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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046817
UUCD1 version UUC-HoS-00981
Ensembl Protein ID ENSP00000314608.3
UniProt Accession Q9NVR0; KLH11_HUMAN
Genbank Protein ID BAA91689.1; AAH34470.1
Protein Name Kelch-like protein 11
Genbank Nucleotide ID AK001434; BC034470
Gene Name KLHL11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000178502.5 ENST00000319121.3 ENSP00000314608.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDHINTMentha
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 23349464
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 2.20e-15 58.4 94 168
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 5.60e-10 38.4 202 233
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvg...geeffahkivLaasSsvFyalflmeleesksklmveikd......vqpevfrallkFlYtgklde 67
           +D++l+ g   g+ef+ah++vLaa+ ++F  l++++++es+ +++ve++        +p+ ++a+++++Ytg+++ 
   Q: 94   CDITLCFGgagGREFRAHRSVLAAATEYFTPLLSGQFSESR-SGRVEMRKwssepgPEPDTVEAVIEYMYTGRIRV 168
           8******7788******************************.*******4456799*****************975 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l+Nc++i ++A++y++++L+++a d+i ++F+
   Q: 202  LSNCVAIHSLAHMYTLSQLALKAADMIRRNFH 233
           69*****************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
 Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
Protein Sequence
(Fasta)
MAAAAVAAAA AAAAAASLQV LEMESMETAA AGSAGLAAEV RGSGTVDFGP GPGISAMEAS 60
GGDPGPEAED FECSSHCSEL SWRQNEQRRQ GLFCDITLCF GGAGGREFRA HRSVLAAATE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046817|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGTGTCGTAC CAACAGCCGC ATCGTTCCGA GGCTGTGGAG GCCGGGCGCA GCGGCGTCAA 60
GATGGCGGCT GCGGCAGTGG CGGCGGCGGC GGCGGCGGCC GCGGCTGCAT CTCTTCAGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046817|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
KEGG hsa:55175
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002239 Ailuropoda melanoleuca 97.89 0.00e+00 1352.00
IUUC-Apl-003928 Anas platyrhynchos 84.59 0.00e+00 1038.00
IUUC-Aca-004801 Anolis carolinensis 81.65 0.00e+00 1097.00
IUUC-Ame-010943 Astyanax mexicanus 76.36 0.00e+00 912.00
IUUC-Bta-012341 Bos taurus 100.00 1.00e-97 348.00
IUUC-Cja-019924 Callithrix jacchus 99.57 0.00e+00 1424.00
IUUC-Cfa-021076 Canis familiaris 99.42 0.00e+00 1414.00
IUUC-Cpo-022193 Cavia porcellus 93.06 0.00e+00 1292.00
IUUC-Csa-023614 Chlorocebus sabaeus 100.00 0.00e+00 1422.00
IUUC-Cho-024806 Choloepus hoffmanni 85.07 0.00e+00 952.00
IUUC-Dre-028622 Danio rerio 75.00 0.00e+00 996.00
IUUC-Dno-029965 Dasypus novemcinctus 96.26 0.00e+00 1368.00
IUUC-Dor-030136 Dipodomys ordii 98.10 0.00e+00 1088.00
IUUC-Eca-034191 Equus caballus 96.72 0.00e+00 1350.00
IUUC-Eeu-034746 Erinaceus europaeus 97.69 0.00e+00 1394.00
IUUC-Fca-035702 Felis catus 92.61 0.00e+00 1273.00
IUUC-Fal-037360 Ficedula albicollis 84.20 0.00e+00 1026.00
IUUC-Gmo-038582 Gadus morhua 75.38 0.00e+00 1006.00
IUUC-Ggr-039747 Gaeumannomyces graminis 25.93 1.00e-08 53.50
IUUC-Gga-040375 Gallus gallus 84.01 0.00e+00 1127.00
IUUC-Gac-042523 Gasterosteus aculeatus 77.10 0.00e+00 998.00
IUUC-Ggo-045632 Gorilla gorilla 100.00 0.00e+00 1111.00
IUUC-Itr-048433 Ictidomys tridecemlineatus 99.42 0.00e+00 1416.00
IUUC-Lch-049985 Latimeria chalumnae 78.86 0.00e+00 1038.00
IUUC-Loc-052594 Lepisosteus oculatus 75.64 0.00e+00 996.00
IUUC-Lma-053111 Leptosphaeria maculans 31.65 2.00e-04 40.00
IUUC-Laf-054357 Loxodonta africana 99.42 0.00e+00 1416.00
IUUC-Mcc-055454 Macaca mulatta 100.00 0.00e+00 1374.00
IUUC-Meu-056012 Macropus eugenii 94.35 9.00e-170 589.00
IUUC-Mga-060048 Meleagris gallopavo 85.34 0.00e+00 862.00
IUUC-Mdo-062082 Monodelphis domestica 86.86 0.00e+00 1269.00
IUUC-Mmu-063119 Mus musculus 96.83 0.00e+00 1386.00
IUUC-Mpu-066511 Mustela putorius furo 99.28 0.00e+00 1414.00
IUUC-Mlu-067301 Myotis lucifugus 97.83 0.00e+00 1362.00
IUUC-Nfi-068503 Neosartorya fischeri 31.88 1.00e-02 33.90
IUUC-Nle-069912 Nomascus leucogenys 100.00 0.00e+00 1433.00
IUUC-Opr-070762 Ochotona princeps 97.53 0.00e+00 835.00
IUUC-Ont-071916 Oreochromis niloticus 77.67 0.00e+00 997.00
IUUC-Oan-072932 Ornithorhynchus anatinus 77.04 0.00e+00 820.00
IUUC-Ocu-074172 Oryctolagus cuniculus 99.04 0.00e+00 1087.00
IUUC-Ola-086483 Oryzias latipes 77.36 0.00e+00 993.00
IUUC-Oga-088112 Otolemur garnettii 98.07 0.00e+00 1353.00
IUUC-Oar-090129 Ovis aries 98.99 0.00e+00 1414.00
IUUC-Ptr-090571 Pan troglodytes 100.00 0.00e+00 1112.00
IUUC-Pan-092073 Papio anubis 99.86 0.00e+00 1432.00
IUUC-Psi-093836 Pelodiscus sinensis 86.08 0.00e+00 1078.00
IUUC-Pno-095007 Phaeosphaeria nodorum 31.08 8.00e-05 41.20
IUUC-Pfo-096477 Poecilia formosa 77.52 0.00e+00 995.00
IUUC-Pab-098473 Pongo abelii 99.86 0.00e+00 1432.00
IUUC-Pca-100239 Procavia capensis 98.61 0.00e+00 850.00
IUUC-Pte-104232 Pyrenophora teres 35.62 9.00e-05 40.80
IUUC-Pyt-104638 Pyrenophora triticirepentis 35.62 9.00e-05 40.80
IUUC-Rno-104859 Rattus norvegicus 96.83 0.00e+00 1389.00
IUUC-Sha-106746 Sarcophilus harrisii 92.04 0.00e+00 1251.00
IUUC-Tgu-117183 Taeniopygia guttata 83.49 0.00e+00 1129.00
IUUC-Tru-118655 Takifugu rubripes 75.26 0.00e+00 989.00
IUUC-Tsy-119430 Tarsius syrichta 99.06 0.00e+00 1335.00
IUUC-Tni-119698 Tetraodon nigroviridis 76.79 0.00e+00 870.00
IUUC-Vda-129848 Verticillium dahliae 33.33 1.00e-03 37.00
IUUC-Vpa-130715 Vicugna pacos 97.97 0.00e+00 1383.00
IUUC-Xtr-132276 Xenopus tropicalis 77.26 0.00e+00 991.00
Created Date 25-Jun-2017

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