iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.50e-05	26.6	21	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCle + + p++lpC H++++dCl ++        ++ rCP Cr
   Q: 21   CKICLEQLHT-PKTLPCLHTYCQDCLAQL-----DIGGQVRCPECR 60
           99******99.***************666.....59*********8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity. In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta. Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (By similarity).

Protein Sequence
(Fasta)

MNSKDSSPTL LEALSSDFLA CKICLEQLHT PKTLPCLHTY CQDCLAQLDI GGQVRCPECR 60
EIVPVPAEGV AAFKTNFFVN GLLDLVKARA PGDVHSGKPT CALCPLVGGK SSGGPATARC 120

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Nucleotide Sequence
(Fasta)

TCAGTTTTGT TTCTCTTGCA GGTAGTCAAC TGCTGGCGGT AGCGGGATTT CGGGGCTCCC 60
CGGTCCTGCT GGGAGAGTCC AGGATCAGCT GTGGCTGGGT AAGGAGAGCC CGGGAAGGCG 120

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Sequence Source

Ensembl

Keyword

KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0032608--P:interferon-beta production
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0070534--P:protein K63-linked ubiquitination
GO:0034340--P:response to type I interferon

KEGG

mmu:384309

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001496	Ailuropoda melanoleuca	78.32	0.00e+00	980.00
IUUC-Aca-004996	Anolis carolinensis	47.98	2.00e-76	280.00
IUUC-Bta-012368	Bos taurus	80.71	0.00e+00	1031.00
IUUC-Cja-019698	Callithrix jacchus	80.16	0.00e+00	1048.00
IUUC-Csa-023090	Chlorocebus sabaeus	81.08	0.00e+00	1003.00
IUUC-Dno-030051	Dasypus novemcinctus	72.27	0.00e+00	884.00
IUUC-Ete-032312	Echinops telfairi	81.57	1.00e-89	322.00
IUUC-Eca-033253	Equus caballus	83.46	2.00e-98	351.00
IUUC-Eeu-034772	Erinaceus europaeus	73.91	1.00e-48	186.00
IUUC-Fca-036198	Felis catus	72.96	0.00e+00	800.00
IUUC-Ggo-045486	Gorilla gorilla	80.56	0.00e+00	1000.00
IUUC-Hsa-046238	Homo sapiens	80.69	0.00e+00	1002.00
IUUC-Itr-048481	Ictidomys tridecemlineatus	82.97	0.00e+00	1013.00
IUUC-Loc-052915	Lepisosteus oculatus	28.53	8.00e-68	251.00
IUUC-Lma-052991	Leptosphaeria maculans	43.06	2.00e-08	55.50
IUUC-Laf-053640	Loxodonta africana	79.51	0.00e+00	968.00
IUUC-Mcc-055540	Macaca mulatta	80.82	0.00e+00	1009.00
IUUC-Mmr-060840	Microcebus murinus	79.66	0.00e+00	1011.00
IUUC-Mpu-066797	Mustela putorius furo	77.46	0.00e+00	979.00
IUUC-Mlu-067996	Myotis lucifugus	77.88	0.00e+00	1004.00
IUUC-Nle-069238	Nomascus leucogenys	85.66	2.00e-108	384.00
IUUC-Oga-089156	Otolemur garnettii	75.66	0.00e+00	1010.00
IUUC-Oar-090056	Ovis aries	74.57	0.00e+00	918.00
IUUC-Ptr-090837	Pan troglodytes	77.58	3.00e-164	572.00
IUUC-Psi-093493	Pelodiscus sinensis	44.53	6.00e-57	215.00
IUUC-Pab-097607	Pongo abelii	80.95	0.00e+00	1009.00
IUUC-Pva-102758	Pteropus vampyrus	88.15	6.00e-150	524.00
IUUC-Pte-104318	Pyrenophora teres	42.65	8.00e-08	53.10
IUUC-Pyt-104520	Pyrenophora triticirepentis	42.65	8.00e-08	53.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence