iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Cel-018287

Ensembl Protein ID

T24C12.2

UniProt Accession

Q22720; GAP1_CAEEL

Genbank Protein ID

AAD13781.1; CCD71505.1

Protein Name

Ras GTPase-activating protein gap-1

Genbank Nucleotide ID

AF118123; FO081420

Gene Name

gap-1; T24C12.2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00001515	T24C12.2	T24C12.2

Annotation

mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	31.87	2.30e-01	32.00	IUUC-Spo-108263

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Caenorhabditis elegans

Functional Description
(View)

GTPase-activating protein, which inhibits the vulval induction by acting as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras.

Protein Sequence
(Fasta)

MVLSCRVVDC GGLKLKENQT LLLLVSTIHN SSEVGKLSID AEEKRSKEWL EMPCAEGMLS 60
LKLTLWQDLL KGINSVFHGQ VRVDVDENWK SGPAKWFYLR SKANEDGEGG EDGGDIGDAT 120

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Nucleotide Sequence
(Fasta)

ATGGTTCTAT CTTGCAGAGT CGTCGACTGT GGTGGATTGA AGCTCAAAGA AAATCAAACC 60
CTTCTTCTTC TTGTCTCTAC TATTCACAAT TCCAGCGTGA GTGCATTTTT CTCTGTGGCT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0343--GTPase activation
KW-1185--Reference proteome

Interpro

IPR011993--PH_dom-like
IPR001849--PH_domain
IPR023152--RasGAP_CS
IPR001936--RasGAP_dom
IPR008936--Rho_GTPase_activation_prot

PROSITE

PS50003--PH_DOMAIN
PS00509--RAS_GTPASE_ACTIV_1
PS50018--RAS_GTPASE_ACTIV_2

Pfam

PF00616--RasGAP

SMART

SM00233--PH
SM00323--RasGAP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031235--C:intrinsic component of the cytoplasmic side of the plasma membrane
GO:0005096--F:GTPase activator activity
GO:0008306--P:associative learning
GO:0007635--P:chemosensory behavior
GO:0007616--P:long-term memory
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0007614--P:short-term memory
GO:0007165--P:signal transduction

KEGG

cel:CELE_T24C12.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ptt-103741	Puccinia triticina	28.57	1.20e+00	26.60
IUUC-Spo-108263	Schizosaccharomyces pombe	31.87	4.30e-02	32.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence