iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-051814

Ensembl Protein ID

ENSLOCP00000011007.1

UniProt Accession

W5MRJ8; W5MRJ8_LEPOC

Genbank Protein ID

ENSLOCP00000011007

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHAT01013894

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000009029.1	ENSLOCT00000011023.1	ENSLOCP00000011007.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.20e-86	290.2	209	822

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.............kepkgellkslqklfeelwkskkkavsprellka 76
           +Gl+NlgNtC++N+vLQ Ls+++ lr+ll+e k ek+  +                ++ g+l+ ++ ++++e++++kk++v+p+el+++
   Q: 209  KGLSNLGNTCFFNAVLQNLSQTQFLRQLLNEMKDEKTTLQITphlssqleplvinLDRPGSLTLAMCQVLNEIQETKKGVVTPKELFSQ 297
           5******************************44444433322467777888888888888***************************** PP
   S: 77   lkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikclec 159
           ++k+a +f+g++qqD+qE+l++lld+++ e  k+ ++ + e+ +++ +  + e      +e++k+   +++++++F+g+l+s+++c+ec
   Q: 298  VCKKAARFKGFQQQDSQELLRYLLDGMKAEEMKRVSSGILEALNNSGKLIEAEeskklvKEYEKNGAPRNFVDQVFGGELTSTVMCKEC 386
           ***************************987766444444443333322222222344457788888888******************** PP
   S: 160  dnvssreepfldlslpvpgkeetkke............................................................... 185
           ++vs  +e fldlslpv+++  +kk+                                                               
   Q: 387  KTVSLVTEMFLDLSLPVSDEAYRKKStkkvvrrtsdneegdskktsvspaeieelpsgskyqqkkakkqakkqakiqrrqqkqagklgl 475
           *******************999988899************************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 476  gstssqdiehvngdesaaqeeidqselgattqgeaclessepnnappsnsqnskqpdhcdeethsgeeaqpedcepsescsdnrfkald 564
           ***************************************************************************************** PP
   S: 186  ......................................................................slqdcLesftkeeelegen 204
                                                                                 s+q+cL +ft+ e+l+ +n
   Q: 565  nkeglgedelvkdmnsltinedfispddidfeidscgdavdtkaytvvdqdpelafttladreapgkqdcSVQSCLYQFTEVEHLTTNN 653
           ***************************************************************************************** PP
   S: 205  kyycekckkkqe................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke... 274
            ++c +c+++++                a k++ ++  P+vL+lhLkRf  ++ ++s  k+n++v fp+ Ldl+pfct++++++ e   
   Q: 654  SLQCVTCTQHKNkgsrsssdgekcvytdALKQMLISLPPPVLTLHLKRF--QQVGYSVCKVNRHVIFPQVLDLAPFCTTNCKNVPEgek 740
           ********99999999999999999999*********************..89999999********************9988877777 PP
   S: 275  kkkYeLiavvvHsGslssGHYvayvkn......................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           k+ Y+L+++v HsG+++sGHY+ayvk                        kg+W++++D++V++v+e++vl+   s+aY+lfY+r
   Q: 741  KVLYRLYGIVEHSGTMRSGHYTAYVKVrpnncltnqlngltpqasdsesVKGSWFHISDTSVQAVPETKVLN---SQAYLLFYER 822
           9**************************99999999888888888777666888*******************...********98 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MGKKRAKEKH LRDEDPVDVT GPNCRHIRKG IDSSLLKKTV QDVNWNACQD CKGEEIPAST 60
SAEENSEGPG IWFCLKCGHR GCGRHSENQH AFKHYEKPHS DPHCLVLSPD TWSVWCYMCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGAAGCGG CTCACGTTAC ACGTTACATG TATTGCTGCA AGTAAAACCA TATGCTGGTC 60
TCAGCGTAAA TATACCGGTG TTTTGCTAGC TTTTGTGTTT TATTTCTGTT AGATTTAGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	33.73	1.00e-26	115.00
IUUC-Aml-001931	Ailuropoda melanoleuca	56.55	1.00e-125	444.00
IUUC-Atr-003015	Amborella trichopoda	31.02	7.00e-35	142.00
IUUC-Apl-004145	Anas platyrhynchos	56.48	1.00e-115	410.00
IUUC-Aca-004314	Anolis carolinensis	48.27	0.00e+00	664.00
IUUC-Aly-006422	Arabidopsis lyrata	40.52	3.00e-24	107.00
IUUC-Ath-006732	Arabidopsis thaliana	38.81	7.00e-27	116.00
IUUC-Ame-011659	Astyanax mexicanus	71.75	2.00e-86	313.00
IUUC-Bta-013362	Bos taurus	49.94	0.00e+00	692.00
IUUC-Bdi-014624	Brachypodium distachyon	34.00	1.00e-24	108.00
IUUC-Bol-015941	Brassica oleracea	29.34	4.00e-27	117.00
IUUC-Bra-016751	Brassica rapa	29.55	1.00e-26	115.00
IUUC-Cja-019177	Callithrix jacchus	51.36	0.00e+00	702.00
IUUC-Cfa-020051	Canis familiaris	56.17	3.00e-124	439.00
IUUC-Cpo-021886	Cavia porcellus	48.99	0.00e+00	697.00
IUUC-Csa-024103	Chlorocebus sabaeus	51.12	0.00e+00	705.00
IUUC-Cho-024315	Choloepus hoffmanni	49.01	1.00e-58	221.00
IUUC-Cin-025775	Ciona intestinalis	50.00	5.00e-37	146.00
IUUC-Csv-026075	Ciona savignyi	47.96	7.00e-49	188.00
IUUC-Cme-027348	Cyanidioschyzon merolae	37.67	8.00e-17	82.00
IUUC-Dre-028388	Danio rerio	55.98	0.00e+00	824.00
IUUC-Dno-029409	Dasypus novemcinctus	56.55	2.00e-123	436.00
IUUC-Dor-030443	Dipodomys ordii	48.00	5.00e-90	325.00
IUUC-Dme-031870	Drosophila melanogaster	50.98	1.00e-34	142.00
IUUC-Ete-032807	Echinops telfairi	51.02	2.00e-102	366.00
IUUC-Eca-033479	Equus caballus	51.54	0.00e+00	706.00
IUUC-Eeu-034835	Erinaceus europaeus	55.73	1.00e-79	291.00
IUUC-Fca-036320	Felis catus	51.11	0.00e+00	712.00
IUUC-Fal-037029	Ficedula albicollis	47.06	3.00e-180	625.00
IUUC-Gmo-039480	Gadus morhua	60.18	2.00e-147	516.00
IUUC-Gga-040527	Gallus gallus	53.90	2.00e-117	417.00
IUUC-Gac-042343	Gasterosteus aculeatus	54.32	0.00e+00	793.00
IUUC-Gma-044402	Glycine max	27.29	1.00e-31	132.00
IUUC-Ggo-045598	Gorilla gorilla	50.83	0.00e+00	698.00
IUUC-Hsa-046598	Homo sapiens	50.76	0.00e+00	698.00
IUUC-Hvu-047146	Hordeum vulgare	33.73	6.00e-26	113.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	51.42	0.00e+00	717.00
IUUC-Lch-050536	Latimeria chalumnae	56.32	2.00e-122	433.00
IUUC-Lpe-050703	Leersia perrieri	35.15	2.00e-25	111.00
IUUC-Laf-053732	Loxodonta africana	51.17	0.00e+00	714.00
IUUC-Mcc-054661	Macaca mulatta	51.24	0.00e+00	706.00
IUUC-Meu-055967	Macropus eugenii	50.49	7.00e-104	371.00
IUUC-Mtr-057945	Medicago truncatula	28.18	2.00e-31	131.00
IUUC-Mga-059551	Meleagris gallopavo	54.46	2.00e-117	416.00
IUUC-Mmr-061747	Microcebus murinus	51.92	0.00e+00	712.00
IUUC-Mdo-062220	Monodelphis domestica	54.79	8.00e-123	434.00
IUUC-Mmu-063582	Mus musculus	53.16	1.00e-112	400.00
IUUC-Mac-064941	Musa acuminata	39.42	6.00e-32	132.00
IUUC-Mpu-066339	Mustela putorius furo	50.70	0.00e+00	702.00
IUUC-Mlu-067248	Myotis lucifugus	47.69	0.00e+00	663.00
IUUC-Nle-069252	Nomascus leucogenys	51.01	0.00e+00	704.00
IUUC-Opr-070969	Ochotona princeps	50.91	0.00e+00	679.00
IUUC-Ont-071786	Oreochromis niloticus	51.04	0.00e+00	783.00
IUUC-Ocu-074704	Oryctolagus cuniculus	50.29	0.00e+00	694.00
IUUC-Oba-075094	Oryza barthii	28.87	7.00e-26	113.00
IUUC-Obr-076743	Oryza brachyantha	39.60	7.00e-26	112.00
IUUC-Ogl-077739	Oryza glaberrima	28.87	5.00e-26	113.00
IUUC-Ogu-078851	Oryza glumaepatula	29.17	2.00e-26	114.00
IUUC-Oin-079402	Oryza indica	29.17	2.00e-26	114.00
IUUC-Olo-080431	Oryza longistaminata	29.17	2.00e-26	114.00
IUUC-Ome-081580	Oryza meridionalis	29.46	1.00e-26	115.00
IUUC-Oni-082644	Oryza nivara	29.17	2.00e-26	114.00
IUUC-Opu-083452	Oryza punctata	36.27	3.00e-26	114.00
IUUC-Oru-084546	Oryza rufipogon	29.17	2.00e-26	114.00
IUUC-Osa-085858	Oryza sativa	29.17	2.00e-26	114.00
IUUC-Ola-086795	Oryzias latipes	56.45	2.00e-134	473.00
IUUC-Oga-088713	Otolemur garnettii	52.01	0.00e+00	709.00
IUUC-Oar-089887	Ovis aries	50.76	0.00e+00	705.00
IUUC-Ptr-091670	Pan troglodytes	51.07	0.00e+00	701.00
IUUC-Pan-092293	Papio anubis	51.24	0.00e+00	706.00
IUUC-Psi-093101	Pelodiscus sinensis	53.79	4.00e-116	412.00
IUUC-Pno-094855	Phaeosphaeria nodorum	28.07	8.00e-12	64.30
IUUC-Ppa-095622	Physcomitrella patens	30.12	1.00e-31	132.00
IUUC-Pfo-097202	Poecilia formosa	52.58	0.00e+00	813.00
IUUC-Pop-099136	Populus trichocarpa	28.29	3.00e-35	143.00
IUUC-Pca-101069	Procavia capensis	46.07	1.00e-80	294.00
IUUC-Ppe-101794	Prunus persica	31.25	2.00e-32	134.00
IUUC-Pva-103092	Pteropus vampyrus	47.09	8.00e-83	301.00
IUUC-Rno-105237	Rattus norvegicus	46.61	0.00e+00	668.00
IUUC-Sha-106889	Sarcophilus harrisii	55.15	1.00e-120	427.00
IUUC-Spo-108149	Schizosaccharomyces pombe	34.13	2.00e-22	101.00
IUUC-Sit-110283	Setaria italica	29.34	4.00e-26	113.00
IUUC-Sly-111491	Solanum lycopersicum	28.02	9.00e-32	132.00
IUUC-Stu-112820	Solanum tuberosum	28.26	7.00e-35	142.00
IUUC-Sar-113530	Sorex araneus	49.58	0.00e+00	697.00
IUUC-Sbi-113785	Sorghum bicolor	39.47	5.00e-23	103.00
IUUC-Ssc-116091	Sus scrofa	50.41	0.00e+00	695.00
IUUC-Tgu-117478	Taeniopygia guttata	52.06	3.00e-109	389.00
IUUC-Tru-118640	Takifugu rubripes	61.34	2.00e-143	503.00
IUUC-Tsy-119042	Tarsius syrichta	39.53	2.00e-109	389.00
IUUC-Tni-120015	Tetraodon nigroviridis	52.49	0.00e+00	760.00
IUUC-Tca-121701	Theobroma cacao	28.89	7.00e-35	142.00
IUUC-Tae-125785	Triticum aestivum	33.60	4.00e-24	107.00
IUUC-Tur-126788	Triticum urartu	33.60	4.00e-24	106.00
IUUC-Tbe-127309	Tupaia belangeri	47.60	6.00e-78	285.00
IUUC-Ttr-128271	Tursiops truncatus	50.89	0.00e+00	693.00
IUUC-Vpa-130674	Vicugna pacos	49.25	0.00e+00	627.00
IUUC-Xtr-131869	Xenopus tropicalis	50.96	4.00e-112	399.00
IUUC-Xma-134195	Xiphophorus maculatus	61.24	8.00e-152	531.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence