iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-134135

Ensembl Protein ID

ENSXMAP00000004463.1

UniProt Accession

M3ZQH0; M3ZQH0_XIPMA

Genbank Protein ID

ENSXMAP00000004463

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01006403

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000004432.1	ENSXMAT00000004468.1	ENSXMAP00000004463.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-86	291.2	4485	4821
E3 adaptor/Cullin RING/DCX/DWD	5.10e-11	42.5	3396	3428

Active Site

Position(s)	Description	Evidence
4790	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++elq+  + l+ +++n+ + +  n d++l np     +h+  F+flG+l+++a+++++
   Q: 4485 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELQSGVVDLLIHTPNSFADVGCNTDRFLLNPgahseDHMVQFRFLGILMAVAIRTKK 4571
           556666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+  +ls  dleevd  +y++l+ i+++++s i++ ++++++  ++    +++ +    +p+G+ni+ t +N+ 
   Q: 4572 PLDLHLAPWVWKQLCCMPLSGADLEEVDLLTYRTLQGILHLENSGITADNFHVMIPLDSFMAHSADGRLvpVVPRGQNISLTFSNRT 4658
           *******************************************************9999887776666555899************* PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ ++yrl+e +++qv+a+reG++++ip  llsl+t+++le+l+cG +e++ve+lkk  +y++ +te+++ i+wFw+ l+ef++
   Q: 4659 EYVERALDYRLHE-MDSQVDAVREGMSTIIPVPLLSLLTAQQLEQLVCGLPEVSVEMLKKLVRYRD-ITENHQLIRWFWQSLKEFTN 4743
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk..dasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  fL+Fv+g+srlP  ++a+++ ++f+i k   +++ + lP+++TCf++L+LP+Y+s+ il e+L+y i++++++++
   Q: 4744 EERVLFLRFVSGRSRLP-SNLADIS-QKFQIIKvdRRQPiNGLPTAQTCFFLLRLPPYTSQAILAERLRYSIHNCTSIDM 4821
           *****************.79*****.55666666745557***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH ++v ++++ sd +ll+++s D+++++W++ 
   Q: 3396 GHYNKVASCSWsSDqGLLATCSQDKVVQLWRVN 3428
           78899*******999****************86 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MVPCQTHVLL KWQEHFNSSW AAEDSVQTAR RHGAAVLYNK LLYNKEVVTL AQPVQELASP 60
RLPDFECESN TSAEKEEYLS SLLHSQRWLA HRMLTQTSYT LGLHQRLVVL QRIYYALHSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGAAGCAG GGAAACGCAG GGGAAGGCTG ACATGATATT TGCGTCCGAG GGAGACCTCA 60
CTGGGACGGG ACGGGTAACG CAAAGCAAAC ACCCTCGGAA GCTCGCCGTG AAGGTAACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006545	Arabidopsis lyrata	35.47	5.00e-50	193.00
IUUC-Ame-011268	Astyanax mexicanus	71.49	0.00e+00	2615.00
IUUC-Bra-017584	Brassica rapa	34.64	2.00e-49	191.00
IUUC-Gac-042444	Gasterosteus aculeatus	76.93	0.00e+00	7037.00
IUUC-Hvu-047529	Hordeum vulgare	35.65	2.00e-50	194.00
IUUC-Loc-052805	Lepisosteus oculatus	63.66	0.00e+00	5419.00
IUUC-Ola-086308	Oryzias latipes	76.56	0.00e+00	6727.00
IUUC-Pfo-096464	Poecilia formosa	92.80	0.00e+00	8408.00
IUUC-Pop-099121	Populus trichocarpa	34.78	2.00e-54	208.00
IUUC-Ppe-101345	Prunus persica	33.08	2.00e-51	198.00
IUUC-Smo-108827	Selaginella moellendorffii	35.47	2.00e-52	201.00
IUUC-Sly-111155	Solanum lycopersicum	37.28	2.00e-53	204.00
IUUC-Stu-112166	Solanum tuberosum	31.87	5.00e-49	190.00
IUUC-Tru-118723	Takifugu rubripes	75.22	0.00e+00	6766.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence