• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046887
UUCD1 version UUC-HoS-00418
Ensembl Protein ID ENSP00000378028.2
UniProt Accession Q9UBS8; A0AV26; A6NMR2; A8MTW5; B3KN72; B7ZLV2; D3DQE4; O94793; Q6IBV0; RNF14_HUMAN
Genbank Protein ID BAA78677.1; AAD21842.1; BAG51234.1; CAG32983.1; EAW61895.1; EAW61896.1; EAW61897.1; AAI26186.1; AAI44062.1; BAA34792.1
Protein Name E3 ubiquitin-protein ligase RNF14; Androgen receptor-associated protein 54; HFB30; RING finger protein 14; Triad2 protein
Genbank Nucleotide ID AB022663; AF060544; AK023884; AK057868; AC005740; CH471062; CH471062; BC126185; BC144061; AB015333
Gene Name RNF14; ARA54; HRIHFB2038
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000013561.17 ENST00000394520.6 ENSP00000378028.2
ENSG00000013561.17 ENST00000512565.5 ENSP00000426832.1
ENSG00000013561.17 ENST00000515613.5 ENSP00000422650.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RBR RBR 17367545
Classification
Family E-value Score Start End
E3 activity/RBR 6.00e-56 190.1 220 433
Active Site
Position(s) Description Evidence
417 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++C++e+  +e++++leC+h++Ck+Clk+y+e++i++gqv++++cp+++cp+ +++ ++ke lve+el++ry++lll+++++ +a++ +
   Q: 220  CSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQVKE-LVEAELFARYDRLLLQSSLDLMADVVY 308
           **************************************************************.7************************** PP
   S: 91   cpapdCslvvllekeaekleve.cekcgkefCveCkeewHeglsCkelkeklakteeek........................eeaeske 155
           cp+p+C+l+v++e+     ++  c++c+++fC+ C+ ++H  + Ck ++ekl++ ++e+                        ee+eske
   Q: 309  CPRPCCQLPVMQEPG---CTMGiCSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYlqadeankrlldqrygkrviqkalEEMESKE 395
           *************95...33337**********************************99******************************* PP
   S: 156  lleanskkCpkCkvyieknegCnhmtCakCkaefCwlC 193
           +le+nsk+Cp+C ++iek +gCn+mtC+ C+++fCw+C
   Q: 396  WLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWIC 433
           ************************************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.
 Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.
Protein Sequence
(Fasta)
MSSEDREAQE DELLALASIY DGDEFRKAES VQGGETRIYL DLPQNFKIFV SGNSNECLQN 60
SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP TQLSALCKHL DNLWEEHRGS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046887|E3,RBR|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGGATGAG GCCGGGGCTC CGGGGACAGG CCAGATGGGA AGCTGCTGTC CACGCAGCAA 60
GGCGGCTGCT GAGGGAAAGG GAGCCTCTGC ATCACCAAGT GAGCAGAAAA CTTGAGCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046887|E3,RBR|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR006575--RWD-domain
IPR016135--UBQ-conjugating_enzyme/RWD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50908--RWD
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF01485--IBR
PF05773--RWD
SMART

SM00647--IBR
SM00591--RWD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0050681--F:androgen receptor binding
GO:0003713--F:transcription coactivator activity
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0019787--F:ubiquitin-like protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030521--P:androgen receptor signaling pathway
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007165--P:signal transduction
GO:0006351--P:transcription, DNA-templated
KEGG hsa:9604
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001130 Aegilops tauschii 29.42 5.00e-50 192.00
IUUC-Aml-001458 Ailuropoda melanoleuca 96.22 0.00e+00 917.00
IUUC-Atr-002560 Amborella trichopoda 29.98 9.00e-45 175.00
IUUC-Apl-003680 Anas platyrhynchos 82.28 0.00e+00 776.00
IUUC-Aca-005000 Anolis carolinensis 71.86 0.00e+00 671.00
IUUC-Aly-006288 Arabidopsis lyrata 30.80 2.00e-53 204.00
IUUC-Ath-006719 Arabidopsis thaliana 30.72 9.00e-53 201.00
IUUC-Acl-008213 Aspergillus clavatus 25.27 1.00e-30 128.00
IUUC-Afl-008433 Aspergillus flavus 25.00 8.00e-31 129.00
IUUC-Afu-008772 Aspergillus fumigatus 25.49 2.00e-32 134.00
IUUC-Ani-009249 Aspergillus nidulans 25.65 4.00e-33 136.00
IUUC-Ang-009757 Aspergillus niger 28.23 3.00e-37 149.00
IUUC-Aor-009963 Aspergillus oryzae 25.00 2.00e-30 128.00
IUUC-Ate-010460 Aspergillus terreus 25.11 3.00e-31 130.00
IUUC-Ame-011312 Astyanax mexicanus 58.61 3.00e-145 508.00
IUUC-Bgr-012052 Blumeria graminis 23.74 7.00e-29 122.00
IUUC-Bta-013529 Bos taurus 95.78 0.00e+00 920.00
IUUC-Bci-013729 Botrytis cinerea 25.16 1.00e-26 115.00
IUUC-Bdi-014940 Brachypodium distachyon 31.67 6.00e-48 185.00
IUUC-Bra-016998 Brassica rapa 29.82 6.00e-50 192.00
IUUC-Cel-018547 Caenorhabditis elegans 31.59 5.00e-51 195.00
IUUC-Cja-019791 Callithrix jacchus 96.84 0.00e+00 929.00
IUUC-Cfa-020403 Canis familiaris 95.78 0.00e+00 920.00
IUUC-Cpo-022229 Cavia porcellus 90.55 0.00e+00 858.00
IUUC-Cre-022601 Chlamydomonas reinhardtii 34.88 6.00e-29 120.00
IUUC-Csa-024115 Chlorocebus sabaeus 98.95 0.00e+00 941.00
IUUC-Cho-024911 Choloepus hoffmanni 95.99 0.00e+00 921.00
IUUC-Cin-025578 Ciona intestinalis 41.65 1.00e-97 350.00
IUUC-Csv-026355 Ciona savignyi 39.86 2.00e-81 296.00
IUUC-Cgl-026439 Colletotrichum gloeosporioides 24.33 7.00e-25 108.00
IUUC-Cne-026782 Cryptococcus neoformans 26.55 2.00e-31 130.00
IUUC-Dre-027380 Danio rerio 56.68 7.00e-153 533.00
IUUC-Dno-029640 Dasypus novemcinctus 95.58 0.00e+00 911.00
IUUC-Dor-030681 Dipodomys ordii 94.73 0.00e+00 907.00
IUUC-Dse-031208 Dothistroma septosporum 24.76 2.00e-31 130.00
IUUC-Ete-033122 Echinops telfairi 60.92 9.00e-135 473.00
IUUC-Eca-033755 Equus caballus 94.22 0.00e+00 888.00
IUUC-Eeu-035034 Erinaceus europaeus 98.63 2.00e-73 269.00
IUUC-Fca-036461 Felis catus 95.99 0.00e+00 921.00
IUUC-Fal-037516 Ficedula albicollis 81.68 0.00e+00 775.00
IUUC-Fso-038307 Fusarium solani 25.16 4.00e-25 109.00
IUUC-Gmo-039563 Gadus morhua 57.27 8.00e-148 516.00
IUUC-Ggr-039920 Gaeumannomyces graminis 25.48 6.00e-23 102.00
IUUC-Gga-040331 Gallus gallus 80.68 0.00e+00 754.00
IUUC-Gac-042164 Gasterosteus aculeatus 59.45 9.00e-160 556.00
IUUC-Gma-044080 Glycine max 31.67 2.00e-56 213.00
IUUC-Ggo-045257 Gorilla gorilla 99.37 0.00e+00 946.00
IUUC-Hvu-047317 Hordeum vulgare 29.27 2.00e-48 187.00
IUUC-Itr-048199 Ictidomys tridecemlineatus 95.36 0.00e+00 917.00
IUUC-Lch-050155 Latimeria chalumnae 64.38 9.00e-165 573.00
IUUC-Lpe-051669 Leersia perrieri 30.65 7.00e-39 155.00
IUUC-Loc-051779 Lepisosteus oculatus 60.05 3.00e-154 538.00
IUUC-Lma-052969 Leptosphaeria maculans 23.68 7.00e-30 125.00
IUUC-Laf-053488 Loxodonta africana 93.25 0.00e+00 890.00
IUUC-Mcc-054701 Macaca mulatta 99.13 0.00e+00 915.00
IUUC-Meu-056577 Macropus eugenii 82.91 1.00e-126 446.00
IUUC-Mor-057157 Magnaporthe oryzae 25.77 2.00e-27 117.00
IUUC-Mpo-057518 Magnaporthe poae 23.70 3.00e-27 117.00
IUUC-Mtr-058125 Medicago truncatula 29.30 5.00e-46 179.00
IUUC-Mga-059906 Meleagris gallopavo 80.47 0.00e+00 751.00
IUUC-Mvi-060374 Microbotryum violaceum 31.71 2.00e-33 137.00
IUUC-Mmr-061786 Microcebus murinus 96.62 0.00e+00 924.00
IUUC-Mdo-062453 Monodelphis domestica 90.13 0.00e+00 832.00
IUUC-Mmu-063521 Mus musculus 90.71 0.00e+00 814.00
IUUC-Mac-065119 Musa acuminata 30.15 3.00e-40 159.00
IUUC-Mpu-066274 Mustela putorius furo 95.57 0.00e+00 917.00
IUUC-Mlu-067202 Myotis lucifugus 92.17 0.00e+00 844.00
IUUC-Nfi-068564 Neosartorya fischeri 24.84 2.00e-31 130.00
IUUC-Ncr-068823 Neurospora crassa 24.89 6.00e-31 129.00
IUUC-Nle-068987 Nomascus leucogenys 99.78 0.00e+00 922.00
IUUC-Opr-070453 Ochotona princeps 91.98 0.00e+00 877.00
IUUC-Ont-072611 Oreochromis niloticus 57.98 5.00e-159 554.00
IUUC-Oan-073738 Ornithorhynchus anatinus 82.39 0.00e+00 748.00
IUUC-Ocu-074396 Oryctolagus cuniculus 94.94 0.00e+00 907.00
IUUC-Oba-075472 Oryza barthii 31.87 6.00e-43 169.00
IUUC-Obr-076277 Oryza brachyantha 31.65 8.00e-45 175.00
IUUC-Ogl-077046 Oryza glaberrima 31.56 2.00e-41 164.00
IUUC-Ogu-078634 Oryza glumaepatula 31.87 4.00e-43 169.00
IUUC-Oin-080080 Oryza indica 29.35 8.00e-44 171.00
IUUC-Olo-080828 Oryza longistaminata 28.77 2.00e-41 165.00
IUUC-Ome-081387 Oryza meridionalis 29.35 1.00e-46 181.00
IUUC-Oni-082934 Oryza nivara 31.87 4.00e-43 169.00
IUUC-Opu-083719 Oryza punctata 28.57 2.00e-40 160.00
IUUC-Oru-084518 Oryza rufipogon 31.87 4.00e-43 169.00
IUUC-Ola-087312 Oryzias latipes 58.68 2.00e-155 542.00
IUUC-Olu-087661 Ostreococcus lucimarinus 28.76 6.00e-46 179.00
IUUC-Oga-089129 Otolemur garnettii 96.62 0.00e+00 920.00
IUUC-Oar-089839 Ovis aries 95.57 0.00e+00 919.00
IUUC-Ptr-091626 Pan troglodytes 99.78 0.00e+00 920.00
IUUC-Pan-092798 Papio anubis 99.13 0.00e+00 915.00
IUUC-Psi-093253 Pelodiscus sinensis 82.45 0.00e+00 788.00
IUUC-Pma-094512 Petromyzon marinus 55.17 1.00e-143 503.00
IUUC-Pno-094937 Phaeosphaeria nodorum 23.46 3.00e-29 123.00
IUUC-Ppa-095211 Physcomitrella patens 30.52 2.00e-53 203.00
IUUC-Pfo-097049 Poecilia formosa 53.39 1.00e-138 486.00
IUUC-Pab-097911 Pongo abelii 99.57 0.00e+00 919.00
IUUC-Pop-099841 Populus trichocarpa 30.62 4.00e-49 189.00
IUUC-Pca-100814 Procavia capensis 74.47 0.00e+00 660.00
IUUC-Ppe-101972 Prunus persica 29.69 5.00e-49 189.00
IUUC-Pva-103038 Pteropus vampyrus 95.36 0.00e+00 912.00
IUUC-Pgr-103277 Puccinia graminis 32.82 8.00e-39 154.00
IUUC-Ptt-103855 Puccinia triticina 30.48 8.00e-35 141.00
IUUC-Pte-104113 Pyrenophora teres 23.25 1.00e-25 111.00
IUUC-Pyt-104619 Pyrenophora triticirepentis 25.27 5.00e-27 115.00
IUUC-Rno-106003 Rattus norvegicus 91.13 0.00e+00 833.00
IUUC-Sce-106287 Saccharomyces cerevisiae 27.45 4.00e-23 102.00
IUUC-Sha-106652 Sarcophilus harrisii 89.80 0.00e+00 840.00
IUUC-Spo-108167 Schizosaccharomyces pombe 31.01 1.00e-50 193.00
IUUC-Ssl-108396 Sclerotinia sclerotiorum 24.55 7.00e-09 56.20
IUUC-Smo-109393 Selaginella moellendorffii 30.82 7.00e-48 185.00
IUUC-Sit-110529 Setaria italica 33.77 8.00e-42 165.00
IUUC-Sly-111829 Solanum lycopersicum 29.71 1.00e-52 201.00
IUUC-Stu-112811 Solanum tuberosum 29.93 4.00e-53 202.00
IUUC-Sar-113259 Sorex araneus 89.93 5.00e-138 484.00
IUUC-Sbi-114591 Sorghum bicolor 32.38 7.00e-35 142.00
IUUC-Sre-115227 Sporisorium reilianum 28.66 2.00e-37 150.00
IUUC-Ssc-115293 Sus scrofa 93.88 0.00e+00 902.00
IUUC-Tgu-117335 Taeniopygia guttata 82.32 0.00e+00 775.00
IUUC-Tru-118458 Takifugu rubripes 56.99 3.00e-154 538.00
IUUC-Tsy-119475 Tarsius syrichta 87.97 0.00e+00 813.00
IUUC-Tni-119827 Tetraodon nigroviridis 56.69 6.00e-153 533.00
IUUC-Tca-121023 Theobroma cacao 31.80 3.00e-50 193.00
IUUC-Tre-121965 Trichoderma reesei 24.03 2.00e-29 123.00
IUUC-Tvi-122564 Trichoderma virens 21.59 2.00e-26 114.00
IUUC-Tae-124793 Triticum aestivum 33.04 5.00e-39 155.00
IUUC-Tur-126258 Triticum urartu 30.88 1.00e-45 178.00
IUUC-Tbe-127227 Tupaia belangeri 72.45 4.00e-77 281.00
IUUC-Ttr-128984 Tursiops truncatus 73.42 0.00e+00 632.00
IUUC-Uma-129565 Ustilago maydis 27.69 4.00e-35 143.00
IUUC-Vpa-130301 Vicugna pacos 96.62 0.00e+00 925.00
IUUC-Vvi-131244 Vitis vinifera 30.79 5.00e-52 199.00
IUUC-Xtr-132880 Xenopus tropicalis 60.17 1.00e-165 576.00
IUUC-Xma-134055 Xiphophorus maculatus 58.61 1.00e-158 553.00
IUUC-Yli-134342 Yarrowia lipolytica 30.17 5.00e-45 175.00
IUUC-Zma-135021 Zea mays 32.58 4.00e-37 149.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved