iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tca-121479

Ensembl Protein ID

EOY15506

UniProt Accession

A0A061FEL4; A0A061FEL4_THECC

Genbank Protein ID

EOY15506.1

Protein Name

E3 ubiquitin-protein ligase UPL2 isoform 1

Genbank Nucleotide ID

CM001886

Gene Name

TCM_034540

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TCM_034540	EOY15506	EOY15506

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-122	409.6	3334	3673
UBD/Alpha-Helix/UBA	3.20e-09	37.5	1306	1345

Active Site

Position(s)	Description	Evidence
3641	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
            +dlk rl v+f+gEeg+d+gG+tre+++lls+ ++++ + lf+ + ++++t+qpnp+s ++ +ehl++F+f+Gr++gkal+dg+lld+++++sfyk++
   Q: 3334 TQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFT-TVGNESTFQPNPNSVYQ-TEHLSYFKFVGRVVGKALFDGQLLDVHFTRSFYKHI 3430
           689************************************99995.55577788******986.5*********************************** PP
   S: 101  lgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.......lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqvea 192
           lg+k++++d+e++dp+++k+lk+++en   di++  ldltfs++ ++         +++++eL+pgG+ni+Vt+eNk++Yv+lv+e+rl++ i+ q++a
   Q: 3431 LGVKVTYHDIEAIDPDYFKNLKWMLEN---DISDV-LDLTFSIDADEeklilyeRTQVTDYELIPGGRNIKVTEENKHQYVDLVAEHRLTTAIRPQINA 3525
           *************************99...99998.99999977777779996556667788************************************* PP
   S: 193  freGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlf 287
           f eGfne+ip el+s+F+ +elelli+G ++id++d++++t+y +gy++ sp+iqwFwev+++fs+e+++++LqFvTg+s++Pl+Gf +l+     ++f
   Q: 3526 FLEGFNELIPRELISIFNDKELELLISGLPDIDLDDMRANTEY-SGYSAASPVIQWFWEVVQGFSKEDKARLLQFVTGTSKVPLEGFTALQgisgSQKF 3623
           *******************************************.55*************************************************9*** PP
   S: 288  virk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +i+k ++s+d+lPs++TCfn+L+LPeY+ske l+e+Ll+Ai+e+ +gF++
   Q: 3624 QIHKaYGSPDHLPSAHTCFNQLDLPEYPSKEHLEERLLLAIHEAnEGFGF 3673
           ****999*************************************9***85 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           +e  ++ +veMGF+r++a +aLr+  +n++e A+e+L+++
   Q: 1306 NETTIATIVEMGFSRSRAEEALRQVgSNSVELAMEWLFSH 1345
           7899**********************************97 PP

Organism

Theobroma cacao

Protein Sequence
(Fasta)

MASIRSTLPS RLRQLLSGET STGPSIKVDS EPPPQIKSFI DKVIQSPLQD IAIPLSGFRW 60
EYSKGNFHHW RPLFLHFDTY FKTYLSCRND LLLSDKILED DSPFPKHAVL QILRVMQTIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCGTTGAAA AAAACTTTCA TTCAATTTTT TTTTTATAAA ATAAAAAAAT AAAGAAAAAG 60
AAGAAGAAGG GAGTAGAAAG AAAAAGAAAA AGAGGAAGCT AGGGAAAAAG GGGGAAAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR003903--UIM_dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50330--UIM

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	59.30	0.00e+00	2246.00
IUUC-Aml-001684	Ailuropoda melanoleuca	51.29	2.00e-124	441.00
IUUC-Atr-002582	Amborella trichopoda	65.41	0.00e+00	4224.00
IUUC-Apl-003400	Anas platyrhynchos	43.64	1.00e-100	359.00
IUUC-Aca-005263	Anolis carolinensis	51.52	2.00e-125	444.00
IUUC-Aly-006157	Arabidopsis lyrata	70.10	0.00e+00	2793.00
IUUC-Ago-008005	Ashbya gossypii	38.47	2.00e-132	468.00
IUUC-Acl-008254	Aspergillus clavatus	41.45	2.00e-141	498.00
IUUC-Afl-008712	Aspergillus flavus	41.83	1.00e-141	496.00
IUUC-Afu-009022	Aspergillus fumigatus	41.06	4.00e-141	497.00
IUUC-Ani-009412	Aspergillus nidulans	34.30	7.00e-158	552.00
IUUC-Ang-009771	Aspergillus niger	41.18	3.00e-142	500.00
IUUC-Aor-010186	Aspergillus oryzae	41.20	1.00e-131	464.00
IUUC-Ate-010253	Aspergillus terreus	41.36	3.00e-141	497.00
IUUC-Ame-011067	Astyanax mexicanus	51.52	4.00e-124	440.00
IUUC-Bgr-012043	Blumeria graminis	32.85	6.00e-149	523.00
IUUC-Bta-012813	Bos taurus	51.29	2.00e-124	442.00
IUUC-Bci-013995	Botrytis cinerea	40.16	1.00e-143	505.00
IUUC-Bdi-014884	Brachypodium distachyon	62.55	0.00e+00	4023.00
IUUC-Bol-015228	Brassica oleracea	68.77	0.00e+00	2387.00
IUUC-Bra-016726	Brassica rapa	67.97	0.00e+00	2495.00
IUUC-Cel-018179	Caenorhabditis elegans	47.49	3.00e-120	427.00
IUUC-Cja-018741	Callithrix jacchus	51.40	8.00e-124	439.00
IUUC-Cfa-020083	Canis familiaris	51.29	2.00e-124	441.00
IUUC-Cpo-021766	Cavia porcellus	44.32	2.00e-103	369.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	61.48	1.00e-159	555.00
IUUC-Csa-023853	Chlorocebus sabaeus	51.29	1.00e-124	442.00
IUUC-Cho-024718	Choloepus hoffmanni	54.79	6.00e-115	409.00
IUUC-Cin-025627	Ciona intestinalis	49.19	6.00e-121	430.00
IUUC-Csv-025872	Ciona savignyi	49.30	2.00e-117	415.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	37.80	7.00e-137	483.00
IUUC-Cme-027267	Cyanidioschyzon merolae	53.52	2.00e-129	456.00
IUUC-Dno-029680	Dasypus novemcinctus	51.29	2.00e-124	442.00
IUUC-Dor-030902	Dipodomys ordii	46.14	4.00e-105	377.00
IUUC-Dse-031197	Dothistroma septosporum	32.85	5.00e-143	503.00
IUUC-Dme-032122	Drosophila melanogaster	47.70	1.00e-120	429.00
IUUC-Ete-032966	Echinops telfairi	44.09	2.00e-103	369.00
IUUC-Eca-033915	Equus caballus	50.70	6.00e-122	433.00
IUUC-Eeu-034963	Erinaceus europaeus	50.93	2.00e-122	435.00
IUUC-Fca-035824	Felis catus	51.29	2.00e-124	442.00
IUUC-Fal-036687	Ficedula albicollis	43.64	4.00e-101	362.00
IUUC-Fox-037756	Fusarium oxysporum	33.06	7.00e-157	549.00
IUUC-Fso-038464	Fusarium solani	32.24	1.00e-152	535.00
IUUC-Gmo-039073	Gadus morhua	51.99	3.00e-126	447.00
IUUC-Ggr-039946	Gaeumannomyces graminis	41.72	2.00e-136	481.00
IUUC-Gga-040845	Gallus gallus	43.64	4.00e-101	362.00
IUUC-Gac-042430	Gasterosteus aculeatus	51.76	2.00e-125	445.00
IUUC-Gma-043129	Glycine max	74.80	0.00e+00	5129.00
IUUC-Ggo-044465	Gorilla gorilla	43.99	1.00e-101	363.00
IUUC-Hsa-046879	Homo sapiens	51.29	2.00e-124	442.00
IUUC-Hvu-047697	Hordeum vulgare	60.33	0.00e+00	2296.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	51.29	1.00e-124	441.00
IUUC-Kpa-049228	Komagataella pastoris	40.62	2.00e-132	468.00
IUUC-Lch-050252	Latimeria chalumnae	51.40	9.00e-124	439.00
IUUC-Lpe-051550	Leersia perrieri	60.45	0.00e+00	2303.00
IUUC-Loc-052472	Lepisosteus oculatus	51.29	9.00e-125	442.00
IUUC-Lma-053159	Leptosphaeria maculans	33.45	2.00e-153	538.00
IUUC-Laf-054154	Loxodonta africana	51.29	1.00e-124	442.00
IUUC-Mcc-055085	Macaca mulatta	51.29	1.00e-124	442.00
IUUC-Meu-056751	Macropus eugenii	45.15	3.00e-78	286.00
IUUC-Mor-057201	Magnaporthe oryzae	33.39	8.00e-146	512.00
IUUC-Mpo-057597	Magnaporthe poae	42.35	1.00e-135	479.00
IUUC-Mtr-057633	Medicago truncatula	74.09	0.00e+00	5083.00
IUUC-Mla-058888	Melampsora laricipopulina	47.32	3.00e-116	410.00
IUUC-Mga-059935	Meleagris gallopavo	43.64	3.00e-101	362.00
IUUC-Mmr-060820	Microcebus murinus	51.29	8.00e-125	442.00
IUUC-Mdo-062930	Monodelphis domestica	51.29	7.00e-125	443.00
IUUC-Mmu-063601	Mus musculus	51.29	1.00e-124	442.00
IUUC-Mac-065499	Musa acuminata	61.83	0.00e+00	3936.00
IUUC-Mpu-066653	Mustela putorius furo	51.29	2.00e-124	441.00
IUUC-Mlu-067418	Myotis lucifugus	51.29	1.00e-124	442.00
IUUC-Nfi-068278	Neosartorya fischeri	41.45	3.00e-142	500.00
IUUC-Ncr-068813	Neurospora crassa	41.03	2.00e-145	511.00
IUUC-Nle-069418	Nomascus leucogenys	51.29	2.00e-124	442.00
IUUC-Opr-070443	Ochotona princeps	46.17	2.00e-94	340.00
IUUC-Ont-071300	Oreochromis niloticus	51.76	2.00e-125	444.00
IUUC-Oan-073046	Ornithorhynchus anatinus	51.05	2.00e-123	438.00
IUUC-Ocu-074178	Oryctolagus cuniculus	51.29	1.00e-124	442.00
IUUC-Oba-075757	Oryza barthii	62.56	0.00e+00	3937.00
IUUC-Obr-076553	Oryza brachyantha	62.71	0.00e+00	4005.00
IUUC-Ogl-077520	Oryza glaberrima	62.70	0.00e+00	4044.00
IUUC-Ogu-078278	Oryza glumaepatula	60.76	0.00e+00	2346.00
IUUC-Oin-079767	Oryza indica	62.50	0.00e+00	4026.00
IUUC-Olo-080380	Oryza longistaminata	61.45	0.00e+00	3971.00
IUUC-Ome-081925	Oryza meridionalis	62.66	0.00e+00	4036.00
IUUC-Oni-082619	Oryza nivara	62.64	0.00e+00	4037.00
IUUC-Opu-083684	Oryza punctata	61.33	0.00e+00	3966.00
IUUC-Oru-084501	Oryza rufipogon	62.75	0.00e+00	4046.00
IUUC-Osa-086251	Oryza sativa	72.92	0.00e+00	1144.00
IUUC-Ola-086777	Oryzias latipes	44.09	1.00e-103	370.00
IUUC-Olu-087813	Ostreococcus lucimarinus	51.82	1.00e-125	442.00
IUUC-Oga-088903	Otolemur garnettii	51.29	1.00e-124	442.00
IUUC-Oar-090210	Ovis aries	51.29	2.00e-124	441.00
IUUC-Ptr-090529	Pan troglodytes	44.09	4.00e-103	368.00
IUUC-Psi-093969	Pelodiscus sinensis	43.86	2.00e-102	365.00
IUUC-Pma-094364	Petromyzon marinus	45.92	4.00e-89	321.00
IUUC-Pno-094871	Phaeosphaeria nodorum	33.67	2.00e-149	524.00
IUUC-Pfo-096232	Poecilia formosa	51.76	1.00e-125	446.00
IUUC-Pab-098583	Pongo abelii	51.29	2.00e-124	441.00
IUUC-Pop-099468	Populus trichocarpa	79.90	0.00e+00	5414.00
IUUC-Pca-100568	Procavia capensis	45.41	2.00e-88	320.00
IUUC-Ppe-101641	Prunus persica	78.39	0.00e+00	5311.00
IUUC-Pva-102116	Pteropus vampyrus	47.42	1.00e-110	396.00
IUUC-Pgr-103465	Puccinia graminis	43.92	2.00e-127	451.00
IUUC-Ptt-103813	Puccinia triticina	41.94	3.00e-118	421.00
IUUC-Pte-104018	Pyrenophora teres	33.53	6.00e-155	543.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	33.42	1.00e-150	528.00
IUUC-Rno-105153	Rattus norvegicus	44.09	2.00e-103	369.00
IUUC-Sce-106449	Saccharomyces cerevisiae	40.38	3.00e-126	447.00
IUUC-Sha-106961	Sarcophilus harrisii	51.29	1.00e-124	442.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	38.86	2.00e-133	471.00
IUUC-Spo-108024	Schizosaccharomyces pombe	39.68	1.00e-135	478.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	44.42	2.00e-95	342.00
IUUC-Sit-110598	Setaria italica	60.25	0.00e+00	2253.00
IUUC-Sly-111706	Solanum lycopersicum	69.94	0.00e+00	4734.00
IUUC-Sar-113291	Sorex araneus	51.19	4.00e-120	427.00
IUUC-Sbi-114042	Sorghum bicolor	58.53	0.00e+00	2224.00
IUUC-Sre-114958	Sporisorium reilianum	51.84	4.00e-145	507.00
IUUC-Ssc-115754	Sus scrofa	51.29	2.00e-124	441.00
IUUC-Tgu-117225	Taeniopygia guttata	43.41	4.00e-101	362.00
IUUC-Tru-118570	Takifugu rubripes	51.76	1.00e-125	446.00
IUUC-Tsy-119407	Tarsius syrichta	47.85	4.00e-97	348.00
IUUC-Tni-120836	Tetraodon nigroviridis	50.82	1.00e-121	432.00
IUUC-Tre-121909	Trichoderma reesei	37.40	5.00e-141	496.00
IUUC-Tvi-122370	Trichoderma virens	36.79	3.00e-140	494.00
IUUC-Tae-125214	Triticum aestivum	63.95	0.00e+00	1720.00
IUUC-Tme-127172	Tuber melanosporum	40.06	9.00e-140	492.00
IUUC-Tbe-127762	Tupaia belangeri	42.30	3.00e-84	306.00
IUUC-Ttr-129253	Tursiops truncatus	51.29	1.00e-124	442.00
IUUC-Uma-129355	Ustilago maydis	51.63	2.00e-147	514.00
IUUC-Vda-129886	Verticillium dahliae	38.30	6.00e-135	476.00
IUUC-Vpa-130708	Vicugna pacos	51.29	4.00e-124	440.00
IUUC-Vvi-131078	Vitis vinifera	78.25	0.00e+00	5302.00
IUUC-Xtr-132123	Xenopus tropicalis	48.84	4.00e-112	400.00
IUUC-Xma-133869	Xiphophorus maculatus	51.76	8.00e-126	446.00
IUUC-Yli-134657	Yarrowia lipolytica	39.31	1.00e-138	488.00
IUUC-Zma-135570	Zea mays	60.21	0.00e+00	3857.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence