iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003400

Ensembl Protein ID

ENSAPLP00000005895.1

UniProt Accession

R0L3H5; R0L3H5_ANAPL

Genbank Protein ID

EOA94807.1

Protein Name

E3 ubiquitin-protein ligase HACE1

Genbank Nucleotide ID

ADON01131852

Gene Name

LOC101796839; Anapl_18557

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000006280.1	ENSAPLT00000006531.1	ENSAPLP00000005895.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.00e-118	394.4	302	631

Active Site

Position(s)	Description	Evidence
602	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G++lg+al +++l+++ 
   Q: 302  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSSEIVNPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGQILGLALNHRQLVNIY 387
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG++i Vt+eNk eYv+lv+e+
   Q: 388  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQENKAEYVQLVTEL 473
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++ +++iqwFw+v+ee+++eer  +LqFvT
   Q: 474  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWLKNTEYTSGYERGDQVIQWFWDVVEELTQEERVLLLQFVT 562
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa ++     + f+i     + + lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 563  GSSRVPHGGFAHIMggsgLQNFTIAAvPYTANLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 631
           ******************888999995667799******************************986555 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

SLSSNYEAQM KSLLRIVRIF CHVFRIGPSS PSNGNDMGYN GNKTPRSQVF KVRKVYDVVR 60
KIDVKEMNFT KHAFINQTSH EQEPLELLWH SLDEWLVLIA TELMKNKRDS ANITSILLKQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTTGTCAA GTAATTATGA AGCTCAAATG AAGAGTCTCT TAAGGATCGT GAGGATATTT 60
TGCCATGTCT TTCGCATTGG CCCATCCTCT CCCAGTAATG GAAATGACAT GGGCTACAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	87.58	0.00e+00	1145.00
IUUC-Atr-002582	Amborella trichopoda	42.95	8.00e-97	350.00
IUUC-Aca-005375	Anolis carolinensis	86.77	0.00e+00	1155.00
IUUC-Aly-006157	Arabidopsis lyrata	44.32	3.00e-100	361.00
IUUC-Ath-007160	Arabidopsis thaliana	42.53	2.00e-93	338.00
IUUC-Ame-011847	Astyanax mexicanus	81.59	0.00e+00	1068.00
IUUC-Bta-012831	Bos taurus	88.19	0.00e+00	1155.00
IUUC-Bdi-014884	Brachypodium distachyon	42.76	3.00e-96	348.00
IUUC-Bol-016533	Brassica oleracea	53.28	4.00e-79	287.00
IUUC-Bra-016726	Brassica rapa	44.55	7.00e-101	363.00
IUUC-Cja-019160	Callithrix jacchus	88.36	0.00e+00	1152.00
IUUC-Cfa-020346	Canis familiaris	87.72	0.00e+00	1150.00
IUUC-Cpo-021766	Cavia porcellus	87.72	0.00e+00	1154.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	42.89	2.00e-97	348.00
IUUC-Csa-023768	Chlorocebus sabaeus	87.87	0.00e+00	1151.00
IUUC-Cho-024688	Choloepus hoffmanni	85.49	0.00e+00	1107.00
IUUC-Cin-025417	Ciona intestinalis	51.50	1.00e-139	490.00
IUUC-Csv-025993	Ciona savignyi	45.21	1.00e-138	486.00
IUUC-Dre-027819	Danio rerio	78.16	0.00e+00	1032.00
IUUC-Dno-029027	Dasypus novemcinctus	87.97	0.00e+00	1154.00
IUUC-Dor-030327	Dipodomys ordii	84.88	0.00e+00	1087.00
IUUC-Ete-032966	Echinops telfairi	87.87	0.00e+00	1159.00
IUUC-Eca-034339	Equus caballus	87.72	0.00e+00	1149.00
IUUC-Eeu-034544	Erinaceus europaeus	78.23	3.00e-141	495.00
IUUC-Fca-035617	Felis catus	87.87	0.00e+00	1150.00
IUUC-Fal-036687	Ficedula albicollis	97.95	0.00e+00	1290.00
IUUC-Gmo-039508	Gadus morhua	87.93	0.00e+00	830.00
IUUC-Gga-040845	Gallus gallus	99.53	0.00e+00	1331.00
IUUC-Gac-041894	Gasterosteus aculeatus	78.09	0.00e+00	1029.00
IUUC-Gma-044216	Glycine max	43.86	9.00e-99	356.00
IUUC-Ggo-044465	Gorilla gorilla	87.89	0.00e+00	1148.00
IUUC-Hsa-045731	Homo sapiens	88.19	0.00e+00	1155.00
IUUC-Hvu-047697	Hordeum vulgare	42.53	2.00e-95	345.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	88.35	0.00e+00	1153.00
IUUC-Lch-050436	Latimeria chalumnae	83.78	0.00e+00	1096.00
IUUC-Lpe-051550	Leersia perrieri	42.99	2.00e-97	352.00
IUUC-Loc-052287	Lepisosteus oculatus	85.96	0.00e+00	1133.00
IUUC-Laf-053846	Loxodonta africana	88.50	0.00e+00	1162.00
IUUC-Mcc-055845	Macaca mulatta	88.03	0.00e+00	1153.00
IUUC-Meu-056060	Macropus eugenii	63.82	1.00e-135	477.00
IUUC-Mtr-057633	Medicago truncatula	42.34	7.00e-100	360.00
IUUC-Mga-059935	Meleagris gallopavo	94.33	0.00e+00	1245.00
IUUC-Mmr-060960	Microcebus murinus	88.35	0.00e+00	1157.00
IUUC-Mdo-061851	Monodelphis domestica	93.07	0.00e+00	1249.00
IUUC-Mmu-063657	Mus musculus	87.40	0.00e+00	1144.00
IUUC-Mac-065229	Musa acuminata	42.95	1.00e-96	349.00
IUUC-Mpu-066161	Mustela putorius furo	96.23	0.00e+00	804.00
IUUC-Mlu-067354	Myotis lucifugus	87.26	0.00e+00	1112.00
IUUC-Nle-069112	Nomascus leucogenys	88.03	0.00e+00	1151.00
IUUC-Opr-070686	Ochotona princeps	86.79	0.00e+00	791.00
IUUC-Ont-072398	Oreochromis niloticus	79.10	0.00e+00	1043.00
IUUC-Oan-073194	Ornithorhynchus anatinus	86.93	0.00e+00	1140.00
IUUC-Ocu-074397	Oryctolagus cuniculus	73.28	0.00e+00	906.00
IUUC-Oba-075757	Oryza barthii	42.76	2.00e-96	348.00
IUUC-Obr-076553	Oryza brachyantha	43.21	3.00e-97	351.00
IUUC-Ogl-077520	Oryza glaberrima	42.76	2.00e-96	348.00
IUUC-Ogu-078278	Oryza glumaepatula	42.76	2.00e-96	348.00
IUUC-Oin-079767	Oryza indica	42.76	2.00e-96	348.00
IUUC-Olo-080380	Oryza longistaminata	42.60	5.00e-95	343.00
IUUC-Ome-081925	Oryza meridionalis	42.60	5.00e-95	344.00
IUUC-Oni-082619	Oryza nivara	42.76	2.00e-96	348.00
IUUC-Opu-083684	Oryza punctata	42.60	3.00e-95	344.00
IUUC-Oru-084501	Oryza rufipogon	42.76	2.00e-96	349.00
IUUC-Osa-086251	Oryza sativa	42.60	1.00e-96	347.00
IUUC-Ola-086777	Oryzias latipes	77.90	0.00e+00	993.00
IUUC-Oga-088684	Otolemur garnettii	88.21	0.00e+00	1152.00
IUUC-Oar-089428	Ovis aries	86.98	0.00e+00	1117.00
IUUC-Ptr-090529	Pan troglodytes	88.03	0.00e+00	1153.00
IUUC-Pan-091702	Papio anubis	87.87	0.00e+00	1152.00
IUUC-Psi-093969	Pelodiscus sinensis	95.91	0.00e+00	1285.00
IUUC-Ppa-095834	Physcomitrella patens	43.40	3.00e-96	348.00
IUUC-Pfo-097364	Poecilia formosa	78.94	0.00e+00	1037.00
IUUC-Pab-098574	Pongo abelii	88.19	0.00e+00	1155.00
IUUC-Pop-099468	Populus trichocarpa	43.86	1.00e-98	356.00
IUUC-Pca-100525	Procavia capensis	68.19	6.00e-164	571.00
IUUC-Ppe-101641	Prunus persica	43.86	3.00e-99	358.00
IUUC-Pva-102365	Pteropus vampyrus	80.94	0.00e+00	1033.00
IUUC-Pgr-103465	Puccinia graminis	40.66	7.00e-100	360.00
IUUC-Ptt-103813	Puccinia triticina	38.12	2.00e-89	325.00
IUUC-Rno-105153	Rattus norvegicus	87.87	0.00e+00	1150.00
IUUC-Sha-107319	Sarcophilus harrisii	93.07	0.00e+00	1243.00
IUUC-Smo-109640	Selaginella moellendorffii	42.82	1.00e-96	349.00
IUUC-Sit-110598	Setaria italica	43.44	8.00e-97	350.00
IUUC-Sly-111706	Solanum lycopersicum	44.77	3.00e-101	364.00
IUUC-Stu-112894	Solanum tuberosum	33.90	1.00e-52	201.00
IUUC-Sar-113449	Sorex araneus	69.95	7.00e-158	550.00
IUUC-Sbi-114042	Sorghum bicolor	43.74	2.00e-97	352.00
IUUC-Sre-114958	Sporisorium reilianum	45.66	2.00e-109	389.00
IUUC-Ssc-115865	Sus scrofa	87.87	0.00e+00	1152.00
IUUC-Tgu-117225	Taeniopygia guttata	97.95	0.00e+00	1314.00
IUUC-Tru-118026	Takifugu rubripes	77.52	0.00e+00	1022.00
IUUC-Tsy-119407	Tarsius syrichta	80.31	0.00e+00	1026.00
IUUC-Tni-120234	Tetraodon nigroviridis	73.84	0.00e+00	698.00
IUUC-Tca-121479	Theobroma cacao	43.64	1.00e-99	359.00
IUUC-Tae-125214	Triticum aestivum	42.04	7.00e-95	342.00
IUUC-Tur-126774	Triticum urartu	29.66	2.00e-46	180.00
IUUC-Tbe-127708	Tupaia belangeri	75.69	1.00e-107	384.00
IUUC-Ttr-128667	Tursiops truncatus	87.72	0.00e+00	1152.00
IUUC-Uma-129355	Ustilago maydis	46.33	5.00e-110	390.00
IUUC-Vpa-130200	Vicugna pacos	87.87	0.00e+00	1150.00
IUUC-Vvi-131078	Vitis vinifera	43.41	2.00e-98	355.00
IUUC-Xtr-132176	Xenopus tropicalis	88.54	0.00e+00	1181.00
IUUC-Xma-133936	Xiphophorus maculatus	81.92	0.00e+00	939.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence