iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054707

Ensembl Protein ID

ENSMMUP00000018504.3

UniProt Accession

F7CE33; H9YYC0; F7CE33_MACMU

Genbank Protein ID

AFH28686.1

Protein Name

Kelch-like protein 8

Genbank Nucleotide ID

JSUE03033942

Gene Name

KLHL8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000014080.3	ENSMMUT00000019766.3	ENSMMUP00000018504.3
ENSMMUG00000014080.3	ENSMMUT00000063158.1	ENSMMUP00000047364.1
ENSMMUG00000014080.3	ENSMMUT00000059074.1	ENSMMUP00000060192.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.60e-17	62.7	67	132
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.10e-09	35.3	166	197

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+l+vg + +++hk+vLa   ++F+a+fl+e+ e k +  +ei+d + ++ ++l+kF+Y+++l++
   Q: 67   CDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAK-QTLIEIRDFDGDAIEDLVKFVYSSRLTL 132
           9************************************9.*************************986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Ncl++++fA+ ++  dL+d a+ ++  hF+
   Q: 166  PSNCLAVRAFAESHNRIDLMDMADQYAYEHFT 197
           89*****************************7 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MASDSVNTKQ ARNHITKGKR QQQHQQIKNR SSISDGDGED SFIFEANEAW KDFHGSLLRF 60
YENGELCDVT LKVGSKLISC HKLVLACVIP YFRAMFLSEM AEAKQTLIEI RDFDGDAIED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGCGGGGG CTGAGGTGAG AAGACGCCAA GCGCCCGCCA GGGCTCTGCG GGGCAGTGCA 60
GGAGAGCGCG CCTCCGCCAG GTGTTGGCGC AGGGCTGGTG AGGTGCCGCT GAGGGCGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030605--KLHL8
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

mcc:700864

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001443	Ailuropoda melanoleuca	97.90	0.00e+00	1244.00
IUUC-Atr-002726	Amborella trichopoda	35.48	6.00e-43	169.00
IUUC-Apl-003978	Anas platyrhynchos	89.37	0.00e+00	1158.00
IUUC-Aca-004958	Anolis carolinensis	85.19	0.00e+00	1090.00
IUUC-Ame-011139	Astyanax mexicanus	82.75	0.00e+00	1065.00
IUUC-Bta-013142	Bos taurus	96.29	0.00e+00	1225.00
IUUC-Bol-015710	Brassica oleracea	25.42	3.00e-11	62.80
IUUC-Cel-018551	Caenorhabditis elegans	42.45	1.00e-130	460.00
IUUC-Cja-019650	Callithrix jacchus	98.55	0.00e+00	1278.00
IUUC-Cfa-021046	Canis familiaris	98.39	0.00e+00	1248.00
IUUC-Cpo-022445	Cavia porcellus	93.71	0.00e+00	1165.00
IUUC-Csa-023642	Chlorocebus sabaeus	99.84	0.00e+00	1291.00
IUUC-Cho-025012	Choloepus hoffmanni	79.03	0.00e+00	887.00
IUUC-Dre-027723	Danio rerio	81.76	0.00e+00	1059.00
IUUC-Dno-028964	Dasypus novemcinctus	95.91	0.00e+00	1026.00
IUUC-Dor-030899	Dipodomys ordii	83.11	9.00e-137	480.00
IUUC-Ete-032815	Echinops telfairi	92.74	0.00e+00	1208.00
IUUC-Eca-034162	Equus caballus	96.77	0.00e+00	1211.00
IUUC-Eeu-034660	Erinaceus europaeus	94.19	0.00e+00	1198.00
IUUC-Fca-035659	Felis catus	98.23	0.00e+00	1247.00
IUUC-Fal-037619	Ficedula albicollis	90.32	0.00e+00	1173.00
IUUC-Fox-037999	Fusarium oxysporum	31.17	4.00e-08	51.60
IUUC-Gmo-038546	Gadus morhua	84.16	0.00e+00	1051.00
IUUC-Ggr-040041	Gaeumannomyces graminis	31.29	2.00e-07	50.10
IUUC-Gga-040770	Gallus gallus	90.02	0.00e+00	1138.00
IUUC-Gac-042557	Gasterosteus aculeatus	79.17	0.00e+00	1046.00
IUUC-Ggo-044741	Gorilla gorilla	99.35	0.00e+00	1287.00
IUUC-Hsa-046025	Homo sapiens	99.19	0.00e+00	1285.00
IUUC-Itr-048541	Ictidomys tridecemlineatus	97.63	0.00e+00	1104.00
IUUC-Loc-052834	Lepisosteus oculatus	81.99	0.00e+00	1014.00
IUUC-Laf-054513	Loxodonta africana	96.29	0.00e+00	1224.00
IUUC-Meu-056779	Macropus eugenii	90.51	0.00e+00	1162.00
IUUC-Mtr-058180	Medicago truncatula	31.54	1.00e-35	145.00
IUUC-Mga-059676	Meleagris gallopavo	89.53	0.00e+00	1134.00
IUUC-Mmr-061359	Microcebus murinus	96.13	0.00e+00	1219.00
IUUC-Mdo-062527	Monodelphis domestica	89.09	0.00e+00	1157.00
IUUC-Mmu-063112	Mus musculus	92.53	0.00e+00	1212.00
IUUC-Mac-064682	Musa acuminata	35.50	2.00e-41	164.00
IUUC-Mpu-065800	Mustela putorius furo	97.42	0.00e+00	1238.00
IUUC-Mlu-067536	Myotis lucifugus	96.75	0.00e+00	1184.00
IUUC-Nle-069397	Nomascus leucogenys	99.35	0.00e+00	1286.00
IUUC-Opr-070599	Ochotona princeps	95.31	0.00e+00	1021.00
IUUC-Ont-072580	Oreochromis niloticus	80.81	0.00e+00	1057.00
IUUC-Oan-073180	Ornithorhynchus anatinus	92.42	0.00e+00	1180.00
IUUC-Ocu-074026	Oryctolagus cuniculus	96.29	0.00e+00	1206.00
IUUC-Ola-086776	Oryzias latipes	80.88	0.00e+00	1022.00
IUUC-Oga-088651	Otolemur garnettii	97.10	0.00e+00	1226.00
IUUC-Oar-089567	Ovis aries	95.16	0.00e+00	1200.00
IUUC-Ptr-091564	Pan troglodytes	99.35	0.00e+00	1287.00
IUUC-Pan-092578	Papio anubis	99.84	0.00e+00	1291.00
IUUC-Psi-093635	Pelodiscus sinensis	88.78	0.00e+00	1100.00
IUUC-Pma-094660	Petromyzon marinus	61.82	0.00e+00	764.00
IUUC-Pfo-097507	Poecilia formosa	80.21	0.00e+00	987.00
IUUC-Pab-098025	Pongo abelii	99.35	0.00e+00	1287.00
IUUC-Pca-101046	Procavia capensis	86.85	0.00e+00	634.00
IUUC-Ppe-101154	Prunus persica	31.50	1.00e-37	151.00
IUUC-Pva-102359	Pteropus vampyrus	97.95	0.00e+00	906.00
IUUC-Rno-105750	Rattus norvegicus	92.75	0.00e+00	1190.00
IUUC-Sha-107513	Sarcophilus harrisii	92.11	0.00e+00	1194.00
IUUC-Sly-111482	Solanum lycopersicum	31.13	1.00e-40	161.00
IUUC-Stu-112032	Solanum tuberosum	32.30	5.00e-42	166.00
IUUC-Sar-113616	Sorex araneus	70.65	6.00e-117	414.00
IUUC-Ssc-116205	Sus scrofa	96.69	0.00e+00	1034.00
IUUC-Tgu-117435	Taeniopygia guttata	90.48	0.00e+00	1165.00
IUUC-Tru-118709	Takifugu rubripes	80.86	0.00e+00	1055.00
IUUC-Tsy-119466	Tarsius syrichta	98.36	0.00e+00	1106.00
IUUC-Tni-119988	Tetraodon nigroviridis	80.56	0.00e+00	1047.00
IUUC-Tae-124761	Triticum aestivum	34.36	1.00e-38	155.00
IUUC-Tbe-127704	Tupaia belangeri	96.35	0.00e+00	1063.00
IUUC-Ttr-128892	Tursiops truncatus	97.62	0.00e+00	922.00
IUUC-Vpa-130545	Vicugna pacos	97.46	0.00e+00	1043.00
IUUC-Xtr-132289	Xenopus tropicalis	83.51	0.00e+00	1030.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence