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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046691
UUCD1 version UUC-HoS-00310
Ensembl Protein ID ENSP00000434797.1
UniProt Accession Q96K19; D3DSY6; E9PIL4; Q7Z483; Q86YC0; Q8IXR7; Q8N2B5; Q8N5G9; Q8NG30; Q9H0V6; RN170_HUMAN
Genbank Protein ID BAB55340.1; BAC03534.1; EAW63201.1; EAW63203.1; AAH13422.1; AAH32393.1; AAH39461.1; AAH44566.1; CAB66555.1; AAM92891.1
Protein Name E3 ubiquitin-protein ligase RNF170; Putative LAG1-interacting protein; RING finger protein 170; RING-type E3 ubiquitin transferase RNF170
Genbank Nucleotide ID AK027748; AK090864; AC009634; CH471080; BC013422; BC032393; BC039461; BC044566; BC058289; AF209504
Gene Name RNF170
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000120925.14 ENST00000319104.7 ENSP00000326138.3
ENSG00000120925.14 ENST00000527424.5 ENSP00000434797.1
ENSG00000120925.14 ENST00000240159.8 ENSP00000240159.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpressTCGAICGCCOSMIC
THPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
TRANSFACRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMPhosphositePlusdbPTMmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 21115467; 25882839
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.80e-05 25.0 87 130
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskef....rCPlCr 46
           C+iCl   +  p+ ++CgH+f+  C+   w       ++++    +CP+Cr
   Q: 87   CPICLHQASF-PVETNCGHLFCGACIiAYW------RYGSWlgaiSCPICR 130
           ****986655.999***********97777......5555533337****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.
 E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.
Protein Sequence
(Fasta)
MAKYQGEVQS LKLDDDSVIE GVSDQVLVAV VVSFALIATL VYALFRNVHQ NIHPENQELV 60
RVLREQLQTE QDAPAATRQQ FYTDMYCPIC LHQASFPVET NCGHLFCGAC IIAYWRYGSW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046691|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGCACCGTCG CCCGCAGCGC TCGCCCCACG GGCCGCGCGT GGAGGGTCCC GGTAGGTGGC 60
GGGGGGAGGG GGTCTTCCCG CCGGCCCGCG GCCCCCACGT ACCCAAGTGA GGAGGCTCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046691|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR010652--DUF1232
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF06803--DUF1232
PF00097--zf-C3HC4
SMART

SM00184--RING
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination
KEGG hsa:81790
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000837 Aegilops tauschii 34.76 1.00e-21 96.30
IUUC-Aml-002276 Ailuropoda melanoleuca 95.74 6.00e-125 439.00
IUUC-Atr-003163 Amborella trichopoda 36.93 4.00e-28 117.00
IUUC-Apl-003771 Anas platyrhynchos 77.13 4.00e-101 360.00
IUUC-Aca-004706 Anolis carolinensis 74.81 1.00e-94 338.00
IUUC-Aly-006202 Arabidopsis lyrata 40.74 6.00e-19 87.00
IUUC-Ath-007325 Arabidopsis thaliana 35.47 9.00e-25 106.00
IUUC-Ame-011453 Astyanax mexicanus 68.60 4.00e-96 343.00
IUUC-Bta-013272 Bos taurus 94.98 1.00e-120 425.00
IUUC-Bdi-014259 Brachypodium distachyon 36.00 7.00e-26 110.00
IUUC-Bol-016302 Brassica oleracea 35.23 2.00e-25 108.00
IUUC-Bra-017738 Brassica rapa 34.50 2.00e-24 105.00
IUUC-Cel-018593 Caenorhabditis elegans 34.85 9.00e-28 117.00
IUUC-Cja-019253 Callithrix jacchus 98.45 4.00e-128 450.00
IUUC-Cfa-020844 Canis familiaris 96.89 5.00e-126 445.00
IUUC-Cpo-021645 Cavia porcellus 96.12 2.00e-125 441.00
IUUC-Csa-024012 Chlorocebus sabaeus 99.22 3.00e-129 454.00
IUUC-Cho-024304 Choloepus hoffmanni 75.97 1.00e-91 329.00
IUUC-Cin-025256 Ciona intestinalis 46.33 4.00e-57 214.00
IUUC-Dre-028166 Danio rerio 68.49 5.00e-79 287.00
IUUC-Dno-029494 Dasypus novemcinctus 96.12 2.00e-125 441.00
IUUC-Dor-030259 Dipodomys ordii 96.90 2.00e-126 444.00
IUUC-Ete-032614 Echinops telfairi 83.72 6.00e-100 356.00
IUUC-Eca-033557 Equus caballus 95.74 6.00e-124 436.00
IUUC-Eeu-035324 Erinaceus europaeus 98.88 5.00e-31 128.00
IUUC-Fca-035812 Felis catus 96.12 9.00e-125 439.00
IUUC-Fal-036654 Ficedula albicollis 81.40 6.00e-110 390.00
IUUC-Gmo-039635 Gadus morhua 67.31 3.00e-91 328.00
IUUC-Gga-040345 Gallus gallus 80.62 4.00e-109 387.00
IUUC-Gac-041668 Gasterosteus aculeatus 65.90 9.00e-89 319.00
IUUC-Gma-043890 Glycine max 34.88 4.00e-25 107.00
IUUC-Ggo-045000 Gorilla gorilla 99.22 3.00e-129 454.00
IUUC-Hvu-047464 Hordeum vulgare 36.57 2.00e-26 112.00
IUUC-Itr-048988 Ictidomys tridecemlineatus 97.29 5.00e-127 446.00
IUUC-Lch-049846 Latimeria chalumnae 78.45 3.00e-62 230.00
IUUC-Loc-051785 Lepisosteus oculatus 69.32 4.00e-106 377.00
IUUC-Laf-054542 Loxodonta africana 91.47 7.00e-117 413.00
IUUC-Mcc-055234 Macaca mulatta 99.22 3.00e-129 454.00
IUUC-Meu-056544 Macropus eugenii 69.77 5.00e-75 273.00
IUUC-Mtr-057996 Medicago truncatula 32.43 5.00e-18 84.00
IUUC-Mmr-060609 Microcebus murinus 95.74 8.00e-132 462.00
IUUC-Mdo-062853 Monodelphis domestica 88.37 9.00e-120 422.00
IUUC-Mmu-064383 Mus musculus 90.70 1.00e-111 396.00
IUUC-Mac-065250 Musa acuminata 36.42 1.00e-27 115.00
IUUC-Mlu-067410 Myotis lucifugus 94.96 1.00e-123 435.00
IUUC-Nle-069537 Nomascus leucogenys 98.85 4.00e-86 310.00
IUUC-Opr-070637 Ochotona princeps 96.00 7.00e-67 247.00
IUUC-Ont-071800 Oreochromis niloticus 67.18 1.00e-84 306.00
IUUC-Oan-073190 Ornithorhynchus anatinus 87.60 7.00e-119 420.00
IUUC-Ocu-073899 Oryctolagus cuniculus 98.06 6.00e-127 446.00
IUUC-Obr-076075 Oryza brachyantha 36.36 1.00e-23 102.00
IUUC-Oin-079850 Oryza indica 34.51 2.00e-23 102.00
IUUC-Ome-081191 Oryza meridionalis 35.21 7.00e-23 100.00
IUUC-Oni-082886 Oryza nivara 34.51 1.00e-23 102.00
IUUC-Osa-085833 Oryza sativa 34.51 2.00e-23 102.00
IUUC-Ola-086372 Oryzias latipes 68.32 1.00e-88 319.00
IUUC-Oga-087988 Otolemur garnettii 97.67 2.00e-123 434.00
IUUC-Oar-089976 Ovis aries 94.21 5.00e-120 423.00
IUUC-Ptr-091377 Pan troglodytes 98.84 3.00e-129 454.00
IUUC-Pan-092348 Papio anubis 98.84 2.00e-128 451.00
IUUC-Psi-092982 Pelodiscus sinensis 80.23 3.00e-102 364.00
IUUC-Ppa-095627 Physcomitrella patens 31.91 6.00e-23 101.00
IUUC-Pfo-096366 Poecilia formosa 66.79 1.00e-85 309.00
IUUC-Pab-098242 Pongo abelii 99.53 5.00e-111 393.00
IUUC-Pop-099622 Populus trichocarpa 28.81 1.00e-20 92.80
IUUC-Pca-100637 Procavia capensis 98.88 2.00e-30 125.00
IUUC-Ppe-101586 Prunus persica 33.33 4.00e-15 73.60
IUUC-Pva-102627 Pteropus vampyrus 95.74 5.00e-132 463.00
IUUC-Rno-105344 Rattus norvegicus 91.09 1.00e-115 409.00
IUUC-Sha-107420 Sarcophilus harrisii 86.87 3.00e-117 414.00
IUUC-Smo-109218 Selaginella moellendorffii 32.56 8.00e-26 109.00
IUUC-Sly-111612 Solanum lycopersicum 31.69 3.00e-18 85.90
IUUC-Stu-112127 Solanum tuberosum 35.75 4.00e-22 97.80
IUUC-Sar-113762 Sorex araneus 95.35 2.00e-123 434.00
IUUC-Sbi-113997 Sorghum bicolor 34.48 2.00e-24 105.00
IUUC-Ssc-115764 Sus scrofa 98.86 4.00e-30 122.00
IUUC-Tgu-116969 Taeniopygia guttata 81.78 2.00e-110 392.00
IUUC-Tru-118414 Takifugu rubripes 69.96 6.00e-82 296.00
IUUC-Tsy-119312 Tarsius syrichta 86.82 6.00e-115 406.00
IUUC-Tni-120687 Tetraodon nigroviridis 72.13 1.00e-85 309.00
IUUC-Tca-121028 Theobroma cacao 36.21 6.00e-18 84.00
IUUC-Tae-122873 Triticum aestivum 38.46 4.00e-26 110.00
IUUC-Tur-126558 Triticum urartu 36.42 3.00e-20 91.30
IUUC-Tbe-127751 Tupaia belangeri 88.37 6.00e-107 380.00
IUUC-Ttr-128731 Tursiops truncatus 85.66 4.00e-110 390.00
IUUC-Vpa-130187 Vicugna pacos 94.96 1.00e-123 435.00
IUUC-Vvi-131393 Vitis vinifera 36.05 9.00e-24 103.00
IUUC-Xtr-132512 Xenopus tropicalis 70.77 4.00e-93 334.00
IUUC-Xma-133203 Xiphophorus maculatus 67.18 3.00e-86 311.00
Created Date 25-Jun-2017

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