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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106382
UUCD1 version UUC-SaC-00010
Ensembl Protein ID YJR090C
UniProt Accession P24814; D6VWQ8; GRR1_YEAST
Genbank Protein ID AAA34652.1; CAA89617.1; AAB39313.1; DAA08874.1
Protein Name SCF E3 ubiquitin ligase complex F-box protein GRR1; F-box and leucine-rich repeat protein GRR1; F-box/LRR-repeat protein GRR1
Genbank Nucleotide ID M59247; Z49590; L47993; BK006943
Gene Name GRR1; CAT80; COT2; YJR090C; J1885
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YJR090C YJR090C YJR090C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 17984223; 11527976; 12052857; 21127045; 17145966; 19243310; 16112084; 16093347; 15456873; 17828247; 18794371; 18988848; 15890364; 15601864
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 25.42 7.00e-23 107.00 IUUC-Mmu-063739
E3 adaptor/Cullin RING/SCF/F-box 30.11 6.00e-43 171.00 IUUC-Spo-108376
E3 adaptor/Cullin RING/SCF/F-box 47.58 3.00e-130 461.00 IUUC-Ots-000001
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2. Probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2. Probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression.
Protein Sequence
(Fasta)
MDQDNNNHND SNRLHPPDIH PNLGPQLWLN SSGDFDDNNN NNNNNNNNNS TRPQMPSRTR 60
ETATSERNAS EVRDATLNNI FRFDSIQRET LLPTNNGQPL NQNFSLTFQP QQQTNALNGI 120
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Protein Fasta Sequence


>IUUC-Sce-106382|E3,F-box|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGGATCAGG ATAACAACAA CCACAATGAC AGCAATAGGC TGCACCCACC TGATATACAT 60
CCAAATTTGG GCCCTCAATT GTGGCTGAAT AGTAGCGGTG ATTTTGACGA CAACAACAAC 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106382|E3,F-box|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0119--Carbohydrate metabolism
KW-0181--Complete proteome
KW-0313--Glucose metabolism
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
PROSITE

PS50181--FBOX
SMART

SM00256--FBOX
SM00367--LRR_CC
Gene Ontology

GO:0000142--C:cellular bud neck contractile ring
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030674--F:protein binding, bridging
GO:0071406--P:cellular response to methylmercury
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0006006--P:glucose metabolic process
GO:0000751--P:mitotic cell cycle G1 arrest in response to pheromone
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG sce:YJR090C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000881 Aegilops tauschii 19.45 1.00e-15 76.60
IUUC-Aml-001686 Ailuropoda melanoleuca 25.42 1.00e-26 112.00
IUUC-Atr-002443 Amborella trichopoda 25.12 7.00e-25 106.00
IUUC-Apl-003807 Anas platyrhynchos 26.51 3.00e-26 110.00
IUUC-Aca-004693 Anolis carolinensis 26.44 4.00e-28 117.00
IUUC-Aly-006077 Arabidopsis lyrata 22.92 4.00e-22 97.80
IUUC-Ath-007544 Arabidopsis thaliana 23.51 1.00e-22 99.00
IUUC-Ago-007921 Ashbya gossypii 49.90 0.00e+00 946.00
IUUC-Acl-008301 Aspergillus clavatus 42.37 2.00e-106 377.00
IUUC-Afl-008738 Aspergillus flavus 42.32 8.00e-107 379.00
IUUC-Afu-009085 Aspergillus fumigatus 41.34 7.00e-105 372.00
IUUC-Ani-009369 Aspergillus nidulans 42.23 2.00e-108 384.00
IUUC-Ang-009719 Aspergillus niger 41.42 3.00e-107 380.00
IUUC-Aor-009957 Aspergillus oryzae 42.32 1.00e-107 381.00
IUUC-Ate-010490 Aspergillus terreus 40.70 2.00e-105 374.00
IUUC-Ame-011441 Astyanax mexicanus 26.35 1.00e-25 108.00
IUUC-Bgr-011980 Blumeria graminis 32.28 6.00e-71 259.00
IUUC-Bta-012431 Bos taurus 25.42 1.00e-26 112.00
IUUC-Bci-013599 Botrytis cinerea 38.19 2.00e-96 344.00
IUUC-Bdi-015021 Brachypodium distachyon 25.75 7.00e-26 110.00
IUUC-Bol-016227 Brassica oleracea 23.21 2.00e-21 95.50
IUUC-Bra-016960 Brassica rapa 21.70 6.00e-20 89.70
IUUC-Cel-018603 Caenorhabditis elegans 24.03 3.00e-23 100.00
IUUC-Cja-019691 Callithrix jacchus 25.42 1.00e-26 112.00
IUUC-Cfa-020128 Canis familiaris 25.42 1.00e-26 112.00
IUUC-Cpo-021658 Cavia porcellus 25.42 1.00e-26 112.00
IUUC-Csa-024001 Chlorocebus sabaeus 25.42 1.00e-26 112.00
IUUC-Cho-024787 Choloepus hoffmanni 24.50 5.00e-22 96.70
IUUC-Cin-025116 Ciona intestinalis 26.77 5.00e-24 103.00
IUUC-Csv-025897 Ciona savignyi 24.84 3.00e-24 103.00
IUUC-Cgl-026645 Colletotrichum gloeosporioides 39.18 6.00e-95 339.00
IUUC-Cne-027024 Cryptococcus neoformans 33.60 3.00e-66 244.00
IUUC-Cme-027303 Cyanidioschyzon merolae 25.64 8.00e-15 73.20
IUUC-Dre-027642 Danio rerio 27.12 8.00e-30 122.00
IUUC-Dno-029404 Dasypus novemcinctus 25.08 7.00e-27 112.00
IUUC-Dor-031069 Dipodomys ordii 25.00 8.00e-13 65.90
IUUC-Dse-031403 Dothistroma septosporum 36.35 2.00e-97 348.00
IUUC-Dme-032125 Drosophila melanogaster 28.25 1.00e-25 109.00
IUUC-Ete-033027 Echinops telfairi 24.31 1.00e-20 92.00
IUUC-Eca-033855 Equus caballus 25.42 1.00e-26 112.00
IUUC-Eeu-034930 Erinaceus europaeus 24.91 3.00e-18 84.30
IUUC-Fca-035529 Felis catus 25.34 4.00e-25 107.00
IUUC-Fal-037266 Ficedula albicollis 25.76 7.00e-28 115.00
IUUC-Fox-037823 Fusarium oxysporum 38.29 2.00e-97 348.00
IUUC-Fso-038381 Fusarium solani 38.08 3.00e-98 350.00
IUUC-Gmo-039470 Gadus morhua 26.35 4.00e-27 113.00
IUUC-Ggr-039725 Gaeumannomyces graminis 38.66 1.00e-101 362.00
IUUC-Gga-040609 Gallus gallus 26.33 3.00e-24 104.00
IUUC-Gac-041522 Gasterosteus aculeatus 26.35 2.00e-27 114.00
IUUC-Gma-043283 Glycine max 24.20 5.00e-18 84.00
IUUC-Ggo-044918 Gorilla gorilla 25.00 7.00e-24 102.00
IUUC-Hsa-045782 Homo sapiens 25.42 1.00e-26 112.00
IUUC-Hvu-047284 Hordeum vulgare 25.43 2.00e-14 71.60
IUUC-Itr-048431 Ictidomys tridecemlineatus 25.42 1.00e-26 112.00
IUUC-Kpa-049356 Komagataella pastoris 43.42 7.00e-122 429.00
IUUC-Lch-050194 Latimeria chalumnae 25.33 3.00e-23 100.00
IUUC-Lpe-051035 Leersia perrieri 25.46 1.00e-22 99.40
IUUC-Loc-052210 Lepisosteus oculatus 26.78 3.00e-29 120.00
IUUC-Lma-053046 Leptosphaeria maculans 40.25 1.00e-102 365.00
IUUC-Laf-054025 Loxodonta africana 25.42 8.00e-27 112.00
IUUC-Mcc-055833 Macaca mulatta 25.42 1.00e-26 112.00
IUUC-Meu-056341 Macropus eugenii 24.53 6.00e-18 83.20
IUUC-Mor-057058 Magnaporthe oryzae 39.51 1.00e-101 362.00
IUUC-Mpo-057320 Magnaporthe poae 37.73 5.00e-99 353.00
IUUC-Mtr-058757 Medicago truncatula 23.23 6.00e-20 90.50
IUUC-Mla-058932 Melampsora laricipopulina 34.47 9.00e-76 276.00
IUUC-Mga-060160 Meleagris gallopavo 26.10 5.00e-28 116.00
IUUC-Mvi-060464 Microbotryum violaceum 36.72 2.00e-80 291.00
IUUC-Mmr-060909 Microcebus murinus 25.42 1.00e-26 112.00
IUUC-Mdo-062490 Monodelphis domestica 25.42 7.00e-27 112.00
IUUC-Mmu-063739 Mus musculus 25.42 6.00e-27 113.00
IUUC-Mac-065608 Musa acuminata 24.14 2.00e-25 107.00
IUUC-Mpu-066176 Mustela putorius furo 25.42 1.00e-26 112.00
IUUC-Mlu-068097 Myotis lucifugus 25.08 3.00e-26 110.00
IUUC-Nfi-068473 Neosartorya fischeri 41.13 3.00e-104 370.00
IUUC-Ncr-068681 Neurospora crassa 38.25 1.00e-98 352.00
IUUC-Nle-070106 Nomascus leucogenys 25.42 1.00e-26 112.00
IUUC-Opr-070452 Ochotona princeps 33.75 2.00e-17 81.60
IUUC-Ont-071380 Oreochromis niloticus 26.44 3.00e-28 117.00
IUUC-Oan-073599 Ornithorhynchus anatinus 25.42 1.00e-26 112.00
IUUC-Ocu-073864 Oryctolagus cuniculus 25.08 2.00e-26 110.00
IUUC-Oba-075119 Oryza barthii 23.64 6.00e-18 83.60
IUUC-Obr-076836 Oryza brachyantha 25.06 2.00e-23 102.00
IUUC-Ogl-077393 Oryza glaberrima 23.64 5.00e-18 84.00
IUUC-Ogu-078431 Oryza glumaepatula 25.31 2.00e-24 105.00
IUUC-Oin-079837 Oryza indica 23.64 4.00e-18 84.30
IUUC-Olo-080891 Oryza longistaminata 23.64 5.00e-18 84.00
IUUC-Ome-082008 Oryza meridionalis 22.75 1.00e-16 79.30
IUUC-Oni-082538 Oryza nivara 23.64 2.00e-18 85.10
IUUC-Opu-083682 Oryza punctata 23.26 1.00e-17 82.80
IUUC-Oru-084309 Oryza rufipogon 23.26 2.00e-17 81.60
IUUC-Osa-085879 Oryza sativa 27.32 1.00e-13 68.60
IUUC-Ola-086829 Oryzias latipes 26.60 3.00e-28 117.00
IUUC-Olu-087656 Ostreococcus lucimarinus 34.12 5.00e-04 36.60
IUUC-Oga-088755 Otolemur garnettii 25.42 1.00e-26 112.00
IUUC-Oar-089707 Ovis aries 25.42 6.00e-27 113.00
IUUC-Ptr-090904 Pan troglodytes 25.42 1.00e-26 112.00
IUUC-Pan-092252 Papio anubis 25.42 1.00e-26 112.00
IUUC-Psi-093859 Pelodiscus sinensis 26.10 1.00e-27 115.00
IUUC-Pma-094141 Petromyzon marinus 24.92 7.00e-23 99.40
IUUC-Pno-095105 Phaeosphaeria nodorum 36.50 3.00e-87 313.00
IUUC-Ppa-095706 Physcomitrella patens 24.79 5.00e-21 94.00
IUUC-Pfo-097333 Poecilia formosa 26.44 9.00e-28 115.00
IUUC-Pab-098166 Pongo abelii 25.42 1.00e-26 112.00
IUUC-Pop-099344 Populus trichocarpa 23.71 6.00e-14 70.50
IUUC-Pca-100518 Procavia capensis 30.69 9.00e-16 75.90
IUUC-Ppe-101524 Prunus persica 24.06 5.00e-20 90.50
IUUC-Pva-102941 Pteropus vampyrus 23.61 5.00e-21 94.40
IUUC-Pgr-103540 Puccinia graminis 32.16 4.00e-68 251.00
IUUC-Pte-104086 Pyrenophora teres 39.09 2.00e-103 367.00
IUUC-Pyt-104451 Pyrenophora triticirepentis 38.67 1.00e-102 365.00
IUUC-Rno-105909 Rattus norvegicus 25.42 6.00e-27 113.00
IUUC-Sha-107652 Sarcophilus harrisii 25.42 2.00e-26 111.00
IUUC-Sja-107860 Schizosaccharomyces japonicus 24.15 7.00e-40 156.00
IUUC-Spo-108376 Schizosaccharomyces pombe 30.11 7.00e-43 166.00
IUUC-Ssl-108476 Sclerotinia sclerotiorum 34.97 5.00e-62 229.00
IUUC-Smo-109637 Selaginella moellendorffii 26.80 2.00e-25 108.00
IUUC-Sit-110171 Setaria italica 25.78 4.00e-19 87.80
IUUC-Sly-110948 Solanum lycopersicum 27.17 4.00e-20 90.50
IUUC-Stu-112043 Solanum tuberosum 27.17 2.00e-20 91.70
IUUC-Sar-113053 Sorex araneus 25.76 7.00e-28 115.00
IUUC-Sbi-114065 Sorghum bicolor 26.62 3.00e-25 108.00
IUUC-Sre-115053 Sporisorium reilianum 30.88 1.00e-69 255.00
IUUC-Ssc-115902 Sus scrofa 25.42 1.00e-26 112.00
IUUC-Tgu-117483 Taeniopygia guttata 25.08 2.00e-23 101.00
IUUC-Tru-117535 Takifugu rubripes 26.44 4.00e-29 120.00
IUUC-Tsy-119203 Tarsius syrichta 23.73 8.00e-23 99.40
IUUC-Tni-120555 Tetraodon nigroviridis 26.78 2.00e-28 117.00
IUUC-Tca-121600 Theobroma cacao 22.37 2.00e-21 95.10
IUUC-Tre-122026 Trichoderma reesei 37.99 8.00e-93 332.00
IUUC-Tvi-122487 Trichoderma virens 37.98 1.00e-95 342.00
IUUC-Tae-125063 Triticum aestivum 21.04 8.00e-19 86.70
IUUC-Tur-126870 Triticum urartu 24.38 1.00e-12 65.50
IUUC-Tme-127056 Tuber melanosporum 41.30 2.00e-101 360.00
IUUC-Tbe-128062 Tupaia belangeri 28.10 3.00e-17 80.90
IUUC-Ttr-128324 Tursiops truncatus 25.42 1.00e-26 112.00
IUUC-Uma-129602 Ustilago maydis 30.00 1.00e-70 259.00
IUUC-Vda-130009 Verticillium dahliae 37.63 2.00e-97 348.00
IUUC-Vpa-130267 Vicugna pacos 24.83 4.00e-26 110.00
IUUC-Vvi-130903 Vitis vinifera 22.32 4.00e-21 94.00
IUUC-Xtr-131847 Xenopus tropicalis 22.06 1.00e-18 85.90
IUUC-Xma-133204 Xiphophorus maculatus 26.44 9.00e-28 115.00
IUUC-Yli-134644 Yarrowia lipolytica 38.90 1.00e-95 342.00
IUUC-Zma-135265 Zea mays 21.79 7.00e-19 87.00
Created Date 25-Jun-2017

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