iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067307

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02011657

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000000389.2	ENSMLUT00000000394.2	ENSMLUP00000000359.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-108	362.6	768	1098

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n + l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 768  TGLRNLGNTCYMNSILQCLCNATHLADYFNRnCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAG 854
           7*****************************9899***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++++ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 855  YSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHRKSRTFEAFM 941
           *********************9855555555444411145566667***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c++++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 942  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 1023
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v++   s aY+lfY+
   Q: 1024 EnLDLSQYVIGPKNS---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVKS---SAAYILFYT 1098
           ***********9987...69*************************88888*******************...********8 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MPSVASDPKE LYLSSSLKDL NKKTEVKPEK ISTKNYVQSA QKIFKTAEES RLDRDEERAY 60
VLYMKFVTVY NLIKNRPDFK QQQDYVHSML GPANIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTTCCG TGGCTTCAGA TCCTAAAGAA CTCTACCTCA GTTCTTCACT AAAAGACCTC 60
AATAAGAAGA CAGAAGTTAA ACCAGAGAAA ATAAGCACTA AGAAGTATGT ATCCATTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	90.20	0.00e+00	1853.00
IUUC-Apl-003226	Anas platyrhynchos	67.08	0.00e+00	1424.00
IUUC-Aca-004936	Anolis carolinensis	64.38	0.00e+00	1272.00
IUUC-Ago-007959	Ashbya gossypii	35.62	2.00e-54	207.00
IUUC-Acl-008102	Aspergillus clavatus	31.59	2.00e-51	197.00
IUUC-Afl-008604	Aspergillus flavus	31.75	2.00e-50	193.00
IUUC-Afu-009001	Aspergillus fumigatus	31.67	1.00e-50	195.00
IUUC-Ani-009291	Aspergillus nidulans	31.45	1.00e-50	194.00
IUUC-Ang-009844	Aspergillus niger	32.73	1.00e-49	191.00
IUUC-Aor-010098	Aspergillus oryzae	30.71	1.00e-49	191.00
IUUC-Ate-010585	Aspergillus terreus	31.94	8.00e-50	192.00
IUUC-Ame-010960	Astyanax mexicanus	77.22	2.00e-85	307.00
IUUC-Bta-013008	Bos taurus	86.68	0.00e+00	1777.00
IUUC-Bol-015281	Brassica oleracea	37.91	8.00e-46	177.00
IUUC-Bra-017228	Brassica rapa	38.81	1.00e-47	184.00
IUUC-Cel-018482	Caenorhabditis elegans	33.53	1.00e-50	194.00
IUUC-Cja-019173	Callithrix jacchus	87.50	0.00e+00	1819.00
IUUC-Cfa-021243	Canis familiaris	90.72	0.00e+00	1867.00
IUUC-Cpo-021522	Cavia porcellus	82.66	0.00e+00	1682.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.35	2.00e-82	299.00
IUUC-Csa-023616	Chlorocebus sabaeus	89.37	0.00e+00	1564.00
IUUC-Cho-024381	Choloepus hoffmanni	75.16	0.00e+00	1513.00
IUUC-Cin-025287	Ciona intestinalis	49.87	3.00e-99	356.00
IUUC-Csv-026253	Ciona savignyi	47.55	8.00e-88	318.00
IUUC-Cne-026821	Cryptococcus neoformans	39.89	1.00e-74	275.00
IUUC-Dre-028440	Danio rerio	70.61	0.00e+00	738.00
IUUC-Dno-029039	Dasypus novemcinctus	88.12	0.00e+00	1864.00
IUUC-Dor-031043	Dipodomys ordii	96.55	8.00e-134	471.00
IUUC-Dse-031463	Dothistroma septosporum	28.86	1.00e-42	168.00
IUUC-Dme-032089	Drosophila melanogaster	44.91	2.00e-83	303.00
IUUC-Ete-033040	Echinops telfairi	78.26	0.00e+00	1490.00
IUUC-Eca-033449	Equus caballus	90.36	0.00e+00	1855.00
IUUC-Eeu-034693	Erinaceus europaeus	96.55	5.00e-132	465.00
IUUC-Fca-035794	Felis catus	97.68	0.00e+00	924.00
IUUC-Fal-037322	Ficedula albicollis	68.37	0.00e+00	1424.00
IUUC-Gmo-038584	Gadus morhua	66.87	0.00e+00	660.00
IUUC-Gga-041188	Gallus gallus	81.50	0.00e+00	916.00
IUUC-Gac-041850	Gasterosteus aculeatus	72.18	0.00e+00	736.00
IUUC-Ggo-045565	Gorilla gorilla	88.48	0.00e+00	1850.00
IUUC-Hsa-046438	Homo sapiens	88.39	0.00e+00	1848.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	86.25	0.00e+00	1768.00
IUUC-Kpa-049321	Komagataella pastoris	32.97	2.00e-48	187.00
IUUC-Lch-050485	Latimeria chalumnae	84.51	0.00e+00	867.00
IUUC-Loc-052769	Lepisosteus oculatus	73.54	0.00e+00	780.00
IUUC-Lma-053021	Leptosphaeria maculans	32.75	2.00e-53	204.00
IUUC-Laf-053432	Loxodonta africana	81.57	0.00e+00	1010.00
IUUC-Mcc-055823	Macaca mulatta	88.12	0.00e+00	1842.00
IUUC-Meu-056099	Macropus eugenii	97.40	1.00e-164	573.00
IUUC-Mla-059089	Melampsora laricipopulina	40.18	3.00e-72	267.00
IUUC-Mga-059739	Meleagris gallopavo	81.68	0.00e+00	914.00
IUUC-Mvi-060559	Microbotryum violaceum	40.54	1.00e-76	281.00
IUUC-Mmr-061158	Microcebus murinus	87.32	0.00e+00	1782.00
IUUC-Mdo-061801	Monodelphis domestica	89.68	0.00e+00	1004.00
IUUC-Mmu-063665	Mus musculus	78.75	0.00e+00	1641.00
IUUC-Mpu-066738	Mustela putorius furo	90.09	0.00e+00	1831.00
IUUC-Nfi-068410	Neosartorya fischeri	31.67	6.00e-51	196.00
IUUC-Nle-069314	Nomascus leucogenys	88.39	0.00e+00	1842.00
IUUC-Opr-070378	Ochotona princeps	76.46	0.00e+00	1145.00
IUUC-Ont-071545	Oreochromis niloticus	76.83	0.00e+00	765.00
IUUC-Oan-073537	Ornithorhynchus anatinus	74.91	0.00e+00	1506.00
IUUC-Ocu-074193	Oryctolagus cuniculus	85.52	0.00e+00	1781.00
IUUC-Ola-086622	Oryzias latipes	57.50	0.00e+00	1088.00
IUUC-Oga-088271	Otolemur garnettii	85.34	0.00e+00	1740.00
IUUC-Oar-090431	Ovis aries	86.81	0.00e+00	1786.00
IUUC-Ptr-091339	Pan troglodytes	88.04	0.00e+00	1892.00
IUUC-Pan-091783	Papio anubis	81.61	0.00e+00	922.00
IUUC-Psi-093187	Pelodiscus sinensis	62.61	4.00e-151	528.00
IUUC-Pma-094626	Petromyzon marinus	57.34	1.00e-142	499.00
IUUC-Pno-094986	Phaeosphaeria nodorum	29.91	4.00e-37	150.00
IUUC-Pfo-096463	Poecilia formosa	75.41	0.00e+00	751.00
IUUC-Pab-097645	Pongo abelii	88.21	0.00e+00	1845.00
IUUC-Pva-103222	Pteropus vampyrus	81.75	0.00e+00	909.00
IUUC-Pgr-103408	Puccinia graminis	35.66	4.00e-54	207.00
IUUC-Ptt-103699	Puccinia triticina	45.80	3.00e-68	254.00
IUUC-Pte-104348	Pyrenophora teres	28.83	3.00e-39	157.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.11	5.00e-51	196.00
IUUC-Rno-105510	Rattus norvegicus	78.75	0.00e+00	1663.00
IUUC-Sce-106166	Saccharomyces cerevisiae	34.44	4.00e-51	196.00
IUUC-Sha-106879	Sarcophilus harrisii	87.52	0.00e+00	985.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.86	5.00e-49	188.00
IUUC-Sar-113019	Sorex araneus	83.21	0.00e+00	1741.00
IUUC-Sre-115031	Sporisorium reilianum	37.05	4.00e-69	256.00
IUUC-Ssc-116334	Sus scrofa	86.35	0.00e+00	1804.00
IUUC-Tgu-117062	Taeniopygia guttata	79.55	0.00e+00	905.00
IUUC-Tru-117908	Takifugu rubripes	59.03	0.00e+00	1174.00
IUUC-Tsy-118867	Tarsius syrichta	86.13	0.00e+00	1072.00
IUUC-Tni-120206	Tetraodon nigroviridis	54.81	0.00e+00	1064.00
IUUC-Tme-127144	Tuber melanosporum	40.56	2.00e-79	291.00
IUUC-Tbe-127877	Tupaia belangeri	84.36	6.00e-99	355.00
IUUC-Ttr-128580	Tursiops truncatus	91.46	0.00e+00	1179.00
IUUC-Uma-129340	Ustilago maydis	35.75	4.00e-71	263.00
IUUC-Vpa-130541	Vicugna pacos	88.74	0.00e+00	1839.00
IUUC-Xtr-132161	Xenopus tropicalis	59.77	0.00e+00	1216.00
IUUC-Xma-134271	Xiphophorus maculatus	75.20	0.00e+00	747.00
IUUC-Yli-134561	Yarrowia lipolytica	35.66	1.00e-59	225.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence