iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt	PHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	15209385

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	1.20e-11	42.8	264	320

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlkvnpsdtVaeLKeki...ekk.lgippeqqrLiykGkiLeddkt 55
            ++ +++ s+++++v+p++tV+++K+ i   +++ l++++++++LiykG++L++++ 
   Q: 264  EFISDATLSITQMNVKPDTTVKQVKDFIcsvYTHsLNLRRNDIKLIYKGQLLHENNF 320
           689999********************999998888*****************88865 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Scaffold protein of the endoplasmic reticulum-associated degradation (ERAD) (also known as endoplasmic reticulum quality control, ERQC) pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Has multiple functions in ERAD including recruitment of DER1 to the HRD1 ubiquitin ligase, and regulation of HRD1 activity. Involved in oligomerization of HRD1, which is required for ERAD-L, and in HRD1 autoubiquitination and degradation.

Protein Sequence
(Fasta)

MSEYLAQTPC KFTIWSSEID LIRTNLLVNA HPLSTVGRLL QYIHYQIYKQ LRAIYQPEEQ 60
CTNSEIPHTP LNSINTYFLS YEGRELSATC LLKDITSSSH PDSNHFIRLQ LEKRTSPSGS 120

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Nucleotide Sequence
(Fasta)

ATGTCTGAAT ATCTAGCTCA GACGCCCTGC AAATTTACTA TATGGTCAAG CGAGATTGAT 60
CTTATCAGAA CAAACCTGTT GGTGAACGCT CACCCTTTAA GCACGGTTGG GCGACTACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0016021--C:integral component of membrane
GO:0042802--F:identical protein binding
GO:0032947--F:protein complex scaffold
GO:0000398--P:mRNA splicing, via spliceosome
GO:0032461--P:positive regulation of protein oligomerization
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

sce:YML029W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002779	Amborella trichopoda	24.71	4.30e-01	27.70
IUUC-Apl-003188	Anas platyrhynchos	28.57	2.10e-02	31.60
IUUC-Aca-004501	Anolis carolinensis	28.21	8.00e-03	34.30
IUUC-Ath-007404	Arabidopsis thaliana	40.00	7.30e-02	28.50
IUUC-Ago-007982	Ashbya gossypii	27.12	1.00e-66	246.00
IUUC-Acl-008019	Aspergillus clavatus	28.95	4.00e-03	32.70
IUUC-Afu-008847	Aspergillus fumigatus	29.33	7.00e-03	32.00
IUUC-Ani-009269	Aspergillus nidulans	24.24	2.30e-02	31.60
IUUC-Bgr-012216	Blumeria graminis	27.83	5.40e-02	32.70
IUUC-Bci-013674	Botrytis cinerea	32.43	5.10e-02	31.20
IUUC-Cre-022656	Chlamydomonas reinhardtii	40.62	8.70e-01	26.20
IUUC-Csa-023191	Chlorocebus sabaeus	26.39	5.40e-02	30.80
IUUC-Cho-024681	Choloepus hoffmanni	36.00	2.70e-01	31.20
IUUC-Cgl-026489	Colletotrichum gloeosporioides	31.91	8.00e-03	32.70
IUUC-Dre-028177	Danio rerio	38.00	7.00e-03	32.70
IUUC-Dme-031642	Drosophila melanogaster	33.33	6.50e-01	26.90
IUUC-Ete-032449	Echinops telfairi	29.23	2.00e-03	34.70
IUUC-Eca-033336	Equus caballus	55.56	6.70e-02	30.40
IUUC-Fca-036560	Felis catus	35.56	8.90e-02	30.00
IUUC-Fox-037669	Fusarium oxysporum	30.00	2.10e-02	32.00
IUUC-Fso-038132	Fusarium solani	25.00	5.00e-03	33.50
IUUC-Gac-041623	Gasterosteus aculeatus	21.09	3.70e-02	32.00
IUUC-Ggo-045450	Gorilla gorilla	28.24	5.10e-01	28.50
IUUC-Hsa-046504	Homo sapiens	35.90	1.70e-02	31.60
IUUC-Hvu-047190	Hordeum vulgare	36.54	1.30e-02	29.60
IUUC-Kpa-049339	Komagataella pastoris	37.21	1.90e-02	32.30
IUUC-Lpe-051231	Leersia perrieri	30.77	1.90e-02	31.60
IUUC-Lma-053282	Leptosphaeria maculans	33.93	1.30e-01	29.30
IUUC-Mtr-058515	Medicago truncatula	26.80	4.70e-02	31.60
IUUC-Mvi-060428	Microbotryum violaceum	27.78	1.80e-02	31.60
IUUC-Mac-065496	Musa acuminata	35.71	6.60e-02	27.30
IUUC-Nfi-068293	Neosartorya fischeri	29.87	5.00e-03	31.60
IUUC-Opr-070673	Ochotona princeps	36.96	3.60e-02	31.20
IUUC-Ont-071647	Oreochromis niloticus	25.25	4.50e-01	30.80
IUUC-Ocu-074907	Oryctolagus cuniculus	36.96	3.60e-02	31.20
IUUC-Obr-076892	Oryza brachyantha	30.49	1.50e-02	31.60
IUUC-Ogu-078501	Oryza glumaepatula	35.71	4.50e-01	27.70
IUUC-Oin-079722	Oryza indica	35.71	5.50e-02	27.30
IUUC-Oru-085116	Oryza rufipogon	35.71	4.80e-01	27.70
IUUC-Osa-085838	Oryza sativa	35.71	5.50e-02	27.30
IUUC-Olu-087832	Ostreococcus lucimarinus	44.12	5.40e-01	28.10
IUUC-Oga-088245	Otolemur garnettii	48.28	3.00e-03	33.10
IUUC-Pan-092244	Papio anubis	26.39	1.30e-02	32.70
IUUC-Psi-093960	Pelodiscus sinensis	33.33	3.40e-01	29.30
IUUC-Ppa-095310	Physcomitrella patens	37.14	3.30e-02	31.20
IUUC-Pab-098082	Pongo abelii	22.73	6.50e-02	30.00
IUUC-Pva-103107	Pteropus vampyrus	34.21	2.90e-01	28.10
IUUC-Pgr-103293	Puccinia graminis	36.84	5.30e-02	30.40
IUUC-Ptt-103741	Puccinia triticina	30.19	5.00e-03	33.90
IUUC-Rno-105302	Rattus norvegicus	41.03	4.00e-03	32.70
IUUC-Sja-107914	Schizosaccharomyces japonicus	26.09	8.00e-03	32.70
IUUC-Ssl-108593	Sclerotinia sclerotiorum	33.33	3.80e-02	30.40
IUUC-Sly-111347	Solanum lycopersicum	31.03	4.00e-03	33.50
IUUC-Stu-112175	Solanum tuberosum	32.08	6.00e-03	32.70
IUUC-Sar-113213	Sorex araneus	35.56	1.30e-01	29.60
IUUC-Sre-115026	Sporisorium reilianum	23.66	1.40e-02	33.90
IUUC-Tgu-116777	Taeniopygia guttata	29.31	3.70e-02	30.00
IUUC-Tbe-127226	Tupaia belangeri	25.42	1.30e-01	29.60
IUUC-Ttr-128912	Tursiops truncatus	28.24	4.20e-01	28.90
IUUC-Vda-130017	Verticillium dahliae	35.19	3.00e-03	34.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence