iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003886

Ensembl Protein ID

ENSAPLP00000003865.1

UniProt Accession

U3I9E4; U3I9E4_ANAPL

Genbank Protein ID

ENSAPLP00000003865

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01021621

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000004254.1	ENSAPLT00000004472.1	ENSAPLP00000003865.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.70e-134	447.1	623	952

Active Site

Position(s)	Description	Evidence
922	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld+++
   Q: 623  FLKARLWIEFDGEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFF 711
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d   ++ldl+f v+ee++g+t+++eLk+gG++i Vtn+Nk++Y++lv+++r
   Q: 712  IRPFYKMMLQKPITLHDMESVDSEYYNSLRWILEN---DP--AELDLRFIVDEELFGQTHQHELKSGGSEIVVTNKNKRDYIHLVIQWR 795
           *********************************99...44..558******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + +++++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv d+k +tkyk+gy+ ++++iqwFw+++ +++se+r ++LqFvTg
   Q: 796  FVSRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVADWKLHTKYKNGYNVNHQVIQWFWKAVLMMDSEKRIRLLQFVTG 884
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p+lf++++++++++lP+++TCfn+L+LP+Y+s e l +kLl+Aie+t+gF+
   Q: 885  TSRVPMNGFAELYgsngPQLFTVEQWGTPEKLPRAHTCFNRLDLPPYDSFEDLWDKLLLAIENTQGFD 952
           *******************************************************************8 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

ILSADLCPLP DDQENTRIVR VKVIAGIGLA KKDILGASDP YVKVTVYDPV TGVLSSVQTK 60
TIRKSLNPKW NEELLFRVNP QKHRLLFEVF DENRLTRDDF LGQVDIPLYQ LPTENPSMER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCTGTCAG CAGACCTCTG TCCTCTGCCG GATGATCAGG GCAGAAGAAT GAGTCACTCC 60
AGGGCAATGT ATTTCTGACT GCTTTTGGGT CAACCTGTCT GAGTTTCTCA TGGTCTGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	76.19	0.00e+00	1307.00
IUUC-Ame-011138	Astyanax mexicanus	84.13	0.00e+00	847.00
IUUC-Bta-012453	Bos taurus	74.48	0.00e+00	1251.00
IUUC-Cel-018564	Caenorhabditis elegans	53.69	0.00e+00	629.00
IUUC-Cfa-020258	Canis familiaris	76.77	0.00e+00	1285.00
IUUC-Cpo-021648	Cavia porcellus	74.18	0.00e+00	1382.00
IUUC-Csa-023334	Chlorocebus sabaeus	76.94	0.00e+00	1427.00
IUUC-Cin-025157	Ciona intestinalis	64.52	0.00e+00	794.00
IUUC-Dme-032166	Drosophila melanogaster	65.36	0.00e+00	717.00
IUUC-Ete-032409	Echinops telfairi	83.13	0.00e+00	858.00
IUUC-Eca-033441	Equus caballus	76.44	0.00e+00	1418.00
IUUC-Eeu-034546	Erinaceus europaeus	66.54	0.00e+00	1032.00
IUUC-Fca-036384	Felis catus	76.94	0.00e+00	1315.00
IUUC-Fal-037547	Ficedula albicollis	86.85	0.00e+00	1555.00
IUUC-Gmo-039679	Gadus morhua	64.70	0.00e+00	1185.00
IUUC-Gga-040524	Gallus gallus	89.55	0.00e+00	1590.00
IUUC-Gac-042607	Gasterosteus aculeatus	64.05	0.00e+00	1198.00
IUUC-Hsa-046479	Homo sapiens	76.77	0.00e+00	1300.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	71.34	0.00e+00	910.00
IUUC-Lch-050445	Latimeria chalumnae	67.98	0.00e+00	1157.00
IUUC-Loc-052645	Lepisosteus oculatus	69.24	0.00e+00	1300.00
IUUC-Laf-053638	Loxodonta africana	75.09	0.00e+00	1240.00
IUUC-Mcc-055585	Macaca mulatta	76.77	0.00e+00	1293.00
IUUC-Meu-056897	Macropus eugenii	93.38	1.00e-166	580.00
IUUC-Mga-059362	Meleagris gallopavo	90.23	0.00e+00	1621.00
IUUC-Mmr-061061	Microcebus murinus	76.54	0.00e+00	1333.00
IUUC-Mpu-066567	Mustela putorius furo	77.01	0.00e+00	1462.00
IUUC-Mlu-068148	Myotis lucifugus	76.77	0.00e+00	1300.00
IUUC-Nle-069225	Nomascus leucogenys	76.19	0.00e+00	1290.00
IUUC-Ont-071664	Oreochromis niloticus	66.67	0.00e+00	1186.00
IUUC-Oan-073019	Ornithorhynchus anatinus	78.57	0.00e+00	1385.00
IUUC-Ocu-074409	Oryctolagus cuniculus	75.84	0.00e+00	1291.00
IUUC-Oga-088241	Otolemur garnettii	70.45	0.00e+00	1155.00
IUUC-Oar-089797	Ovis aries	76.85	0.00e+00	1359.00
IUUC-Psi-093618	Pelodiscus sinensis	83.84	0.00e+00	1350.00
IUUC-Pno-095118	Phaeosphaeria nodorum	49.32	2.00e-161	562.00
IUUC-Pab-098394	Pongo abelii	76.88	0.00e+00	1422.00
IUUC-Pca-100568	Procavia capensis	65.86	0.00e+00	1017.00
IUUC-Pte-104016	Pyrenophora teres	48.81	1.00e-160	559.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	48.81	1.00e-160	559.00
IUUC-Rno-106095	Rattus norvegicus	68.19	0.00e+00	1245.00
IUUC-Sha-107370	Sarcophilus harrisii	71.63	0.00e+00	1219.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.64	5.00e-152	531.00
IUUC-Sre-114929	Sporisorium reilianum	48.64	2.00e-155	542.00
IUUC-Tgu-117474	Taeniopygia guttata	86.76	0.00e+00	1569.00
IUUC-Tru-117675	Takifugu rubripes	63.81	0.00e+00	1153.00
IUUC-Tni-119993	Tetraodon nigroviridis	64.23	0.00e+00	1161.00
IUUC-Tbe-127408	Tupaia belangeri	70.72	0.00e+00	994.00
IUUC-Ttr-128437	Tursiops truncatus	68.39	0.00e+00	1001.00
IUUC-Uma-129332	Ustilago maydis	53.62	4.00e-142	498.00
IUUC-Vpa-130503	Vicugna pacos	80.61	0.00e+00	964.00
IUUC-Xtr-132431	Xenopus tropicalis	70.11	0.00e+00	1337.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence