iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aml-001223

Ensembl Protein ID

ENSAMEP00000006368.1

UniProt Accession

G1LHH3; G1LHH3_AILME

Genbank Protein ID

ENSAMEP00000006368

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01171332

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000006042.1	ENSAMET00000006629.1	ENSAMEP00000006368.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	2.60e-13	49.3	328	356
ULD/UDP/UBQ/UBQ_Other	5.60e-14	51.9	209	270

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           +++W+C++CTf+N+P++++CemCs++++c
   Q: 328  QPGWSCPSCTFINAPSRPGCEMCSTQKPC 356
           689*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglk 62
           qvtv+++ +s + +l+v+p++t+a+L+e++++++g+pp+ qr+++ G++L  + ++La+yg++
   Q: 209  QVTVEDAASSaHVSLQVHPHCTIATLQEQVFSEFGFPPAVQRWVI-GRCLcVPECSLASYGVR 270
           89*******************************************.**************995 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MAPPSDPASA AVLLAVHAAV RPLGAGPDAE AQLRKLQLST DPERPGRFRL ELLGAGPVSL 60
EWPLESVSYT VRGPSQHELQ PPPGGPGTLS LHFLNPQEAQ RWAALVRGAT MEGQNGSLSQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCCGC CCTCGGACCC GGCCTCGGCC GCGGTGCTCC TGGCTGTGCA CGCCGCGGTG 60
AGGCCACTGG GCGCGGGGCC GGACGCCGAG GCACAATTGC GGAAGCTGCA GCTGAGCACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH
PF00641--zf-RanBP

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000111	Aegilops tauschii	34.21	7.30e-02	31.20
IUUC-Apl-004151	Anas platyrhynchos	68.09	9.00e-18	80.90
IUUC-Bta-012948	Bos taurus	82.49	2.00e-136	478.00
IUUC-Cja-019031	Callithrix jacchus	80.22	1.00e-130	459.00
IUUC-Cfa-020863	Canis familiaris	86.14	2.00e-132	464.00
IUUC-Cpo-022499	Cavia porcellus	74.58	1.00e-119	422.00
IUUC-Csa-023641	Chlorocebus sabaeus	77.81	1.00e-122	432.00
IUUC-Dre-027612	Danio rerio	36.27	1.00e-46	180.00
IUUC-Dno-029459	Dasypus novemcinctus	69.95	8.00e-65	240.00
IUUC-Dor-030914	Dipodomys ordii	59.55	6.00e-79	287.00
IUUC-Ete-032940	Echinops telfairi	70.96	4.00e-98	351.00
IUUC-Eca-033537	Equus caballus	86.13	1.00e-144	505.00
IUUC-Eeu-035176	Erinaceus europaeus	71.18	2.00e-58	219.00
IUUC-Fca-035971	Felis catus	89.97	2.00e-138	485.00
IUUC-Gmo-039219	Gadus morhua	38.73	1.00e-47	183.00
IUUC-Gga-040198	Gallus gallus	43.67	5.00e-29	121.00
IUUC-Ggo-044678	Gorilla gorilla	80.94	6.00e-128	450.00
IUUC-Hsa-046578	Homo sapiens	82.17	5.00e-132	464.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	75.00	5.00e-135	474.00
IUUC-Mcc-055686	Macaca mulatta	73.74	1.00e-123	436.00
IUUC-Meu-055912	Macropus eugenii	52.60	2.00e-61	229.00
IUUC-Mmr-060584	Microcebus murinus	77.25	2.00e-134	471.00
IUUC-Mdo-062191	Monodelphis domestica	57.10	2.00e-83	302.00
IUUC-Mmu-063740	Mus musculus	69.94	1.00e-109	389.00
IUUC-Mpu-066878	Mustela putorius furo	84.73	5.00e-129	453.00
IUUC-Mlu-067878	Myotis lucifugus	83.14	2.00e-135	475.00
IUUC-Nle-069748	Nomascus leucogenys	79.87	3.00e-120	424.00
IUUC-Ont-072270	Oreochromis niloticus	40.17	2.00e-48	186.00
IUUC-Oba-075102	Oryza barthii	42.22	1.00e-03	37.40
IUUC-Obr-076087	Oryza brachyantha	54.17	8.00e-04	37.00
IUUC-Ogl-077291	Oryza glaberrima	42.22	1.00e-03	37.40
IUUC-Oin-079800	Oryza indica	44.68	4.00e-04	38.90
IUUC-Ome-081262	Oryza meridionalis	42.22	2.00e-03	36.60
IUUC-Oni-082829	Oryza nivara	44.68	4.00e-04	38.90
IUUC-Opu-083275	Oryza punctata	40.91	6.00e-03	35.40
IUUC-Oga-088300	Otolemur garnettii	76.53	7.00e-132	463.00
IUUC-Oar-089549	Ovis aries	82.76	1.00e-140	492.00
IUUC-Ptr-090961	Pan troglodytes	81.27	1.00e-117	416.00
IUUC-Pan-092687	Papio anubis	80.28	1.00e-125	442.00
IUUC-Pab-097872	Pongo abelii	77.98	1.00e-118	419.00
IUUC-Pca-100363	Procavia capensis	68.69	6.00e-62	231.00
IUUC-Ppe-101337	Prunus persica	52.00	2.00e-03	37.00
IUUC-Pva-102595	Pteropus vampyrus	82.53	3.00e-122	431.00
IUUC-Rno-105856	Rattus norvegicus	70.94	1.00e-108	386.00
IUUC-Sha-106838	Sarcophilus harrisii	55.62	2.00e-73	269.00
IUUC-Ssl-108588	Sclerotinia sclerotiorum	38.71	3.90e-02	32.70
IUUC-Sar-113611	Sorex araneus	61.26	6.00e-26	111.00
IUUC-Ssc-116263	Sus scrofa	83.57	4.00e-142	497.00
IUUC-Tru-118089	Takifugu rubripes	43.34	2.00e-56	212.00
IUUC-Tni-120004	Tetraodon nigroviridis	41.69	2.00e-49	189.00
IUUC-Tbe-127471	Tupaia belangeri	66.96	4.00e-94	338.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence