iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117819

UUCD1 version

UUC-TaR-00834

Ensembl Protein ID

ENSTRUP00000039022.1

UniProt Accession

H2UQ01; H2UQ01_TAKRU

Protein Name

Uncharacterized protein

Gene Name

fbxw7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000015272.1	ENSTRUT00000039162.1	ENSTRUP00000039022.1
ENSTRUG00000015272.1	ENSTRUT00000039163.1	ENSTRUP00000039023.1
ENSTRUG00000015272.1	ENSTRUT00000039164.1	ENSTRUP00000039024.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-59	196.8	636	669
UBD/Beta-Prp	1.80e-102	343.8	387	669

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 636  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 669
           9*********449******************976 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 387  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAITGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 471
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 472  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 554
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq+++++ ++
   Q: 555  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPHKHQSA 639
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 640  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 669
           *************************98776 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MNQDLLSGGS SSRRSRAPGG PAVRGNASST ARAPQQAADE GDEDEHMNRV VEEEEQLQQR 60
VRASRGETSV DMCSLAEEEE EEEEEGEENN NSSSHQEDDE TEERTEGGDE RGREDEGEGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACCAGG ATCTGCTGTC GGGGGGCAGC AGCAGCAGGC GGAGTCGGGC ACCGGGGGGT 60
CCGGCCGTGC GAGGTAACGC CTCGTCCACA GCCCGGGCGC CTCAGCAGGC GGCAGACGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0001525--P:angiogenesis
GO:0031642--P:negative regulation of myelination
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0032006--P:regulation of TOR signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	93.60	0.00e+00	1059.00
IUUC-Apl-003489	Anas platyrhynchos	91.98	0.00e+00	1065.00
IUUC-Aca-005318	Anolis carolinensis	95.01	0.00e+00	1058.00
IUUC-Ago-007794	Ashbya gossypii	30.86	1.00e-61	231.00
IUUC-Acl-008123	Aspergillus clavatus	31.34	4.00e-75	276.00
IUUC-Afl-008730	Aspergillus flavus	31.95	3.00e-72	266.00
IUUC-Afu-009014	Aspergillus fumigatus	32.33	1.00e-73	271.00
IUUC-Ani-009332	Aspergillus nidulans	32.60	3.00e-79	289.00
IUUC-Ang-009529	Aspergillus niger	33.40	3.00e-74	273.00
IUUC-Aor-010215	Aspergillus oryzae	30.31	4.00e-73	269.00
IUUC-Ate-010535	Aspergillus terreus	37.54	3.00e-67	249.00
IUUC-Ame-010898	Astyanax mexicanus	95.38	0.00e+00	1053.00
IUUC-Bgr-012075	Blumeria graminis	33.20	5.00e-79	288.00
IUUC-Bta-012391	Bos taurus	95.01	0.00e+00	1057.00
IUUC-Bci-013725	Botrytis cinerea	33.00	3.00e-77	283.00
IUUC-Cel-018495	Caenorhabditis elegans	48.04	7.00e-130	457.00
IUUC-Cja-018902	Callithrix jacchus	93.97	0.00e+00	1061.00
IUUC-Cfa-020237	Canis familiaris	93.97	0.00e+00	1061.00
IUUC-Cpo-022234	Cavia porcellus	95.01	0.00e+00	1059.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	37.42	9.00e-49	187.00
IUUC-Csa-023532	Chlorocebus sabaeus	93.97	0.00e+00	1061.00
IUUC-Cho-025026	Choloepus hoffmanni	77.51	0.00e+00	700.00
IUUC-Cin-025516	Ciona intestinalis	70.95	6.00e-141	493.00
IUUC-Csv-026312	Ciona savignyi	71.09	0.00e+00	750.00
IUUC-Cgl-026492	Colletotrichum gloeosporioides	34.82	4.00e-85	308.00
IUUC-Cne-027018	Cryptococcus neoformans	33.33	6.00e-73	269.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.10	7.00e-31	129.00
IUUC-Dre-028303	Danio rerio	93.35	0.00e+00	1044.00
IUUC-Dno-029576	Dasypus novemcinctus	91.96	0.00e+00	1042.00
IUUC-Dor-030196	Dipodomys ordii	92.50	0.00e+00	1036.00
IUUC-Dse-031558	Dothistroma septosporum	38.98	2.00e-70	260.00
IUUC-Dme-031702	Drosophila melanogaster	72.99	0.00e+00	797.00
IUUC-Ete-032791	Echinops telfairi	87.59	0.00e+00	973.00
IUUC-Eca-033424	Equus caballus	95.01	0.00e+00	1058.00
IUUC-Eeu-034996	Erinaceus europaeus	91.22	0.00e+00	1028.00
IUUC-Fca-036422	Felis catus	93.97	0.00e+00	1061.00
IUUC-Fal-037267	Ficedula albicollis	94.45	0.00e+00	1054.00
IUUC-Fox-037800	Fusarium oxysporum	33.87	5.00e-84	305.00
IUUC-Fso-038258	Fusarium solani	34.01	2.00e-83	303.00
IUUC-Gmo-039119	Gadus morhua	87.25	0.00e+00	929.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.86	2.00e-85	310.00
IUUC-Gga-040667	Gallus gallus	93.82	0.00e+00	1066.00
IUUC-Gac-042423	Gasterosteus aculeatus	75.09	0.00e+00	812.00
IUUC-Ggo-044422	Gorilla gorilla	93.97	0.00e+00	1062.00
IUUC-Hsa-045898	Homo sapiens	93.97	0.00e+00	1062.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	97.64	0.00e+00	952.00
IUUC-Kpa-049097	Komagataella pastoris	31.92	2.00e-75	276.00
IUUC-Lch-050414	Latimeria chalumnae	93.33	0.00e+00	1068.00
IUUC-Loc-052348	Lepisosteus oculatus	97.04	0.00e+00	1078.00
IUUC-Lma-053185	Leptosphaeria maculans	31.20	2.00e-69	257.00
IUUC-Laf-054054	Loxodonta africana	93.78	0.00e+00	1060.00
IUUC-Mcc-055056	Macaca mulatta	93.97	0.00e+00	1061.00
IUUC-Meu-056778	Macropus eugenii	89.81	3.00e-169	588.00
IUUC-Mor-057076	Magnaporthe oryzae	34.92	2.00e-84	306.00
IUUC-Mpo-057423	Magnaporthe poae	39.77	2.00e-71	263.00
IUUC-Mla-059081	Melampsora laricipopulina	33.90	9.00e-80	291.00
IUUC-Mga-059255	Meleagris gallopavo	91.62	0.00e+00	1062.00
IUUC-Mvi-060490	Microbotryum violaceum	38.75	1.00e-66	249.00
IUUC-Mmr-061292	Microcebus murinus	93.97	0.00e+00	1061.00
IUUC-Mdo-062304	Monodelphis domestica	94.33	0.00e+00	1069.00
IUUC-Mmu-063610	Mus musculus	93.97	0.00e+00	1063.00
IUUC-Mpu-065931	Mustela putorius furo	93.97	0.00e+00	1060.00
IUUC-Mlu-066976	Myotis lucifugus	93.61	0.00e+00	1063.00
IUUC-Nfi-068428	Neosartorya fischeri	31.47	5.00e-74	272.00
IUUC-Ncr-068688	Neurospora crassa	36.17	5.00e-88	318.00
IUUC-Nle-070174	Nomascus leucogenys	93.97	0.00e+00	1063.00
IUUC-Opr-070851	Ochotona princeps	80.00	1.00e-176	612.00
IUUC-Ont-071997	Oreochromis niloticus	98.71	0.00e+00	1117.00
IUUC-Oan-072936	Ornithorhynchus anatinus	94.15	0.00e+00	1066.00
IUUC-Ocu-074742	Oryctolagus cuniculus	93.80	0.00e+00	1064.00
IUUC-Obr-076806	Oryza brachyantha	31.52	1.00e-29	125.00
IUUC-Oin-079809	Oryza indica	31.52	1.00e-29	125.00
IUUC-Ola-087098	Oryzias latipes	97.78	0.00e+00	1098.00
IUUC-Olu-087837	Ostreococcus lucimarinus	34.85	9.00e-39	153.00
IUUC-Oga-088884	Otolemur garnettii	97.36	0.00e+00	767.00
IUUC-Oar-090220	Ovis aries	93.47	0.00e+00	1058.00
IUUC-Ptr-090492	Pan troglodytes	93.97	0.00e+00	1062.00
IUUC-Pan-091770	Papio anubis	93.97	0.00e+00	1061.00
IUUC-Psi-093207	Pelodiscus sinensis	95.01	0.00e+00	1058.00
IUUC-Pma-094749	Petromyzon marinus	82.57	0.00e+00	935.00
IUUC-Pno-095026	Phaeosphaeria nodorum	38.83	5.00e-71	262.00
IUUC-Pfo-096493	Poecilia formosa	97.63	0.00e+00	1093.00
IUUC-Pab-098141	Pongo abelii	95.01	0.00e+00	1058.00
IUUC-Pca-100571	Procavia capensis	91.49	0.00e+00	740.00
IUUC-Pva-102988	Pteropus vampyrus	94.51	0.00e+00	1063.00
IUUC-Pgr-103612	Puccinia graminis	35.48	5.00e-62	232.00
IUUC-Pte-104275	Pyrenophora teres	31.98	1.00e-73	271.00
IUUC-Pyt-104438	Pyrenophora triticirepentis	31.79	1.00e-72	267.00
IUUC-Rno-105706	Rattus norvegicus	93.78	0.00e+00	1061.00
IUUC-Sce-106314	Saccharomyces cerevisiae	29.98	3.00e-62	233.00
IUUC-Sha-107653	Sarcophilus harrisii	94.33	0.00e+00	1064.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	33.83	5.00e-79	289.00
IUUC-Spo-108115	Schizosaccharomyces pombe	32.08	2.00e-63	237.00
IUUC-Sar-113600	Sorex araneus	87.39	0.00e+00	967.00
IUUC-Sre-114901	Sporisorium reilianum	48.13	2.00e-67	251.00
IUUC-Ssc-115787	Sus scrofa	92.14	0.00e+00	1033.00
IUUC-Tgu-117510	Taeniopygia guttata	92.16	0.00e+00	1065.00
IUUC-Tsy-118828	Tarsius syrichta	93.97	0.00e+00	1062.00
IUUC-Tni-120468	Tetraodon nigroviridis	99.26	0.00e+00	1124.00
IUUC-Tre-122193	Trichoderma reesei	35.97	3.00e-85	309.00
IUUC-Tvi-122615	Trichoderma virens	34.22	2.00e-82	300.00
IUUC-Tme-127021	Tuber melanosporum	35.29	3.00e-84	306.00
IUUC-Tbe-127925	Tupaia belangeri	95.00	0.00e+00	1058.00
IUUC-Ttr-128899	Tursiops truncatus	93.60	0.00e+00	1058.00
IUUC-Uma-129449	Ustilago maydis	46.89	9.00e-67	249.00
IUUC-Vda-129802	Verticillium dahliae	36.20	3.00e-87	316.00
IUUC-Vpa-130082	Vicugna pacos	93.01	0.00e+00	882.00
IUUC-Xtr-132213	Xenopus tropicalis	92.91	0.00e+00	1079.00
IUUC-Xma-133646	Xiphophorus maculatus	98.34	0.00e+00	1087.00
IUUC-Yli-134429	Yarrowia lipolytica	33.80	3.00e-86	312.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence