iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062648

Ensembl Protein ID

ENSMODP00000017499.3

UniProt Accession

F6QK83; F6QK83_MONDO

Protein Name

Histone-lysine N-methyltransferase

Gene Name

KMT2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000013994.3	ENSMODT00000017825.3	ENSMODP00000017499.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.40e-28	97.1	1065	1118

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++g+++k+l+eCe+Cr+++HpaCl++s ++++ ++++  wiC+ C ++
   Q: 1065 KFCHVCGRKGRSTKHLLECERCRHAYHPACLGPS-YPTRATRKRrhWICSACVRC 1118
           58********************************.88888877777******876 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

EEFRGFHSDE DVAPSSLRSA LRSQRGGTPR GRARKHRTIP PPPPRPAEAV FPSQKAPSRR 60
RGETGKERMV QVLAELLQRA QAPPAPRIRG SESPTPRRPR GRPPGSSKKK KLPAVVAATS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGAATTTC GAGGGTTCCA CTCAGATGAA GATGTTGCCC CCAGTTCCCT GCGCTCTGCG 60
CTCCGGTCCC AGCGAGGTGA GTGAGGGGCA GAGACTTTAC CAACTCTCTA GAGAACTATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR017956--AT_hook_DNA-bd_motif
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00384--AT_hook
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0080182--P:histone H3-K4 trimethylation
GO:0007613--P:memory
GO:0009994--P:oocyte differentiation
GO:0001541--P:ovarian follicle development
GO:0030728--P:ovulation
GO:0051569--P:regulation of histone H3-K4 methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002367	Ailuropoda melanoleuca	77.56	0.00e+00	2072.00
IUUC-Aca-004718	Anolis carolinensis	57.53	0.00e+00	1485.00
IUUC-Ame-010705	Astyanax mexicanus	45.25	0.00e+00	943.00
IUUC-Bta-013578	Bos taurus	83.15	0.00e+00	1904.00
IUUC-Bdi-014882	Brachypodium distachyon	32.34	6.00e-26	112.00
IUUC-Bra-017404	Brassica rapa	32.45	4.00e-24	106.00
IUUC-Cja-019138	Callithrix jacchus	77.94	0.00e+00	2089.00
IUUC-Cfa-020020	Canis familiaris	77.16	0.00e+00	2012.00
IUUC-Cpo-021552	Cavia porcellus	76.44	0.00e+00	2016.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	53.12	8.00e-38	154.00
IUUC-Csa-024216	Chlorocebus sabaeus	79.14	0.00e+00	2080.00
IUUC-Dre-027700	Danio rerio	48.38	0.00e+00	731.00
IUUC-Dno-029583	Dasypus novemcinctus	83.50	0.00e+00	1949.00
IUUC-Dor-030903	Dipodomys ordii	75.19	0.00e+00	1868.00
IUUC-Dme-032023	Drosophila melanogaster	47.85	1.00e-93	339.00
IUUC-Eca-034026	Equus caballus	84.84	0.00e+00	1690.00
IUUC-Eeu-034687	Erinaceus europaeus	87.24	0.00e+00	1018.00
IUUC-Fca-036311	Felis catus	77.20	0.00e+00	2095.00
IUUC-Gmo-039265	Gadus morhua	45.79	0.00e+00	838.00
IUUC-Gac-042202	Gasterosteus aculeatus	49.68	0.00e+00	765.00
IUUC-Ggo-044791	Gorilla gorilla	83.10	0.00e+00	1828.00
IUUC-Hsa-046988	Homo sapiens	78.35	0.00e+00	2053.00
IUUC-Itr-048907	Ictidomys tridecemlineatus	77.84	0.00e+00	2111.00
IUUC-Lpe-051476	Leersia perrieri	30.59	1.00e-22	102.00
IUUC-Loc-052252	Lepisosteus oculatus	50.35	0.00e+00	793.00
IUUC-Laf-053703	Loxodonta africana	83.65	0.00e+00	1916.00
IUUC-Mcc-054782	Macaca mulatta	78.08	0.00e+00	2068.00
IUUC-Meu-056046	Macropus eugenii	92.82	0.00e+00	2035.00
IUUC-Mmr-061316	Microcebus murinus	76.49	0.00e+00	1968.00
IUUC-Mmu-063579	Mus musculus	81.72	0.00e+00	1960.00
IUUC-Mpu-066710	Mustela putorius furo	83.88	0.00e+00	1930.00
IUUC-Mlu-067559	Myotis lucifugus	78.88	0.00e+00	2092.00
IUUC-Nle-070085	Nomascus leucogenys	76.50	0.00e+00	1854.00
IUUC-Opr-071148	Ochotona princeps	75.58	0.00e+00	2056.00
IUUC-Ont-071626	Oreochromis niloticus	46.31	0.00e+00	916.00
IUUC-Ocu-074475	Oryctolagus cuniculus	77.10	0.00e+00	1875.00
IUUC-Obr-076458	Oryza brachyantha	33.50	1.00e-26	114.00
IUUC-Ogl-077851	Oryza glaberrima	35.16	1.00e-26	115.00
IUUC-Ogu-078706	Oryza glumaepatula	35.16	6.00e-27	116.00
IUUC-Oin-079802	Oryza indica	30.00	9.00e-22	98.60
IUUC-Osa-085421	Oryza sativa	35.16	2.00e-26	114.00
IUUC-Ola-086609	Oryzias latipes	46.92	0.00e+00	837.00
IUUC-Oga-088140	Otolemur garnettii	76.85	0.00e+00	2008.00
IUUC-Oar-089447	Ovis aries	82.75	0.00e+00	1802.00
IUUC-Ptr-090902	Pan troglodytes	78.29	0.00e+00	2058.00
IUUC-Pan-091930	Papio anubis	78.97	0.00e+00	2079.00
IUUC-Ppa-095221	Physcomitrella patens	36.06	1.00e-29	125.00
IUUC-Pfo-096884	Poecilia formosa	45.94	0.00e+00	906.00
IUUC-Pab-098404	Pongo abelii	69.20	0.00e+00	1380.00
IUUC-Pca-100949	Procavia capensis	74.33	0.00e+00	1087.00
IUUC-Pva-102634	Pteropus vampyrus	78.75	0.00e+00	2080.00
IUUC-Rno-105870	Rattus norvegicus	76.27	0.00e+00	2105.00
IUUC-Sit-110552	Setaria italica	33.33	2.00e-27	117.00
IUUC-Sar-113289	Sorex araneus	79.85	0.00e+00	1524.00
IUUC-Ssc-115509	Sus scrofa	83.25	0.00e+00	1918.00
IUUC-Tru-117736	Takifugu rubripes	45.18	0.00e+00	835.00
IUUC-Tca-121624	Theobroma cacao	32.32	5.00e-26	113.00
IUUC-Tbe-127825	Tupaia belangeri	73.20	0.00e+00	1211.00
IUUC-Ttr-128754	Tursiops truncatus	85.68	0.00e+00	1110.00
IUUC-Xtr-132838	Xenopus tropicalis	46.67	0.00e+00	1067.00
IUUC-Xma-133119	Xiphophorus maculatus	41.73	0.00e+00	958.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence