iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132374

UUCD1 version

UUC-XeT-01092

Ensembl Protein ID

ENSXETP00000048254.3

UniProt Accession

A4QNN3; Q28CN8; UBP30_XENTR

Genbank Protein ID

CAJ81380.1; AAI35926.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30

Genbank Nucleotide ID

CR926280; BC135925

Gene Name

usp30; TEgg099b09.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000022301.3	ENSXETT00000048254.3	ENSXETP00000048254.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.60e-71	240.3	86	503

Active Site

Position(s)	Description	Evidence
94	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
455	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw...kskkkavsprellkalkkeaeefsgy 87
           Gl NlgNtC+mNS+LQ L+++p++ + l + +++k ++en+++++++l+ +l +l+++l     +++++ + + ll++l++   ++s++
   Q: 86   GLLNLGNTCFMNSLLQGLASCPSFIRWLAD-FTSKYRQENNTTEHQHLSVTLLHLLKALCnqeGTEDEVLDASPLLEVLRAHRWQISSF 173
           9*****************************.****************************87777888899******************* PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknk.........slisdlFqgqlksqikclecdnvs.sre 166
           e+qDa+E++++l ++le+e    ++ +++++++ d+ e + e +++ + +++            ++ F+g+l+s+++c++c+++s  r+
   Q: 174  EEQDAHELFHVLTSSLEDER--DRRPHVTHLFDLDSLEFPLEPQRQIHCRTQvpiypipsqWKSQHPFHGRLTSNMVCKHCQHQSpMRY 260
           *******************9..6799999999999999999966666666666777788778899************************ PP
   S: 167  epfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekck...............kkqeaekklklkklPevLilhLkRfsfs 240
           ++f +lsl++p  +  ++ +l++cL++f ++e++++   + ce+c+               +k++ +k+lkl klP++L++hL+R s+s
   Q: 261  DTFDSLSLSIPVATWGHPITLDQCLQHFISTESVKD---VVCENCTkihaaqipnsqsvenRKTTFVKQLKLGKLPQCLCIHLQRLSWS 346
           **********************************97...9******8888888888888888888***********************9 PP
   S: 241  eeqksrekinkkvefpleLdlspfcts.......peekqke................................................ 274
           ++ +s+ k n++v+f + L +++f  +       +     +                                                
   Q: 347  NQ-GSPLKRNEHVQFSEFLAMDRFKYRisgcstsK-----Qpanhlsaaeqettdgkeggaqnptmpflngacstsyisppftsplptn 429
           96.9999*********99****7666644444440.....3555666666666667777777788888888888888888888888888 PP
   S: 275  ......kkkYeLiavvvHsGslssGHYvayvkn........ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
                 ++ ++L+avvvH+G ++sGH+v+y ++        ++++Wl ++D++V+ ++ +evl+   s+aY+lfY+r
   Q: 430  pewtssSYLFRLMAVVVHHGDMHSGHFVTYRRSpaaknqklTSQQWLWISDDTVRRTNFQEVLS---SSAYLLFYER 503
           8888889999***********************887766666677*******************...********98 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park2).

Protein Sequence
(Fasta)

MSWAPVSTWS RRTPLAACCS APELPPAGAW KACAAGSLRI GPQGRCKMMK NWGMIGGIAA 60
ALAAGIYVLW GPISDRKKYR KGLVPGLLNL GNTCFMNSLL QGLASCPSFI RWLADFTSKY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCAGACGCA GCTGCCTTAC AGCATTTGCA GGAGTTGTGA CATGTCCTGG GCTCCAGTGA 60
GTACTTGGAG CAGGCGGACA CCTTTGGCAG CTTGCTGTAG TGCCCCAGAG CTCCCTCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008053--P:mitochondrial fusion
GO:0000422--P:mitophagy
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

xtr:733894

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000204	Aegilops tauschii	25.73	7.00e-19	88.60
IUUC-Aml-001733	Ailuropoda melanoleuca	64.62	2.00e-162	565.00
IUUC-Atr-002510	Amborella trichopoda	27.08	4.00e-25	109.00
IUUC-Apl-003645	Anas platyrhynchos	62.18	4.00e-91	327.00
IUUC-Aca-004583	Anolis carolinensis	69.33	2.00e-24	103.00
IUUC-Aly-005754	Arabidopsis lyrata	26.29	4.00e-28	119.00
IUUC-Ath-007622	Arabidopsis thaliana	27.80	4.00e-29	122.00
IUUC-Ago-007761	Ashbya gossypii	20.97	1.00e-07	52.00
IUUC-Afl-008729	Aspergillus flavus	20.67	5.00e-15	76.30
IUUC-Afu-009119	Aspergillus fumigatus	22.33	2.00e-13	71.20
IUUC-Aor-009965	Aspergillus oryzae	20.87	4.00e-15	76.30
IUUC-Ame-010896	Astyanax mexicanus	61.47	2.00e-159	555.00
IUUC-Bgr-012133	Blumeria graminis	24.63	8.00e-18	85.50
IUUC-Bta-012321	Bos taurus	66.60	2.00e-161	562.00
IUUC-Bci-013590	Botrytis cinerea	22.69	1.00e-19	91.70
IUUC-Bdi-014795	Brachypodium distachyon	26.17	2.00e-19	89.70
IUUC-Bol-015637	Brassica oleracea	27.94	5.00e-28	119.00
IUUC-Bra-016801	Brassica rapa	28.89	1.00e-29	124.00
IUUC-Cel-018308	Caenorhabditis elegans	28.10	5.00e-41	162.00
IUUC-Cja-018826	Callithrix jacchus	65.66	1.00e-170	592.00
IUUC-Cfa-021206	Canis familiaris	65.68	1.00e-162	566.00
IUUC-Cpo-021343	Cavia porcellus	67.62	3.00e-165	574.00
IUUC-Csa-023419	Chlorocebus sabaeus	66.27	1.00e-170	592.00
IUUC-Cho-024475	Choloepus hoffmanni	63.70	4.00e-90	325.00
IUUC-Cgl-026621	Colletotrichum gloeosporioides	20.63	3.00e-15	77.00
IUUC-Cne-027061	Cryptococcus neoformans	28.15	3.00e-13	70.50
IUUC-Dre-027563	Danio rerio	60.38	2.00e-161	561.00
IUUC-Dno-029929	Dasypus novemcinctus	65.79	1.00e-165	575.00
IUUC-Dor-030166	Dipodomys ordii	59.05	3.00e-133	468.00
IUUC-Dse-031517	Dothistroma septosporum	22.52	3.00e-14	73.60
IUUC-Dme-031627	Drosophila melanogaster	35.02	1.00e-35	144.00
IUUC-Ete-032634	Echinops telfairi	65.47	2.00e-153	535.00
IUUC-Eca-033968	Equus caballus	67.64	1.00e-161	563.00
IUUC-Eeu-035279	Erinaceus europaeus	67.88	1.00e-46	181.00
IUUC-Fca-036525	Felis catus	65.07	2.00e-166	578.00
IUUC-Fal-036606	Ficedula albicollis	67.92	8.00e-139	486.00
IUUC-Fox-037837	Fusarium oxysporum	22.70	6.00e-13	68.90
IUUC-Gmo-038726	Gadus morhua	56.71	4.00e-138	484.00
IUUC-Gga-040718	Gallus gallus	69.04	3.00e-140	491.00
IUUC-Gac-042645	Gasterosteus aculeatus	56.99	7.00e-150	523.00
IUUC-Gma-042890	Glycine max	25.89	5.00e-23	102.00
IUUC-Ggo-045021	Gorilla gorilla	66.47	4.00e-171	594.00
IUUC-Hsa-045832	Homo sapiens	66.47	4.00e-171	594.00
IUUC-Itr-048392	Ictidomys tridecemlineatus	66.46	1.00e-163	568.00
IUUC-Kpa-049268	Komagataella pastoris	22.44	3.00e-18	86.70
IUUC-Lch-050662	Latimeria chalumnae	67.95	2.00e-167	582.00
IUUC-Lpe-051078	Leersia perrieri	26.10	2.00e-33	136.00
IUUC-Loc-052611	Lepisosteus oculatus	62.03	4.00e-160	557.00
IUUC-Lma-053048	Leptosphaeria maculans	21.53	1.00e-18	88.60
IUUC-Laf-053752	Loxodonta africana	66.46	5.00e-163	567.00
IUUC-Mcc-054892	Macaca mulatta	66.47	2.00e-171	595.00
IUUC-Meu-056673	Macropus eugenii	60.10	9.00e-120	423.00
IUUC-Mor-057143	Magnaporthe oryzae	22.05	4.00e-13	69.70
IUUC-Mtr-057976	Medicago truncatula	27.06	1.00e-33	137.00
IUUC-Mla-058970	Melampsora laricipopulina	25.56	4.00e-27	116.00
IUUC-Mga-059543	Meleagris gallopavo	68.41	2.00e-161	561.00
IUUC-Mmr-061534	Microcebus murinus	66.46	3.00e-163	568.00
IUUC-Mdo-062140	Monodelphis domestica	57.55	3.00e-129	455.00
IUUC-Mmu-063673	Mus musculus	66.87	5.00e-162	563.00
IUUC-Mpu-066328	Mustela putorius furo	65.46	2.00e-164	571.00
IUUC-Mlu-067938	Myotis lucifugus	66.20	8.00e-170	589.00
IUUC-Nfi-068306	Neosartorya fischeri	22.54	3.00e-18	86.30
IUUC-Nle-069426	Nomascus leucogenys	65.91	2.00e-155	542.00
IUUC-Opr-070796	Ochotona princeps	58.24	2.00e-77	282.00
IUUC-Ont-072248	Oreochromis niloticus	59.75	2.00e-151	528.00
IUUC-Oan-072916	Ornithorhynchus anatinus	66.04	8.00e-167	580.00
IUUC-Ocu-074459	Oryctolagus cuniculus	62.47	2.00e-133	468.00
IUUC-Oba-075765	Oryza barthii	28.00	2.00e-31	130.00
IUUC-Obr-076005	Oryza brachyantha	27.79	2.00e-31	130.00
IUUC-Ogl-077916	Oryza glaberrima	28.17	1.00e-32	134.00
IUUC-Ogu-078263	Oryza glumaepatula	28.00	9.00e-32	131.00
IUUC-Oin-080096	Oryza indica	27.55	4.00e-23	102.00
IUUC-Ome-081928	Oryza meridionalis	27.00	1.00e-30	127.00
IUUC-Oni-082424	Oryza nivara	28.00	6.00e-32	131.00
IUUC-Oru-085117	Oryza rufipogon	28.00	6.00e-32	131.00
IUUC-Ola-087429	Oryzias latipes	56.37	6.00e-143	500.00
IUUC-Oga-087981	Otolemur garnettii	64.60	3.00e-166	578.00
IUUC-Oar-089927	Ovis aries	66.67	2.00e-162	565.00
IUUC-Ptr-090878	Pan troglodytes	66.47	4.00e-171	594.00
IUUC-Pan-092698	Papio anubis	66.47	2.00e-171	595.00
IUUC-Psi-093451	Pelodiscus sinensis	66.46	7.00e-172	596.00
IUUC-Pno-094802	Phaeosphaeria nodorum	21.60	7.00e-13	68.60
IUUC-Pfo-096096	Poecilia formosa	57.38	3.00e-147	514.00
IUUC-Pab-098676	Pongo abelii	65.60	3.00e-167	581.00
IUUC-Pca-100418	Procavia capensis	75.00	1.00e-95	343.00
IUUC-Ppe-101898	Prunus persica	25.97	2.00e-25	110.00
IUUC-Pva-103018	Pteropus vampyrus	63.98	3.00e-158	551.00
IUUC-Pgr-103686	Puccinia graminis	24.26	2.00e-13	70.90
IUUC-Ptt-103779	Puccinia triticina	22.47	7.00e-15	76.30
IUUC-Pte-104330	Pyrenophora teres	22.60	4.00e-19	89.70
IUUC-Pyt-104518	Pyrenophora triticirepentis	23.05	2.00e-22	101.00
IUUC-Rno-105708	Rattus norvegicus	66.19	3.00e-163	568.00
IUUC-Sha-106971	Sarcophilus harrisii	63.95	1.00e-168	586.00
IUUC-Ssl-108648	Sclerotinia sclerotiorum	22.08	2.00e-19	90.90
IUUC-Sit-110442	Setaria italica	27.41	7.00e-28	118.00
IUUC-Ssc-116397	Sus scrofa	65.60	2.00e-162	565.00
IUUC-Tgu-117446	Taeniopygia guttata	65.76	2.00e-172	598.00
IUUC-Tru-118268	Takifugu rubripes	56.67	1.00e-136	479.00
IUUC-Tsy-119484	Tarsius syrichta	59.66	1.00e-31	130.00
IUUC-Tni-119735	Tetraodon nigroviridis	54.67	9.00e-122	430.00
IUUC-Tca-121660	Theobroma cacao	27.29	1.00e-29	124.00
IUUC-Tre-121937	Trichoderma reesei	22.47	2.00e-14	74.30
IUUC-Tvi-122428	Trichoderma virens	21.29	6.00e-13	68.90
IUUC-Tae-125203	Triticum aestivum	27.65	1.00e-27	117.00
IUUC-Tur-126458	Triticum urartu	27.47	4.00e-27	115.00
IUUC-Tbe-127740	Tupaia belangeri	59.80	2.00e-142	498.00
IUUC-Ttr-129273	Tursiops truncatus	64.33	7.00e-160	556.00
IUUC-Vda-129789	Verticillium dahliae	22.12	2.00e-13	70.90
IUUC-Vvi-131177	Vitis vinifera	27.15	2.00e-24	107.00
IUUC-Xma-133267	Xiphophorus maculatus	57.58	1.00e-157	549.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence