iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000006323.2	ENSMLUT00000023314.1	ENSMLUP00000020252.1
ENSMLUG00000006323.2	ENSMLUT00000006332.2	ENSMLUP00000005783.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-134	448.5	992	1321

Active Site

Position(s)	Description	Evidence
1291	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 992  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1078
           5899*********************************************************************************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           ++ ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv
   Q: 1079 FFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFVIDEELFGQTHQHELKVGGSEIVVTNKNKKEYIYLV 1160
           ***********************************99...6666..79*************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           +++r+ ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy+ ++++iqwFw+++ +++se+r ++
   Q: 1161 IQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSVNHQVIQWFWKAVLMMDSEKRIRL 1247
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           LqFvTg+sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 1248 LQFVTGTSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQVAIENTQGFD 1321
           *************************************************************************8 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MAQSLRLHFA ARRSNTFPLS ETSGDDPDSN AHMGFQRPTR ISASNVVQMK LTPRQTALAP 60
LIKENVKSQE RSPAPSPENV TKKSSCLQIS LQPTRYGSCL QSSSALADGE DAPFACVLQD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAAATGTTC GAATTGTGAG GGTGAAAGTT ATAGCTGGAA TAGGCCTTGC CAAGAAGGAT 60
ATCTTGGGAT CTAGGTAAGT ATATTAGTAT ATTAATTTGG GCTGCAATTT TAAAATTTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	89.58	0.00e+00	2305.00
IUUC-Apl-003886	Anas platyrhynchos	75.61	0.00e+00	1263.00
IUUC-Ame-011138	Astyanax mexicanus	83.75	0.00e+00	852.00
IUUC-Bta-012453	Bos taurus	88.94	0.00e+00	2246.00
IUUC-Bci-013785	Botrytis cinerea	46.91	2.00e-157	549.00
IUUC-Cja-019034	Callithrix jacchus	94.00	0.00e+00	1404.00
IUUC-Cfa-020258	Canis familiaris	89.88	0.00e+00	2251.00
IUUC-Cpo-021648	Cavia porcellus	89.30	0.00e+00	1441.00
IUUC-Csa-023334	Chlorocebus sabaeus	95.02	0.00e+00	1476.00
IUUC-Cho-024672	Choloepus hoffmanni	78.08	0.00e+00	665.00
IUUC-Cin-025157	Ciona intestinalis	56.00	0.00e+00	876.00
IUUC-Dno-029159	Dasypus novemcinctus	91.41	0.00e+00	1321.00
IUUC-Dor-030729	Dipodomys ordii	77.51	0.00e+00	1019.00
IUUC-Dme-032166	Drosophila melanogaster	65.93	0.00e+00	714.00
IUUC-Ete-032409	Echinops telfairi	85.81	0.00e+00	1181.00
IUUC-Eca-033441	Equus caballus	95.27	0.00e+00	1456.00
IUUC-Eeu-034546	Erinaceus europaeus	78.04	0.00e+00	1178.00
IUUC-Fca-036384	Felis catus	89.97	0.00e+00	2308.00
IUUC-Fal-037547	Ficedula albicollis	81.02	0.00e+00	1315.00
IUUC-Gmo-039679	Gadus morhua	77.18	0.00e+00	909.00
IUUC-Gga-040524	Gallus gallus	82.75	0.00e+00	1319.00
IUUC-Gac-042607	Gasterosteus aculeatus	66.87	0.00e+00	1080.00
IUUC-Hsa-046479	Homo sapiens	88.52	0.00e+00	2259.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	82.10	0.00e+00	1197.00
IUUC-Lch-050445	Latimeria chalumnae	59.24	0.00e+00	1425.00
IUUC-Loc-052645	Lepisosteus oculatus	72.88	0.00e+00	1174.00
IUUC-Lma-052980	Leptosphaeria maculans	44.59	2.00e-89	323.00
IUUC-Laf-053638	Loxodonta africana	85.01	0.00e+00	1355.00
IUUC-Mcc-055585	Macaca mulatta	89.35	0.00e+00	2255.00
IUUC-Meu-056897	Macropus eugenii	95.47	1.00e-171	597.00
IUUC-Mga-059362	Meleagris gallopavo	76.12	0.00e+00	1287.00
IUUC-Mmr-061061	Microcebus murinus	89.20	0.00e+00	2297.00
IUUC-Mmu-063318	Mus musculus	79.73	0.00e+00	1246.00
IUUC-Mpu-066567	Mustela putorius furo	94.30	0.00e+00	1516.00
IUUC-Ncr-068918	Neurospora crassa	47.77	6.00e-157	548.00
IUUC-Nle-069225	Nomascus leucogenys	88.52	0.00e+00	2273.00
IUUC-Ont-071664	Oreochromis niloticus	66.90	0.00e+00	1059.00
IUUC-Oan-073019	Ornithorhynchus anatinus	85.34	0.00e+00	1377.00
IUUC-Ocu-074409	Oryctolagus cuniculus	86.42	0.00e+00	2164.00
IUUC-Oga-088241	Otolemur garnettii	84.77	0.00e+00	2065.00
IUUC-Oar-089797	Ovis aries	95.02	0.00e+00	1491.00
IUUC-Ptr-091629	Pan troglodytes	94.54	0.00e+00	1377.00
IUUC-Psi-093618	Pelodiscus sinensis	67.00	0.00e+00	1606.00
IUUC-Pfo-097145	Poecilia formosa	68.73	0.00e+00	1056.00
IUUC-Pab-098394	Pongo abelii	94.53	0.00e+00	1482.00
IUUC-Pca-100568	Procavia capensis	78.72	0.00e+00	1159.00
IUUC-Pva-102303	Pteropus vampyrus	89.79	0.00e+00	1077.00
IUUC-Pte-104016	Pyrenophora teres	49.06	3.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.06	3.00e-162	565.00
IUUC-Rno-106095	Rattus norvegicus	79.35	0.00e+00	1253.00
IUUC-Sha-107370	Sarcophilus harrisii	66.57	0.00e+00	1734.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.45	6.00e-157	547.00
IUUC-Tgu-117474	Taeniopygia guttata	82.26	0.00e+00	1326.00
IUUC-Tru-117675	Takifugu rubripes	64.54	0.00e+00	1061.00
IUUC-Tni-119993	Tetraodon nigroviridis	64.27	0.00e+00	1057.00
IUUC-Tvi-122595	Trichoderma virens	46.58	1.00e-154	540.00
IUUC-Tbe-127408	Tupaia belangeri	86.98	0.00e+00	1150.00
IUUC-Ttr-128437	Tursiops truncatus	85.55	0.00e+00	1199.00
IUUC-Uma-129332	Ustilago maydis	52.17	7.00e-142	498.00
IUUC-Vpa-130503	Vicugna pacos	89.42	0.00e+00	1305.00
IUUC-Xtr-132431	Xenopus tropicalis	70.30	0.00e+00	1201.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence