iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134445

Ensembl Protein ID

CAG82928

UniProt Accession

Q6CF78; BRE1_YARLI

Genbank Protein ID

CAG82928.1

Protein Name

E3 ubiquitin-protein ligase BRE1; RING-type E3 ubiquitin transferase BRE1

Genbank Nucleotide ID

CR382128

Gene Name

BRE1; YALI0B09559g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_B09559g	CAG82928	CAG82928

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	33.10	1.00e-10	65.90	IUUC-Dme-032034
E3 activity/RING/RING	39.06	2.00e-11	68.90	IUUC-Hsa-046462
E3 activity/RING/RING	40.62	1.00e-11	68.90	IUUC-Rno-105165
E3 activity/RING/RING	28.17	1.00e-42	169.00	IUUC-Sce-106384
E3 activity/RING/RING	22.82	8.00e-22	100.00	IUUC-Spo-108304
E3 activity/RING/RING	37.74	5.00e-05	40.00	IUUC-Ots-000013
E3 activity/RING/RING	40.00	7.00e-07	46.20	IUUC-Ots-000012

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Yarrowia lipolytica

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.

Protein Sequence
(Fasta)

MEDKRNAESA SLGASSGGDS KRARVAARPV SLEDVAEFQK EAIFRAMETY RREKETLEKQ 60
LETQGEKERE LEERVVRLGT WWDKVADRLA LVVGKYEFEK SKVKTEDVKK EEDTERDAGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGACA AACGCAACGC TGAAAGCGCA AGTTTGGGCG CTTCTTCCGG CGGCGACAGC 60
AAGCGGGCCC GTGTTGCGGC TCGCCCGGTG TCGCTGGAAG ACGTGGCCGA GTTCCAGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR013956--E3_ubiquit_lig_BRE1
IPR013087--Znf_C2H2_type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF08647--BRE1

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0016567--P:protein ubiquitination

KEGG

yli:YALI0B09559g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000484	Aegilops tauschii	33.96	1.00e-07	48.10
IUUC-Aml-002295	Ailuropoda melanoleuca	26.76	2.00e-14	72.80
IUUC-Atr-002563	Amborella trichopoda	33.96	1.00e-07	48.10
IUUC-Apl-003407	Anas platyrhynchos	39.06	2.00e-13	69.30
IUUC-Aca-004850	Anolis carolinensis	25.56	4.00e-15	75.10
IUUC-Aly-006469	Arabidopsis lyrata	37.50	2.00e-11	62.80
IUUC-Ath-006615	Arabidopsis thaliana	37.50	2.00e-11	62.40
IUUC-Ago-007988	Ashbya gossypii	34.37	8.00e-44	169.00
IUUC-Acl-008319	Aspergillus clavatus	29.52	9.00e-69	252.00
IUUC-Afl-008679	Aspergillus flavus	28.49	1.00e-44	172.00
IUUC-Afu-008884	Aspergillus fumigatus	28.89	2.00e-42	165.00
IUUC-Ani-009487	Aspergillus nidulans	27.76	6.00e-38	150.00
IUUC-Ang-009601	Aspergillus niger	30.97	4.00e-71	260.00
IUUC-Aor-010142	Aspergillus oryzae	30.04	7.00e-69	253.00
IUUC-Ate-010547	Aspergillus terreus	29.93	1.00e-70	258.00
IUUC-Ame-011916	Astyanax mexicanus	25.81	1.00e-16	80.10
IUUC-Bgr-012245	Blumeria graminis	29.81	3.00e-63	234.00
IUUC-Bta-013173	Bos taurus	26.76	2.00e-14	72.80
IUUC-Bci-013926	Botrytis cinerea	29.76	1.00e-65	242.00
IUUC-Bdi-015006	Brachypodium distachyon	42.19	8.00e-14	70.50
IUUC-Bol-016588	Brassica oleracea	35.94	5.00e-11	61.20
IUUC-Bra-017335	Brassica rapa	35.94	5.00e-11	61.20
IUUC-Cel-018659	Caenorhabditis elegans	33.33	1.00e-09	56.60
IUUC-Cja-019042	Callithrix jacchus	25.35	1.00e-11	63.50
IUUC-Cfa-020318	Canis familiaris	26.76	2.00e-14	72.40
IUUC-Cpo-021617	Cavia porcellus	24.16	1.00e-13	70.50
IUUC-Cre-022940	Chlamydomonas reinhardtii	36.51	2.00e-06	45.40
IUUC-Csa-023509	Chlorocebus sabaeus	39.06	3.00e-13	68.90
IUUC-Cho-024616	Choloepus hoffmanni	39.06	7.00e-13	67.80
IUUC-Cin-025174	Ciona intestinalis	26.64	1.00e-17	84.00
IUUC-Csv-025830	Ciona savignyi	39.06	8.00e-12	64.30
IUUC-Cgl-026569	Colletotrichum gloeosporioides	52.17	7.00e-24	103.00
IUUC-Cne-026878	Cryptococcus neoformans	30.89	1.00e-24	106.00
IUUC-Cme-027134	Cyanidioschyzon merolae	32.26	5.00e-09	53.90
IUUC-Dre-028146	Danio rerio	25.81	2.00e-16	79.70
IUUC-Dno-028892	Dasypus novemcinctus	26.76	2.00e-14	72.80
IUUC-Dor-030250	Dipodomys ordii	39.06	3.00e-13	68.90
IUUC-Dse-031300	Dothistroma septosporum	28.57	9.00e-49	186.00
IUUC-Dme-032034	Drosophila melanogaster	40.62	3.00e-12	65.50
IUUC-Ete-033164	Echinops telfairi	40.62	1.00e-13	70.50
IUUC-Eca-033347	Equus caballus	39.06	3.00e-13	68.90
IUUC-Eeu-034801	Erinaceus europaeus	39.06	1.00e-12	66.60
IUUC-Fca-035720	Felis catus	26.76	2.00e-14	72.80
IUUC-Fal-037622	Ficedula albicollis	39.06	2.00e-13	69.30
IUUC-Fox-038017	Fusarium oxysporum	26.82	6.00e-53	200.00
IUUC-Fso-038414	Fusarium solani	30.15	4.00e-55	207.00
IUUC-Gmo-039446	Gadus morhua	27.19	3.00e-14	72.40
IUUC-Ggr-040117	Gaeumannomyces graminis	28.93	4.00e-48	184.00
IUUC-Gga-040412	Gallus gallus	39.06	2.00e-13	69.30
IUUC-Gac-042205	Gasterosteus aculeatus	38.46	9.00e-14	70.50
IUUC-Gma-042797	Glycine max	39.06	1.00e-12	67.00
IUUC-Ggo-044703	Gorilla gorilla	39.06	3.00e-13	68.90
IUUC-Hsa-046462	Homo sapiens	39.06	3.00e-13	68.90
IUUC-Hvu-047689	Hordeum vulgare	34.92	2.00e-10	59.70
IUUC-Itr-048724	Ictidomys tridecemlineatus	26.76	2.00e-14	72.80
IUUC-Kpa-049345	Komagataella pastoris	32.56	1.00e-38	152.00
IUUC-Lch-049429	Latimeria chalumnae	28.57	6.00e-14	70.90
IUUC-Lpe-051253	Leersia perrieri	34.92	4.00e-11	61.60
IUUC-Loc-052847	Lepisosteus oculatus	39.06	1.00e-12	65.50
IUUC-Lma-053312	Leptosphaeria maculans	28.70	5.00e-53	200.00
IUUC-Laf-054267	Loxodonta africana	26.76	2.00e-14	72.80
IUUC-Mcc-054647	Macaca mulatta	39.06	3.00e-13	68.90
IUUC-Meu-056559	Macropus eugenii	39.06	2.00e-13	69.30
IUUC-Mor-057068	Magnaporthe oryzae	27.81	5.00e-48	184.00
IUUC-Mpo-057568	Magnaporthe poae	28.79	1.00e-51	195.00
IUUC-Mtr-057632	Medicago truncatula	39.68	1.00e-11	63.50
IUUC-Mla-059072	Melampsora laricipopulina	24.35	3.00e-16	79.00
IUUC-Mga-059731	Meleagris gallopavo	39.06	1.00e-12	67.00
IUUC-Mvi-060341	Microbotryum violaceum	29.10	2.00e-18	85.90
IUUC-Mmr-061495	Microcebus murinus	24.16	1.00e-13	69.70
IUUC-Mdo-062415	Monodelphis domestica	26.29	2.00e-14	72.80
IUUC-Mmu-063981	Mus musculus	26.76	4.00e-14	72.00
IUUC-Mac-065103	Musa acuminata	39.68	3.00e-13	68.60
IUUC-Mpu-066498	Mustela putorius furo	26.76	3.00e-14	72.40
IUUC-Mlu-067242	Myotis lucifugus	26.76	2.00e-14	72.40
IUUC-Nfi-068269	Neosartorya fischeri	28.91	2.00e-43	168.00
IUUC-Ncr-068695	Neurospora crassa	29.49	1.00e-59	222.00
IUUC-Nle-069058	Nomascus leucogenys	39.06	3.00e-13	68.90
IUUC-Opr-071149	Ochotona princeps	39.06	3.00e-13	68.60
IUUC-Ont-072543	Oreochromis niloticus	37.88	2.00e-13	69.30
IUUC-Oan-072996	Ornithorhynchus anatinus	39.06	2.00e-13	68.90
IUUC-Ocu-073799	Oryctolagus cuniculus	26.76	3.00e-14	72.40
IUUC-Oba-075000	Oryza barthii	36.51	4.00e-12	64.70
IUUC-Obr-076532	Oryza brachyantha	36.51	6.00e-12	64.30
IUUC-Ogl-077200	Oryza glaberrima	36.51	5.00e-12	64.70
IUUC-Ogu-078279	Oryza glumaepatula	36.51	4.00e-12	64.70
IUUC-Oin-079097	Oryza indica	36.51	5.00e-12	64.70
IUUC-Olo-080612	Oryza longistaminata	42.37	2.00e-12	66.20
IUUC-Ome-081304	Oryza meridionalis	42.62	4.00e-13	68.20
IUUC-Oni-082162	Oryza nivara	36.51	5.00e-12	64.70
IUUC-Opu-083683	Oryza punctata	40.62	4.00e-13	68.20
IUUC-Oru-084382	Oryza rufipogon	36.51	5.00e-12	64.70
IUUC-Osa-085839	Oryza sativa	40.62	5.00e-13	68.20
IUUC-Ola-087287	Oryzias latipes	40.00	3.00e-14	72.40
IUUC-Olu-087683	Ostreococcus lucimarinus	30.00	2.00e-10	55.80
IUUC-Oga-088961	Otolemur garnettii	39.06	2.00e-13	69.30
IUUC-Oar-089589	Ovis aries	26.76	2.00e-14	72.40
IUUC-Ptr-091602	Pan troglodytes	39.06	3.00e-13	68.90
IUUC-Pan-092263	Papio anubis	39.06	3.00e-13	68.90
IUUC-Psi-093554	Pelodiscus sinensis	39.06	3.00e-13	68.90
IUUC-Pno-095079	Phaeosphaeria nodorum	27.90	4.00e-50	191.00
IUUC-Ppa-095735	Physcomitrella patens	40.62	3.00e-14	72.00
IUUC-Pfo-097527	Poecilia formosa	40.00	2.00e-14	73.20
IUUC-Pab-098598	Pongo abelii	39.06	3.00e-13	68.90
IUUC-Pop-100039	Populus trichocarpa	38.75	7.00e-14	70.90
IUUC-Pca-100544	Procavia capensis	26.76	3.00e-14	72.40
IUUC-Ppe-102065	Prunus persica	36.51	2.00e-11	62.80
IUUC-Pva-102479	Pteropus vampyrus	26.76	2.00e-14	72.80
IUUC-Pgr-103536	Puccinia graminis	26.14	5.00e-19	87.80
IUUC-Ptt-104014	Puccinia triticina	22.54	2.00e-06	45.80
IUUC-Pte-104415	Pyrenophora teres	29.08	4.00e-57	214.00
IUUC-Pyt-104762	Pyrenophora triticirepentis	28.91	1.00e-55	209.00
IUUC-Rno-105165	Rattus norvegicus	26.76	3.00e-14	72.00
IUUC-Sce-106384	Saccharomyces cerevisiae	28.53	5.00e-47	180.00
IUUC-Sha-107602	Sarcophilus harrisii	26.29	1.00e-14	73.60
IUUC-Sja-108010	Schizosaccharomyces japonicus	26.86	3.00e-25	108.00
IUUC-Spo-108304	Schizosaccharomyces pombe	25.69	1.00e-21	95.90
IUUC-Ssl-108546	Sclerotinia sclerotiorum	30.89	2.00e-66	244.00
IUUC-Smo-109550	Selaginella moellendorffii	37.50	5.00e-12	64.70
IUUC-Sit-110382	Setaria italica	34.92	2.00e-11	63.20
IUUC-Sly-111490	Solanum lycopersicum	38.33	1.00e-10	60.10
IUUC-Sar-113349	Sorex araneus	39.06	4.00e-13	68.60
IUUC-Sbi-114734	Sorghum bicolor	34.92	1.00e-10	57.40
IUUC-Sre-115087	Sporisorium reilianum	25.38	2.00e-17	82.40
IUUC-Ssc-116134	Sus scrofa	40.62	2.00e-13	69.30
IUUC-Tgu-116549	Taeniopygia guttata	39.06	3.00e-13	68.90
IUUC-Tru-118776	Takifugu rubripes	40.00	4.00e-14	71.60
IUUC-Tsy-118808	Tarsius syrichta	39.06	3.00e-13	68.60
IUUC-Tni-120790	Tetraodon nigroviridis	40.00	5.00e-14	71.60
IUUC-Tca-121060	Theobroma cacao	36.51	9.00e-11	60.50
IUUC-Tre-122150	Trichoderma reesei	27.79	4.00e-54	204.00
IUUC-Tvi-122431	Trichoderma virens	27.75	3.00e-59	221.00
IUUC-Tae-123217	Triticum aestivum	37.18	2.00e-13	68.90
IUUC-Tur-126160	Triticum urartu	44.07	1.00e-13	70.10
IUUC-Tme-127177	Tuber melanosporum	28.84	6.00e-66	243.00
IUUC-Tbe-127597	Tupaia belangeri	26.76	8.00e-14	70.90
IUUC-Ttr-128303	Tursiops truncatus	40.62	2.00e-13	69.70
IUUC-Uma-129488	Ustilago maydis	23.73	3.00e-23	101.00
IUUC-Vda-129815	Verticillium dahliae	30.61	8.00e-50	189.00
IUUC-Vpa-130237	Vicugna pacos	39.06	2.00e-13	69.30
IUUC-Vvi-131316	Vitis vinifera	38.10	1.00e-11	63.50
IUUC-Xtr-132589	Xenopus tropicalis	39.06	5.00e-13	67.80
IUUC-Xma-133365	Xiphophorus maculatus	40.00	2.00e-14	73.20
IUUC-Zma-135598	Zea mays	23.53	5.00e-12	64.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence