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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063525
UUCD1 version UUC-MuM-00596
Ensembl Protein ID ENSMUSP00000108825.1
UniProt Accession Q80ZI6; LRSM1_MOUSE
Genbank Protein ID AAH49146.1
Protein Name E3 ubiquitin-protein ligase LRSAM1; Leucine-rich repeat and sterile alpha motif-containing protein 1; RING-type E3 ubiquitin transferase LRSAM1; Tsg101-associated ligase
Genbank Nucleotide ID BC049146
Gene Name Lrsam1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026792.16 ENSMUST00000113200.7 ENSMUSP00000108825.1
ENSMUSG00000026792.16 ENSMUST00000195713.1 ENSMUSP00000141675.1
ENSMUSG00000026792.16 ENSMUST00000191838.5 ENSMUSP00000141713.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 87.48 0.00e+00 1102.00 IUUC-Hsa-046865
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (viral proteins) cargos (By similarity). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (By similarity). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (By similarity).
 E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (viral proteins) cargos (By similarity). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (By similarity). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (By similarity).
Protein Sequence
(Fasta)
MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LSEIPFGAFA TCKVLQKKVL 60
IVHTNHLTSL LPKSCSLLSL VTIKVLDLHE NQLTALPDDM GQLTVLQVLN VERNQLTHLP 120
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Protein Fasta Sequence


>IUUC-Mmu-063525|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
TGTTTCTTAT GGGCAGGCGT CTGCGGCAGA GGACTGCAGA GCTTGGTCTG TGGGTGAGCT 60
CGGGATTCGG AAGGGGTAAA TGTTCGGAGC ACCTTGCCTG GGCAACAGAG TAGGGCTGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063525|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001370--BIR_rpt
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR003591--Leu-rich_rpt_typical-subtyp
IPR001660--SAM
IPR013761--SAM/pointed
IPR001841--Znf_RING
PROSITE

PS51450--LRR
PS50105--SAM_DOMAIN
PS50089--ZF_RING_2
Pfam

PF13855--LRR_8
PF00536--SAM_1
SMART

SM00369--LRR_TYP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0045806--P:negative regulation of endocytosis
GO:2000786--P:positive regulation of autophagosome assembly
GO:1904417--P:positive regulation of xenophagy
GO:0051865--P:protein autoubiquitination
GO:0030163--P:protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0007165--P:signal transduction
GO:0070086--P:ubiquitin-dependent endocytosis
GO:0046755--P:viral budding
KEGG mmu:227738
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001663 Ailuropoda melanoleuca 85.52 0.00e+00 1078.00
IUUC-Atr-002772 Amborella trichopoda 44.26 1.00e-08 53.50
IUUC-Apl-004029 Anas platyrhynchos 70.81 6.00e-180 624.00
IUUC-Aca-004487 Anolis carolinensis 63.08 0.00e+00 706.00
IUUC-Aly-005571 Arabidopsis lyrata 32.12 2.00e-13 71.20
IUUC-Ath-006853 Arabidopsis thaliana 34.39 4.00e-18 85.50
IUUC-Ame-011792 Astyanax mexicanus 55.80 0.00e+00 733.00
IUUC-Bta-012937 Bos taurus 87.52 0.00e+00 1111.00
IUUC-Bdi-014104 Brachypodium distachyon 38.38 6.00e-10 58.50
IUUC-Bol-016339 Brassica oleracea 30.82 9.00e-15 74.30
IUUC-Bra-016795 Brassica rapa 30.82 2.00e-14 73.60
IUUC-Cja-019359 Callithrix jacchus 86.50 0.00e+00 1046.00
IUUC-Cfa-020908 Canis familiaris 87.50 0.00e+00 1090.00
IUUC-Cpo-021744 Cavia porcellus 85.69 0.00e+00 1028.00
IUUC-Csa-023784 Chlorocebus sabaeus 88.58 0.00e+00 1110.00
IUUC-Cin-025241 Ciona intestinalis 35.67 4.00e-101 362.00
IUUC-Dre-027424 Danio rerio 56.53 0.00e+00 700.00
IUUC-Dno-028857 Dasypus novemcinctus 88.17 0.00e+00 1078.00
IUUC-Dor-030397 Dipodomys ordii 82.01 7.00e-107 381.00
IUUC-Ete-032958 Echinops telfairi 68.12 5.00e-148 518.00
IUUC-Eca-033505 Equus caballus 87.90 0.00e+00 1121.00
IUUC-Eeu-035089 Erinaceus europaeus 78.30 0.00e+00 857.00
IUUC-Fca-036318 Felis catus 86.68 0.00e+00 1083.00
IUUC-Fal-037299 Ficedula albicollis 70.19 0.00e+00 809.00
IUUC-Gmo-038494 Gadus morhua 57.10 0.00e+00 668.00
IUUC-Gga-041180 Gallus gallus 71.02 0.00e+00 888.00
IUUC-Gac-041975 Gasterosteus aculeatus 53.51 3.00e-180 625.00
IUUC-Gma-043846 Glycine max 34.52 2.00e-09 57.00
IUUC-Ggo-045293 Gorilla gorilla 84.18 0.00e+00 1030.00
IUUC-Hsa-046865 Homo sapiens 87.48 0.00e+00 1099.00
IUUC-Hvu-047769 Hordeum vulgare 28.50 5.00e-15 75.50
IUUC-Itr-048290 Ictidomys tridecemlineatus 89.55 0.00e+00 1108.00
IUUC-Lch-049955 Latimeria chalumnae 54.58 4.00e-180 625.00
IUUC-Loc-052396 Lepisosteus oculatus 52.46 7.00e-148 517.00
IUUC-Laf-054274 Loxodonta africana 87.64 0.00e+00 1052.00
IUUC-Mcc-055328 Macaca mulatta 88.31 0.00e+00 1105.00
IUUC-Meu-056407 Macropus eugenii 72.43 1.00e-77 284.00
IUUC-Mtr-057683 Medicago truncatula 28.80 4.00e-14 72.40
IUUC-Mla-059138 Melampsora laricipopulina 31.08 5.40e-01 27.70
IUUC-Mga-059898 Meleagris gallopavo 71.02 0.00e+00 896.00
IUUC-Mmr-061558 Microcebus murinus 87.23 0.00e+00 1115.00
IUUC-Mdo-062877 Monodelphis domestica 79.95 0.00e+00 982.00
IUUC-Mac-064501 Musa acuminata 29.35 2.00e-14 73.90
IUUC-Mpu-066491 Mustela putorius furo 86.24 0.00e+00 1040.00
IUUC-Mlu-068182 Myotis lucifugus 83.26 0.00e+00 966.00
IUUC-Nle-069349 Nomascus leucogenys 87.21 0.00e+00 1074.00
IUUC-Opr-070326 Ochotona princeps 77.38 0.00e+00 867.00
IUUC-Ont-071685 Oreochromis niloticus 55.16 0.00e+00 712.00
IUUC-Oan-072957 Ornithorhynchus anatinus 80.36 0.00e+00 966.00
IUUC-Obr-076454 Oryza brachyantha 28.99 4.00e-16 79.30
IUUC-Ogl-077480 Oryza glaberrima 27.73 8.00e-15 74.70
IUUC-Olo-081076 Oryza longistaminata 29.81 5.00e-07 50.40
IUUC-Oni-083060 Oryza nivara 28.83 8.00e-03 36.60
IUUC-Oga-088129 Otolemur garnettii 87.62 0.00e+00 1084.00
IUUC-Oar-089353 Ovis aries 81.67 0.00e+00 986.00
IUUC-Ptr-091511 Pan troglodytes 88.03 0.00e+00 1102.00
IUUC-Pan-092251 Papio anubis 88.31 0.00e+00 1106.00
IUUC-Psi-093778 Pelodiscus sinensis 61.99 0.00e+00 716.00
IUUC-Pma-094158 Petromyzon marinus 45.60 6.00e-130 457.00
IUUC-Ppa-095427 Physcomitrella patens 32.48 9.00e-14 71.20
IUUC-Pfo-096094 Poecilia formosa 53.80 0.00e+00 655.00
IUUC-Pab-098187 Pongo abelii 83.63 0.00e+00 1017.00
IUUC-Pop-099197 Populus trichocarpa 30.25 1.00e-13 70.90
IUUC-Pca-100526 Procavia capensis 84.95 1.00e-138 486.00
IUUC-Ppe-101851 Prunus persica 40.00 6.00e-15 75.10
IUUC-Pva-102557 Pteropus vampyrus 84.07 0.00e+00 1005.00
IUUC-Pgr-103622 Puccinia graminis 33.93 3.00e-11 65.10
IUUC-Pyt-104751 Pyrenophora triticirepentis 37.50 1.00e-13 72.40
IUUC-Rno-105540 Rattus norvegicus 93.41 0.00e+00 1197.00
IUUC-Sha-107485 Sarcophilus harrisii 78.71 0.00e+00 962.00
IUUC-Spo-108106 Schizosaccharomyces pombe 33.93 8.00e-14 72.80
IUUC-Sit-110214 Setaria italica 36.90 1.00e-09 57.80
IUUC-Sar-113098 Sorex araneus 73.11 0.00e+00 808.00
IUUC-Sbi-114187 Sorghum bicolor 39.29 4.00e-10 58.90
IUUC-Ssc-116105 Sus scrofa 82.67 0.00e+00 999.00
IUUC-Tgu-116857 Taeniopygia guttata 70.74 0.00e+00 643.00
IUUC-Tru-117930 Takifugu rubripes 52.39 0.00e+00 664.00
IUUC-Tsy-119382 Tarsius syrichta 75.00 1.00e-89 323.00
IUUC-Tni-120714 Tetraodon nigroviridis 52.72 0.00e+00 634.00
IUUC-Tca-121678 Theobroma cacao 32.43 8.00e-15 74.70
IUUC-Tae-125723 Triticum aestivum 26.86 4.00e-15 75.90
IUUC-Tbe-127528 Tupaia belangeri 73.31 4.00e-77 282.00
IUUC-Ttr-128282 Tursiops truncatus 87.43 0.00e+00 1077.00
IUUC-Vda-129866 Verticillium dahliae 35.71 5.00e-07 50.40
IUUC-Vpa-130740 Vicugna pacos 75.44 0.00e+00 743.00
IUUC-Vvi-131120 Vitis vinifera 35.16 5.00e-11 62.00
IUUC-Xtr-132037 Xenopus tropicalis 59.28 0.00e+00 685.00
Created Date 25-Jun-2017

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