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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018594
Ensembl Protein ID Y92H12A.1b
UniProt Accession G5EE56; W6RRW6; W6RTE9; W6SBD5; SRC1_CAEEL
Genbank Protein ID AAL84635.1; AAN31394.1; CCD71465.1; CDM63506.1; CDM63507.1; CDM63508.1
Protein Name Tyrosine protein-kinase src-1; SRC oncogene related protein 1
Genbank Nucleotide ID AF475094; AF419171; BX284601; BX284601; BX284601; BX284601
Gene Name src-1; Y92H12A.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00005077 Y92H12A.1a Y92H12A.1a
WBGene00005077 Y92H12A.1b Y92H12A.1b
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
iRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFUniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.00e-12 47.2 77 133
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            e++ +ly+y++  d++L+++kGd ++++  ++ + +W++  ++ +g+ G +P nFv+k
   Q: 77   RETLVALYPYDSRADGDLSFQKGDAMYLL--DHSNCDWWYVRHQRTGQTGYVPRNFVAK 133
           57889************************..9999**********************87 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine (PubMed:12110172, PubMed:12527374, PubMed:19210548). May be dispensable for pharyngeal muscle organization in the adult (PubMed:19210548). Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion (PubMed:16024786, PubMed:16251208). Plays a role in the migration of the QR neuroblast, a precursor of the AVM neuron, and in the migration of axon cone of AVM, ALM, CAN and PVM neurons (PubMed:16251208). Probably downstream of integrin ina-1/pat-3, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672).
 Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine (PubMed:12110172, PubMed:12527374, PubMed:19210548). May be dispensable for pharyngeal muscle organization in the adult (PubMed:19210548). Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion (PubMed:16024786, PubMed:16251208). Plays a role in the migration of the QR neuroblast, a precursor of the AVM neuron, and in the migration of axon cone of AVM, ALM, CAN and PVM neurons (PubMed:16251208). Probably downstream of integrin ina-1/pat-3, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672).
Protein Sequence
(Fasta)
MGCLFSKERR SGGSDMGVSE RIDVSRYPRR FQTPQQQTVF HVNNGGNEGT ISQLNGTSDG 60
MMGNGRGGGG GGGAQERETL VALYPYDSRA DGDLSFQKGD AMYLLDHSNC DWWYVRHQRT 120
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Protein Fasta Sequence


>IUUC-Cel-018594|UBD,SH3|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
AAAAAAAACC TCGAAAATAA GAAGAAGAAG CAACCATTCC ATATGCATGC TCAATAATTG 60
TTGTTTGCAC AAAAATACTG GTGTCTTGTG TGAGTTTTTT TGGAAAATTC AGAAAATTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018594|UBD,SH3|Caenorhabditis elegans
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0460--Magnesium
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0042995--C:cell projection
GO:0043292--C:contractile fiber
GO:0001891--C:phagocytic cup
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:1990890--F:netrin receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0071679--P:commissural neuron axon guidance
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0048557--P:embryonic digestive tract morphogenesis
GO:0001714--P:endodermal cell fate specification
GO:0000132--P:establishment of mitotic spindle orientation
GO:0035262--P:gonad morphogenesis
GO:0070986--P:left/right axis specification
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0040019--P:positive regulation of embryonic development
GO:0040017--P:positive regulation of locomotion
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0046777--P:protein autophosphorylation
KEGG cel:CELE_Y92H12A.1
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002778 Amborella trichopoda 32.16 4.00e-23 102.00
IUUC-Aly-005712 Arabidopsis lyrata 31.46 5.00e-19 88.60
IUUC-Ath-007146 Arabidopsis thaliana 31.47 4.00e-22 99.00
IUUC-Ame-011816 Astyanax mexicanus 55.92 4.00e-147 513.00
IUUC-Bdi-014324 Brachypodium distachyon 32.67 5.00e-22 98.60
IUUC-Bol-016049 Brassica oleracea 30.73 3.00e-17 82.80
IUUC-Bra-017486 Brassica rapa 30.88 1.00e-21 97.10
IUUC-Dre-028216 Danio rerio 56.14 3.00e-148 517.00
IUUC-Eca-033970 Equus caballus 56.02 7.00e-146 509.00
IUUC-Eeu-035173 Erinaceus europaeus 41.43 2.00e-87 315.00
IUUC-Fal-036786 Ficedula albicollis 55.26 8.00e-147 512.00
IUUC-Gma-043938 Glycine max 33.33 2.00e-23 103.00
IUUC-Hvu-047310 Hordeum vulgare 30.32 4.00e-17 82.40
IUUC-Lpe-051166 Leersia perrieri 31.68 1.00e-21 97.40
IUUC-Mtr-058733 Medicago truncatula 32.52 5.00e-22 98.60
IUUC-Mac-064539 Musa acuminata 31.55 2.00e-19 89.70
IUUC-Ont-072127 Oreochromis niloticus 55.92 2.00e-146 511.00
IUUC-Oba-075747 Oryza barthii 33.17 4.00e-20 92.80
IUUC-Obr-076676 Oryza brachyantha 33.66 4.00e-21 95.50
IUUC-Ogl-077331 Oryza glaberrima 32.18 7.00e-23 101.00
IUUC-Ogu-078962 Oryza glumaepatula 32.18 8.00e-23 101.00
IUUC-Oin-079172 Oryza indica 32.18 6.00e-23 101.00
IUUC-Olo-080286 Oryza longistaminata 32.18 7.00e-23 101.00
IUUC-Ome-081788 Oryza meridionalis 30.53 3.00e-24 105.00
IUUC-Oni-082734 Oryza nivara 32.18 1.00e-22 100.00
IUUC-Oru-084741 Oryza rufipogon 32.18 6.00e-23 101.00
IUUC-Osa-085779 Oryza sativa 32.39 6.00e-23 101.00
IUUC-Pop-099554 Populus trichocarpa 31.71 2.00e-22 99.80
IUUC-Ppe-102072 Prunus persica 32.35 4.00e-24 105.00
IUUC-Sit-110213 Setaria italica 29.67 8.00e-20 90.90
IUUC-Sly-111528 Solanum lycopersicum 33.00 4.00e-23 102.00
IUUC-Stu-112831 Solanum tuberosum 33.50 1.00e-23 103.00
IUUC-Sbi-114480 Sorghum bicolor 30.35 1.00e-20 93.60
IUUC-Tru-117596 Takifugu rubripes 51.77 1.00e-147 515.00
IUUC-Tca-121389 Theobroma cacao 32.34 4.00e-23 102.00
IUUC-Tae-123414 Triticum aestivum 28.85 7.00e-19 88.20
IUUC-Vvi-131057 Vitis vinifera 33.00 2.00e-22 100.00
Created Date 25-Jun-2017

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