iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059739

UUCD1 version

UUC-MeG-00839

Ensembl Protein ID

ENSMGAP00000007610.2

UniProt Accession

G1N6C3; G1N6C3_MELGA

Protein Name

Uncharacterized protein

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000007448.2	ENSMGAT00000008389.2	ENSMGAP00000007610.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.50e-110	367.0	774	1104

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l+e++++  ++ ++n++n  ++kge+++++  ++++lw+++ k++sp++++ +++k++ +f g
   Q: 774  TGLRNLGNTCYMNSILQCLCNAPHLAEYFNRnLYHDDINRSNFLGHKGEVAEEFGVIMKALWTGQYKYISPKDFKITIGKINDQFAG 860
           7*****************************9999***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+qqD+qE+l fl+d+l+e+l+k +n ++ +ee++d  +l+d      a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e 
   Q: 861  YSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENND--HLDDLraaelAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEA 945
           *********************885555544444444..5555556677*************************************** PP
   S: 169  fldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvef 255
           f++lslp+ + +++   +lq+cL+ f+kee+l+++n++yc++ck ++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+f
   Q: 946  FMYLSLPLASTSKC---TLQECLRLFSKEEKLTDNNRFYCSHCKTRRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDF 1027
           *************9...******************************************************996.55.6******** PP
   S: 256  ple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           ple Ldls++++ p+++    k+Y+L++v +H+G+l++GHY+ay+kn +++ W++fdD++V+e++ ++v++   s aY+lfY+
   Q: 1028 PLEtLDLSQYVIGPKNN---LKRYNLFSVSNHYGGLDGGHYTAYCKNASKQrWFKFDDHEVSEISASSVKS---SAAYILFYT 1104
           *************9988...69*************************88778*******************...********8 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MPAVASVPKE LYLCTSLKDL NKKTEIKPEK TSTKSYVQSA LKIFKAAEES RLDRDEEKAY 60
ILYMKYVAVY NFIKKRPDFK QQQDYFHSIL GPTNIKKAIE EAERLSDSLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAGGGAGA TAAATAACTA CATTAACATG CCTGCTGTGG CATCTGTACC TAAGGAGCTG 60
TATCTTTGTA CTTCATTGAA AGATCTCAAC AAGAAGACGG AAATAAAACC TGAAAAGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	82.96	0.00e+00	934.00
IUUC-Apl-003226	Anas platyrhynchos	86.47	0.00e+00	999.00
IUUC-Aca-004936	Anolis carolinensis	68.92	0.00e+00	1326.00
IUUC-Ago-007959	Ashbya gossypii	35.89	3.00e-55	209.00
IUUC-Acl-008102	Aspergillus clavatus	31.04	4.00e-52	199.00
IUUC-Afl-008604	Aspergillus flavus	31.16	2.00e-50	193.00
IUUC-Ani-009291	Aspergillus nidulans	30.22	2.00e-51	197.00
IUUC-Aor-010098	Aspergillus oryzae	31.16	9.00e-50	191.00
IUUC-Ame-010960	Astyanax mexicanus	78.33	2.00e-86	310.00
IUUC-Bta-013008	Bos taurus	81.27	0.00e+00	898.00
IUUC-Bra-017228	Brassica rapa	39.70	2.00e-50	192.00
IUUC-Cel-018482	Caenorhabditis elegans	34.40	1.00e-53	204.00
IUUC-Cja-019173	Callithrix jacchus	82.96	0.00e+00	937.00
IUUC-Cfa-021243	Canis familiaris	82.96	0.00e+00	933.00
IUUC-Cpo-021522	Cavia porcellus	71.57	0.00e+00	1438.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.35	7.00e-82	296.00
IUUC-Csa-023616	Chlorocebus sabaeus	82.61	0.00e+00	930.00
IUUC-Cho-024381	Choloepus hoffmanni	71.24	0.00e+00	751.00
IUUC-Cin-025287	Ciona intestinalis	50.38	1.00e-98	353.00
IUUC-Csv-026253	Ciona savignyi	49.62	2.00e-88	320.00
IUUC-Cne-026821	Cryptococcus neoformans	40.72	2.00e-75	277.00
IUUC-Dre-028440	Danio rerio	67.11	0.00e+00	730.00
IUUC-Dno-029039	Dasypus novemcinctus	72.50	0.00e+00	1516.00
IUUC-Dor-031043	Dipodomys ordii	90.95	1.00e-127	450.00
IUUC-Dme-032089	Drosophila melanogaster	46.52	8.00e-85	308.00
IUUC-Ete-033040	Echinops telfairi	66.70	0.00e+00	1289.00
IUUC-Eca-033449	Equus caballus	82.43	0.00e+00	942.00
IUUC-Eeu-034693	Erinaceus europaeus	90.95	3.00e-123	436.00
IUUC-Fca-035794	Felis catus	90.95	0.00e+00	858.00
IUUC-Fal-037322	Ficedula albicollis	85.07	0.00e+00	1754.00
IUUC-Gmo-038584	Gadus morhua	63.44	0.00e+00	671.00
IUUC-Gga-041188	Gallus gallus	96.80	0.00e+00	1080.00
IUUC-Gac-041850	Gasterosteus aculeatus	74.95	0.00e+00	735.00
IUUC-Ggo-045565	Gorilla gorilla	82.96	0.00e+00	937.00
IUUC-Hsa-046438	Homo sapiens	82.96	0.00e+00	937.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	73.11	0.00e+00	1464.00
IUUC-Kpa-049321	Komagataella pastoris	33.70	1.00e-49	191.00
IUUC-Lch-050485	Latimeria chalumnae	85.28	0.00e+00	849.00
IUUC-Loc-052769	Lepisosteus oculatus	73.90	0.00e+00	777.00
IUUC-Laf-053432	Loxodonta africana	89.16	0.00e+00	886.00
IUUC-Mcc-055823	Macaca mulatta	82.78	0.00e+00	936.00
IUUC-Meu-056099	Macropus eugenii	94.80	1.00e-160	560.00
IUUC-Mla-059089	Melampsora laricipopulina	39.89	2.00e-72	267.00
IUUC-Mvi-060559	Microbotryum violaceum	41.30	2.00e-78	286.00
IUUC-Mmr-061158	Microcebus murinus	81.71	0.00e+00	915.00
IUUC-Mdo-061801	Monodelphis domestica	85.12	0.00e+00	932.00
IUUC-Mmu-063665	Mus musculus	69.18	0.00e+00	1406.00
IUUC-Mpu-066738	Mustela putorius furo	83.13	0.00e+00	935.00
IUUC-Mlu-067307	Myotis lucifugus	81.46	0.00e+00	938.00
IUUC-Nfi-068410	Neosartorya fischeri	31.11	9.00e-52	198.00
IUUC-Nle-069314	Nomascus leucogenys	82.61	0.00e+00	934.00
IUUC-Opr-070378	Ochotona princeps	61.20	0.00e+00	904.00
IUUC-Ont-071545	Oreochromis niloticus	76.22	0.00e+00	758.00
IUUC-Oan-073537	Ornithorhynchus anatinus	71.97	0.00e+00	1445.00
IUUC-Ocu-074193	Oryctolagus cuniculus	72.46	0.00e+00	1479.00
IUUC-Ola-086622	Oryzias latipes	75.76	0.00e+00	739.00
IUUC-Oga-088271	Otolemur garnettii	81.01	0.00e+00	922.00
IUUC-Oar-090431	Ovis aries	81.45	0.00e+00	902.00
IUUC-Ptr-091339	Pan troglodytes	73.23	0.00e+00	1544.00
IUUC-Pan-091783	Papio anubis	65.90	3.00e-179	621.00
IUUC-Psi-093187	Pelodiscus sinensis	71.37	2.00e-175	608.00
IUUC-Pma-094626	Petromyzon marinus	57.01	2.00e-142	498.00
IUUC-Pfo-096463	Poecilia formosa	75.61	0.00e+00	756.00
IUUC-Pab-097645	Pongo abelii	82.96	0.00e+00	937.00
IUUC-Pva-103222	Pteropus vampyrus	89.01	0.00e+00	707.00
IUUC-Pgr-103408	Puccinia graminis	36.59	9.00e-55	208.00
IUUC-Ptt-103699	Puccinia triticina	46.15	4.00e-67	249.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	30.49	1.00e-52	201.00
IUUC-Rno-105510	Rattus norvegicus	69.10	0.00e+00	1436.00
IUUC-Sce-106166	Saccharomyces cerevisiae	35.54	3.00e-51	196.00
IUUC-Sha-106879	Sarcophilus harrisii	84.81	0.00e+00	934.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.29	6.00e-50	191.00
IUUC-Sar-113019	Sorex araneus	68.57	0.00e+00	1406.00
IUUC-Sre-115031	Sporisorium reilianum	36.98	1.00e-69	258.00
IUUC-Ssc-116334	Sus scrofa	72.44	0.00e+00	1465.00
IUUC-Tgu-117062	Taeniopygia guttata	89.90	0.00e+00	1024.00
IUUC-Tru-117908	Takifugu rubripes	75.82	0.00e+00	747.00
IUUC-Tsy-118867	Tarsius syrichta	75.48	0.00e+00	821.00
IUUC-Tni-120206	Tetraodon nigroviridis	74.40	0.00e+00	729.00
IUUC-Tme-127144	Tuber melanosporum	40.00	2.00e-79	290.00
IUUC-Tbe-127877	Tupaia belangeri	91.50	5.00e-78	285.00
IUUC-Ttr-128580	Tursiops truncatus	81.91	0.00e+00	917.00
IUUC-Uma-129340	Ustilago maydis	37.85	1.00e-72	268.00
IUUC-Vpa-130541	Vicugna pacos	80.24	0.00e+00	900.00
IUUC-Xtr-132161	Xenopus tropicalis	77.15	0.00e+00	793.00
IUUC-Xma-134271	Xiphophorus maculatus	75.00	0.00e+00	750.00
IUUC-Yli-134561	Yarrowia lipolytica	36.63	4.00e-61	229.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence