iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088776

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03177819

Gene Name

UBE3C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000000964.2	ENSOGAT00000000966.2	ENSOGAP00000000864.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.90e-104	348.7	736	1073

Active Site

Position(s)	Description	Evidence
1041	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ + +    ++++flGr+lgkal++
   Q: 736  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGD-SFARHYYFLGRMLGKALYE 821
           689**********99**9************************************9999999999965.999**************** PP
   S: 85   grlldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           + l++lp++ +f+++llg+  ++++++l+++dpe+yk+l ++k++ e+d+eelgl++t+   ++ lge++++eLk gG++ipVt +N
   Q: 822  NMLVELPFAGFFLSKLLGTsaDVDIHHLASLDPEVYKNLLFLKSY-EDDVEELGLNFTV--VNNDLGEAQVVELKFGGKDIPVTSAN 905
           ******************9666889********************.6788887666665..5889********************** PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevlee 255
           + +Y++lv++yrl+++i+ ++ afr+G+ +v++le+l++F+++e+++li+G    i++edlk++t+y ggy++d+p+i+ Fw+v+e+
   Q: 906  RIAYIHLVADYRLNKQIRPHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAqVPISLEDLKSFTNYSGGYSADHPVIKIFWRVVEG 992
           ****************************************************899******************************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           f++ee++++L+FvT++sr Pl Gf++l p  f+i++ +sd +rlP+++TC+n+LkLPe+  +  l++kLlyAie ++gFels
   Q: 993  FTDEEKRKLLKFVTSCSRPPLLGFKQLYPA-FCIHNGGSDlERLPTASTCMNLLKLPEFYDEVLLRSKLLYAIECAAGFELS 1073
           ****************************88.*****99999**************************************985 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAV IIQSFIRGYR 60
DRKQQYSVQR SAFDRCARLA QSGGSFPIAN GPNLTLLVRQ LLFFYKQDED SKRLIWLYQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTCAGCT TTGAAGGGGA CTTCAAGACG CGGCCCAAGG TGTCCCTCGG CGGCGCGAGT 60
CGGAAGGTGA GCTCCGCCCG TGCGCTCGGG GCCTCCCGAG GTGGCGGCCG GCGGCCTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	87.33	0.00e+00	1800.00
IUUC-Apl-003731	Anas platyrhynchos	85.24	0.00e+00	1806.00
IUUC-Aca-005248	Anolis carolinensis	84.40	0.00e+00	1783.00
IUUC-Aly-005768	Arabidopsis lyrata	35.18	2.00e-107	384.00
IUUC-Ath-006576	Arabidopsis thaliana	35.02	6.00e-107	382.00
IUUC-Ago-007748	Ashbya gossypii	41.67	1.00e-76	281.00
IUUC-Acl-008158	Aspergillus clavatus	38.17	3.00e-76	280.00
IUUC-Afl-008398	Aspergillus flavus	33.85	1.00e-77	285.00
IUUC-Afu-008937	Aspergillus fumigatus	38.64	2.00e-78	288.00
IUUC-Ani-009252	Aspergillus nidulans	37.95	6.00e-80	292.00
IUUC-Ang-009773	Aspergillus niger	33.85	4.00e-78	286.00
IUUC-Aor-009940	Aspergillus oryzae	33.85	1.00e-77	285.00
IUUC-Ate-010395	Aspergillus terreus	38.81	2.00e-76	281.00
IUUC-Ame-010769	Astyanax mexicanus	59.98	0.00e+00	968.00
IUUC-Bgr-012269	Blumeria graminis	38.26	1.00e-74	273.00
IUUC-Bta-012841	Bos taurus	88.02	0.00e+00	1831.00
IUUC-Bci-013743	Botrytis cinerea	30.93	4.00e-84	306.00
IUUC-Bdi-014123	Brachypodium distachyon	46.32	6.00e-101	362.00
IUUC-Bol-015390	Brassica oleracea	34.36	1.00e-99	357.00
IUUC-Bra-016853	Brassica rapa	35.12	2.00e-106	380.00
IUUC-Cel-018638	Caenorhabditis elegans	39.37	1.00e-89	324.00
IUUC-Cja-019743	Callithrix jacchus	88.57	0.00e+00	1806.00
IUUC-Cfa-021031	Canis familiaris	88.97	0.00e+00	1877.00
IUUC-Cpo-022401	Cavia porcellus	87.90	0.00e+00	1847.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	44.25	3.00e-85	308.00
IUUC-Csa-024107	Chlorocebus sabaeus	90.86	0.00e+00	1878.00
IUUC-Cho-024750	Choloepus hoffmanni	83.12	0.00e+00	804.00
IUUC-Cin-025432	Ciona intestinalis	45.12	3.00e-97	348.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	34.26	2.00e-87	318.00
IUUC-Cne-026841	Cryptococcus neoformans	36.62	2.00e-94	340.00
IUUC-Cme-027265	Cyanidioschyzon merolae	46.62	7.00e-103	368.00
IUUC-Dre-028196	Danio rerio	75.16	0.00e+00	1526.00
IUUC-Dno-029024	Dasypus novemcinctus	89.39	0.00e+00	1865.00
IUUC-Dor-030483	Dipodomys ordii	92.43	0.00e+00	694.00
IUUC-Dse-031416	Dothistroma septosporum	33.91	6.00e-79	289.00
IUUC-Dme-031946	Drosophila melanogaster	47.92	2.00e-175	609.00
IUUC-Ete-032240	Echinops telfairi	83.86	7.00e-174	604.00
IUUC-Eca-033828	Equus caballus	89.08	0.00e+00	1837.00
IUUC-Eeu-034604	Erinaceus europaeus	85.38	5.00e-127	448.00
IUUC-Fca-035907	Felis catus	87.36	0.00e+00	1861.00
IUUC-Fal-037389	Ficedula albicollis	85.89	0.00e+00	1816.00
IUUC-Fox-037788	Fusarium oxysporum	37.61	7.00e-93	335.00
IUUC-Fso-038088	Fusarium solani	36.20	4.00e-89	323.00
IUUC-Gmo-039254	Gadus morhua	62.81	0.00e+00	1134.00
IUUC-Ggr-039941	Gaeumannomyces graminis	34.32	1.00e-83	305.00
IUUC-Gga-040310	Gallus gallus	85.52	0.00e+00	1810.00
IUUC-Gac-042054	Gasterosteus aculeatus	66.70	0.00e+00	1200.00
IUUC-Gma-042836	Glycine max	35.93	2.00e-102	367.00
IUUC-Ggo-045031	Gorilla gorilla	91.23	0.00e+00	1885.00
IUUC-Hsa-045880	Homo sapiens	91.14	0.00e+00	1883.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	76.54	3.00e-162	564.00
IUUC-Kpa-049307	Komagataella pastoris	36.75	7.00e-65	242.00
IUUC-Lch-050403	Latimeria chalumnae	78.36	0.00e+00	1583.00
IUUC-Lpe-051428	Leersia perrieri	46.15	7.00e-95	342.00
IUUC-Loc-052218	Lepisosteus oculatus	77.79	0.00e+00	1610.00
IUUC-Lma-053096	Leptosphaeria maculans	38.58	6.00e-80	293.00
IUUC-Laf-054162	Loxodonta africana	85.52	0.00e+00	1565.00
IUUC-Mcc-055127	Macaca mulatta	90.86	0.00e+00	1878.00
IUUC-Meu-056187	Macropus eugenii	82.61	3.00e-105	376.00
IUUC-Mor-057021	Magnaporthe oryzae	35.02	5.00e-80	293.00
IUUC-Mpo-057570	Magnaporthe poae	36.68	2.00e-76	280.00
IUUC-Mtr-058154	Medicago truncatula	34.76	2.00e-105	377.00
IUUC-Mla-059124	Melampsora laricipopulina	47.78	1.00e-100	360.00
IUUC-Mga-059581	Meleagris gallopavo	85.53	0.00e+00	1796.00
IUUC-Mvi-060445	Microbotryum violaceum	37.87	2.00e-103	370.00
IUUC-Mmr-061360	Microcebus murinus	88.17	0.00e+00	1762.00
IUUC-Mdo-062194	Monodelphis domestica	83.16	0.00e+00	1811.00
IUUC-Mmu-064189	Mus musculus	88.09	0.00e+00	1865.00
IUUC-Mac-065275	Musa acuminata	49.14	5.00e-108	385.00
IUUC-Mpu-066439	Mustela putorius furo	87.27	0.00e+00	1782.00
IUUC-Mlu-068228	Myotis lucifugus	85.21	0.00e+00	1784.00
IUUC-Nfi-068280	Neosartorya fischeri	38.64	7.00e-79	289.00
IUUC-Ncr-068869	Neurospora crassa	36.14	9.00e-83	301.00
IUUC-Nle-069687	Nomascus leucogenys	90.86	0.00e+00	1831.00
IUUC-Opr-070592	Ochotona princeps	98.00	1.00e-115	410.00
IUUC-Ont-071836	Oreochromis niloticus	86.18	0.00e+00	1239.00
IUUC-Oan-072800	Ornithorhynchus anatinus	86.16	0.00e+00	1815.00
IUUC-Ocu-074587	Oryctolagus cuniculus	91.32	0.00e+00	1909.00
IUUC-Ola-087209	Oryzias latipes	86.12	0.00e+00	1238.00
IUUC-Olu-087699	Ostreococcus lucimarinus	42.59	1.00e-85	310.00
IUUC-Oar-089441	Ovis aries	87.29	0.00e+00	1812.00
IUUC-Ptr-091273	Pan troglodytes	91.04	0.00e+00	1882.00
IUUC-Pan-091981	Papio anubis	91.04	0.00e+00	1880.00
IUUC-Psi-093203	Pelodiscus sinensis	83.92	0.00e+00	1551.00
IUUC-Pma-094738	Petromyzon marinus	63.65	0.00e+00	1256.00
IUUC-Pno-095132	Phaeosphaeria nodorum	29.38	1.00e-59	225.00
IUUC-Ppa-095682	Physcomitrella patens	35.61	9.00e-111	394.00
IUUC-Pfo-097511	Poecilia formosa	75.16	0.00e+00	1563.00
IUUC-Pab-098634	Pongo abelii	88.01	0.00e+00	1801.00
IUUC-Pop-099574	Populus trichocarpa	41.86	7.00e-94	338.00
IUUC-Pca-100987	Procavia capensis	98.69	0.00e+00	791.00
IUUC-Ppe-102040	Prunus persica	34.98	2.00e-95	343.00
IUUC-Pva-103034	Pteropus vampyrus	84.65	0.00e+00	1724.00
IUUC-Pgr-103513	Puccinia graminis	39.52	2.00e-106	380.00
IUUC-Ptt-103967	Puccinia triticina	37.16	1.00e-93	338.00
IUUC-Pte-104105	Pyrenophora teres	34.55	2.00e-81	297.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	37.72	4.00e-78	286.00
IUUC-Rno-105380	Rattus norvegicus	87.01	0.00e+00	1614.00
IUUC-Sce-106446	Saccharomyces cerevisiae	40.77	1.00e-67	251.00
IUUC-Sha-107108	Sarcophilus harrisii	79.93	0.00e+00	1662.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	42.49	7.00e-94	338.00
IUUC-Spo-108097	Schizosaccharomyces pombe	44.12	3.00e-93	336.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	30.66	2.00e-82	301.00
IUUC-Sit-110457	Setaria italica	48.28	7.00e-98	352.00
IUUC-Sar-113687	Sorex araneus	81.44	0.00e+00	911.00
IUUC-Sre-115038	Sporisorium reilianum	44.96	5.00e-98	352.00
IUUC-Ssc-115378	Sus scrofa	95.49	0.00e+00	751.00
IUUC-Tgu-116729	Taeniopygia guttata	85.81	0.00e+00	1809.00
IUUC-Tru-118068	Takifugu rubripes	85.15	0.00e+00	1212.00
IUUC-Tsy-118942	Tarsius syrichta	95.64	0.00e+00	721.00
IUUC-Tni-120732	Tetraodon nigroviridis	84.32	0.00e+00	1197.00
IUUC-Tre-121892	Trichoderma reesei	37.30	5.00e-89	322.00
IUUC-Tvi-122354	Trichoderma virens	35.68	5.00e-90	326.00
IUUC-Tme-127102	Tuber melanosporum	35.99	1.00e-91	332.00
IUUC-Tbe-127351	Tupaia belangeri	77.88	0.00e+00	1436.00
IUUC-Ttr-129061	Tursiops truncatus	85.33	0.00e+00	1759.00
IUUC-Uma-129343	Ustilago maydis	44.96	6.00e-99	355.00
IUUC-Vda-129748	Verticillium dahliae	38.60	3.00e-80	293.00
IUUC-Vvi-131234	Vitis vinifera	35.04	2.00e-102	367.00
IUUC-Xtr-132094	Xenopus tropicalis	81.58	0.00e+00	1677.00
IUUC-Xma-133923	Xiphophorus maculatus	75.25	0.00e+00	1565.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence