iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.80e-09	39.1	14	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkw.....pglknssskefrCPlCr 46
           C++C+e f   +   ++l+CgHvf++dCl k+     ++ +   ++++ CP+Cr
   Q: 14   CPVCYEKFrdlDGASRTLSCGHVFCHDCLVKYllstrVDGQ--VQRTIVCPICR 65
           ********655334999************999888665555..889999****8 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MSEGGSKDSS GSECPVCYEK FRDLDGASRT LSCGHVFCHD CLVKYLLSTR VDGQVQRTIV 60
CPICRYVTFL SKKSSRWPSM LDKSSQTLTV PVGLPSTPSP DRGGHTNPLV ISHQVWRQSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCATTAGG AAATGCCTCC ACAGCAGGCA CAGTGACAGC AGCTGTCAGT CCAGCTGGGT 60
GGCTCCCATC TGTGAAGGAC TTGGGTAGAA AGACCGACGC CACTCTCTCA GGTACTGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0033768--C:SUMO-targeted ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0033234--P:negative regulation of protein sumoylation
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

mmu:320040

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001331	Ailuropoda melanoleuca	87.10	2.00e-45	174.00
IUUC-Atr-002488	Amborella trichopoda	31.75	2.00e-06	45.80
IUUC-Apl-003509	Anas platyrhynchos	47.71	8.00e-37	146.00
IUUC-Aca-004916	Anolis carolinensis	36.63	2.00e-23	102.00
IUUC-Bta-013443	Bos taurus	82.94	3.00e-70	258.00
IUUC-Cja-019637	Callithrix jacchus	82.13	8.00e-71	259.00
IUUC-Cfa-020737	Canis familiaris	80.59	6.00e-66	243.00
IUUC-Cpo-022224	Cavia porcellus	88.96	4.00e-75	273.00
IUUC-Csa-024175	Chlorocebus sabaeus	79.89	2.00e-79	288.00
IUUC-Dre-028060	Danio rerio	37.62	5.00e-24	103.00
IUUC-Dno-030024	Dasypus novemcinctus	79.14	1.00e-64	239.00
IUUC-Dor-030936	Dipodomys ordii	90.59	2.00e-86	311.00
IUUC-Eca-033759	Equus caballus	86.34	4.00e-82	296.00
IUUC-Fal-037142	Ficedula albicollis	43.28	4.00e-31	127.00
IUUC-Gmo-039196	Gadus morhua	38.10	9.00e-23	99.80
IUUC-Gga-041189	Gallus gallus	47.10	3.00e-33	134.00
IUUC-Gac-041497	Gasterosteus aculeatus	42.68	1.00e-25	109.00
IUUC-Ggo-045020	Gorilla gorilla	80.61	1.00e-72	265.00
IUUC-Hsa-046317	Homo sapiens	80.61	4.00e-71	260.00
IUUC-Itr-048656	Ictidomys tridecemlineatus	91.76	6.00e-90	323.00
IUUC-Lch-049885	Latimeria chalumnae	40.59	9.00e-26	109.00
IUUC-Laf-053457	Loxodonta africana	75.42	2.00e-72	265.00
IUUC-Mcc-054653	Macaca mulatta	80.38	1.00e-69	256.00
IUUC-Mga-059753	Meleagris gallopavo	48.91	4.00e-37	147.00
IUUC-Mdo-062993	Monodelphis domestica	72.48	2.00e-73	268.00
IUUC-Mpu-066299	Mustela putorius furo	81.18	6.00e-64	236.00
IUUC-Mlu-066988	Myotis lucifugus	81.98	5.00e-67	246.00
IUUC-Nle-069011	Nomascus leucogenys	80.38	2.00e-69	254.00
IUUC-Opr-070258	Ochotona princeps	84.36	4.00e-76	277.00
IUUC-Ont-071886	Oreochromis niloticus	43.48	1.00e-24	105.00
IUUC-Ocu-074282	Oryctolagus cuniculus	90.00	5.00e-79	286.00
IUUC-Oga-088403	Otolemur garnettii	74.86	8.00e-73	266.00
IUUC-Oar-089665	Ovis aries	83.67	3.00e-20	89.40
IUUC-Ptr-090580	Pan troglodytes	81.21	1.00e-72	265.00
IUUC-Pan-092447	Papio anubis	81.01	2.00e-70	258.00
IUUC-Psi-093673	Pelodiscus sinensis	46.02	1.00e-40	159.00
IUUC-Ppa-095340	Physcomitrella patens	37.84	3.00e-08	52.40
IUUC-Pfo-096933	Poecilia formosa	39.88	2.00e-21	95.50
IUUC-Pab-097867	Pongo abelii	81.01	7.00e-69	253.00
IUUC-Pva-102146	Pteropus vampyrus	89.41	3.00e-76	277.00
IUUC-Rno-105897	Rattus norvegicus	97.06	1.00e-85	308.00
IUUC-Sha-107282	Sarcophilus harrisii	69.31	4.00e-60	223.00
IUUC-Sar-113260	Sorex araneus	88.24	8.00e-87	312.00
IUUC-Ssc-115449	Sus scrofa	80.00	7.00e-58	216.00
IUUC-Tgu-117349	Taeniopygia guttata	43.33	4.00e-30	124.00
IUUC-Xtr-132180	Xenopus tropicalis	43.02	4.00e-26	110.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence