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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106287
UUCD1 version UUC-SaC-00189
Ensembl Protein ID YML068W
UniProt Accession Q04638; D6VZA5; ITT1_YEAST
Genbank Protein ID CAA86252.1; DAA09829.1
Protein Name Translation termination inhibitor protein ITT1
Genbank Nucleotide ID Z38114; BK006946
Gene Name ITT1; YML068W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YML068W YML068W YML068W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RBR 27.45 9.00e-22 102.00 IUUC-Hsa-046887
Active Site
Position(s) Description Evidence
415 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA.
 Modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA.
Protein Sequence
(Fasta)
MALTQFENDL EILRDMYPEL EMKSVKVEEE GEFPQRINGK LLFKISLLAD VNIEFGEQHM 60
LLSNLSNECV EFTIYSCHYP DIRRCVVMDI KSLWISTDEK KMLIDKALRL VEETVDMSIE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106287|E3,RBR|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCTTTGA CTCAGTTTGA AAATGATTTG GAAATATTAA GAGATATGTA CCCAGAACTG 60
GAAATGAAAT CGGTAAAAGT AGAGGAGGAA GGTGAATTCC CTCAAAGAAT TAACGGAAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106287|E3,RBR|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0810--Translation regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF01485--IBR
SMART

SM00647--IBR
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006449--P:regulation of translational termination
KEGG sce:YML068W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001130 Aegilops tauschii 25.45 5.00e-17 80.50
IUUC-Aml-001458 Ailuropoda melanoleuca 27.41 5.00e-23 100.00
IUUC-Atr-002560 Amborella trichopoda 28.83 2.00e-21 95.50
IUUC-Apl-003680 Anas platyrhynchos 27.27 5.00e-24 103.00
IUUC-Aca-005000 Anolis carolinensis 29.50 2.00e-25 108.00
IUUC-Aly-006288 Arabidopsis lyrata 23.53 6.00e-22 97.10
IUUC-Ath-006719 Arabidopsis thaliana 24.36 1.00e-23 103.00
IUUC-Acl-008213 Aspergillus clavatus 22.17 6.00e-19 87.00
IUUC-Afl-008433 Aspergillus flavus 21.71 1.00e-19 89.40
IUUC-Afu-008772 Aspergillus fumigatus 22.63 1.00e-17 82.80
IUUC-Ani-009249 Aspergillus nidulans 21.74 8.00e-18 83.20
IUUC-Ang-009757 Aspergillus niger 21.73 8.00e-17 79.70
IUUC-Aor-009963 Aspergillus oryzae 20.59 3.00e-18 85.10
IUUC-Ate-010460 Aspergillus terreus 22.73 1.00e-21 95.90
IUUC-Ame-011312 Astyanax mexicanus 25.17 2.00e-24 104.00
IUUC-Bgr-012052 Blumeria graminis 25.08 3.00e-21 94.70
IUUC-Bta-013529 Bos taurus 27.80 1.00e-23 102.00
IUUC-Bci-013729 Botrytis cinerea 44.64 7.00e-13 67.00
IUUC-Bdi-014940 Brachypodium distachyon 21.88 5.00e-17 80.90
IUUC-Bra-016998 Brassica rapa 23.76 6.00e-23 100.00
IUUC-Cel-018547 Caenorhabditis elegans 26.25 8.00e-21 92.80
IUUC-Cja-019791 Callithrix jacchus 27.84 1.00e-24 105.00
IUUC-Cfa-020403 Canis familiaris 28.29 2.00e-25 107.00
IUUC-Cpo-022229 Cavia porcellus 27.91 3.00e-24 103.00
IUUC-Cre-022601 Chlamydomonas reinhardtii 23.23 7.00e-12 61.60
IUUC-Csa-024115 Chlorocebus sabaeus 27.45 5.00e-24 103.00
IUUC-Cho-024911 Choloepus hoffmanni 27.52 3.00e-24 104.00
IUUC-Cin-025578 Ciona intestinalis 29.02 3.00e-25 107.00
IUUC-Csv-026355 Ciona savignyi 27.73 1.00e-16 79.00
IUUC-Cgl-026439 Colletotrichum gloeosporioides 21.29 8.00e-23 100.00
IUUC-Cne-026782 Cryptococcus neoformans 26.85 6.00e-24 103.00
IUUC-Dre-027380 Danio rerio 24.84 3.00e-24 104.00
IUUC-Dno-029640 Dasypus novemcinctus 27.52 1.00e-24 105.00
IUUC-Dor-030681 Dipodomys ordii 27.52 2.00e-24 104.00
IUUC-Dse-031208 Dothistroma septosporum 24.70 3.00e-20 91.30
IUUC-Dme-031816 Drosophila melanogaster 24.06 9.00e-10 58.90
IUUC-Eca-033755 Equus caballus 27.91 4.00e-25 107.00
IUUC-Eeu-035034 Erinaceus europaeus 35.59 1.00e-14 72.40
IUUC-Fca-036461 Felis catus 27.91 8.00e-25 106.00
IUUC-Fal-037516 Ficedula albicollis 28.19 5.00e-24 103.00
IUUC-Fso-038307 Fusarium solani 23.06 3.00e-20 91.30
IUUC-Gmo-039563 Gadus morhua 25.71 7.00e-22 96.30
IUUC-Ggr-039920 Gaeumannomyces graminis 37.25 1.00e-07 50.10
IUUC-Gga-040331 Gallus gallus 28.08 3.00e-23 100.00
IUUC-Gac-042164 Gasterosteus aculeatus 25.23 7.00e-26 109.00
IUUC-Gma-044080 Glycine max 26.67 5.00e-24 103.00
IUUC-Ggo-045257 Gorilla gorilla 27.45 6.00e-24 103.00
IUUC-Hsa-046887 Homo sapiens 27.45 6.00e-24 103.00
IUUC-Hvu-047317 Hordeum vulgare 27.44 6.00e-17 80.50
IUUC-Itr-048199 Ictidomys tridecemlineatus 27.13 8.00e-24 102.00
IUUC-Lch-050155 Latimeria chalumnae 25.58 4.00e-23 100.00
IUUC-Lpe-051669 Leersia perrieri 23.13 1.00e-08 53.10
IUUC-Loc-051779 Lepisosteus oculatus 25.93 4.00e-24 103.00
IUUC-Lma-052969 Leptosphaeria maculans 22.72 3.00e-17 80.90
IUUC-Laf-053488 Loxodonta africana 27.52 2.00e-24 105.00
IUUC-Mcc-054701 Macaca mulatta 27.45 5.00e-24 103.00
IUUC-Meu-056577 Macropus eugenii 36.36 9.00e-15 72.80
IUUC-Mor-057157 Magnaporthe oryzae 23.08 5.00e-18 84.30
IUUC-Mpo-057518 Magnaporthe poae 22.63 2.00e-16 79.30
IUUC-Mtr-058125 Medicago truncatula 28.33 2.00e-19 89.00
IUUC-Mla-059062 Melampsora laricipopulina 34.94 7.00e-08 49.70
IUUC-Mga-059906 Meleagris gallopavo 28.08 3.00e-23 100.00
IUUC-Mvi-060374 Microbotryum violaceum 29.04 8.00e-21 93.20
IUUC-Mmr-061786 Microcebus murinus 27.52 1.00e-24 105.00
IUUC-Mdo-062453 Monodelphis domestica 27.27 4.00e-22 97.40
IUUC-Mmu-063521 Mus musculus 27.31 3.00e-24 104.00
IUUC-Mac-065119 Musa acuminata 23.91 3.00e-15 74.70
IUUC-Mpu-066274 Mustela putorius furo 27.91 9.00e-25 105.00
IUUC-Mlu-067202 Myotis lucifugus 27.84 1.00e-24 105.00
IUUC-Nfi-068564 Neosartorya fischeri 22.63 2.00e-17 82.00
IUUC-Ncr-068823 Neurospora crassa 24.76 3.00e-22 98.20
IUUC-Nle-068987 Nomascus leucogenys 27.45 6.00e-24 103.00
IUUC-Opr-070453 Ochotona princeps 28.46 2.00e-24 105.00
IUUC-Ont-072611 Oreochromis niloticus 26.58 9.00e-27 112.00
IUUC-Oan-073738 Ornithorhynchus anatinus 28.29 1.00e-23 102.00
IUUC-Ocu-074396 Oryctolagus cuniculus 27.13 6.00e-24 103.00
IUUC-Oba-075472 Oryza barthii 23.90 3.00e-13 68.20
IUUC-Obr-076277 Oryza brachyantha 24.35 1.00e-13 69.30
IUUC-Ogl-077046 Oryza glaberrima 23.90 3.00e-13 68.20
IUUC-Ogu-078634 Oryza glumaepatula 23.90 3.00e-13 68.20
IUUC-Oin-080080 Oryza indica 24.90 2.00e-14 72.00
IUUC-Olo-080828 Oryza longistaminata 25.48 8.00e-15 74.30
IUUC-Ome-081387 Oryza meridionalis 25.29 1.00e-14 72.80
IUUC-Oni-082934 Oryza nivara 23.90 3.00e-13 68.20
IUUC-Opu-083719 Oryza punctata 23.87 1.00e-11 62.40
IUUC-Oru-084518 Oryza rufipogon 23.90 3.00e-13 68.20
IUUC-Ola-087312 Oryzias latipes 27.70 3.00e-26 110.00
IUUC-Olu-087661 Ostreococcus lucimarinus 23.61 2.00e-13 68.90
IUUC-Oga-089129 Otolemur garnettii 27.52 3.00e-24 104.00
IUUC-Oar-089839 Ovis aries 27.80 1.00e-23 102.00
IUUC-Ptr-091626 Pan troglodytes 27.45 6.00e-24 103.00
IUUC-Pan-092798 Papio anubis 27.45 5.00e-24 103.00
IUUC-Psi-093253 Pelodiscus sinensis 27.13 1.00e-22 99.00
IUUC-Pma-094512 Petromyzon marinus 27.59 3.00e-27 114.00
IUUC-Pno-094937 Phaeosphaeria nodorum 22.38 2.00e-20 91.70
IUUC-Ppa-095211 Physcomitrella patens 29.73 1.00e-24 106.00
IUUC-Pfo-097049 Poecilia formosa 27.75 1.00e-20 92.00
IUUC-Pab-097911 Pongo abelii 27.45 6.00e-24 103.00
IUUC-Pop-099841 Populus trichocarpa 25.00 3.00e-19 88.20
IUUC-Pca-100814 Procavia capensis 34.51 1.00e-14 72.80
IUUC-Ppe-101972 Prunus persica 23.01 9.00e-24 102.00
IUUC-Pva-103038 Pteropus vampyrus 27.13 3.00e-23 100.00
IUUC-Pgr-103277 Puccinia graminis 28.37 8.00e-25 106.00
IUUC-Ptt-103855 Puccinia triticina 28.00 4.00e-27 114.00
IUUC-Pte-104113 Pyrenophora teres 21.73 3.00e-16 77.80
IUUC-Pyt-104619 Pyrenophora triticirepentis 21.98 9.00e-17 79.30
IUUC-Rno-106003 Rattus norvegicus 27.65 6.00e-24 103.00
IUUC-Sha-106652 Sarcophilus harrisii 27.52 7.00e-24 103.00
IUUC-Spo-108167 Schizosaccharomyces pombe 29.21 7.00e-33 132.00
IUUC-Ssl-108396 Sclerotinia sclerotiorum 24.31 1.00e-06 46.60
IUUC-Smo-109393 Selaginella moellendorffii 29.37 3.00e-21 94.40
IUUC-Sit-110529 Setaria italica 23.08 2.00e-11 62.00
IUUC-Sly-111829 Solanum lycopersicum 27.43 9.00e-25 106.00
IUUC-Stu-112811 Solanum tuberosum 27.78 2.00e-24 105.00
IUUC-Sar-113259 Sorex araneus 35.40 5.00e-14 70.10
IUUC-Sbi-114591 Sorghum bicolor 24.44 3.00e-11 61.20
IUUC-Sre-115227 Sporisorium reilianum 26.42 3.00e-23 101.00
IUUC-Ssc-115293 Sus scrofa 28.29 3.00e-25 107.00
IUUC-Tgu-117335 Taeniopygia guttata 27.80 2.00e-23 101.00
IUUC-Tru-118458 Takifugu rubripes 27.45 4.00e-27 113.00
IUUC-Tsy-119475 Tarsius syrichta 23.44 2.00e-10 58.20
IUUC-Tni-119827 Tetraodon nigroviridis 26.64 4.00e-24 103.00
IUUC-Tca-121023 Theobroma cacao 26.67 1.00e-20 92.80
IUUC-Tre-121965 Trichoderma reesei 21.59 2.00e-20 91.70
IUUC-Tvi-122564 Trichoderma virens 20.45 1.00e-17 83.20
IUUC-Tae-123173 Triticum aestivum 26.33 1.00e-16 78.60
IUUC-Tur-126258 Triticum urartu 27.70 4.00e-13 67.80
IUUC-Tbe-127227 Tupaia belangeri 26.49 5.00e-08 50.10
IUUC-Uma-129565 Ustilago maydis 35.37 7.00e-23 100.00
IUUC-Vpa-130301 Vicugna pacos 27.52 3.00e-24 104.00
IUUC-Vvi-131244 Vitis vinifera 27.68 5.00e-23 100.00
IUUC-Xtr-132880 Xenopus tropicalis 27.53 6.00e-22 96.70
IUUC-Xma-134055 Xiphophorus maculatus 25.84 1.00e-24 105.00
IUUC-Yli-134342 Yarrowia lipolytica 27.96 2.00e-34 137.00
IUUC-Zma-135021 Zea mays 24.07 1.00e-11 62.80
Created Date 25-Jun-2017

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