iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-006707

UUCD1 version

UUC-ArT-01710

Ensembl Protein ID

AT3G14400.1

UniProt Accession

Q9FPS2; Q8VZF5; Q9LUK9; UBP25_ARATH

Genbank Protein ID

AAG42763.1; BAB01045.1; AEE75513.1; AAL57643.1; AAX22263.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 25; Deubiquitinating enzyme 25; Ubiquitin thioesterase 25; Ubiquitin-specific-processing protease 25

Genbank Nucleotide ID

AF302673; AB022220; CP002686; AY064992; BT021128

Gene Name

UBP25; At3g14400; MLN21.18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT3G14400	AT3G14400.1	AT3G14400.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-77	262.4	25	334

Active Site

Position(s)	Description	Evidence
33	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
294	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenp..kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEfl 96
           Gl+NlgNtCY+NSvLQcL+++p+l++++l+ k++++++   +   +++ +++   +++ ++l + + +  +p+++ ++lk +ae+f+  +q+Da+Efl
   Q: 25   GLRNLGNTCYLNSVLQCLTFTPPLANFCLThKHSSHCDTYVDgeRKRDCPFCIVEKRIARSL-SVDLTTDAPNKISSCLKIFAEHFKLGRQEDAHEFL 121
           9****************************976777777655522556668888889999999.8888999**************************** PP
   S: 97   aflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesf 194
           ++++d+ +++  +    +k +             + +++  ++s+++++F+g l+sq+kcl+c+ +s++ ++ +d+sl++ +++     s++++L++f
   Q: 122  RYVIDACHNTSLR---LKKLRY------------NGNEPFNGNSVVKEIFGGALQSQVKCLSCGAESNKADEIMDISLEILQSS-----SVKESLQKF 199
           *********9922...222222............235677889*****************************************.....9******** PP
   S: 195  tkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.sls 291
           ++ e l+g+nky ce+c+k+++a+k++++ + P++L+++LkRf     + +  ki+k ++f + L ls+f+++ +++   + +Y+L++++vHsG s++
   Q: 200  FQSEILDGNNKYRCESCEKLVTARKQMSILQAPNILVIQLKRF----GGIFGGKIDKAISFGEILVLSNFMSKASKDP--QPEYKLFGIIVHSGfSPE 291
           *******************************************....568899********************77666..9***************** PP
   S: 292  sGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           sGHY+ayvk++ g+W++++Ds V+ ++ +evl+   ++aY+lf+ r
   Q: 292  SGHYYAYVKDSLGRWYCCNDSFVSLSTLQEVLS---EKAYILFFSR 334
           *********************************...*******987 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MGFKLQMSWM PSLLSQKRRN GPPLGLRNLG NTCYLNSVLQ CLTFTPPLAN FCLTHKHSSH 60
CDTYVDGERK RDCPFCIVEK RIARSLSVDL TTDAPNKISS CLKIFAEHFK LGRQEDAHEF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCGCGAAGG GATTGTGGGG TTTGTTGCTG GGCGGGTCTC TTCCCTCGGC AGTTACCTTC 60
ATCGAATTCG ATCTTCATCT TCTTCCTTCC CCAACTCTTT CAAATTCGTG AAAATCTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT3G14400

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001017	Aegilops tauschii	38.73	2.00e-95	342.00
IUUC-Atr-002832	Amborella trichopoda	45.57	2.00e-132	465.00
IUUC-Aly-005983	Arabidopsis lyrata	94.86	0.00e+00	1289.00
IUUC-Bdi-014044	Brachypodium distachyon	41.04	2.00e-111	395.00
IUUC-Bol-016356	Brassica oleracea	75.66	0.00e+00	977.00
IUUC-Bra-018096	Brassica rapa	75.58	0.00e+00	969.00
IUUC-Gma-043410	Glycine max	50.73	2.00e-173	602.00
IUUC-Hvu-047673	Hordeum vulgare	61.06	2.00e-72	266.00
IUUC-Lpe-050888	Leersia perrieri	55.94	3.00e-107	381.00
IUUC-Mtr-058396	Medicago truncatula	51.62	2.00e-177	615.00
IUUC-Mac-065596	Musa acuminata	61.48	1.00e-116	413.00
IUUC-Oba-075223	Oryza barthii	58.36	6.00e-109	387.00
IUUC-Obr-076589	Oryza brachyantha	40.03	4.00e-100	358.00
IUUC-Ogl-077769	Oryza glaberrima	58.36	6.00e-109	387.00
IUUC-Ogu-078416	Oryza glumaepatula	56.61	5.00e-94	337.00
IUUC-Oin-079451	Oryza indica	58.66	4.00e-110	391.00
IUUC-Olo-080569	Oryza longistaminata	58.66	4.00e-110	391.00
IUUC-Ome-081320	Oryza meridionalis	39.05	2.00e-98	352.00
IUUC-Oni-082823	Oryza nivara	56.61	5.00e-94	337.00
IUUC-Opu-083432	Oryza punctata	51.89	2.00e-89	322.00
IUUC-Oru-084652	Oryza rufipogon	51.19	3.00e-80	291.00
IUUC-Osa-085846	Oryza sativa	58.66	3.00e-110	391.00
IUUC-Ppa-095241	Physcomitrella patens	55.75	3.00e-114	405.00
IUUC-Pop-098875	Populus trichocarpa	52.54	0.00e+00	651.00
IUUC-Ppe-101980	Prunus persica	55.52	1.00e-169	589.00
IUUC-Spo-108119	Schizosaccharomyces pombe	41.94	3.00e-66	245.00
IUUC-Smo-108780	Selaginella moellendorffii	57.10	1.00e-105	375.00
IUUC-Sit-109696	Setaria italica	41.87	7.00e-113	400.00
IUUC-Sly-111085	Solanum lycopersicum	47.59	3.00e-156	545.00
IUUC-Stu-111972	Solanum tuberosum	48.89	2.00e-150	525.00
IUUC-Sbi-114319	Sorghum bicolor	41.11	6.00e-112	397.00
IUUC-Tca-121693	Theobroma cacao	65.96	1.00e-159	556.00
IUUC-Tae-123342	Triticum aestivum	49.11	2.00e-110	392.00
IUUC-Tur-126469	Triticum urartu	39.02	5.00e-97	347.00
IUUC-Tbe-127377	Tupaia belangeri	31.29	8.00e-41	162.00
IUUC-Ttr-128764	Tursiops truncatus	36.63	3.00e-57	216.00
IUUC-Vvi-131135	Vitis vinifera	52.53	0.00e+00	630.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence