLETFTD 4479
           ************.**********************************************999966.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer+ fL+Fv+g+ rlP + +a+++ r fvi+        d+ lP+s TCf++LkLP+Ys k +l ekL yAi+ +k++++
   Q: 4480 EERSLFLRFVWGRTRLP-RSIADFRGRDFVIQVpdkyHPPDHYLPESYTCFFMLKLPRYSCKPVLAEKLKYAIHFCKSIDT 4559
           *****************.8*************9999777789**********************************99875 PP

Organism

Ciona savignyi

Protein Sequence
(Fasta)

LSSIGSRYIL SFAFSFLRRA WRMGEDTDLC TEMLQDTLDS FREFLPATLF DQSQLTPAWI 60
EILERSDKFL RSVACPAASS TRGDIPLSDQ QTALNLMLEL CIQRGRLGVM LDAVVFLLNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAGCAGCA TAGGGAGTCG ATATATCTTG TCGTTTGCGT TCTCGTTCCT CCGTCGAGCG 60
TGGAGGATGG GTGAGGATAC CGACTTGTGC ACTGAGATGT TGCAGGTGAC AATGGTGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR021097--CPH_domain
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000696	Aegilops tauschii	27.63	1.00e-26	114.00
IUUC-Aml-002112	Ailuropoda melanoleuca	59.73	0.00e+00	1452.00
IUUC-Atr-003065	Amborella trichopoda	32.98	1.00e-46	180.00
IUUC-Apl-003983	Anas platyrhynchos	41.95	0.00e+00	3047.00
IUUC-Aca-004300	Anolis carolinensis	42.09	0.00e+00	3044.00
IUUC-Aly-006441	Arabidopsis lyrata	32.61	3.00e-40	159.00
IUUC-Ath-007268	Arabidopsis thaliana	29.34	9.00e-28	117.00
IUUC-Ame-010621	Astyanax mexicanus	59.52	0.00e+00	1445.00
IUUC-Bta-013067	Bos taurus	36.23	0.00e+00	1558.00
IUUC-Bdi-014093	Brachypodium distachyon	32.21	2.00e-48	186.00
IUUC-Bol-015203	Brassica oleracea	31.90	8.00e-48	184.00
IUUC-Bra-016737	Brassica rapa	32.95	8.00e-44	171.00
IUUC-Cja-019687	Callithrix jacchus	36.31	0.00e+00	1512.00
IUUC-Cfa-020672	Canis familiaris	36.29	0.00e+00	1576.00
IUUC-Cpo-021819	Cavia porcellus	59.60	0.00e+00	1450.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	37.32	1.00e-49	188.00
IUUC-Csa-023817	Chlorocebus sabaeus	36.41	0.00e+00	1564.00
IUUC-Cho-024387	Choloepus hoffmanni	49.80	0.00e+00	827.00
IUUC-Cin-025709	Ciona intestinalis	79.73	0.00e+00	2085.00
IUUC-Dre-027717	Danio rerio	59.46	0.00e+00	1445.00
IUUC-Dno-029296	Dasypus novemcinctus	41.99	0.00e+00	3064.00
IUUC-Dor-030979	Dipodomys ordii	66.36	0.00e+00	768.00
IUUC-Dme-032171	Drosophila melanogaster	49.59	0.00e+00	1221.00
IUUC-Ete-032687	Echinops telfairi	45.50	0.00e+00	799.00
IUUC-Eca-034046	Equus caballus	35.91	0.00e+00	1533.00
IUUC-Eeu-034859	Erinaceus europaeus	56.05	0.00e+00	766.00
IUUC-Fca-036262	Felis catus	36.31	0.00e+00	1575.00
IUUC-Fal-037562	Ficedula albicollis	41.94	0.00e+00	3030.00
IUUC-Gmo-038739	Gadus morhua	61.89	0.00e+00	717.00
IUUC-Gga-040359	Gallus gallus	45.27	0.00e+00	2668.00
IUUC-Gac-041879	Gasterosteus aculeatus	61.19	0.00e+00	734.00
IUUC-Gma-043808	Glycine max	32.02	1.00e-44	173.00
IUUC-Ggo-044692	Gorilla gorilla	59.22	0.00e+00	1420.00
IUUC-Hsa-045995	Homo sapiens	36.53	0.00e+00	1591.00
IUUC-Hvu-047529	Hordeum vulgare	35.01	2.00e-49	189.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	37.08	0.00e+00	627.00
IUUC-Lch-049808	Latimeria chalumnae	52.72	0.00e+00	1882.00
IUUC-Lpe-051482	Leersia perrieri	32.76	2.00e-43	169.00
IUUC-Loc-052685	Lepisosteus oculatus	36.17	0.00e+00	1511.00
IUUC-Laf-053372	Loxodonta africana	43.54	0.00e+00	2655.00
IUUC-Mcc-054693	Macaca mulatta	36.41	0.00e+00	1579.00
IUUC-Meu-056660	Macropus eugenii	64.47	0.00e+00	1289.00
IUUC-Mtr-058277	Medicago truncatula	34.58	1.00e-46	178.00
IUUC-Mga-059371	Meleagris gallopavo	45.21	0.00e+00	2655.00
IUUC-Mmr-060787	Microcebus murinus	41.83	0.00e+00	3021.00
IUUC-Mdo-062518	Monodelphis domestica	36.34	0.00e+00	1608.00
IUUC-Mmu-063690	Mus musculus	41.97	0.00e+00	3007.00
IUUC-Mpu-066478	Mustela putorius furo	35.69	0.00e+00	1519.00
IUUC-Mlu-067596	Myotis lucifugus	40.36	0.00e+00	1108.00
IUUC-Nle-069633	Nomascus leucogenys	37.13	1.00e-175	611.00
IUUC-Opr-070990	Ochotona princeps	59.90	0.00e+00	1444.00
IUUC-Ont-072285	Oreochromis niloticus	35.88	0.00e+00	1469.00
IUUC-Oan-072721	Ornithorhynchus anatinus	58.77	0.00e+00	1429.00
IUUC-Ocu-074273	Oryctolagus cuniculus	41.57	0.00e+00	2947.00
IUUC-Oba-075262	Oryza barthii	31.31	1.00e-42	165.00
IUUC-Obr-076107	Oryza brachyantha	33.07	3.00e-47	182.00
IUUC-Ogl-077586	Oryza glaberrima	31.31	1.00e-42	165.00
IUUC-Ogu-078817	Oryza glumaepatula	32.48	2.00e-42	166.00
IUUC-Oin-079609	Oryza indica	32.84	4.00e-48	184.00
IUUC-Olo-080629	Oryza longistaminata	32.48	2.00e-42	166.00
IUUC-Ome-081686	Oryza meridionalis	32.48	5.00e-43	168.00
IUUC-Oni-082049	Oryza nivara	31.07	6.00e-42	163.00
IUUC-Opu-084137	Oryza punctata	32.76	2.00e-43	169.00
IUUC-Oru-085013	Oryza rufipogon	32.48	2.00e-42	166.00
IUUC-Osa-085597	Oryza sativa	32.48	2.00e-42	166.00
IUUC-Ola-087346	Oryzias latipes	64.62	0.00e+00	866.00
IUUC-Olu-087836	Ostreococcus lucimarinus	31.29	2.00e-31	128.00
IUUC-Oga-088742	Otolemur garnettii	41.94	0.00e+00	2977.00
IUUC-Oar-090093	Ovis aries	41.80	0.00e+00	2990.00
IUUC-Ptr-091034	Pan troglodytes	53.05	0.00e+00	1182.00
IUUC-Pan-092783	Papio anubis	36.29	0.00e+00	1566.00
IUUC-Psi-094027	Pelodiscus sinensis	36.37	0.00e+00	1571.00
IUUC-Pma-094275	Petromyzon marinus	38.38	3.00e-58	218.00
IUUC-Pfo-096208	Poecilia formosa	38.29	0.00e+00	1170.00
IUUC-Pab-097760	Pongo abelii	36.89	0.00e+00	631.00
IUUC-Pop-099121	Populus trichocarpa	33.87	3.00e-49	189.00
IUUC-Pca-100465	Procavia capensis	37.59	0.00e+00	630.00
IUUC-Ppe-101345	Prunus persica	33.61	3.00e-47	182.00
IUUC-Pva-103147	Pteropus vampyrus	53.61	0.00e+00	796.00
IUUC-Rno-105458	Rattus norvegicus	41.86	0.00e+00	3003.00
IUUC-Sha-106959	Sarcophilus harrisii	34.47	0.00e+00	1456.00
IUUC-Smo-108827	Selaginella moellendorffii	33.42	2.00e-47	182.00
IUUC-Sit-109917	Setaria italica	33.80	3.00e-46	178.00
IUUC-Sly-110961	Solanum lycopersicum	35.00	8.00e-52	197.00
IUUC-Stu-112166	Solanum tuberosum	33.06	4.00e-47	182.00
IUUC-Sar-113532	Sorex araneus	48.42	1.00e-132	468.00
IUUC-Sbi-114352	Sorghum bicolor	32.27	1.00e-49	190.00
IUUC-Ssc-116304	Sus scrofa	67.57	0.00e+00	680.00
IUUC-Tgu-116789	Taeniopygia guttata	41.99	0.00e+00	3042.00
IUUC-Tru-118129	Takifugu rubripes	59.63	0.00e+00	1448.00
IUUC-Tsy-119302	Tarsius syrichta	44.27	1.00e-130	461.00
IUUC-Tni-120374	Tetraodon nigroviridis	35.76	0.00e+00	1456.00
IUUC-Tca-121094	Theobroma cacao	31.75	6.00e-45	174.00
IUUC-Tae-124157	Triticum aestivum	33.42	1.00e-49	190.00
IUUC-Tur-126300	Triticum urartu	35.01	2.00e-50	193.00
IUUC-Tbe-128137	Tupaia belangeri	64.03	1.00e-161	564.00
IUUC-Ttr-128273	Tursiops truncatus	65.89	0.00e+00	919.00
IUUC-Vpa-130471	Vicugna pacos	44.99	2.00e-138	486.00
IUUC-Xtr-132185	Xenopus tropicalis	43.98	0.00e+00	2529.00
IUUC-Xma-133233	Xiphophorus maculatus	59.36	0.00e+00	1423.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence