iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-131869

UUCD1 version

UUC-XeT-01077

Ensembl Protein ID

ENSXETP00000043701.3

UniProt Accession

Q0VA64; F7BZB4; UBP16_XENTR

Genbank Protein ID

AAI21231.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AAMC01089338

Gene Name

usp16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000020255.3	ENSXETT00000043701.3	ENSXETP00000043701.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-87	293.9	196	863

Active Site

Position(s)	Description	Evidence
205	Nucleophile	ECO:0000255\|HAMAP-Rule:MF_03062}
798	Proton acceptor	ECO:0000255\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenp..............kepkgellkslqklfeelwkskkk 66
           +Gl+NlgNtC++N+v+Q Ls++p +rell+e                   p              +++ g+l+ ++ ++++e++++kk+
   Q: 196  KGLSNLGNTCFFNAVMQNLSQTPAVRELLNEaktlkkpvtV---------PlpdsssptnvevhlEQQPGPLTLAMWQFLTEMQETKKG 275
           5******************************5555333330.........24455666666666678888******************* PP
   S: 67   avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk....eknkpkeeeeeedkselsde......aeekkkkknkslisdl 145
           +v+p+e++++++k+a +f+gy+qqD+qE+l++lld+++ e  +      +k+ +++ +e       e      ++++k +  ++++++l
   Q: 276  VVTPKEVFSQVCKKAIRFKGYQQQDSQELLRYLLDGMRGEEIQrvslAMSKSLQNTLDE-------EeikkivKDSEKRRTIPNFVDHL 357
           *************************************9777443443333333333333.......22233346777888889****** PP
   S: 146  Fqgqlksqikclecdnvssreepfldlslpvpgkeetkke................................................. 185
           F+g+l+s+i+c+ec++vs  +epfldlslpv ++   kk+                                                 
   Q: 358  FGGELTSTIMCEECHTVSLVHEPFLDLSLPVLDDVIVKKNsqkssapaperkeeeenddgyikerdeaspgaskhlqkkakkaakkqak 446
           ********************************9888777788899******************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 447  nqrrqlkmqgktvlltdvakqecsedeeeiapnnteseantrpddevpiadglntmksdlsalengsetiesamervtedtdldtsghn 535
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 536  tesvemnamelvrnmennnnnntdvnktlertegsgvdsmeataavdngnadtvcvddteaanglldcsaasmdneltnslnrlklssd 624
           ***************************************************************************************** PP
   S: 186  ...............................................slqdcLesftkeeelegenkyycekckkkqe........... 216
                                                          s+ +cL +ft +e+l+g+nk+ c+ c++kq            
   Q: 625  ieptqveieilpdqqqphtqiyevinedpktafstlserkdlpldgySVLSCLYQFTHKETLTGNNKLLCNVCTRKQAsrlnnsnkgek 713
           **************************************************************************999999999999999 PP
   S: 217  ......aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYv 296
                 a+k++ ++  +++L+lhLkRf  ++++ + +kin++++fp+ Ldl+pfcts++++      +  Y+L++v+ HsGs++sGHY+
   Q: 714  tfvytnAKKQMLVSDPSPILTLHLKRF--QQNGFNLRKINRHIKFPEVLDLAPFCTSKCKNIPAgesRLLYSLYGVIEHSGSMRSGHYT 800
           999999*********************..99999***********************998876577799******************** PP
   S: 297  ayvkn........................ekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           a+vk                          +g+W++++Ds+V++v+ ++vl+   s+aY+lfY+r+
   Q: 801  AFVKLrrpnqqlcemvlkgvipevsgsepGQGSWYHISDSHVQAVSLSRVLS---SQAYLLFYERM 863
           *****9999999999999999998888766888*******************...*********96 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MVKKRGKNLP AQDSLDAEPV CKHLRKALDE GSVKKALVNV EWTVCQECQA DNKEKNNSDD 60
ELVEDPSVWL CLKCGHRGCG RNSASQHALN HYNTPRSEPH CLVLSVDMWS AWCYLCDNEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCTGGACG TGTGTGAGTT GTGTGTGGGA GACCGGAAGC AACGGGAGCC GGTAACGTGG 60
GGCGGAAGTA GTTAGTCGCC TGCGGGAGTA ACACGTGGGT AGAAAGCCGG TGCTGAGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0042393--F:histone binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

xtr:447956

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	29.57	5.00e-26	113.00
IUUC-Aml-001931	Ailuropoda melanoleuca	51.48	0.00e+00	760.00
IUUC-Atr-003015	Amborella trichopoda	30.90	5.00e-35	143.00
IUUC-Apl-004145	Anas platyrhynchos	52.83	0.00e+00	753.00
IUUC-Aca-004314	Anolis carolinensis	50.17	0.00e+00	735.00
IUUC-Aly-006422	Arabidopsis lyrata	27.84	7.00e-30	126.00
IUUC-Ath-006732	Arabidopsis thaliana	29.67	2.00e-36	147.00
IUUC-Ame-011659	Astyanax mexicanus	45.24	1.00e-100	360.00
IUUC-Bta-013362	Bos taurus	51.30	0.00e+00	776.00
IUUC-Bdi-014624	Brachypodium distachyon	28.05	9.00e-25	108.00
IUUC-Bol-015941	Brassica oleracea	29.77	6.00e-33	136.00
IUUC-Bra-016751	Brassica rapa	29.50	1.00e-32	135.00
IUUC-Cja-019177	Callithrix jacchus	52.22	0.00e+00	793.00
IUUC-Cfa-020051	Canis familiaris	58.68	7.00e-141	494.00
IUUC-Cpo-021886	Cavia porcellus	48.08	0.00e+00	766.00
IUUC-Csa-024103	Chlorocebus sabaeus	52.22	0.00e+00	797.00
IUUC-Cho-024315	Choloepus hoffmanni	46.56	5.00e-62	232.00
IUUC-Cin-025775	Ciona intestinalis	48.94	3.00e-39	153.00
IUUC-Csv-026075	Ciona savignyi	48.72	2.00e-53	203.00
IUUC-Dre-028388	Danio rerio	47.85	5.00e-104	372.00
IUUC-Dno-029409	Dasypus novemcinctus	51.08	0.00e+00	790.00
IUUC-Dor-030443	Dipodomys ordii	48.35	8.00e-102	364.00
IUUC-Ete-032807	Echinops telfairi	53.65	2.00e-120	426.00
IUUC-Eca-033479	Equus caballus	52.06	0.00e+00	791.00
IUUC-Eeu-034835	Erinaceus europaeus	57.48	4.00e-87	315.00
IUUC-Fca-036320	Felis catus	51.77	0.00e+00	794.00
IUUC-Fal-037029	Ficedula albicollis	49.66	0.00e+00	696.00
IUUC-Gmo-039480	Gadus morhua	49.14	4.00e-104	372.00
IUUC-Gga-040527	Gallus gallus	52.17	0.00e+00	747.00
IUUC-Gac-042343	Gasterosteus aculeatus	46.84	1.00e-107	384.00
IUUC-Gma-044402	Glycine max	28.50	1.00e-33	138.00
IUUC-Ggo-045598	Gorilla gorilla	52.00	0.00e+00	791.00
IUUC-Hsa-046598	Homo sapiens	52.17	0.00e+00	788.00
IUUC-Hvu-047146	Hordeum vulgare	29.14	4.00e-26	113.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	52.86	0.00e+00	796.00
IUUC-Lch-050536	Latimeria chalumnae	51.94	6.00e-111	395.00
IUUC-Lpe-050703	Leersia perrieri	37.63	4.00e-26	113.00
IUUC-Loc-051814	Lepisosteus oculatus	51.22	2.00e-112	399.00
IUUC-Laf-053732	Loxodonta africana	52.11	0.00e+00	799.00
IUUC-Mcc-054661	Macaca mulatta	52.22	0.00e+00	797.00
IUUC-Meu-055967	Macropus eugenii	53.05	4.00e-112	399.00
IUUC-Mtr-057945	Medicago truncatula	29.52	8.00e-34	139.00
IUUC-Mga-059551	Meleagris gallopavo	51.64	0.00e+00	737.00
IUUC-Mmr-061747	Microcebus murinus	51.57	0.00e+00	781.00
IUUC-Mdo-062220	Monodelphis domestica	53.69	8.00e-128	451.00
IUUC-Mmu-063582	Mus musculus	51.43	0.00e+00	734.00
IUUC-Mac-064941	Musa acuminata	32.22	1.00e-35	144.00
IUUC-Mpu-066339	Mustela putorius furo	51.36	0.00e+00	793.00
IUUC-Mlu-067511	Myotis lucifugus	52.40	0.00e+00	773.00
IUUC-Nle-069252	Nomascus leucogenys	52.45	0.00e+00	800.00
IUUC-Opr-070969	Ochotona princeps	51.57	0.00e+00	759.00
IUUC-Ont-071786	Oreochromis niloticus	47.21	2.00e-104	373.00
IUUC-Ocu-074704	Oryctolagus cuniculus	51.04	0.00e+00	780.00
IUUC-Oba-075094	Oryza barthii	29.31	2.00e-27	117.00
IUUC-Obr-076743	Oryza brachyantha	37.11	4.00e-27	117.00
IUUC-Ogl-077739	Oryza glaberrima	29.61	5.00e-28	119.00
IUUC-Ogu-078851	Oryza glumaepatula	29.61	6.00e-28	119.00
IUUC-Oin-079402	Oryza indica	29.61	6.00e-28	119.00
IUUC-Olo-080431	Oryza longistaminata	29.61	6.00e-28	119.00
IUUC-Ome-081580	Oryza meridionalis	29.91	4.00e-28	120.00
IUUC-Oni-082644	Oryza nivara	29.61	6.00e-28	119.00
IUUC-Opu-083452	Oryza punctata	29.00	3.00e-27	117.00
IUUC-Oru-084546	Oryza rufipogon	29.61	7.00e-28	119.00
IUUC-Osa-085858	Oryza sativa	29.61	7.00e-28	119.00
IUUC-Ola-086795	Oryzias latipes	44.91	1.00e-98	354.00
IUUC-Oga-088713	Otolemur garnettii	51.82	0.00e+00	793.00
IUUC-Oar-089887	Ovis aries	52.85	0.00e+00	777.00
IUUC-Ptr-091670	Pan troglodytes	52.00	0.00e+00	791.00
IUUC-Pan-092293	Papio anubis	52.22	0.00e+00	797.00
IUUC-Psi-093101	Pelodiscus sinensis	51.99	0.00e+00	748.00
IUUC-Ppa-095622	Physcomitrella patens	29.51	4.00e-34	140.00
IUUC-Pfo-097202	Poecilia formosa	48.14	3.00e-113	402.00
IUUC-Pab-098773	Pongo abelii	51.88	6.00e-169	587.00
IUUC-Pop-099136	Populus trichocarpa	30.61	2.00e-42	167.00
IUUC-Pca-101069	Procavia capensis	44.10	4.00e-87	315.00
IUUC-Ppe-101794	Prunus persica	29.63	5.00e-33	136.00
IUUC-Pva-103092	Pteropus vampyrus	42.76	8.00e-90	324.00
IUUC-Rno-105237	Rattus norvegicus	51.37	0.00e+00	738.00
IUUC-Sha-106889	Sarcophilus harrisii	55.26	9.00e-125	441.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	31.14	1.00e-21	98.60
IUUC-Spo-108149	Schizosaccharomyces pombe	34.58	3.00e-23	103.00
IUUC-Sit-110283	Setaria italica	31.71	2.00e-26	114.00
IUUC-Sly-111487	Solanum lycopersicum	30.41	8.00e-41	162.00
IUUC-Stu-112820	Solanum tuberosum	29.95	1.00e-40	162.00
IUUC-Sar-113530	Sorex araneus	58.39	9.00e-137	480.00
IUUC-Sbi-113785	Sorghum bicolor	34.18	6.00e-23	103.00
IUUC-Ssc-116091	Sus scrofa	51.89	0.00e+00	787.00
IUUC-Tgu-117478	Taeniopygia guttata	58.29	2.00e-121	429.00
IUUC-Tru-118640	Takifugu rubripes	46.88	8.00e-111	394.00
IUUC-Tsy-119042	Tarsius syrichta	42.05	7.00e-129	454.00
IUUC-Tni-120015	Tetraodon nigroviridis	43.18	2.00e-167	582.00
IUUC-Tca-121701	Theobroma cacao	28.81	8.00e-38	152.00
IUUC-Tae-125351	Triticum aestivum	28.83	3.00e-25	110.00
IUUC-Tur-126788	Triticum urartu	34.50	1.00e-24	108.00
IUUC-Tbe-127309	Tupaia belangeri	54.64	2.00e-84	306.00
IUUC-Ttr-128271	Tursiops truncatus	51.65	0.00e+00	768.00
IUUC-Vpa-130674	Vicugna pacos	51.83	0.00e+00	722.00
IUUC-Xma-134195	Xiphophorus maculatus	49.23	5.00e-113	401.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence