iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000078902.15	ENST00000317204.10	ENSP00000314733.5
ENSG00000078902.15	ENST00000525159.5	ENSP00000432668.1
ENSG00000078902.15	ENST00000263646.11	ENSP00000263646.6
ENSG00000078902.15	ENST00000530506.5	ENSP00000436393.1
ENSG00000078902.15	ENST00000527938.5	ENSP00000432778.1
ENSG00000078902.15	ENST00000530541.1	ENSP00000434494.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	23880770
UBD/Alpha-Helix/CUE	CUE	23880770

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/CUE	3.60e-15	57.1	230	271

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
            e++l++++++FPn+d++vi++vLea++g+ +aa+n+LL++ 
   Q: 230  SEEDLKAIQDMFPNMDQEVIRSVLEAQRGNKDAAINSLLQMG 271
           699*************************************96 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).

Protein Sequence
(Fasta)

MATTVSTQRG PVYIGELPQD FLRITPTQQQ RQVQLDAQAA QQLQYGGAVG TVGRLNITVV 60
QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW NKVIHCTVPP GVDSFYLEIF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGTGCCGG GGGCGGGGCG CGGCGGCTGT CAGCTGACTG TGGCGGCGGC GGCCTCGAGG 60
TGACAACTGT CTCCGTCGCA GGCTCCGGCG GGGGCGCAGG AGGTCGCCCG GCGCGTCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0399--Innate immunity
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR000008--C2_dom
IPR003892--CUE
IPR009060--UBA-like

PROSITE

PS51140--CUE

Pfam

PF00168--C2
PF02845--CUE

SMART

SM00239--C2
SM00546--CUE

Gene Ontology

GO:0035578--C:azurophil granule lumen
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:0045323--C:interleukin-1 receptor complex
GO:0045092--C:interleukin-18 receptor complex
GO:0016604--C:nuclear body
GO:0048471--C:perinuclear region of cytoplasm
GO:0035580--C:specific granule lumen
GO:0019900--F:kinase binding
GO:0004871--F:signal transducer activity
GO:0035325--F:Toll-like receptor binding
GO:0043130--F:ubiquitin binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0006914--P:autophagy
GO:0007267--P:cell-cell signaling
GO:0030855--P:epithelial cell differentiation
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0035556--P:intracellular signal transduction
GO:0045321--P:leukocyte activation
GO:0043312--P:neutrophil degranulation
GO:0016310--P:phosphorylation
GO:0033235--P:positive regulation of protein sumoylation
GO:0036010--P:protein localization to endosome
GO:0007165--P:signal transduction
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:54472

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001566	Ailuropoda melanoleuca	91.98	1.00e-110	392.00
IUUC-Apl-003706	Anas platyrhynchos	86.45	8.00e-116	409.00
IUUC-Aca-004943	Anolis carolinensis	80.95	1.00e-107	382.00
IUUC-Ago-007813	Ashbya gossypii	25.98	2.00e-04	40.00
IUUC-Ame-011082	Astyanax mexicanus	81.82	4.00e-122	430.00
IUUC-Bgr-011976	Blumeria graminis	32.26	2.00e-04	40.40
IUUC-Bta-013259	Bos taurus	89.74	6.00e-116	410.00
IUUC-Bci-013731	Botrytis cinerea	36.11	6.10e-01	28.90
IUUC-Bdi-014407	Brachypodium distachyon	35.14	1.50e-01	30.00
IUUC-Cel-018399	Caenorhabditis elegans	36.94	1.00e-45	176.00
IUUC-Cja-018753	Callithrix jacchus	98.15	6.00e-136	476.00
IUUC-Cfa-020087	Canis familiaris	92.31	3.00e-111	394.00
IUUC-Cpo-021735	Cavia porcellus	83.58	9.00e-115	405.00
IUUC-Csa-023623	Chlorocebus sabaeus	100.00	3.00e-133	467.00
IUUC-Cin-025139	Ciona intestinalis	41.95	7.00e-40	156.00
IUUC-Csv-025877	Ciona savignyi	39.38	3.00e-51	195.00
IUUC-Dre-028691	Danio rerio	80.36	7.00e-112	396.00
IUUC-Dno-029753	Dasypus novemcinctus	88.60	5.00e-109	387.00
IUUC-Dor-030201	Dipodomys ordii	81.03	4.00e-91	327.00
IUUC-Dse-031373	Dothistroma septosporum	28.46	2.00e-06	48.50
IUUC-Ete-032378	Echinops telfairi	85.26	5.00e-95	340.00
IUUC-Eca-034156	Equus caballus	92.37	3.00e-119	420.00
IUUC-Fca-035386	Felis catus	90.53	3.00e-113	401.00
IUUC-Fal-036799	Ficedula albicollis	88.21	6.00e-121	426.00
IUUC-Gmo-038999	Gadus morhua	77.06	5.00e-114	403.00
IUUC-Gga-041068	Gallus gallus	89.01	3.00e-128	451.00
IUUC-Ggo-044809	Gorilla gorilla	82.48	1.00e-97	349.00
IUUC-Itr-048912	Ictidomys tridecemlineatus	93.51	3.00e-120	424.00
IUUC-Lch-049986	Latimeria chalumnae	83.52	2.00e-133	468.00
IUUC-Loc-052419	Lepisosteus oculatus	52.84	8.00e-59	220.00
IUUC-Lma-053222	Leptosphaeria maculans	35.59	1.40e-02	34.30
IUUC-Laf-053390	Loxodonta africana	90.46	2.00e-114	405.00
IUUC-Mcc-054649	Macaca mulatta	99.62	3.00e-126	444.00
IUUC-Meu-056690	Macropus eugenii	69.95	2.00e-71	262.00
IUUC-Mor-057041	Magnaporthe oryzae	47.06	6.00e-03	35.80
IUUC-Mga-059674	Meleagris gallopavo	86.45	5.00e-116	410.00
IUUC-Mvi-060273	Microbotryum violaceum	29.82	7.00e-02	30.80
IUUC-Mmr-060744	Microcebus murinus	93.16	1.00e-121	429.00
IUUC-Mdo-062591	Monodelphis domestica	87.18	5.00e-128	450.00
IUUC-Mmu-063685	Mus musculus	93.04	6.00e-126	443.00
IUUC-Mac-064554	Musa acuminata	27.50	8.00e-08	50.80
IUUC-Mpu-066005	Mustela putorius furo	91.22	8.00e-113	399.00
IUUC-Nle-069520	Nomascus leucogenys	100.00	3.00e-133	467.00
IUUC-Opr-071036	Ochotona princeps	94.27	2.00e-86	311.00
IUUC-Ont-071379	Oreochromis niloticus	79.71	7.00e-118	416.00
IUUC-Oan-073508	Ornithorhynchus anatinus	91.43	6.00e-58	216.00
IUUC-Ocu-074753	Oryctolagus cuniculus	92.67	2.00e-114	404.00
IUUC-Ola-086417	Oryzias latipes	80.87	2.00e-123	434.00
IUUC-Olu-087609	Ostreococcus lucimarinus	40.00	3.00e-04	39.30
IUUC-Oga-088770	Otolemur garnettii	91.08	2.00e-125	441.00
IUUC-Oar-089528	Ovis aries	48.54	5.00e-33	134.00
IUUC-Pan-091998	Papio anubis	100.00	3.00e-133	467.00
IUUC-Psi-093365	Pelodiscus sinensis	88.93	1.00e-116	412.00
IUUC-Pma-094505	Petromyzon marinus	52.38	4.00e-73	267.00
IUUC-Pno-094817	Phaeosphaeria nodorum	43.75	1.60e-01	30.80
IUUC-Pfo-096152	Poecilia formosa	80.51	1.00e-130	458.00
IUUC-Pab-097752	Pongo abelii	100.00	3.00e-133	467.00
IUUC-Pop-099461	Populus trichocarpa	45.24	1.90e-01	29.60
IUUC-Pca-100823	Procavia capensis	78.36	1.00e-118	419.00
IUUC-Pva-102815	Pteropus vampyrus	90.51	5.00e-110	390.00
IUUC-Pyt-104628	Pyrenophora triticirepentis	41.18	4.30e-01	29.30
IUUC-Rno-105011	Rattus norvegicus	93.41	2.00e-126	444.00
IUUC-Sce-106317	Saccharomyces cerevisiae	35.42	3.30e-01	29.60
IUUC-Sha-107028	Sarcophilus harrisii	83.77	1.00e-67	248.00
IUUC-Ssl-108621	Sclerotinia sclerotiorum	36.11	4.30e-01	29.60
IUUC-Smo-109303	Selaginella moellendorffii	25.00	2.00e-08	50.40
IUUC-Stu-112916	Solanum tuberosum	30.33	9.00e-11	59.30
IUUC-Sar-113252	Sorex araneus	64.04	9.00e-47	179.00
IUUC-Sre-115062	Sporisorium reilianum	48.48	2.00e-04	40.40
IUUC-Ssc-116217	Sus scrofa	56.76	5.00e-57	214.00
IUUC-Tgu-116503	Taeniopygia guttata	90.11	1.00e-122	432.00
IUUC-Tru-118257	Takifugu rubripes	81.52	9.00e-128	449.00
IUUC-Tni-120576	Tetraodon nigroviridis	75.09	5.00e-116	410.00
IUUC-Tca-121166	Theobroma cacao	29.17	2.00e-07	49.70
IUUC-Tre-121981	Trichoderma reesei	38.24	3.00e-01	29.60
IUUC-Tvi-122320	Trichoderma virens	40.62	2.90e-01	29.60
IUUC-Tbe-128094	Tupaia belangeri	94.17	2.00e-105	375.00
IUUC-Ttr-128957	Tursiops truncatus	95.90	1.00e-52	199.00
IUUC-Uma-129647	Ustilago maydis	39.68	3.00e-05	43.50
IUUC-Vda-129734	Verticillium dahliae	50.00	1.00e-03	38.10
IUUC-Vvi-131188	Vitis vinifera	22.08	9.90e-01	29.30
IUUC-Xtr-132846	Xenopus tropicalis	78.23	3.00e-109	387.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence