iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071867

Ensembl Protein ID

ENSONIP00000008635.1

UniProt Accession

I3JIE1; I3JIE1_ORENI

Genbank Protein ID

ENSONIP00000008635

Protein Name

Presenilin

Genbank Nucleotide ID

AERX01041656

Gene Name

psen2; LOC100710620

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000006843.1	ENSONIT00000008640.1	ENSONIP00000008635.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.30e-06	27.5	274	300

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLean 28
           +eta+e++++iFP+l+ys+ +v+ + +
   Q: 274  VETAQERNEPIFPALIYSSAMVWTVGM 300
           89*********************9876 PP

Organism

Oreochromis niloticus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MNASDSDEDI YNERSALVRS ESPALPSYIP DSDLTPPNGT PTKRLKAGIS RRPGAAAADG 60
GGSDPEVEAE EEELTLKYGA KHVIMLFIPV TLCMVVVVAT IKSVSFYTEK TDQQLIYTPF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCACAGTGA ATAAAATTCG CTGCGTGGAT TTTGAACCCA AACGATAATA AATCGGTCCT 60
GATGTGCTTA CGTCGGTACG TACACGGGAG AAATGATTTC ACTATGTTAG CTGTCCAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0034205--P:beta-amyloid formation
GO:0007420--P:brain development
GO:0035556--P:intracellular signal transduction
GO:0030318--P:melanocyte differentiation
GO:0022008--P:neurogenesis
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0061053--P:somite development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	64.49	2.00e-112	399.00
IUUC-Apl-003959	Anas platyrhynchos	69.11	3.00e-138	485.00
IUUC-Aca-005160	Anolis carolinensis	71.69	2.00e-147	516.00
IUUC-Ame-010686	Astyanax mexicanus	80.95	2.00e-156	545.00
IUUC-Bta-013097	Bos taurus	67.17	5.00e-137	481.00
IUUC-Bra-017580	Brassica rapa	53.21	2.00e-19	90.50
IUUC-Cja-018824	Callithrix jacchus	68.68	2.00e-134	472.00
IUUC-Cfa-020253	Canis familiaris	70.11	2.00e-137	482.00
IUUC-Cpo-021401	Cavia porcellus	70.47	1.00e-138	486.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	32.26	8.00e-29	122.00
IUUC-Csa-023369	Chlorocebus sabaeus	70.25	3.00e-139	488.00
IUUC-Dre-028526	Danio rerio	76.02	3.00e-155	541.00
IUUC-Dor-031127	Dipodomys ordii	65.87	2.00e-135	476.00
IUUC-Ete-033081	Echinops telfairi	64.89	2.00e-65	243.00
IUUC-Eca-034387	Equus caballus	68.19	4.00e-134	471.00
IUUC-Fca-035396	Felis catus	70.88	1.00e-145	509.00
IUUC-Fal-037457	Ficedula albicollis	69.96	4.00e-139	488.00
IUUC-Gmo-038550	Gadus morhua	75.78	2.00e-144	505.00
IUUC-Gga-040706	Gallus gallus	71.15	4.00e-141	494.00
IUUC-Gac-042511	Gasterosteus aculeatus	81.74	2.00e-165	575.00
IUUC-Gma-043822	Glycine max	36.24	5.00e-23	102.00
IUUC-Ggo-045338	Gorilla gorilla	70.25	3.00e-139	488.00
IUUC-Hsa-046455	Homo sapiens	70.25	3.00e-139	488.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	70.47	7.00e-140	490.00
IUUC-Lch-049638	Latimeria chalumnae	67.91	3.00e-138	484.00
IUUC-Loc-052427	Lepisosteus oculatus	75.11	4.00e-156	544.00
IUUC-Laf-053758	Loxodonta africana	69.33	1.00e-146	513.00
IUUC-Mcc-054755	Macaca mulatta	67.97	5.00e-139	487.00
IUUC-Mtr-058392	Medicago truncatula	32.26	2.00e-28	120.00
IUUC-Mmr-060890	Microcebus murinus	66.95	1.00e-139	489.00
IUUC-Mdo-062197	Monodelphis domestica	71.05	2.00e-145	509.00
IUUC-Mmu-063823	Mus musculus	70.47	4.00e-140	491.00
IUUC-Mac-064858	Musa acuminata	46.58	3.00e-24	105.00
IUUC-Mpu-066181	Mustela putorius furo	69.00	2.00e-137	482.00
IUUC-Opr-070344	Ochotona princeps	68.41	1.00e-142	499.00
IUUC-Oan-073378	Ornithorhynchus anatinus	66.75	5.00e-131	460.00
IUUC-Ocu-074652	Oryctolagus cuniculus	70.95	3.00e-137	481.00
IUUC-Obr-076302	Oryza brachyantha	51.20	2.00e-17	84.30
IUUC-Ola-086707	Oryzias latipes	81.58	2.00e-121	428.00
IUUC-Olu-087811	Ostreococcus lucimarinus	38.14	2.00e-49	189.00
IUUC-Oga-088560	Otolemur garnettii	67.89	3.00e-139	488.00
IUUC-Oar-089200	Ovis aries	68.13	4.00e-138	484.00
IUUC-Ptr-090569	Pan troglodytes	70.25	6.00e-140	490.00
IUUC-Pan-091742	Papio anubis	67.97	7.00e-139	487.00
IUUC-Pab-098531	Pongo abelii	70.25	3.00e-139	488.00
IUUC-Pop-099661	Populus trichocarpa	34.44	2.00e-35	143.00
IUUC-Pca-101120	Procavia capensis	66.23	7.00e-133	467.00
IUUC-Pva-102934	Pteropus vampyrus	64.44	8.00e-135	473.00
IUUC-Rno-106052	Rattus norvegicus	70.69	5.00e-145	507.00
IUUC-Sha-106876	Sarcophilus harrisii	70.02	4.00e-143	501.00
IUUC-Sly-110865	Solanum lycopersicum	55.56	2.00e-07	47.40
IUUC-Ssc-115380	Sus scrofa	70.02	2.00e-143	502.00
IUUC-Tgu-117280	Taeniopygia guttata	70.39	6.00e-141	494.00
IUUC-Tca-121865	Theobroma cacao	28.93	5.00e-29	122.00
IUUC-Tbe-127632	Tupaia belangeri	65.51	6.00e-117	414.00
IUUC-Ttr-129008	Tursiops truncatus	66.31	6.00e-137	481.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence