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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046041
UUCD1 version UUC-HoS-01105
Ensembl Protein ID ENSP00000386864.1
UniProt Accession Q53GS9; A8K086; B3KM40; B4DHT4; D6W5L4; G5E9H0; Q6NX47; Q96RK9; Q9BV89; Q9H381; Q9P050; Q9Y310; SNUT2_HUMAN
Genbank Protein ID AAK49524.1; AAD27730.1; BAF82140.1; BAG50852.1; BAG58246.1; BAD96572.1; EAW99490.1; EAW99492.1; EAW99493.1; EAW99494.1; AAH01384.2; AAH67273.1; AAG35521.1; AAF29010.1
Protein Name U4/U6.U5 tri-snRNP-associated protein 2; Inactive ubiquitin-specific peptidase 39; SAD1 homolog; U4/U6.U5 tri-snRNP-associated 65 kDa protein
Genbank Nucleotide ID AF353989; AF132955; AK289451; AK001047; AK295257; AK222852; AC012454; CH471053; CH471053; CH471053; BC001384; BC067273; AF130096; AF161450
Gene Name USP39; CGI-21; HSPC332; PRO2855
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000168883.19 ENST00000409025.5 ENSP00000386572.1
ENSG00000168883.19 ENST00000409470.5 ENSP00000386864.1
ENSG00000168883.19 ENST00000458268.5 ENSP00000400690.1
ENSG00000168883.19 ENST00000409766.7 ENSP00000386803.3
ENSG00000168883.19 ENST00000467885.6 ENSP00000479885.1
ENSG00000168883.19 ENST00000613444.4 ENSP00000484024.1
ENSG00000168883.19 ENST00000450066.6 ENSP00000396133.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 19615732
Classification
Family E-value Score Start End
DUB/USP 3.40e-51 176.1 225 555
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaee.fsgyeq 89
           +Gl+N+ +  Y N+vLQ+Lsn+p+lr+++le+++ k  ++ p +    l++ + +l+++lw   + k +vsp+e+l+a+  ++++ f+ ++q
   Q: 225  VGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWnpRNFKAHVSPHEMLQAVVLCSKKtFQITKQ 316
           6*********************************9999***********************999999**************99999****** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk................sqikclecdnvssr 165
            D  +fl+++l++l+++l                          +kkk+k++++d+Fqg+++                +q+  ++  +++  
   Q: 317  GDGVDFLSWFLNALHSAL------------------------GGTKKKKKTIVTDVFQGSMRiftkklphpdlpaeekEQLLHNDEYQETMV 384
           ******************........................4578888889999999999888899999999998889************* PP
   S: 166  eepfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           e++f++l+l++p     k e          l ++L++f    e e    y++ k     +  k+++l+klP++Li+ +kRf  ++++ + ek
   Q: 385  ESTFMYLTLDLPTAPLYKDEkeqliipqvPLFNILAKFNGITEKE----YKTYK----ENFLKRFQLTKLPPYLIFCIKRF--TKNNFFVEK 466
           ************877776664455566666666666666666655....44333....3489*******************..88889**** PP
   S: 249  inkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           + + v+fp++ +dl+++++++ ++++++++Y+Lia +vH G++s+G Y  +v +  +gkW+++ D +Vt +  + +     s+aY+ ++krr
   Q: 467  NPTIVNFPITnVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHhGTGKWYELQDLQVTDILPQMITL---SEAYIQIWKRR 555
           ****************************************************9935666******************9...********985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs).
 Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs).
Protein Sequence
(Fasta)
MSGRSKRESR GSTRGKRESE SRGSSGRVKR ERDREREPEA ASSRGSPVRV KREFEPASAR 60
EAPASVVPFV RVKREREVDE DSEPEREVRA KNGRVDSEDR RSRHCPYLDT INRSVLDFDF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046041|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCCCAACTT CGGAGGACCT GGGCGCGGAG GGCTGTGGCG TGAAGACCGC TCTAAAACCG 60
AGATGACTAG AGGTTCCGTT TAACCGATTC CTGCCGGGGA AGCGTCAGCA GGTGGGGATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046041|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0747--Spliceosome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR033809--USP39
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005681--C:spliceosomal complex
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0006397--P:mRNA processing
GO:0000398--P:mRNA splicing, via spliceosome
GO:0016579--P:protein deubiquitination
GO:0008380--P:RNA splicing
GO:0000245--P:spliceosomal complex assembly
KEGG hsa:10713
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000483 Aegilops tauschii 52.93 6.00e-128 451.00
IUUC-Aml-001846 Ailuropoda melanoleuca 98.28 0.00e+00 1056.00
IUUC-Atr-002758 Amborella trichopoda 51.28 3.00e-128 452.00
IUUC-Apl-003336 Anas platyrhynchos 91.62 9.00e-176 609.00
IUUC-Aca-004846 Anolis carolinensis 97.36 0.00e+00 905.00
IUUC-Aly-005683 Arabidopsis lyrata 50.98 7.00e-117 414.00
IUUC-Ath-007661 Arabidopsis thaliana 50.33 4.00e-116 411.00
IUUC-Ago-007802 Ashbya gossypii 31.60 1.00e-60 227.00
IUUC-Acl-008304 Aspergillus clavatus 41.43 4.00e-91 328.00
IUUC-Afl-008735 Aspergillus flavus 58.12 1.00e-40 160.00
IUUC-Afu-009100 Aspergillus fumigatus 39.23 4.00e-89 322.00
IUUC-Ani-009138 Aspergillus nidulans 48.89 6.00e-94 338.00
IUUC-Ang-009661 Aspergillus niger 44.61 1.00e-94 340.00
IUUC-Aor-010235 Aspergillus oryzae 38.57 1.00e-78 287.00
IUUC-Ate-010346 Aspergillus terreus 36.33 2.00e-71 263.00
IUUC-Ame-011688 Astyanax mexicanus 89.25 0.00e+00 845.00
IUUC-Bgr-011998 Blumeria graminis 47.82 6.00e-115 407.00
IUUC-Bta-013407 Bos taurus 97.88 0.00e+00 1025.00
IUUC-Bci-013977 Botrytis cinerea 49.13 3.00e-115 408.00
IUUC-Bdi-014361 Brachypodium distachyon 53.13 2.00e-134 472.00
IUUC-Bol-016317 Brassica oleracea 50.44 4.00e-115 408.00
IUUC-Bra-017952 Brassica rapa 49.17 5.00e-116 411.00
IUUC-Cel-018491 Caenorhabditis elegans 62.39 1.00e-177 616.00
IUUC-Cja-019134 Callithrix jacchus 99.24 0.00e+00 1071.00
IUUC-Cfa-020098 Canis familiaris 98.86 0.00e+00 1064.00
IUUC-Cpo-021595 Cavia porcellus 98.25 0.00e+00 999.00
IUUC-Cre-022886 Chlamydomonas reinhardtii 50.81 2.00e-31 127.00
IUUC-Csa-024121 Chlorocebus sabaeus 99.42 0.00e+00 1056.00
IUUC-Cho-025057 Choloepus hoffmanni 77.34 4.00e-86 311.00
IUUC-Cin-025473 Ciona intestinalis 62.96 2.00e-64 238.00
IUUC-Csv-025815 Ciona savignyi 81.62 2.00e-117 416.00
IUUC-Cgl-026416 Colletotrichum gloeosporioides 44.71 1.00e-108 387.00
IUUC-Cne-026802 Cryptococcus neoformans 43.17 1.00e-99 357.00
IUUC-Dre-027870 Danio rerio 88.87 0.00e+00 838.00
IUUC-Dno-029655 Dasypus novemcinctus 94.41 0.00e+00 1046.00
IUUC-Dor-030762 Dipodomys ordii 98.67 0.00e+00 1016.00
IUUC-Dse-031441 Dothistroma septosporum 45.59 2.00e-107 383.00
IUUC-Dme-032101 Drosophila melanogaster 64.71 1.00e-179 622.00
IUUC-Ete-032841 Echinops telfairi 92.40 0.00e+00 979.00
IUUC-Eca-033463 Equus caballus 99.80 0.00e+00 1014.00
IUUC-Eeu-034438 Erinaceus europaeus 72.08 0.00e+00 736.00
IUUC-Fca-035774 Felis catus 98.67 0.00e+00 1062.00
IUUC-Fal-036988 Ficedula albicollis 93.45 0.00e+00 914.00
IUUC-Fox-037895 Fusarium oxysporum 45.57 9.00e-105 374.00
IUUC-Fso-038450 Fusarium solani 46.87 4.00e-106 378.00
IUUC-Gmo-038874 Gadus morhua 87.69 0.00e+00 823.00
IUUC-Ggr-040115 Gaeumannomyces graminis 44.82 3.00e-103 369.00
IUUC-Gac-041650 Gasterosteus aculeatus 85.71 0.00e+00 850.00
IUUC-Gma-043697 Glycine max 50.64 4.00e-128 451.00
IUUC-Ggo-044707 Gorilla gorilla 93.45 0.00e+00 1041.00
IUUC-Hvu-047816 Hordeum vulgare 50.00 1.00e-121 430.00
IUUC-Itr-048945 Ictidomys tridecemlineatus 99.71 0.00e+00 688.00
IUUC-Lch-050419 Latimeria chalumnae 92.08 0.00e+00 899.00
IUUC-Lpe-051593 Leersia perrieri 53.70 3.00e-134 471.00
IUUC-Loc-052930 Lepisosteus oculatus 86.23 0.00e+00 859.00
IUUC-Lma-053256 Leptosphaeria maculans 48.05 2.00e-112 399.00
IUUC-Laf-053555 Loxodonta africana 98.46 0.00e+00 1016.00
IUUC-Mcc-055630 Macaca mulatta 99.42 0.00e+00 1056.00
IUUC-Meu-056579 Macropus eugenii 95.06 0.00e+00 627.00
IUUC-Mor-057078 Magnaporthe oryzae 42.44 1.00e-103 370.00
IUUC-Mpo-057607 Magnaporthe poae 37.86 1.00e-84 307.00
IUUC-Mtr-058644 Medicago truncatula 49.36 1.00e-127 449.00
IUUC-Mla-059120 Melampsora laricipopulina 40.88 9.00e-101 361.00
IUUC-Mvi-060429 Microbotryum violaceum 46.33 3.00e-68 253.00
IUUC-Mmr-061313 Microcebus murinus 98.29 0.00e+00 1019.00
IUUC-Mdo-062801 Monodelphis domestica 91.67 0.00e+00 1035.00
IUUC-Mmu-064424 Mus musculus 96.28 0.00e+00 1016.00
IUUC-Mac-064694 Musa acuminata 52.65 3.00e-130 458.00
IUUC-Mpu-065980 Mustela putorius furo 100.00 0.00e+00 859.00
IUUC-Mlu-067007 Myotis lucifugus 96.65 0.00e+00 1046.00
IUUC-Nfi-068274 Neosartorya fischeri 39.23 1.00e-89 324.00
IUUC-Ncr-068829 Neurospora crassa 47.53 4.00e-106 378.00
IUUC-Nle-069171 Nomascus leucogenys 100.00 0.00e+00 977.00
IUUC-Opr-070494 Ochotona princeps 90.49 0.00e+00 895.00
IUUC-Ont-072290 Oreochromis niloticus 86.21 0.00e+00 873.00
IUUC-Oan-073099 Ornithorhynchus anatinus 97.28 0.00e+00 957.00
IUUC-Ocu-074642 Oryctolagus cuniculus 98.46 0.00e+00 1013.00
IUUC-Oba-075886 Oryza barthii 53.04 2.00e-133 469.00
IUUC-Obr-076220 Oryza brachyantha 53.04 8.00e-134 470.00
IUUC-Ogl-077682 Oryza glaberrima 53.04 8.00e-134 470.00
IUUC-Ogu-078492 Oryza glumaepatula 52.83 1.00e-133 469.00
IUUC-Oin-079956 Oryza indica 53.04 1.00e-133 470.00
IUUC-Olo-080239 Oryza longistaminata 46.82 2.00e-105 377.00
IUUC-Ome-081573 Oryza meridionalis 53.04 5.00e-134 471.00
IUUC-Oni-082975 Oryza nivara 53.04 1.00e-133 470.00
IUUC-Opu-083724 Oryza punctata 53.26 5.00e-134 471.00
IUUC-Oru-084566 Oryza rufipogon 53.04 1.00e-133 470.00
IUUC-Osa-086008 Oryza sativa 53.04 8.00e-134 470.00
IUUC-Ola-086967 Oryzias latipes 89.40 0.00e+00 850.00
IUUC-Olu-087614 Ostreococcus lucimarinus 43.91 1.00e-96 346.00
IUUC-Oga-088047 Otolemur garnettii 80.90 0.00e+00 669.00
IUUC-Oar-089393 Ovis aries 99.03 0.00e+00 1050.00
IUUC-Ptr-090561 Pan troglodytes 99.81 0.00e+00 1063.00
IUUC-Pan-091812 Papio anubis 99.23 0.00e+00 1054.00
IUUC-Psi-093507 Pelodiscus sinensis 99.32 8.00e-172 595.00
IUUC-Pno-095104 Phaeosphaeria nodorum 46.92 5.00e-110 391.00
IUUC-Ppa-095995 Physcomitrella patens 51.63 5.00e-134 471.00
IUUC-Pfo-096754 Poecilia formosa 89.01 0.00e+00 863.00
IUUC-Pab-098053 Pongo abelii 99.81 0.00e+00 1063.00
IUUC-Pop-099230 Populus trichocarpa 51.34 5.00e-133 468.00
IUUC-Pca-100407 Procavia capensis 89.98 0.00e+00 914.00
IUUC-Ppe-101699 Prunus persica 52.39 2.00e-128 452.00
IUUC-Pva-103159 Pteropus vampyrus 95.58 0.00e+00 1057.00
IUUC-Pgr-103433 Puccinia graminis 42.62 3.00e-103 369.00
IUUC-Ptt-103701 Puccinia triticina 39.44 4.00e-91 328.00
IUUC-Pte-104281 Pyrenophora teres 47.61 3.00e-112 399.00
IUUC-Pyt-104714 Pyrenophora triticirepentis 47.61 4.00e-112 398.00
IUUC-Rno-105531 Rattus norvegicus 96.99 0.00e+00 1061.00
IUUC-Sce-106368 Saccharomyces cerevisiae 29.32 4.00e-46 179.00
IUUC-Sha-107093 Sarcophilus harrisii 96.82 0.00e+00 999.00
IUUC-Sja-108004 Schizosaccharomyces japonicus 43.60 3.00e-114 405.00
IUUC-Spo-108018 Schizosaccharomyces pombe 47.38 9.00e-113 400.00
IUUC-Ssl-108460 Sclerotinia sclerotiorum 46.65 1.00e-106 380.00
IUUC-Smo-108892 Selaginella moellendorffii 52.37 1.00e-131 463.00
IUUC-Sit-110782 Setaria italica 54.19 2.00e-136 479.00
IUUC-Sly-111308 Solanum lycopersicum 52.17 2.00e-137 482.00
IUUC-Stu-112447 Solanum tuberosum 52.83 5.00e-137 481.00
IUUC-Sar-113352 Sorex araneus 82.65 0.00e+00 815.00
IUUC-Sbi-114806 Sorghum bicolor 54.74 2.00e-135 476.00
IUUC-Sre-115059 Sporisorium reilianum 53.57 5.00e-72 265.00
IUUC-Ssc-115677 Sus scrofa 97.35 0.00e+00 750.00
IUUC-Tru-118478 Takifugu rubripes 86.58 0.00e+00 863.00
IUUC-Tsy-119082 Tarsius syrichta 86.67 0.00e+00 737.00
IUUC-Tni-120419 Tetraodon nigroviridis 86.01 0.00e+00 841.00
IUUC-Tca-121294 Theobroma cacao 51.17 3.00e-134 471.00
IUUC-Tre-121962 Trichoderma reesei 46.02 1.00e-101 363.00
IUUC-Tvi-122280 Trichoderma virens 45.69 4.00e-109 388.00
IUUC-Tae-124442 Triticum aestivum 54.00 7.00e-135 474.00
IUUC-Tur-126551 Triticum urartu 54.00 7.00e-134 470.00
IUUC-Tme-126959 Tuber melanosporum 47.40 5.00e-113 401.00
IUUC-Tbe-127737 Tupaia belangeri 94.30 0.00e+00 950.00
IUUC-Ttr-129211 Tursiops truncatus 97.59 2.00e-171 595.00
IUUC-Uma-129591 Ustilago maydis 39.16 1.00e-95 343.00
IUUC-Vda-129674 Verticillium dahliae 44.30 3.00e-95 342.00
IUUC-Vpa-130793 Vicugna pacos 87.78 0.00e+00 879.00
IUUC-Xtr-132430 Xenopus tropicalis 90.10 0.00e+00 894.00
IUUC-Xma-133515 Xiphophorus maculatus 88.48 0.00e+00 852.00
IUUC-Yli-134488 Yarrowia lipolytica 38.19 4.00e-79 288.00
IUUC-Zma-134748 Zea mays 54.51 5.00e-136 478.00
Created Date 25-Jun-2017

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