iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000011296.1	ENSLOCT00000013929.1	ENSLOCP00000013900.1
ENSLOCG00000011296.1	ENSLOCT00000013935.1	ENSLOCP00000013906.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.90e-98	328.5	732	1055

Active Site

Position(s)	Description	Evidence
1024	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e+++lF+++G ++g+a+++  +++l
   Q: 732  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEESRLIWFSDKTF-----EEIDLFYLIGAICGLAIYNLTIIEL 813
           78999***********************************************98877.....68*********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+k  +l+dl+e++p++ ++l+e++++ e+d++e  ++l+f+++ +++g t+++eL+p+G++i V+++N++e+v+++
   Q: 814  QFPLALYKKLLKKTATLDDLKELMPDVGRNLQELLDYTEDDLDEV-FCLNFTITMDNYGVTEVKELVPNGAEICVNKSNRQEFVNAY 899
           *************************************98888886.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y+++++++  ++af+ Gf++v+  ++l+lF+++el+ ++ G++++d+++l+k t+ykg+y +++p+i+ Fwe+++e+  e++k+f
   Q: 900  VDYIFNKSVAPLFDAFYVGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKATEYKGEYWAEHPTIKLFWEIFHELPLEKKKQF 986
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + d+ lP ++TCfn+L+LP+Y+  e+l++kL+ Ai++ +gF+l
   Q: 987  LLFLTGSDRIPIMGMKSLK---LVIQPtGGGDHYLPVAHTCFNLLDLPKYTDRETLQSKLIQAIDHYEGFNL 1055
           *******************...6666658999**************************************87 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE IVVEPRNCEF FNGKKVCDVG CGRRHTVFVL DDGAVYTCGC 60
NDLGQLGHEK SRKKPEQVGA LDAQNIVAVS CGEAHTLALN DKGQVFAWGL ASDGQLGLPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTGTATT TAATCTGCGT TTTATTTTAA ATAACAAAGG TAAACAAACT GCAGTTAGAG 60
CTACACAACA CATTAGTGTA CACCGTACCG GTTATAATCC CCTTTGAGGC CCGATCACGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	81.17	0.00e+00	1681.00
IUUC-Apl-003295	Anas platyrhynchos	79.58	0.00e+00	1696.00
IUUC-Aca-004336	Anolis carolinensis	78.85	0.00e+00	1684.00
IUUC-Ame-010768	Astyanax mexicanus	77.24	0.00e+00	1665.00
IUUC-Bta-013279	Bos taurus	81.27	0.00e+00	1685.00
IUUC-Cja-019023	Callithrix jacchus	80.98	0.00e+00	1677.00
IUUC-Cfa-021074	Canis familiaris	81.27	0.00e+00	1685.00
IUUC-Cpo-021461	Cavia porcellus	79.41	0.00e+00	1644.00
IUUC-Csa-024261	Chlorocebus sabaeus	81.17	0.00e+00	1684.00
IUUC-Cho-024513	Choloepus hoffmanni	64.05	0.00e+00	1226.00
IUUC-Cin-025232	Ciona intestinalis	42.43	0.00e+00	817.00
IUUC-Dre-028829	Danio rerio	78.00	0.00e+00	1644.00
IUUC-Dno-029445	Dasypus novemcinctus	78.02	0.00e+00	1357.00
IUUC-Dor-030158	Dipodomys ordii	82.86	0.00e+00	767.00
IUUC-Dme-032103	Drosophila melanogaster	44.92	0.00e+00	900.00
IUUC-Ete-033072	Echinops telfairi	72.82	0.00e+00	1464.00
IUUC-Eca-033317	Equus caballus	80.70	0.00e+00	1673.00
IUUC-Fca-035682	Felis catus	80.97	0.00e+00	1674.00
IUUC-Fal-036969	Ficedula albicollis	78.81	0.00e+00	1686.00
IUUC-Gmo-038671	Gadus morhua	75.85	0.00e+00	1633.00
IUUC-Gga-041174	Gallus gallus	79.09	0.00e+00	1694.00
IUUC-Gac-042600	Gasterosteus aculeatus	77.40	0.00e+00	1597.00
IUUC-Ggo-044589	Gorilla gorilla	80.61	0.00e+00	1700.00
IUUC-Hsa-046772	Homo sapiens	80.70	0.00e+00	1699.00
IUUC-Lch-050147	Latimeria chalumnae	77.92	0.00e+00	1398.00
IUUC-Laf-053844	Loxodonta africana	80.51	0.00e+00	1674.00
IUUC-Mcc-055531	Macaca mulatta	79.28	0.00e+00	1668.00
IUUC-Mga-060151	Meleagris gallopavo	77.24	0.00e+00	1380.00
IUUC-Mmr-060954	Microcebus murinus	80.98	0.00e+00	1681.00
IUUC-Mdo-062246	Monodelphis domestica	78.59	0.00e+00	1532.00
IUUC-Mmu-063369	Mus musculus	79.26	0.00e+00	1663.00
IUUC-Mpu-065936	Mustela putorius furo	80.75	0.00e+00	1551.00
IUUC-Mlu-067326	Myotis lucifugus	81.08	0.00e+00	1657.00
IUUC-Nle-069453	Nomascus leucogenys	80.49	0.00e+00	1667.00
IUUC-Ont-071720	Oreochromis niloticus	79.45	0.00e+00	1670.00
IUUC-Oan-073464	Ornithorhynchus anatinus	79.84	0.00e+00	1553.00
IUUC-Ocu-074207	Oryctolagus cuniculus	78.26	0.00e+00	1531.00
IUUC-Ola-086762	Oryzias latipes	76.99	0.00e+00	1583.00
IUUC-Oga-088435	Otolemur garnettii	81.17	0.00e+00	1683.00
IUUC-Oar-089233	Ovis aries	81.27	0.00e+00	1685.00
IUUC-Ptr-091368	Pan troglodytes	80.89	0.00e+00	1704.00
IUUC-Pan-092300	Papio anubis	81.17	0.00e+00	1684.00
IUUC-Psi-093406	Pelodiscus sinensis	80.32	0.00e+00	1709.00
IUUC-Pma-094113	Petromyzon marinus	68.03	0.00e+00	1099.00
IUUC-Ppa-095354	Physcomitrella patens	33.21	4.00e-137	482.00
IUUC-Pfo-097021	Poecilia formosa	77.29	0.00e+00	1671.00
IUUC-Pab-098327	Pongo abelii	80.98	0.00e+00	1702.00
IUUC-Pva-102909	Pteropus vampyrus	71.71	0.00e+00	1414.00
IUUC-Rno-105457	Rattus norvegicus	79.85	0.00e+00	1678.00
IUUC-Sha-106632	Sarcophilus harrisii	79.64	0.00e+00	1682.00
IUUC-Sar-113679	Sorex araneus	71.13	0.00e+00	922.00
IUUC-Tgu-116849	Taeniopygia guttata	75.21	0.00e+00	1589.00
IUUC-Tru-118206	Takifugu rubripes	76.88	0.00e+00	1563.00
IUUC-Tsy-119521	Tarsius syrichta	68.12	0.00e+00	1328.00
IUUC-Tni-120233	Tetraodon nigroviridis	75.59	0.00e+00	1547.00
IUUC-Tbe-127941	Tupaia belangeri	64.94	0.00e+00	1114.00
IUUC-Vpa-130448	Vicugna pacos	80.79	0.00e+00	1677.00
IUUC-Xtr-132719	Xenopus tropicalis	67.30	0.00e+00	1316.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence