iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033519

UUCD1 version

UUC-EqC-00170

Ensembl Protein ID

ENSECAP00000022763.1

UniProt Accession

F6SF14; F6SF14_HORSE

Protein Name

Uncharacterized protein

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000026965.1	ENSECAT00000028923.1	ENSECAP00000022763.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.70e-13	50.4	162	209

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 162  GAPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 209
           6789*************************...***************9986 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MVAHNQVAAD NAITAAEPRQ RPEPSSSSSS SPRAPARLRP CPSISRPPRS RETHFRTFRS 60
HADYRRITRA SALLDACSFY GPLSVHEAHE RLRAEPVGTF LVRDSRQRNC FFALSVKMAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAGCAC ACAATCAGGT GGCAGCCGAC AATGCAATCT CACGGCAGCA GAGCCTCGAC 60
AGCGACCAGA GCCTTCCTCC TCCTCCTCCT CCTCCTCCTC TTCTTCCTCC GCCTCCTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0004860--F:protein kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	91.19	3.00e-79	287.00
IUUC-Apl-003313	Anas platyrhynchos	62.74	2.00e-72	265.00
IUUC-Aca-005109	Anolis carolinensis	67.09	2.00e-59	221.00
IUUC-Ame-011550	Astyanax mexicanus	48.45	1.00e-45	176.00
IUUC-Bta-013411	Bos taurus	79.37	2.00e-87	314.00
IUUC-Cja-019595	Callithrix jacchus	83.89	7.00e-90	322.00
IUUC-Cfa-020563	Canis familiaris	94.38	2.00e-84	304.00
IUUC-Cpo-021374	Cavia porcellus	80.65	9.00e-89	319.00
IUUC-Csa-023333	Chlorocebus sabaeus	82.63	1.00e-88	318.00
IUUC-Dre-028507	Danio rerio	41.98	1.00e-41	162.00
IUUC-Dno-029406	Dasypus novemcinctus	82.94	9.00e-88	315.00
IUUC-Ete-032399	Echinops telfairi	82.94	2.00e-87	315.00
IUUC-Fal-036726	Ficedula albicollis	61.61	7.00e-71	259.00
IUUC-Gmo-039667	Gadus morhua	49.56	1.00e-26	112.00
IUUC-Gga-040970	Gallus gallus	63.98	1.00e-73	268.00
IUUC-Gac-041838	Gasterosteus aculeatus	39.62	6.00e-35	140.00
IUUC-Ggo-045569	Gorilla gorilla	80.57	4.00e-90	323.00
IUUC-Hsa-046010	Homo sapiens	83.89	6.00e-90	322.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	96.88	1.00e-86	312.00
IUUC-Lch-050219	Latimeria chalumnae	61.39	3.00e-59	220.00
IUUC-Loc-052494	Lepisosteus oculatus	49.53	3.00e-52	197.00
IUUC-Laf-054219	Loxodonta africana	93.43	2.00e-68	250.00
IUUC-Mcc-054830	Macaca mulatta	81.86	3.00e-88	317.00
IUUC-Meu-056565	Macropus eugenii	71.09	3.00e-81	294.00
IUUC-Mga-060153	Meleagris gallopavo	61.01	2.00e-71	261.00
IUUC-Mmr-061365	Microcebus murinus	80.82	1.00e-87	315.00
IUUC-Mdo-062824	Monodelphis domestica	70.23	8.00e-78	282.00
IUUC-Mmu-064120	Mus musculus	83.96	7.00e-87	312.00
IUUC-Mpu-066839	Mustela putorius furo	82.41	7.00e-89	319.00
IUUC-Mlu-067829	Myotis lucifugus	85.31	5.00e-86	310.00
IUUC-Nle-069592	Nomascus leucogenys	80.57	5.00e-85	306.00
IUUC-Ont-072173	Oreochromis niloticus	42.51	2.00e-34	138.00
IUUC-Oan-073586	Ornithorhynchus anatinus	53.27	1.00e-24	105.00
IUUC-Ocu-073996	Oryctolagus cuniculus	96.88	1.00e-86	311.00
IUUC-Oba-075150	Oryza barthii	30.30	1.10e-01	29.30
IUUC-Ola-087158	Oryzias latipes	45.18	2.00e-36	144.00
IUUC-Oga-088076	Otolemur garnettii	83.49	4.00e-88	316.00
IUUC-Ptr-091241	Pan troglodytes	83.89	2.00e-90	324.00
IUUC-Pan-091836	Papio anubis	80.57	1.00e-89	322.00
IUUC-Psi-093628	Pelodiscus sinensis	65.42	1.00e-75	275.00
IUUC-Pfo-097501	Poecilia formosa	44.03	1.00e-33	135.00
IUUC-Pab-098170	Pongo abelii	83.10	2.00e-88	318.00
IUUC-Pop-100072	Populus trichocarpa	30.77	4.30e-02	32.00
IUUC-Pva-102796	Pteropus vampyrus	83.10	4.00e-88	317.00
IUUC-Rno-105319	Rattus norvegicus	83.96	7.00e-87	312.00
IUUC-Sha-107201	Sarcophilus harrisii	80.52	1.00e-71	261.00
IUUC-Ssc-116004	Sus scrofa	84.16	2.00e-92	331.00
IUUC-Tgu-116836	Taeniopygia guttata	61.68	3.00e-72	264.00
IUUC-Tru-118090	Takifugu rubripes	41.25	2.00e-32	132.00
IUUC-Tni-120719	Tetraodon nigroviridis	40.66	4.00e-29	120.00
IUUC-Vpa-130235	Vicugna pacos	82.79	2.00e-88	318.00
IUUC-Xtr-132610	Xenopus tropicalis	56.81	3.00e-65	241.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence